Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
April-2018 Volume 39 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2018 Volume 39 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Secretory leukocyte peptidase inhibitor expression and apoptosis effect in oral leukoplakia and oral squamous cell carcinoma

  • Authors:
    • Xin Wang
    • Yu Jin
    • Yue-Xiu Li
    • Ya Yang
  • View Affiliations / Copyright

    Affiliations: Department of General Dentistry, The Ninth People's Hospital Affiliated to Shanghai JiaoTong University School of Medicine, Shanghai 200000, P.R. China, Department of Stomatology, Tai'an Central Hospital, Tai'an, Shandong 271000, P.R. China
  • Pages: 1793-1804
    |
    Published online on: February 7, 2018
       https://doi.org/10.3892/or.2018.6251
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Oral leukoplakia (OL) is one of the most common oral precancerous lesions with the possibility of malignant transformation, ranging from 17 to 24% of patients with a median follow-up of >7 years. Previous research has revealed that compared with normal oral epithelial tissues, the expression of secretory leukocyte peptidase inhibitor (SLPI) protein is significantly reduced in oral squamous cell carcinoma (OSCC). Based on the above-mentioned research, it is known that SLPI is a potential predictive and diagnostic tool for the progression of oral carcinogenesis. Therefore, we investigated the correlation between the abundance of SLPI protein and the different histological grades of OL by immunohistochemistry. The results indicated that the level of SLPI was negatively correlated with the histological grades of the oral premalignant lesions, indicating that it may be a potential predictive tool for the malignant transformation presented in oral precancerous patients. Subsequently, we investigated the biological effects of SLPI using Cell Counting Kit (CCK)-8, Annexin V/PI apoptosis assay and Caspase-Glo® 3/7 assay. The findings revealed that SLPI promoted apoptosis in the Leuk1 and WSU-HN4 cell lines. Mechanistic studies indicated that SLPI, at least in part, regulated cell apoptosis by inhibiting the expression of TNF receptor-associated factor 1 (TRAF1), which has a close relationship with the nuclear factor-κB (NF-κB) pathway.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Ding YM, Dong JH, Chen LL and Zhang HD: Increased expression of galectin-1 is associated with human oral squamous cell carcinoma development. Oncol Rep. 21:983–987. 2009.PubMed/NCBI

3 

Yang Y, Rhodus NL, Ondrey FG, Wuertz BR, Chen X, Zhu Y and Griffin TJ: Quantitative proteomic analysis of oral brush biopsies identifies secretory leukocyte protease inhibitor as a promising, mechanism-based oral cancer biomarker. PLoS One. 9:e953892014. View Article : Google Scholar : PubMed/NCBI

4 

Bouchard D, Morisset D, Bourbonnais Y and Tremblay GM: Proteins with whey-acidic-protein motifs and cancer. Lancet Oncol. 7:167–174. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Cordes C, Häsler R, Werner C, Görögh T, Röcken C, Hebebrand L, Kast WM, Hoffmann M, Schreiber S and Ambrosch P: The level of secretory leukocyte protease inhibitor is decreased in metastatic head and neck squamous cell carcinoma. Int J Oncol. 39:185–191. 2011.PubMed/NCBI

6 

Scott A, Weldon S and Taggart CC: SLPI and elafin: Multifunctional antiproteases of the WFDC family. Biochem Soc Trans. 39:1437–1440. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Williams SE, Brown TI, Roghanian A and Sallenave JM: SLPI and elafin: One glove, many fingers. Clin Sci. 110:21–35. 2006. View Article : Google Scholar : PubMed/NCBI

