Function of miR-212 as a tumor suppressor in thyroid cancer by targeting SIRT1

Retraction in: /10.3892/or.2021.8173

  • Authors:
    • Dandan Li
    • Lin Bai
    • Tongtong Wang
    • Qian Xie
    • Minglong Chen
    • Yantao Fu
    • Qiang Wen
  • View Affiliations

  • Published online on: November 28, 2017     https://doi.org/10.3892/or.2017.6119
  • Pages: 695-702
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Abstract

miR-212 as a tumor suppressor has been reported to be downregulated in multiple cancer cells lines and tumor tissues. However, its role in thyroid cancer has nor been investigated. Therefore, the present study aimed to investigate the role of miR-212 in human thyroid cancer and the underlying mechanisms. In the present study, we demonstrated that miR-212 expression was significantly decreased in thyroid cancer specimens and cell lines compared with adjacent normal tissues and normal thyroid cell lines. In addition, we demonstrated that miR-212 downrwegulation in thyroid cancer tissues was negatively associated with lymph node metastasis and advanced clinical stage. Functionally, ectopic expression of miR-212 by transfection with miR-212 mimic significantly inhibited proliferation, colony formation, migration and invasion in TPC-1 cells. In addition, Sirtuin 1 (SIRT1) was identified as a direct target of miR-212 and its expression was inversely correlated with miR-212 expression in thyroid cancer tissues. Overexpression of SIRT1 could effectively rescue miR-212 mimic-induced suppression of cell proliferation, migration and invasion in TPC-1 cells. In vivo, miR-212 overexpression significantly inhibited tumor growth in a nude mice model. In light of these findings, miR-212 may function as a tumor suppressor in thyroid cancer by targeting SIRT1.
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February-2018
Volume 39 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Li D, Bai L, Wang T, Xie Q, Chen M, Fu Y and Wen Q: Function of miR-212 as a tumor suppressor in thyroid cancer by targeting SIRT1 Retraction in /10.3892/or.2021.8173. Oncol Rep 39: 695-702, 2018
APA
Li, D., Bai, L., Wang, T., Xie, Q., Chen, M., Fu, Y., & Wen, Q. (2018). Function of miR-212 as a tumor suppressor in thyroid cancer by targeting SIRT1 Retraction in /10.3892/or.2021.8173. Oncology Reports, 39, 695-702. https://doi.org/10.3892/or.2017.6119
MLA
Li, D., Bai, L., Wang, T., Xie, Q., Chen, M., Fu, Y., Wen, Q."Function of miR-212 as a tumor suppressor in thyroid cancer by targeting SIRT1 Retraction in /10.3892/or.2021.8173". Oncology Reports 39.2 (2018): 695-702.
Chicago
Li, D., Bai, L., Wang, T., Xie, Q., Chen, M., Fu, Y., Wen, Q."Function of miR-212 as a tumor suppressor in thyroid cancer by targeting SIRT1 Retraction in /10.3892/or.2021.8173". Oncology Reports 39, no. 2 (2018): 695-702. https://doi.org/10.3892/or.2017.6119