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Article

MIG7 is involved in vasculogenic mimicry formation rendering invasion and metastasis in hepatocellular carcinoma

  • Authors:
    • Bo Qu
    • Guannan Sheng
    • Long Guo
    • Fei Yu
    • Guannan Chen
    • Qi Lu
    • Renjie Wang
    • Bing Han
    • Yi Lu
  • View Affiliations / Copyright

    Affiliations: Department of Oncological Surgery, Affiliated Hospital of the Logistics University of Chinese People's Armed Police Forces, Tianjin 300162, P.R. China, Department of Oncological Surgery, Postgraduate Training Basement of Jinzhou Medical University in the Affiliated Hospital of the Logistics University of Chinese People's Armed Police Forces, Tianjin 300162, P.R. China, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China, Institute of Disaster Medicine and Public Health, Affiliated Hospital of the Logistic University of Chinese People's Armed Police Force, Tianjin 300162, P.R. China, Department of clinical Laboratory, Affiliated Hospital of the Logistics University of Chinese People's Armed Police Forces, Tianjin 300162, P.R. China
  • Pages: 679-686
    |
    Published online on: December 7, 2017
       https://doi.org/10.3892/or.2017.6138
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Abstract

Migration-inducing gene 7 (MIG7) is highly expressed and is implicated in multiple malignant tumors with vasculogenic mimicry (VM) which renders possible routes without the endothelium for invasion and metastasis. However, there are few reports in the literature describing the relationship between MIG7 expression and VM formation in hepatocellular carcinoma (HCC). In the present study, we found a significantly positive correlation between MIG7 expression and VM in 40 HCC specimens. Three-dimensional (3D) culture showed that VM formation in the HCC cell line MHCC-97H with high metastatic potential was enhanced to a greater extent than that of MHCC-97L and Huh-7 with low and non-metastatic potential. There was no VM formation in human normal hepatocyte line L-02. Moreover, MIG7 expression was higher in MHCC-97H than in MHCC-97L and Huh-7 cells and non-detectable in L-02 cells. MIG7 knockdown in MHCC-97H cells reduced VM formation, and weakened the invasive properties accompanying the enhanced cellular adhesion. Notably, there was no significant effect of endostatin (ES), a broad-spectrum angiogenesis inhibitor applied to clinical treatment, on both MIG7 expression and VM formation. Thus, the present study presents a causal link between MIG7 expression and VM formation in HCC, suggesting a potential treatment target for invasion and metastasis.
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1 

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D and Bray F: Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 136:E359–E386. 2015. View Article : Google Scholar : PubMed/NCBI

2 

European Association for Study of Liver, ; European Organisation for Research and Treatment of Cancer, . EASL-EORTC clinical practice guidelines: management of hepatocellular carcinoma. Eur J Cancer. 48:599–641. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Folberg R, Hendrix MJC and Maniotis AJ: Vasculogenic mimicry and tumor angiogenesis. Am J Pathol. 156:361–381. 2000. View Article : Google Scholar : PubMed/NCBI

4 

Chen L, He Y, Sun S, Sun B and Tang X: Vasculogenic mimicry is a major feature and novel predictor of poor prognosis in patients with orbital rhabdomyosarcoma. Oncol Lett. 10:1635–1641. 2015.PubMed/NCBI

5 

Yang JP, Liao YD, Mai DM, Xie P, Qiang YY, Zheng LS, Wang MY, Mei Y, Meng DF, Xu L, et al: Tumor vasculogenic mimicry predicts poor prognosis in cancer patients: A meta-analysis. Angiogenesis. 19:191–200. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Zhao N, Sun BC, Zhao XL, Wang Y, Meng J, Che N, Dong XY and Gu Q: Role of Bcl-2 and its associated miRNAs in vasculogenic mimicry of hepatocellular carcinoma. Int J Clin Exp Pathol. 8:15759–15768. 2015.PubMed/NCBI

7 

Tang J, Wang J, Fan L, Li X, Liu N, Luo W, Wang J and Wang Y and Wang Y: cRGD inhibits vasculogenic mimicry formation by down-regulating uPA expression and reducing EMT in ovarian cancer. Oncotarget. 7:24050–24062. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Hendrix MJ, Seftor EA, Seftor RE, Chao JT, Chien DS and Chu YW: Tumor cell vascular mimicry: Novel targeting opportunity in melanoma. Pharmacol Ther. 159:83–92. 2016. View Article : Google Scholar : PubMed/NCBI