8 

Zuo J, Zhang C, Ren C, Pang D, Li Y, Xie X, Tang Z and Jiang X: Secretory leukocyte protease inhibitor is a proliferation and survival factor for pancreatic cancer cells. Clin Transl Oncol. 17:314–321. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Cheng WL, Wang CS, Huang YH, Liang Y, Lin PY, Hsueh C, Wu YC, Chen WJ, Yu CJ, Lin SR and Lin KH: Overexpression of a secretory leukocyte protease inhibitor in human gastric cancer. Int J Cancer. 123:1787–1796. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Brodt P, Fallavollita L, Khatib AM, Samani AA and Zhang D: Cooperative regulation of the invasive and metastatic phenotypes by different domains of the type I insulin-like growth factor receptor beta subunit. J Biol Chem. 276:33608–33615. 2001. View Article : Google Scholar : PubMed/NCBI

11 

Jan Treda C, Fukuhara T, Suzuki T, Nakamura A, Zaini J, Kikuchi T, Ebina M and Nukiwa T: Secretory leukocyte protease inhibitor modulates urethane-induced lung carcinogenesis. Carcinogenesis. 35:896–904. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Velarde MC, Parisek SI, Eason RR, Simmen FA and Simmen RC: The secretory leukocyte protease inhibitor gene is a target of epidermal growth factor receptor action in endometrial epithelial cells. J Endocrinol. 184:141–151. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Tsukishiro S, Suzumori N, Nishikawa H, Arakawa A and Suzumori K: Use of serum secretory leukocyte protease inhibitor levels in patients to improve specificity of ovarian cancer diagnosis. Gynecol Oncol. 96:516–519. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Tse KP, Wu CS, Hsueh C, Chang KP, Hao SP, Chang YS and Tsang NM: The relationship between secretory leukocyte protease inhibitor expression and Epstein-Barr virus status among patients with nasopharyngeal carcinoma. Anticancer Res. 32:1299–1307. 2012.PubMed/NCBI

15 

Quabius ES, Görögh T, Fischer GS, Hoffmann AS, Gebhard M, Evert M, Beule A, Maune S, Knecht R, Óvári A, et al: The antileukoprotease secretory leukocyte protease inhibitor (SLPI) and its role in the prevention of HPV-infections in head and neck squamous cell carcinoma. Cancer Lett. 357:339–345. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Rosso M, Lapyckyj L, Amiano N, Besso MJ, Sánchez M, Chuluyan E and Vazquez-Levin MH: Secretory Leukocyte Protease Inhibitor (SLPI) expression downregulates E-cadherin, induces β-catenin re-localisation and triggers apoptosis-related events in breast cancer cells. Biol Cell. 106:308–322. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Simpkins FA, Devoogdt NM, Rasool N, Tchabo NE, Alejandro EU, Kamrava MM and Kohn EC: The alarm anti-protease, secretory leukocyte protease inhibitor, is a proliferation and survival factor for ovarian cancer cells. Carcinogenesis. 29:466–472. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Wen J, Nikitakis NG, Chaisuparat R, Greenwell-Wild T, Gliozzi M, Jin W, Adli A, Moutsopoulos N, Wu T, Warburton G and Wahl SM: Secretory leukocyte protease inhibitor (SLPI) expression and tumor invasion in oral squamous cell carcinoma. Am J Pathol. 178:2866–2878. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Sano C, Shimizu T and Tomioka H: Effects of secretory leukocyte protease inhibitor on the tumor necrosis factor-alpha production and NF-kappaB activation of lipopolysaccharide-stimulated macrophages. Cytokine. 21:38–42. 2003. View Article : Google Scholar : PubMed/NCBI

20 

Lentsch AB, Jordan JA, Czermak BJ, Diehl KM, Younkin EM, Sarma V and Ward PA: Inhibition of NF-kappaB activation and augmentation of IkappaBbeta by secretory leukocyte protease inhibitor during lung inflammation. Am J Pathol. 154:239–247. 1999. View Article : Google Scholar : PubMed/NCBI

21 

Mikami Y, Iwase T, Komiyama Y, Matsumoto N, Oki H and Komiyama K: Secretory leukocyte protease inhibitor inhibits expression of polymeric immunoglobulin receptor via the NF-κB signaling pathway. Mol Immunol. 67:568–574. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Barkett M and Gilmore TD: Control of apoptosis by Rel/NF-kappaB transcription factors. Oncogene. 18:6910–6924. 1999. View Article : Google Scholar : PubMed/NCBI

