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Article

Inhibition effect of triptolide on human epithelial ovarian cancer via adjusting cellular immunity and angiogenesis

  • Authors:
    • Hui Hu
    • Genhua Huang
    • Haibin Wang
    • Xiaoli Li
    • Xiaobing Wang
    • Ying Feng
    • Buzhen Tan
    • Tingtao Chen
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China, Institute of Translational Medicine, Nanchang University, Nanchang, Jiangxi 330031, P.R. China
  • Pages: 1191-1196
    |
    Published online on: December 15, 2017
       https://doi.org/10.3892/or.2017.6158
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Abstract

Chemotherapy resistance of advanced ovarian cancers is responsible for death of most cancer patients, so it is necessary to seek safe and effective natural ingredients to lower the chemotherapy resistance of ovarian cancer. In the present study, we studied the anticancer effects of triptolide (TPL) and TPL + cisplatin (DDP) in vitro and in vivo using SKOV3/DDP cell line and a mouse model. In vitro results showed that TPL and TPL + DDP inhibited cellular invasion and migration of SKOV3/DDP cells (P<0.05), and significantly reduced the expression of adhesion-related proteins integrin β1 (ITGβ1) and apoptosis-inhibiting proteins survivin, matrix metalloproteinase 2 (MMP-2) and MMP-9 (P<0.05). Animal results demonstrated that TPL and TPL + DDP had significantly enhanced the inflammatory factor-2 (IL-2) and tumor necrosis factor-α (TNF-α) in serum of mice, and significantly increased the NK cell-related protein levels of CD16 and CD56, while significantly inhibited the production of vascular endothelial growth factor (VEGF) related protein clusters of differentiation 31 (CD31) and CD105. Collectively, the combination of TPL and DDP may produce a synergistic anticancer effect on epithelial ovarian cancer (EOC).
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Copy and paste a formatted citation
Spandidos Publications style
Hu H, Huang G, Wang H, Li X, Wang X, Feng Y, Tan B and Chen T: Inhibition effect of triptolide on human epithelial ovarian cancer via adjusting cellular immunity and angiogenesis. Oncol Rep 39: 1191-1196, 2018.
APA
Hu, H., Huang, G., Wang, H., Li, X., Wang, X., Feng, Y. ... Chen, T. (2018). Inhibition effect of triptolide on human epithelial ovarian cancer via adjusting cellular immunity and angiogenesis. Oncology Reports, 39, 1191-1196. https://doi.org/10.3892/or.2017.6158
MLA
Hu, H., Huang, G., Wang, H., Li, X., Wang, X., Feng, Y., Tan, B., Chen, T."Inhibition effect of triptolide on human epithelial ovarian cancer via adjusting cellular immunity and angiogenesis". Oncology Reports 39.3 (2018): 1191-1196.
Chicago
Hu, H., Huang, G., Wang, H., Li, X., Wang, X., Feng, Y., Tan, B., Chen, T."Inhibition effect of triptolide on human epithelial ovarian cancer via adjusting cellular immunity and angiogenesis". Oncology Reports 39, no. 3 (2018): 1191-1196. https://doi.org/10.3892/or.2017.6158
Copy and paste a formatted citation
x
Spandidos Publications style
Hu H, Huang G, Wang H, Li X, Wang X, Feng Y, Tan B and Chen T: Inhibition effect of triptolide on human epithelial ovarian cancer via adjusting cellular immunity and angiogenesis. Oncol Rep 39: 1191-1196, 2018.
APA
Hu, H., Huang, G., Wang, H., Li, X., Wang, X., Feng, Y. ... Chen, T. (2018). Inhibition effect of triptolide on human epithelial ovarian cancer via adjusting cellular immunity and angiogenesis. Oncology Reports, 39, 1191-1196. https://doi.org/10.3892/or.2017.6158
MLA
Hu, H., Huang, G., Wang, H., Li, X., Wang, X., Feng, Y., Tan, B., Chen, T."Inhibition effect of triptolide on human epithelial ovarian cancer via adjusting cellular immunity and angiogenesis". Oncology Reports 39.3 (2018): 1191-1196.
Chicago
Hu, H., Huang, G., Wang, H., Li, X., Wang, X., Feng, Y., Tan, B., Chen, T."Inhibition effect of triptolide on human epithelial ovarian cancer via adjusting cellular immunity and angiogenesis". Oncology Reports 39, no. 3 (2018): 1191-1196. https://doi.org/10.3892/or.2017.6158
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