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Article

Garcinone C exerts antitumor activity by modulating the expression of ATR/Stat3/4E‑BP1 in nasopharyngeal carcinoma cells

  • Authors:
    • Yudui Xia
    • Xia Liu
    • Chunlin Zou
    • Shixiu Feng
    • Hongwei Guo
    • Yeguo Yang
    • Yong Lei
    • Jian Zhang
    • Yi Lu
  • View Affiliations / Copyright

    Affiliations: Key Laboratory of Longevity and Ageing‑Related Diseases, Ministry of Education, Nanning, Guangxi 530021, P.R. China, Key Laboratory of Southern Subtropical Plant Diversity, Shenzhen Fairy Lake Botanical Garden, Chinese Academy of Sciences, Shenzhen, Guangdong 518004, P.R. China
  • Pages: 1485-1493
    |
    Published online on: January 16, 2018
       https://doi.org/10.3892/or.2018.6218
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Abstract

Nasopharyngeal carcinoma (NPC) is one of the most common head and neck malignancies and is typically treated with radiotherapy and chemotherapy. Garcinone C, a natural compound isolated from Garcinia oblongifolia Champ., is a xanthone derivative with potential cytotoxic effects on certain cancers. However, there are limited studies regarding its effects on NPC cells, and its mechanism of action in NPC remains unknown. In the present study, we found that garcinone C significantly inhibited cell viability of the human NPC cell lines CNE1, CNE2, HK1 and HONE1. This inhibition was exerted in a time‑ and dose‑dependent manner. Flow cytometry demonstrated that garcinone C arrested the cell cycle at the S phase. Moreover, with 10 µM of high‑dose garcinone C treatment, the cells exhibited necrotic morphology changes including cell swelling, rough endoplasmic reticulum degranulation, endoplasmic reticulum dilatation, mitochondrial swelling and vacuolar degeneration. In addition, we found that garcinone C stimulated the expression levels of ATR and 4E‑BP1, while efficiently inhibiting the expression levels of cyclin B1, cyclin D1, cyclin E2, cdc2, CDK7 and Stat3. Collectively, the ability of garcinone C to inhibit NPC in growth in vitro suggested that garcinone C may be a novel agent for the management of NPC.
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1 

Zou M, Zhang X and Xu C: IL6-induced metastasis modulators p-STAT3, MMP-2 and MMP-9 are targets of 3,3′-diindolylmethane in ovarian cancer cells. Cell Oncol (Dordr). 39:47–57. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Guigay J, Temam S, Bourhis J, Pignon JP and Armand JP: Nasopharyngeal carcinoma and therapeutic management: The place of chemotherapy. Ann Oncol. 17 Suppl 10:x304–x307. 2006. View Article : Google Scholar : PubMed/NCBI

3 

Shanmugaratnam K: Histological typing of nasopharyngeal carcinoma. IARC Sci Publ. 1–12. 1978.

4 

Liu X, Gao Y, Lu Y, Zhang J, Li L and Yin F: Downregulation of NEK11 is associated with drug resistance in ovarian cancer. Int J Oncol. 45:1266–1274. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Wang L, Kuang L, Pan X, Liu J, Wang Q, Du B, Li D, Luo J, Liu M, Hou A and Qian M: Isoalvaxanthone inhibits colon cancer cell proliferation, migration and invasion through inactivating Rac1 and AP-1. Int J Cancer. 127:1220–1229. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Aisha AF, Abu-Salah KM, Ismail Z and Majid AM: In vitro and in vivo anti-colon cancer effects of Garcinia mangostana xanthones extract. BMC Complement Altern Med. 12:1042012. View Article : Google Scholar : PubMed/NCBI

