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February-2018 Volume 39 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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Article

In vitro and in vivo anticancer effects of marmesin in U937 human leukemia cells are mediated via mitochondrial-mediated apoptosis, cell cycle arrest, and inhibition of cancer cell migration

Retraction in: /10.3892/or.2021.8065
  • Authors:
    • Lin Dong
    • Wen-Wei Xu
    • Hong Li
    • Ke-Hong Bi
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Qianfoshan Hospital Affiliated to Shandong University, Jinan, Shandong 250014, P.R. China
  • Pages: 597-602
    |
    Published online on: December 11, 2017
       https://doi.org/10.3892/or.2017.6147
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Abstract

Leukemia is one of the highly lethal cancers among all pediatric cancers. With limited drug options and the severe side effects associated with the current chemotherapy, there is pressing need to look for new and novel anticancer agents. Against this backdrop, in the present study we evaluated the anticancer activity of a natural coumarin, marmesin against human leukemia cell line U937 and normal human monocytes It was observed that marmesin exhibited an IC50 value of 40 µM and exerted its cytotoxic effects in a dose-dependent manner. However, the cytotoxic effects of marmesin were comparatively lower for the normal human monocytes as evident from the IC50 of 125 µM. Our results indicated that marmesin inhibits colony formation and induces apoptosis dose-dependently. We also investigated the effect of marmesin on the expression of Bax and Bcl-2 proteins. It was observed that marmesin treatment triggered upregulation of Bax and downregulation of Bcl-2 causing significant increase in the Bax/Bcl-2 ratio, marmesin could also induce ROS mediated alterations in mitochondrial membrane potential. Additionally, marmesin induced G2/M cell cycle arrest and significantly inhibited cell migration potential of leukemia cells at the IC50. Remarkably, marmesin prevent tumor growth significantly in vivo at the dosage of 30 mg/kg in vivo. These results strongly indicate that marmesin may prove to be a novel anticancer lead for the management of leukemia.
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View References

1 

Mardiros A, Brown CE, Budde LE, Wang X and Forman SJ: Acute myeloid leukemia therapeutics: CARs in the driver's seat. Oncoimmunology. 2:e272142013. View Article : Google Scholar : PubMed/NCBI

2 

Hoffbrand AV, Moss PAH and Pettit JE: Essential haematology. 5th. Wiley-Blackwell; Malden, MA: 2006

3 

Badura S, Tesanovic T, Pfeifer H, Wystub S, Nijmeijer BA, Liebermann M, Falkenburg JH, Ruthardt M and Ottmann OG: Differential effects of selective inhibitors targeting the PI3K/AKT/mTOR pathway in acute lymphoblastic leukemia. PLoS One. 8:e800702013. View Article : Google Scholar : PubMed/NCBI

4 

Baba SA, Malik AH, Wani ZA, Mohiuddin T, Shah Z, Abbas N and Ashraf N: Phytochemical analysis and antioxidant activity of different tissue types of Crocus sativus and oxidative stress alleviating potential of saffron extract in plants, bacteria, and yeast. S Afr J Bot. 31:80–87. 2015. View Article : Google Scholar

5 

Yadav JP and Panghal M: Balanitesaegyptiaca (L.) Del. (Hingot): A review of its traditional uses, phytochemistry and pharmacological properties. Int J Green Pharm. 4:140–145. 2010. View Article : Google Scholar

6 

Chipuk JE, Bouchier-Hayes L and Green DR: Mitochondrial outer membrane permeabilization during apoptosis: The innocent bystander scenario. Cell Death Differ. 13:1396–1402. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Maitra R, Porter MA, Huang S and Gilmour BP: Inhibition of NFkappaB by the natural product Withaferin A in cellular models of cystic fibrosis inflammation. J Inflamm (Lond). 6:152009. View Article : Google Scholar : PubMed/NCBI

8 

Hissin PJ and Hilf R: A fluorometric method for determination of oxidized and reduced glutathione in tissues. Anal Biochem. 74:214–226. 1976. View Article : Google Scholar : PubMed/NCBI

9 

Azuma M, Tamatani T, Ashida Y, Takashima R, Harada K and Sato M: Cisplatin induces apoptosis in oral squamous carcinoma cells by the mitochondria-mediated but not the NF-kappaB-suppressed pathway. Oral Oncol. 39:282–289. 2003. View Article : Google Scholar : PubMed/NCBI

10 

Amirghofran Z, Bahmani M, Azadmehr A and Javidnia K: Induction of apoptosis in leukemia cell lines by Linum persicum and Euphorbia cheiradenia. J Cancer Res Clin Oncol. 132:427–432. 2006. View Article : Google Scholar : PubMed/NCBI

