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Article

A screening method for gastric cancer by oral microbiome detection

  • Authors:
    • Jing‑Hua Sun
    • Xiao‑Lin Li
    • Jie Yin
    • Yi‑Hong Li
    • Ben‑Xiang Hou
    • Zhongtao Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Endodontics, Beijing Stomatological Hospital, Capital Medical University, Beijing 100050, P.R. China, Experimental Center, Annoroad Gene Technology (Beijing) Co., Ltd., Beijing 101100, P.R. China, Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center of Digestive Diseases, Beijing 100050, P.R. China, Department of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, NY 10010, USA
  • Pages: 2217-2224
    |
    Published online on: March 1, 2018
       https://doi.org/10.3892/or.2018.6286
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Abstract

Gastric cancer is the second most common malig­nancy and one of the principal causes of cancer‑related mortality worldwide. Early diagnostic and screening methods for gastric cancer are limited at present, most of them involving invasive procedures. We aimed to investigate the characteristics of the oral microbiome in gastric cancer individuals and to conduct a screening method for gastric cancer by oral microbiome detection. We used high‑throughput sequencing to examine the total bacterial profile of saliva and plaque samples of 50 subjects, including 37 individuals with gastric cancer and 13 controls. The Venn diagram and species abundance clusters were generated from the data. The results indicated that the oral bacteria were more complex in patients with gastric cancer. Based on the characteristics of the oral microbiome in individuals with gastric cancer, a scoring system was designed to screen gastric cancer. In the present study, 36 out of 37 individuals in the gastric cancer group were identified as a high‑risk population, giving a sensitivity rate of 97%. One out of 13 individuals in the control group was identified as a high‑risk population, providing a false-positive rate of 7.7%. The scoring system we designed may be a potential method for screening suspected gastric cancer patients by oral microbiome detection. Further calibration of this scoring system is needed by recruiting a larger study population.
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Copy and paste a formatted citation
Spandidos Publications style
Sun JH, Li XL, Yin J, Li YH, Hou BX and Zhang Z: A screening method for gastric cancer by oral microbiome detection. Oncol Rep 39: 2217-2224, 2018.
APA
Sun, J., Li, X., Yin, J., Li, Y., Hou, B., & Zhang, Z. (2018). A screening method for gastric cancer by oral microbiome detection. Oncology Reports, 39, 2217-2224. https://doi.org/10.3892/or.2018.6286
MLA
Sun, J., Li, X., Yin, J., Li, Y., Hou, B., Zhang, Z."A screening method for gastric cancer by oral microbiome detection". Oncology Reports 39.5 (2018): 2217-2224.
Chicago
Sun, J., Li, X., Yin, J., Li, Y., Hou, B., Zhang, Z."A screening method for gastric cancer by oral microbiome detection". Oncology Reports 39, no. 5 (2018): 2217-2224. https://doi.org/10.3892/or.2018.6286
Copy and paste a formatted citation
x
Spandidos Publications style
Sun JH, Li XL, Yin J, Li YH, Hou BX and Zhang Z: A screening method for gastric cancer by oral microbiome detection. Oncol Rep 39: 2217-2224, 2018.
APA
Sun, J., Li, X., Yin, J., Li, Y., Hou, B., & Zhang, Z. (2018). A screening method for gastric cancer by oral microbiome detection. Oncology Reports, 39, 2217-2224. https://doi.org/10.3892/or.2018.6286
MLA
Sun, J., Li, X., Yin, J., Li, Y., Hou, B., Zhang, Z."A screening method for gastric cancer by oral microbiome detection". Oncology Reports 39.5 (2018): 2217-2224.
Chicago
Sun, J., Li, X., Yin, J., Li, Y., Hou, B., Zhang, Z."A screening method for gastric cancer by oral microbiome detection". Oncology Reports 39, no. 5 (2018): 2217-2224. https://doi.org/10.3892/or.2018.6286
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