23 

Duffey DC, Chen Z, Dong G, Ondrey FG, Wolf JS, Brown K, Siebenlist U and Van Waes C: Expression of a dominant-negative mutant inhibitor-kappaBalpha of nuclear factor-kappaB in human head and neck squamous cell carcinoma inhibits survival, proinflammatory cytokine expression, and tumor growth in vivo. Cancer Res. 59:3468–3474. 1999.PubMed/NCBI

24 

Nottingham LK, Yan CH, Yang X, Si H, Coupar J, Bian Y, Cheng TF, Allen C, Arun P, Gius D, et al: Aberrant IKKα and IKKβ cooperatively activate NF-κB and induce EGFR/AP1 signaling to promote survival and migration of head and neck cancer. Oncogene. 33:1135–1147. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Ondrey FG, Dong G, Sunwoo J, Chen Z, Wolf JS, Crowl-Bancroft CV, Mukaida N and Van Waes C: Constitutive activation of transcription factors NF-(kappa)B, AP-1, and NF-IL6 in human head and neck squamous cell carcinoma cell lines that express pro-inflammatory and pro-angiogenic cytokines. Mol Carcinog. 26:119–129. 1999. View Article : Google Scholar : PubMed/NCBI

26 

Liu H, Zhu R, Liu C, Ma R, Wang L, Chen B, Li L, Niu J, Zhao D, Mo F, et al: Evaluation of decalcification techniques for rat femurs using HE and immunohistochemical staining. Biomed Res Int. 2017:90507542017.PubMed/NCBI

27 

Cai B, Miao Y and Liu Y, Xu X, Guan S, Wu J and Liu Y: Nuclear multidrug-resistance related protein 1 contributes to multidrug-resistance of mucoepidermoid carcinoma mainly via regulating multidrug-resistance protein 1: A human mucoepidermoid carcinoma cells model and Spearman's rank correlation analysis. PLoS One. 8:e696112013. View Article : Google Scholar : PubMed/NCBI

28 

Dalley AJ, Pitty LP, Major AG, Abdulmajeed AA and Farah CS: Expression of ABCG2 and Bmi-1 in oral potentially malignant lesions and oral squamous cell carcinoma. Cancer Med. 3:273–283. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Okamoto A, Higo M, Shiiba M, Nakashima D, Koyama T, Miyamoto I, Kasama H, Kasamatsu A, Ogawara K, Yokoe H, et al: Down-regulation of nucleolar and spindle-associated protein 1 (NUSAP1) expression suppresses tumor and cell proliferation and enhances anti-tumor effect of paclitaxel in oral squamous cell carcinoma. PLoS One. 10:e01422522015. View Article : Google Scholar : PubMed/NCBI

30 

Liu S, Ye D, Guo W, Yu W, He Y, Hu J, Wang Y, Zhang L, Liao Y, Song H, et al: G9a is essential for EMT-mediated metastasis and maintenance of cancer stem cell-like characters in head and neck squamous cell carcinoma. Oncotarget. 6:6887–6901. 2015.PubMed/NCBI

31 

Taggart CC, Cryan SA, Weldon S, Gibbons A, Greene CM, Kelly E, Low TB, O'neill SJ and McElvaney NG: Secretory leucoprotease inhibitor binds to NF-kappaB binding sites in monocytes and inhibits p65 binding. J Exp Med. 202:1659–1668. 2005. View Article : Google Scholar : PubMed/NCBI

32 

Westin U, Nyström M, Ljungcrantz I, Eriksson B and Ohlsson K: The presence of elafin, SLPI, IL1-RA and STNFalpha RI in head and neck squamous cell carcinomas and their relation to the degree of tumour differentiation. Mediators Inflamm. 11:7–12. 2002. View Article : Google Scholar : PubMed/NCBI

