Novel structural approaches concerning HPV proteins: Insight into targeted therapies for cervical cancer (Review)

  • Authors:
    • Kalliopi I. Pappa
    • Georgia Kontostathi
    • Vasiliki Lygirou
    • Jerome Zoidakis
    • Nicholas P. Anagnou
  • View Affiliations

  • Published online on: February 9, 2018     https://doi.org/10.3892/or.2018.6257
  • Pages: 1547-1554
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Cervical cancer incidence is tightly linked to HPV infection, and particularly virus types 16 and 18 cause the majority of cases presenting with pre-cancerous stages of cervical intraepithelial neoplasia (CIN). Structural and functional information concerning HPV proteins can offer novel insight into the mechanism(s) of cancer progression in the cervical epithelium. Recently, novel structural determinants of the interactions of viral proteins with their targets in keratinocytes have been elucidated. These exciting findings open the way for the development of targeted anti-oncogenic therapies, and may eventually allow the introduction of novel approaches for a rational cervical cancer treatment.
View Figures
View References

Related Articles

Journal Cover

April-2018
Volume 39 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Pappa KI, Kontostathi G, Lygirou V, Zoidakis J and Anagnou NP: Novel structural approaches concerning HPV proteins: Insight into targeted therapies for cervical cancer (Review). Oncol Rep 39: 1547-1554, 2018
APA
Pappa, K.I., Kontostathi, G., Lygirou, V., Zoidakis, J., & Anagnou, N.P. (2018). Novel structural approaches concerning HPV proteins: Insight into targeted therapies for cervical cancer (Review). Oncology Reports, 39, 1547-1554. https://doi.org/10.3892/or.2018.6257
MLA
Pappa, K. I., Kontostathi, G., Lygirou, V., Zoidakis, J., Anagnou, N. P."Novel structural approaches concerning HPV proteins: Insight into targeted therapies for cervical cancer (Review)". Oncology Reports 39.4 (2018): 1547-1554.
Chicago
Pappa, K. I., Kontostathi, G., Lygirou, V., Zoidakis, J., Anagnou, N. P."Novel structural approaches concerning HPV proteins: Insight into targeted therapies for cervical cancer (Review)". Oncology Reports 39, no. 4 (2018): 1547-1554. https://doi.org/10.3892/or.2018.6257