11 

Yoneda K, Yamamoto T and Osaki T: p53- and p21-independent apoptosis of squamous cell carcinoma cells induced by 5-fluorouracil and radiation. Oral Oncol. 34:529–537. 1998. View Article : Google Scholar : PubMed/NCBI

12 

Abal M, Andreu JM and Barasoain I: Taxanes: Microtubule and centrosome targets, and cell cycle dependent mechanisms of action. Curr Cancer Drug Targets. 3:193–203. 2003. View Article : Google Scholar : PubMed/NCBI

13 

Ferreira CG, Epping M, Kruyt FA and Giaccone G: Apoptosis: Target of cancer therapy. Clin Cancer Res. 8:2024–2034. 2002.PubMed/NCBI

14 

Malaguarnera L: Implications of apoptosis regulators in tumorigenesis. Cancer Metastasis Rev. 23:367–387. 2004. View Article : Google Scholar : PubMed/NCBI

15 

Ding H, Han C, Guo D, Chin YW, Ding Y, Kinghorn AD and D'Ambrosio SM: Selective induction of apoptosis of human oral cancer cell lines by avocado extracts via a ROS-mediated mechanism. Nutr Cancer. 61:348–356. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Kowaltowski AJ, de Souza-Pinto NC, Castilho RF and Vercesi AE: Mitochondria and reactive oxygen species. Free Radic Biol Med. 47:333–343. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Khursheed A, Rather MA and Rashid R: Plant-based natural compounds and herbal extracts as promising apoptotic agents: Their implications for cancer prevention and treatment. Adv Biomed Pharma. 3:225–248. 2016. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Dong L, Xu W, Li H and Bi K: In vitro and in vivo anticancer effects of marmesin in U937 human leukemia cells are mediated via mitochondrial-mediated apoptosis, cell cycle arrest, and inhibition of cancer cell migration Retraction in /10.3892/or.2021.8065. Oncol Rep 39: 597-602, 2018.
APA
Dong, L., Xu, W., Li, H., & Bi, K. (2018). In vitro and in vivo anticancer effects of marmesin in U937 human leukemia cells are mediated via mitochondrial-mediated apoptosis, cell cycle arrest, and inhibition of cancer cell migration Retraction in /10.3892/or.2021.8065. Oncology Reports, 39, 597-602. https://doi.org/10.3892/or.2017.6147
MLA
Dong, L., Xu, W., Li, H., Bi, K."In vitro and in vivo anticancer effects of marmesin in U937 human leukemia cells are mediated via mitochondrial-mediated apoptosis, cell cycle arrest, and inhibition of cancer cell migration Retraction in /10.3892/or.2021.8065". Oncology Reports 39.2 (2018): 597-602.
Chicago
Dong, L., Xu, W., Li, H., Bi, K."In vitro and in vivo anticancer effects of marmesin in U937 human leukemia cells are mediated via mitochondrial-mediated apoptosis, cell cycle arrest, and inhibition of cancer cell migration Retraction in /10.3892/or.2021.8065". Oncology Reports 39, no. 2 (2018): 597-602. https://doi.org/10.3892/or.2017.6147
Copy and paste a formatted citation
x
Spandidos Publications style
Dong L, Xu W, Li H and Bi K: In vitro and in vivo anticancer effects of marmesin in U937 human leukemia cells are mediated via mitochondrial-mediated apoptosis, cell cycle arrest, and inhibition of cancer cell migration Retraction in /10.3892/or.2021.8065. Oncol Rep 39: 597-602, 2018.
APA
Dong, L., Xu, W., Li, H., & Bi, K. (2018). In vitro and in vivo anticancer effects of marmesin in U937 human leukemia cells are mediated via mitochondrial-mediated apoptosis, cell cycle arrest, and inhibition of cancer cell migration Retraction in /10.3892/or.2021.8065. Oncology Reports, 39, 597-602. https://doi.org/10.3892/or.2017.6147
MLA
Dong, L., Xu, W., Li, H., Bi, K."In vitro and in vivo anticancer effects of marmesin in U937 human leukemia cells are mediated via mitochondrial-mediated apoptosis, cell cycle arrest, and inhibition of cancer cell migration Retraction in /10.3892/or.2021.8065". Oncology Reports 39.2 (2018): 597-602.
Chicago
Dong, L., Xu, W., Li, H., Bi, K."In vitro and in vivo anticancer effects of marmesin in U937 human leukemia cells are mediated via mitochondrial-mediated apoptosis, cell cycle arrest, and inhibition of cancer cell migration Retraction in /10.3892/or.2021.8065". Oncology Reports 39, no. 2 (2018): 597-602. https://doi.org/10.3892/or.2017.6147
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