7 

Panda SS, Chand M, Sakhuja R and Jain SC: Xanthones as potential antioxidants. Curr Med Chem. 20:4481–4507. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Yi T, Yi Z, Cho SG, Luo J, Pandey MK, Aggarwal BB and Liu M: Gambogic acid inhibits angiogenesis and prostate tumor growth by suppressing vascular endothelial growth factor receptor 2 signaling. Cancer Res. 68:1843–1850. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Rong JJ, Hu R, Song XM, Ha J, Lu N, Qi Q, Tao L, You QD and Guo QL: Gambogic acid triggers DNA damage signaling that induces p53/p21Waf1/CIP1 activation through the ATR-Chk1 pathway. Cancer Lett. 296:55–64. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Wang X and Chen W: Gambogic acid is a novel anti-cancer agent that inhibits cell proliferation, angiogenesis and metastasis. Anticancer Agents Med Chem. 12:994–1000. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Shi X, Chen X, Li X, Lan X, Zhao C, Liu S, Huang H, Liu N, Liao S, Song W, et al: Gambogic acid induces apoptosis in imatinib-resistant chronic myeloid leukemia cells via inducing proteasome inhibition and caspase-dependent Bcr-Abl downregulation. Clin Cancer Res. 20:151–163. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Zhang H, Lei Y, Yuan P, Li L, Luo C, Gao R, Tian J, Feng Z, Nice EC and Sun J: ROS-mediated autophagy induced by dysregulation of lipid metabolism plays a protective role in colorectal cancer cells treated with gambogic acid. PLoS One. 9:e964182014. View Article : Google Scholar : PubMed/NCBI

13 

Shibata MA, Iinuma M, Morimoto J, Kurose H, Akamatsu K, Okuno Y, Akao Y and Otsuki Y: α-Mangostin extracted from the pericarp of the mangosteen (Garcinia mangostana Linn) reduces tumor growth and lymph node metastasis in an immunocompetent xenograft model of metastatic mammary cancer carrying a p53 mutation. BMC Med. 9:692011. View Article : Google Scholar : PubMed/NCBI

14 

Jittiporn K, Suwanpradid J, Patel C, Rojas M, Thirawarapan S, Moongkarndi P, Suvitayavat W and Caldwell RB: Anti-angiogenic actions of the mangosteen polyphenolic xanthone derivative α-mangostin. Microvasc Res. 93:72–79. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Lei J, Huo X, Duan W, Xu Q, Li R, Ma J, Li X, Han L, Li W, Sun H, et al: α-Mangostin inhibits hypoxia-driven ROS-induced PSC activation and pancreatic cancer cell invasion. Cancer Lett. 347:129–138. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Li P, Tian W and Ma X: Alpha-mangostin inhibits intracellular fatty acid synthase and induces apoptosis in breast cancer cells. Mol Cancer. 13:1382014. View Article : Google Scholar : PubMed/NCBI

17 

Fu M, Qiu SX, Xu Y, Wu J, Chen Y, Yu Y and Xiao G: A new xanthone from the pericarp of Garcinia mangostana. Nat Prod Commun. 8:1733–1734. 2013.PubMed/NCBI

18 

Poon RY: DNA damage checkpoints in nasopharyngeal carcinoma. Oral Oncol. 50:339–344. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Johnson SW, Ozols RF and Hamilton TC: Mechanisms of drug resistance in ovarian cancer. Cancer. 71(2 Supp1): S644–S649. 1993.

20 

Sancar A, Lindsey-Boltz LA, Unsal-Kacmaz K and Linn S: Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annu Rev Biochem. 73:39–85. 2004. View Article : Google Scholar : PubMed/NCBI

21 

Fink SL and Cookson BT: Apoptosis, pyroptosis, and necrosis: Mechanistic description of dead and dying eukaryotic cells. Infect Immun. 73:1907–1916. 2005. View Article : Google Scholar : PubMed/NCBI

22 

Bromberg JF, Wrzeszczynska MH, Devgan G, Zhao Y, Pestell RG, Albanese C and Darnell JE Jr: Stat3 as an oncogene. Cell. 98:295–303. 1999. View Article : Google Scholar : PubMed/NCBI

