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Review

Novel structural approaches concerning HPV proteins: Insight into targeted therapies for cervical cancer (Review)

  • Authors:
    • Kalliopi I. Pappa
    • Georgia Kontostathi
    • Vasiliki Lygirou
    • Jerome Zoidakis
    • Nicholas P. Anagnou
  • View Affiliations / Copyright

    Affiliations: First Department of Obstetrics and Gynecology, University of Athens School of Medicine, Alexandra Hospital, Athens 11528, Greece, Laboratory of Cell and Gene Therapy, Biomedical Research Foundation of the Academy of Athens, Athens 11527, Greece, Biotechnology Division, Biomedical Research Foundation of the Academy of Athens, Athens 11527, Greece
  • Pages: 1547-1554
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    Published online on: February 9, 2018
       https://doi.org/10.3892/or.2018.6257
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Abstract

Cervical cancer incidence is tightly linked to HPV infection, and particularly virus types 16 and 18 cause the majority of cases presenting with pre-cancerous stages of cervical intraepithelial neoplasia (CIN). Structural and functional information concerning HPV proteins can offer novel insight into the mechanism(s) of cancer progression in the cervical epithelium. Recently, novel structural determinants of the interactions of viral proteins with their targets in keratinocytes have been elucidated. These exciting findings open the way for the development of targeted anti-oncogenic therapies, and may eventually allow the introduction of novel approaches for a rational cervical cancer treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Pappa KI, Kontostathi G, Lygirou V, Zoidakis J and Anagnou NP: Novel structural approaches concerning HPV proteins: Insight into targeted therapies for cervical cancer (Review). Oncol Rep 39: 1547-1554, 2018.
APA
Pappa, K.I., Kontostathi, G., Lygirou, V., Zoidakis, J., & Anagnou, N.P. (2018). Novel structural approaches concerning HPV proteins: Insight into targeted therapies for cervical cancer (Review). Oncology Reports, 39, 1547-1554. https://doi.org/10.3892/or.2018.6257
MLA
Pappa, K. I., Kontostathi, G., Lygirou, V., Zoidakis, J., Anagnou, N. P."Novel structural approaches concerning HPV proteins: Insight into targeted therapies for cervical cancer (Review)". Oncology Reports 39.4 (2018): 1547-1554.
Chicago
Pappa, K. I., Kontostathi, G., Lygirou, V., Zoidakis, J., Anagnou, N. P."Novel structural approaches concerning HPV proteins: Insight into targeted therapies for cervical cancer (Review)". Oncology Reports 39, no. 4 (2018): 1547-1554. https://doi.org/10.3892/or.2018.6257
Copy and paste a formatted citation
x
Spandidos Publications style
Pappa KI, Kontostathi G, Lygirou V, Zoidakis J and Anagnou NP: Novel structural approaches concerning HPV proteins: Insight into targeted therapies for cervical cancer (Review). Oncol Rep 39: 1547-1554, 2018.
APA
Pappa, K.I., Kontostathi, G., Lygirou, V., Zoidakis, J., & Anagnou, N.P. (2018). Novel structural approaches concerning HPV proteins: Insight into targeted therapies for cervical cancer (Review). Oncology Reports, 39, 1547-1554. https://doi.org/10.3892/or.2018.6257
MLA
Pappa, K. I., Kontostathi, G., Lygirou, V., Zoidakis, J., Anagnou, N. P."Novel structural approaches concerning HPV proteins: Insight into targeted therapies for cervical cancer (Review)". Oncology Reports 39.4 (2018): 1547-1554.
Chicago
Pappa, K. I., Kontostathi, G., Lygirou, V., Zoidakis, J., Anagnou, N. P."Novel structural approaches concerning HPV proteins: Insight into targeted therapies for cervical cancer (Review)". Oncology Reports 39, no. 4 (2018): 1547-1554. https://doi.org/10.3892/or.2018.6257
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