9 

Ren K, Yao N, Wang G, Tian L, Ma J, Shi X, Zhang L, Zhang J, Zhou X, Zhou G, et al: Vasculogenic mimicry: A new prognostic sign of human osteosarcoma. Hum Pathol. 45:2120–2129. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Luo F, Yang K, Liu RL, Meng C, Dang RF and Xu Y: Formation of vasculogenic mimicry in bone metastasis of prostate cancer: Correlation with cell apoptosis and senescence regulation pathways. Pathol Res Pract. 210:291–295. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Folkman J: Antiangiogenesis in cancer therapy - endostatin and its mechanisms of action. Exp Cell Res. 312:594–607. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Skovseth DK, Veuger MJ, Sorensen DR, De Angelis PM and Haraldsen G: Endostatin dramatically inhibits endothelial cell migration, vascular morphogenesis, and perivascular cell recruitment in vivo. Blood. 105:1044–1051. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Alahuhta I, Aikio M, Väyrynen O, Nurmenniemi S, Suojanen J, Teppo S, Pihlajaniemi T, Heljasvaara R, Salo T and Nyberg P: Endostatin induces proliferation of oral carcinoma cells but its effect on invasion is modified by the tumor microenvironment. Exp Cell Res. 336:130–140. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Qu B, Guo L, Ma J and Lv Y: Antiangiogenesis therapy might have the unintended effect of promoting tumor metastasis by increasing an alternative circulatory system. Med Hypotheses. 74:360–361. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Eikesdal HP and Kalluri R: Drug resistance associated with antiangiogenesis therapy. Semin Cancer Biol. 19:310–317. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Liu YR, Sun B, Zhao XL, Gu Q, Liu ZY, Dong XY, Che N and Mo J: Basal caspase-3 activity promotes migration, invasion, and vasculogenic mimicry formation of melanoma cells. Melanoma Res. 23:243–253. 2013.PubMed/NCBI

17 

Linder M and Tschernig T: Vasculogenic mimicry: Possible role of effector caspase-3, caspase-6 and caspase-7. Ann Anat. 204:114–117. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Petty AP, Garman KL, Winn VD, Spidel CM and Lindsey JS: Overexpression of carcinoma and embryonic cytotrophoblast cell-specific Mig-7 induces invasion and vessel-like structure formation. Am J Pathol. 170:1763–1780. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Feng X, Yao J, Gao X, Jing Y, Kang T, Jiang D, Jiang T, Feng J, Zhu Q, Jiang X, et al: Multi-targeting peptide-functionalized nanoparticles recognized vasculogenic mimicry, tumor neovasculature and glioma cells for enhanced anti-glioma therapy. ACS Appl Mater Interfaces. 7:27885–27899. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Ho MY, Liang CM and Liang SM: MIG-7 and phosphorylated prohibitin coordinately regulate lung cancer invasion/metastasis. Oncotarget. 6:381–393. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Li WL and Gao Q: Mig-7 enhances vasculogenic mimicry in gastric cancer cells. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 28:1142–1145. 2012.(In Chinese). PubMed/NCBI

22 

Lissitzky JC, Parriaux D, Ristorcelli E, Vérine A, Lombardo D and Verrando P: Cyclic AMP signaling as a mediator of vasculogenic mimicry in aggressive human melanoma cells in vitro. Cancer Res. 69:802–809. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Liu WB, Xu GL, Jia WD, Li JS, Ma JL, Chen K, Wang ZH, Ge YS, Ren WH, Yu JH, et al: Prognostic significance and mechanisms of patterned matrix vasculogenic mimicry in hepatocellular carcinoma. Med Oncol. 28 Suppl 1:S228–S238. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Yang Z, Sun B, Zhao X, Shao B, An J, Gu Q, Wang Y, Dong X, Zhang Y and Qiu Z: Erythropoietin and erythropoietin receptor in hepatocellular carcinoma: Correlation with vasculogenic mimicry and poor prognosis. Int J Clin Exp Pathol. 8:4033–4043. 2015.PubMed/NCBI

25 

Li S, Meng W, Guan Z, Guo Y and Han X: The hypoxia-related signaling pathways of vasculogenic mimicry in tumor treatment. Biomed Pharmacother. 80:127–135. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Liu X, Wang JH, Li S, Li LL, Huang M, Zhang YH, Liu Y, Yang YT, Ding R and Ke YQ: Histone deacetylase 3 expression correlates with vasculogenic mimicry through the phosphoinositide3-kinase/ERK-MMP-laminin5γ2 signaling pathway. Cancer Sci. 106:857–866. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Lin H, Pan JC, Zhang FM, Huang B, Chen X, Zhuang JT, Wang H, Mo CQ, Wang DH and Qiu SP: Matrix metalloproteinase-9 is required for vasculogenic mimicry by clear cell renal carcinoma cells. Urol Oncol. 33:168.e9–168.e16. 2015. View Article : Google Scholar