23 

Liao Q, Zeng Z, Guo X, Li X, Wei F, Zhang W, Li X, Chen P, Liang F, Xiang B, et al: LPLUNC1 suppresses IL-6-induced nasopharyngeal carcinoma cell proliferation via inhibiting the Stat3 activation. Oncogene. 33:2098–2109. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Constantinou C, Elia A and Clemens MJ: Activation of p53 stimulates proteasome-dependent truncation of eIF4E-binding protein 1 (4E-BP1). Biol Cell. 100:279–289. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Chakravarthy R, Clemens MJ, Pirianov G, Perdios N, Mudan S, Cartwright JE and Elia A: Role of the eIF4E binding protein 4E-BP1 in regulation of the sensitivity of human pancreatic cancer cells to TRAIL and celastrol-induced apoptosis. Biol Cell. 105:414–429. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Ma BB, Lui VW, Hui CW, Lau CP, Wong CH, Hui EP, Ng MH, Tsao SW, Li Y and Chan AT: Preclinical evaluation of the AKT inhibitor MK-2206 in nasopharyngeal carcinoma cell lines. Invest New Drugs. 31:567–575. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Xia Y, Liu X, Zou C, Feng S, Guo H, Yang Y, Lei Y, Zhang J and Lu Y: Garcinone C exerts antitumor activity by modulating the expression of ATR/Stat3/4E‑BP1 in nasopharyngeal carcinoma cells. Oncol Rep 39: 1485-1493, 2018.
APA
Xia, Y., Liu, X., Zou, C., Feng, S., Guo, H., Yang, Y. ... Lu, Y. (2018). Garcinone C exerts antitumor activity by modulating the expression of ATR/Stat3/4E‑BP1 in nasopharyngeal carcinoma cells. Oncology Reports, 39, 1485-1493. https://doi.org/10.3892/or.2018.6218
MLA
Xia, Y., Liu, X., Zou, C., Feng, S., Guo, H., Yang, Y., Lei, Y., Zhang, J., Lu, Y."Garcinone C exerts antitumor activity by modulating the expression of ATR/Stat3/4E‑BP1 in nasopharyngeal carcinoma cells". Oncology Reports 39.3 (2018): 1485-1493.
Chicago
Xia, Y., Liu, X., Zou, C., Feng, S., Guo, H., Yang, Y., Lei, Y., Zhang, J., Lu, Y."Garcinone C exerts antitumor activity by modulating the expression of ATR/Stat3/4E‑BP1 in nasopharyngeal carcinoma cells". Oncology Reports 39, no. 3 (2018): 1485-1493. https://doi.org/10.3892/or.2018.6218
Copy and paste a formatted citation
x
Spandidos Publications style
Xia Y, Liu X, Zou C, Feng S, Guo H, Yang Y, Lei Y, Zhang J and Lu Y: Garcinone C exerts antitumor activity by modulating the expression of ATR/Stat3/4E‑BP1 in nasopharyngeal carcinoma cells. Oncol Rep 39: 1485-1493, 2018.
APA
Xia, Y., Liu, X., Zou, C., Feng, S., Guo, H., Yang, Y. ... Lu, Y. (2018). Garcinone C exerts antitumor activity by modulating the expression of ATR/Stat3/4E‑BP1 in nasopharyngeal carcinoma cells. Oncology Reports, 39, 1485-1493. https://doi.org/10.3892/or.2018.6218
MLA
Xia, Y., Liu, X., Zou, C., Feng, S., Guo, H., Yang, Y., Lei, Y., Zhang, J., Lu, Y."Garcinone C exerts antitumor activity by modulating the expression of ATR/Stat3/4E‑BP1 in nasopharyngeal carcinoma cells". Oncology Reports 39.3 (2018): 1485-1493.
Chicago
Xia, Y., Liu, X., Zou, C., Feng, S., Guo, H., Yang, Y., Lei, Y., Zhang, J., Lu, Y."Garcinone C exerts antitumor activity by modulating the expression of ATR/Stat3/4E‑BP1 in nasopharyngeal carcinoma cells". Oncology Reports 39, no. 3 (2018): 1485-1493. https://doi.org/10.3892/or.2018.6218
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