33 

Rasool N, LaRochelle W, Zhong H, Ara G, Cohen J and Kohn EC: Secretory leukocyte protease inhibitor antagonizes paclitaxel in ovarian cancer cells. Clin Cancer Res. 16:600–609. 2010. View Article : Google Scholar : PubMed/NCBI

34 

Devoogdt N, Hassanzadeh Ghassabeh G, Zhang J, Brys L, De Baetselier P and Revets H: Secretory leukocyte protease inhibitor promotes the tumorigenic and metastatic potential of cancer cells. Proc Natl Acad Sci USA. 100:pp. 5778–5782. 2003; View Article : Google Scholar : PubMed/NCBI

35 

Zheng D, Gui B, Gray KP, Tinay I, Rafiei S, Huang Q, Sweeney CJ, Kibel AS and Jia L: Secretory leukocyte protease inhibitor is a survival and proliferation factor for castration-resistant prostate cancer. Oncogene. 35:4807–4815. 2016. View Article : Google Scholar : PubMed/NCBI

36 

Nakamura K, Takamoto N, Hongo A, Kodama J, Abrzua F, Nasu Y, Kumon H and Hiramatsu Y: Secretory leukoprotease inhibitor inhibits cell growth through apoptotic pathway on ovarian cancer. Oncol Rep. 19:1085–1091. 2008.PubMed/NCBI

37 

Amiano NO, Costa MJ, Reiteri RM, Payés C, Guerrieri D, Tateosian NL, Sánchez ML, Maffia PC, Diament M, Karas R, et al: Anti-tumor effect of SLPI on mammary but not colon tumor growth. J Cell Physiol. 228:469–475. 2013. View Article : Google Scholar : PubMed/NCBI

38 

Amiano N, Reiteri RM, Costa MJ, Tateosian N and Chuluyan HE: Immunotherapy with SLPI over-expressing mammary tumor cells decreases tumor growth. Cancer Immunol Immunother. 60:895–900. 2011. View Article : Google Scholar : PubMed/NCBI

39 

Choi BD, Jeong SJ, Wang G, Park JJ, Lim DS, Kim BH, Cho YI, Kim CS and Jeong MJ: Secretory leukocyte protease inhibitor is associated with MMP-2 and MMP-9 to promote migration and invasion in SNU638 gastric cancer cells. Int J Mol Med. 28:527–534. 2011.PubMed/NCBI

40 

Devoogdt N, Rasool N, Hoskins E, Simpkins F, Tchabo N and Kohn EC: Overexpression of protease inhibitor-dead secretory leukocyte protease inhibitor causes more aggressive ovarian cancer in vitro and in vivo. Cancer Sci. 100:434–440. 2009. View Article : Google Scholar : PubMed/NCBI

41 

Li Y, Li LJ, Zhang ST, Wang LJ, Zhang Z, Gao N, Zhang YY and Chen QM: In vitro and clinical studies of gene therapy with recombinant human adenovirus-p53 injection for oral leukoplakia. Clin Cancer Res. 15:6724–6731. 2009. View Article : Google Scholar : PubMed/NCBI

42 

Tsuzuki H, Fujieda S, Sunaga H, Narita N, Tokuriki M and Saito H: Expression of p27 and apoptosis in oral leukoplakia. Anticancer Res. 23:1265–1270. 2003.PubMed/NCBI

43 

Taggart CC, Greene CM, McElvaney NG and O'Neill S: Secretory leucoprotease inhibitor prevents lipopolysaccharide-induced IkappaBalpha degradation without affecting phosphorylation or ubiquitination. J Biol Chem. 277:33648–33653. 2002. View Article : Google Scholar : PubMed/NCBI

44 

Bindhu OS, Ramadas K, Sebastian P and Pillai MR: High expression levels of nuclear factor kappa B and gelatinase in the tumorigenesis of oral squamous cell carcinoma. Head Neck. 28:916–925. 2006. View Article : Google Scholar : PubMed/NCBI