28 

Zang M, Zhang Y, Zhang B, Hu L, Li J, Fan Z, Wang H, Su L, Zhu Z, Li C, et al: CEACAM6 promotes tumor angiogenesis and vasculogenic mimicry in gastric cancer via FAK signaling. Biochim Biophys Acta. 1852:1020–1028. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Zhao N, Sun H, Sun B, Zhu D, Zhao X, Wang Y, Gu Q, Dong X, Liu F, Zhang Y, et al: miR-27a-3p suppresses tumor metastasis and VM by down-regulating VE-cadherin expression and inhibiting EMT: An essential role for Twist-1 in HCC. Sci Rep. 6:230912016. View Article : Google Scholar : PubMed/NCBI

30 

Vukoja V, Brandenbusch T, Tura A, Nassar K, Rohrbach DJ, Lüke M, Grisanti S and Lüke J: Expression of EphA2 in metastatic and non-metastatic primary uveal melanoma. Klin Monatsbl Augenheilkd. 232:290–297. 2016.(In German). View Article : Google Scholar : PubMed/NCBI

31 

Liao S and Gao Q: Expressions and clinical significance of vasculogenic mimicry and related protein Mig-7 and MMP-2 in gastric carcinoma. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 29:194–196. 2013.(In Chinese). PubMed/NCBI

32 

Xue R, Li R, Guo H, Guo L, Su Z, Ni X, Qi L, Zhang T, Li Q, Zhang Z, et al: Variable intra-tumor genomic heterogeneity of multiple lesions in patients with hepatocellular carcinoma. Gastroenterology. 150:998–1008. 2016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Qu B, Sheng G, Guo L, Yu F, Chen G, Lu Q, Wang R, Han B and Lu Y: MIG7 is involved in vasculogenic mimicry formation rendering invasion and metastasis in hepatocellular carcinoma. Oncol Rep 39: 679-686, 2018.
APA
Qu, B., Sheng, G., Guo, L., Yu, F., Chen, G., Lu, Q. ... Lu, Y. (2018). MIG7 is involved in vasculogenic mimicry formation rendering invasion and metastasis in hepatocellular carcinoma. Oncology Reports, 39, 679-686. https://doi.org/10.3892/or.2017.6138
MLA
Qu, B., Sheng, G., Guo, L., Yu, F., Chen, G., Lu, Q., Wang, R., Han, B., Lu, Y."MIG7 is involved in vasculogenic mimicry formation rendering invasion and metastasis in hepatocellular carcinoma". Oncology Reports 39.2 (2018): 679-686.
Chicago
Qu, B., Sheng, G., Guo, L., Yu, F., Chen, G., Lu, Q., Wang, R., Han, B., Lu, Y."MIG7 is involved in vasculogenic mimicry formation rendering invasion and metastasis in hepatocellular carcinoma". Oncology Reports 39, no. 2 (2018): 679-686. https://doi.org/10.3892/or.2017.6138
Copy and paste a formatted citation
x
Spandidos Publications style
Qu B, Sheng G, Guo L, Yu F, Chen G, Lu Q, Wang R, Han B and Lu Y: MIG7 is involved in vasculogenic mimicry formation rendering invasion and metastasis in hepatocellular carcinoma. Oncol Rep 39: 679-686, 2018.
APA
Qu, B., Sheng, G., Guo, L., Yu, F., Chen, G., Lu, Q. ... Lu, Y. (2018). MIG7 is involved in vasculogenic mimicry formation rendering invasion and metastasis in hepatocellular carcinoma. Oncology Reports, 39, 679-686. https://doi.org/10.3892/or.2017.6138
MLA
Qu, B., Sheng, G., Guo, L., Yu, F., Chen, G., Lu, Q., Wang, R., Han, B., Lu, Y."MIG7 is involved in vasculogenic mimicry formation rendering invasion and metastasis in hepatocellular carcinoma". Oncology Reports 39.2 (2018): 679-686.
Chicago
Qu, B., Sheng, G., Guo, L., Yu, F., Chen, G., Lu, Q., Wang, R., Han, B., Lu, Y."MIG7 is involved in vasculogenic mimicry formation rendering invasion and metastasis in hepatocellular carcinoma". Oncology Reports 39, no. 2 (2018): 679-686. https://doi.org/10.3892/or.2017.6138
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