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Article Open Access

Paeoniflorin exerts antitumor effects by inactivating S phase kinase-associated protein 2 in glioma cells

  • Authors:
    • Jia Ouyang
    • Hui Xu
    • Ming Li
    • Xingliang Dai
    • Fengqing Fu
    • Xueguang Zhang
    • Qing Lan
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, the Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, P.R. China, Clinical Immunology Institute, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China
    Copyright: © Ouyang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1052-1062
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    Published online on: December 28, 2017
       https://doi.org/10.3892/or.2017.6175
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Abstract

Paeoniflorin (PF), a natural compound isolated from Paeoniae radix, has been shown to exert antitumor effects in various types of human cancers including glioma. However, the mechanism of action is not well understood. S-phase kinase-associated protein (Skp)2 functions as an oncogene in many cancers. In the present study, we investigated whether Skp2 mediates the anti-glioma activity of PF. We found that PF inhibited glioma cell proliferation, migration and invasion, and induced G2/M arrest and apoptosis. Skp2 expression was downregulated in glioma cells treated with PF. PF-induced antitumor effects in glioma cells were abolished by Skp2 overexpression but were enhanced by RNA interference of Skp2. Moreover, PF treatment inhibited U87 cell-derived tumor growth in a xenograft mouse model. These results demonstrate that PF exerts its antitumor effects in part by inhibiting Skp2 expression in glioma cells and could be a promising therapeutic agent for glioma therapy.
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Copy and paste a formatted citation
Spandidos Publications style
Ouyang J, Xu H, Li M, Dai X, Fu F, Zhang X and Lan Q: Paeoniflorin exerts antitumor effects by inactivating S phase kinase-associated protein 2 in glioma cells. Oncol Rep 39: 1052-1062, 2018.
APA
Ouyang, J., Xu, H., Li, M., Dai, X., Fu, F., Zhang, X., & Lan, Q. (2018). Paeoniflorin exerts antitumor effects by inactivating S phase kinase-associated protein 2 in glioma cells. Oncology Reports, 39, 1052-1062. https://doi.org/10.3892/or.2017.6175
MLA
Ouyang, J., Xu, H., Li, M., Dai, X., Fu, F., Zhang, X., Lan, Q."Paeoniflorin exerts antitumor effects by inactivating S phase kinase-associated protein 2 in glioma cells". Oncology Reports 39.3 (2018): 1052-1062.
Chicago
Ouyang, J., Xu, H., Li, M., Dai, X., Fu, F., Zhang, X., Lan, Q."Paeoniflorin exerts antitumor effects by inactivating S phase kinase-associated protein 2 in glioma cells". Oncology Reports 39, no. 3 (2018): 1052-1062. https://doi.org/10.3892/or.2017.6175
Copy and paste a formatted citation
x
Spandidos Publications style
Ouyang J, Xu H, Li M, Dai X, Fu F, Zhang X and Lan Q: Paeoniflorin exerts antitumor effects by inactivating S phase kinase-associated protein 2 in glioma cells. Oncol Rep 39: 1052-1062, 2018.
APA
Ouyang, J., Xu, H., Li, M., Dai, X., Fu, F., Zhang, X., & Lan, Q. (2018). Paeoniflorin exerts antitumor effects by inactivating S phase kinase-associated protein 2 in glioma cells. Oncology Reports, 39, 1052-1062. https://doi.org/10.3892/or.2017.6175
MLA
Ouyang, J., Xu, H., Li, M., Dai, X., Fu, F., Zhang, X., Lan, Q."Paeoniflorin exerts antitumor effects by inactivating S phase kinase-associated protein 2 in glioma cells". Oncology Reports 39.3 (2018): 1052-1062.
Chicago
Ouyang, J., Xu, H., Li, M., Dai, X., Fu, F., Zhang, X., Lan, Q."Paeoniflorin exerts antitumor effects by inactivating S phase kinase-associated protein 2 in glioma cells". Oncology Reports 39, no. 3 (2018): 1052-1062. https://doi.org/10.3892/or.2017.6175
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