45 

Pontes HA, Pontes FS, Fonseca FP, de Carvalho PL, Pereira EM, de Abreu MC, de Freitas Silva BS and dos Santos Pinto D Jr: Nuclear factor κB and cyclooxygenase-2 immunoexpression in oral dysplasia and oral squamous cell carcinoma. Ann Diagn Pathol. 17:45–50. 2013. View Article : Google Scholar : PubMed/NCBI

46 

Irmler M, Steiner V, Ruegg C, Wajant H and Tschopp J: Caspase-induced inactivation of the anti-apoptotic TRAF1 during Fas ligand-mediated apoptosis. Febs Lett. 468:129–133. 2000. View Article : Google Scholar : PubMed/NCBI

47 

Lee SY and Choi Y: TRAF1 and its biological functions. Adv Exp Med Biol. 597:25–31. 2007. View Article : Google Scholar : PubMed/NCBI

48 

Wang CY, Mayo MW, Korneluk RG, Goeddel DV and Baldwin AS Jr: NF-kappaB antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science. 281:1680–1683. 1998. View Article : Google Scholar : PubMed/NCBI

49 

Speiser DE, Lee SY, Wong B, Arron J, Santana A, Kong YY, Ohashi PS and Choi Y: A regulatory role for TRAF1 in antigen-induced apoptosis of T cells. J Exp Med. 185:1777–1783. 1997. View Article : Google Scholar : PubMed/NCBI

50 

Wan XK, Yuan SL, Tao HX, Diao LP, Wang YC, Cao C and Liu CJ: The upregulation of TRAF1 induced by helicobacter pylori plays an antiapoptotic effect on the infected cells. Helicobacter. 21:554–564. 2016. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wang X, Jin Y, Li Y and Yang Y: Secretory leukocyte peptidase inhibitor expression and apoptosis effect in oral leukoplakia and oral squamous cell carcinoma. Oncol Rep 39: 1793-1804, 2018.
APA
Wang, X., Jin, Y., Li, Y., & Yang, Y. (2018). Secretory leukocyte peptidase inhibitor expression and apoptosis effect in oral leukoplakia and oral squamous cell carcinoma. Oncology Reports, 39, 1793-1804. https://doi.org/10.3892/or.2018.6251
MLA
Wang, X., Jin, Y., Li, Y., Yang, Y."Secretory leukocyte peptidase inhibitor expression and apoptosis effect in oral leukoplakia and oral squamous cell carcinoma". Oncology Reports 39.4 (2018): 1793-1804.
Chicago
Wang, X., Jin, Y., Li, Y., Yang, Y."Secretory leukocyte peptidase inhibitor expression and apoptosis effect in oral leukoplakia and oral squamous cell carcinoma". Oncology Reports 39, no. 4 (2018): 1793-1804. https://doi.org/10.3892/or.2018.6251
Copy and paste a formatted citation
x
Spandidos Publications style
Wang X, Jin Y, Li Y and Yang Y: Secretory leukocyte peptidase inhibitor expression and apoptosis effect in oral leukoplakia and oral squamous cell carcinoma. Oncol Rep 39: 1793-1804, 2018.
APA
Wang, X., Jin, Y., Li, Y., & Yang, Y. (2018). Secretory leukocyte peptidase inhibitor expression and apoptosis effect in oral leukoplakia and oral squamous cell carcinoma. Oncology Reports, 39, 1793-1804. https://doi.org/10.3892/or.2018.6251
MLA
Wang, X., Jin, Y., Li, Y., Yang, Y."Secretory leukocyte peptidase inhibitor expression and apoptosis effect in oral leukoplakia and oral squamous cell carcinoma". Oncology Reports 39.4 (2018): 1793-1804.
Chicago
Wang, X., Jin, Y., Li, Y., Yang, Y."Secretory leukocyte peptidase inhibitor expression and apoptosis effect in oral leukoplakia and oral squamous cell carcinoma". Oncology Reports 39, no. 4 (2018): 1793-1804. https://doi.org/10.3892/or.2018.6251
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team