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Article Open Access

The role of molecular breast imaging in predicting complete tumor response to treatment and residual tumor extent following neoadjuvant therapy

  • Authors:
    • Susanna Nuvoli
    • Sarah Galassi
    • Ilaria Gelo
    • Gaia Rocchitta
    • Alessandro  Fancellu
    • Pier Andrea Serra
    • Giuseppe Madeddu
    • Angela Spanu
  • View Affiliations / Copyright

    Affiliations: Unit of Nuclear Medicine, Department of Clinical and Experimental Medicine, University of Sassari, I‑07100 Sassari, Italy, Unit of Pharmacology, Department of Clinical and Experimental Medicine, University of Sassari, I‑07100 Sassari, Italy, Unit of Surgery, Department of Clinical and Experimental Medicine, University of Sassari, I‑07100 Sassari, Italy
    Copyright: © Nuvoli et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2055-2062
    |
    Published online on: March 6, 2018
       https://doi.org/10.3892/or.2018.6299
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Abstract

The aim of the present study was to investigate the usefulness of molecular breast imaging (MBI) in predicting complete tumor response to treatment and residual tumor extent following neoadjuvant therapy. A consecutive series of 43 female patients with large or locally advanced primary breast cancer, scheduled for surgery following neoadjuvant therapy, was retrospectively reviewed. Prior to surgery, all patients underwent MBI using a high‑resolution semiconductor‑based device for image acquisition. MBI data were correlated with surgical histopathological findings. Spearman's correlation coefficient was calculated to assess differences in residual tumor size with MBI and histopathological examination. From the images obtained using MBI, 7 patients were negative for residual tumors with pathological complete response (specificity, 100%) and positive in 34/36 patients with residual disease (sensitivity, 94.4%), including 26/27 patients with unifocal and 8/9 patients with multicentric/multifocal tumors, 5 of which exhibited multiple microscopic foci scattered in a fibrotic area. Overall accuracy was 95.3% and the positive predictive value (PPV) and negative predictive value (NPV) were 100 and 77.8%, respectively. MBI was false‑negative in one patient with a 2.5‑cm invasive ductal carcinoma located close to the chest wall and in one patient with microscopic foci of epithelial carcinoma. In the patients with unifocal residual tumors, correlation of tumor size between MBI and histopathology was r=0.981 (P<0.0001); however, MBI overestimated the number of lesions in one of these cases. In the patients with multifocal/multicentric tumors, MBI adequately assessed residual tumor extent in 5/8 positive cases, overestimating the number of lesions in one case and underestimating tumor extent in 2 further cases with microscopic foci scattered in a fibrotic area. MBI proved to be a highly accurate diagnostic tool in predicting complete tumor response to neoadjuvant therapy and residual tumor extent, correlating with surgical histopathological findings in 86% of overall cases. A positive result was always associated with the presence of residual disease and MBI tumor size was strongly correlated with histopathological analysis mainly in unifocal residual tumors.
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1 

Untch M, Konecny GE, Paepke S and von Minckwitz G: Current and future role of neoadjuvant therapy for breast cancer. Breast. 23:526–537. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Newman LA: Management of patients with locally advanced breast cancer. Curr Oncol Rep. 6:53–61. 2004. View Article : Google Scholar : PubMed/NCBI

3 

Kong X, Moran MS, Zhang N, Haffty B and Yang Q: Meta-analysis confirms achieving pathological complete response after neoadjuvant chemotherapy predicts favourable prognosis for breast cancer patients. Eur J Cancer. 47:2084–2090. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Chagpar AB, Middleton LP, Sahin AA, Dempsey P, Buzdar AU, Mirza AN, Ames FC, Babiera GV, Feig BW, Hunt KK, et al: Accuracy of physical examination, ultrasonography, and mammography in predicting residual pathologic tumor size in patients treated with neoadjuvant chemotherapy. Ann Surg. 243:257–264. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Spanu A, Farris A, Schillaci O, Chessa F, Solinas ME, Falchi A and Madeddu G, Nuvoli S and Madeddu G: The usefulness of 99mTc tetrofosmin scintigraphy in patients with breast cancer recurrences. Nucl Med Commun. 24:145–154. 2003. View Article : Google Scholar : PubMed/NCBI

6 

Spanu A, Schillaci O and Madeddu G: 99mTc labelled cationic lipophilic complexes in malignant and benign tumors: The role of SPET and pinhole-SPET in breast cancer, differentiated thyroid carcinoma and hyperparathyroidism. Q J Nucl Med Mol Imaging. 49:145–169. 2005.PubMed/NCBI

7 

Schillaci O, Spanu A, Danieli R and Madeddu G: Molecular breast imaging with gamma emitters. Q J Nucl Med Mol Imaging. 57:340–351. 2013.PubMed/NCBI

8 

Arbab AS, Koizumi K, Toyama K, Arai T and Araki T: Ion transport systems in the uptake of 99Tcm-tetrofosmin, 99Tcm-MIBI and 201Tl in a tumour cell line. Nucl Med Commun. 18:235–240. 1997. View Article : Google Scholar : PubMed/NCBI

9 

Bernard BF, Krenning EP, Breeman WA, Ensing G, Benjamins H, Bakker WH, Visser TJ and de Jong M: 99mTc-MIBI, 99mTc-tetrofosmin and 99mTc-Q12 in vitro and in vivo. Nucl Med Biol. 25:233–240. 1998. View Article : Google Scholar : PubMed/NCBI

10 

Arbab AS, Koizumi K, Toyama K, Arai T and Araki T: Technetium-99m-tetrofosmin, technetium-99m-MIBI and thallium-201 uptake in rat myocardial cells. J Nucl Med. 39:266–271. 1998.PubMed/NCBI

11 

Spanu A, Dettori G, Nuvoli S, Porcu A, Falchi A, Cottu P, Solinas ME, Scanu AM, Chessa F and Madeddu G: (99)mTc-tetrofosmin SPET in the detection of both primary breast cancer and axillary lymph node metastasis. Eur J Nucl Med. 28:1781–1794. 2001. View Article : Google Scholar : PubMed/NCBI

12 

Spanu A, Schillaci O, Meloni GB, Porcu A, Cottu P, Nuvoli S, Falchi A, Chessa F, Solinas ME and Madeddu G: The usefulness of 99mTc-tetrofosmin SPECT scintimammography in the detection of small size primary breast carcinomas. Int J Oncol. 21:831–840. 2002.PubMed/NCBI

13 

Goldsmith SJ, Parsons W, Guiberteau MJ, Stern LH, Lanzkowsky L, Weigert J, Heston TF, Jones E, Buscombe J and Stabin MG: Society of Nuclear Medicine: SNM practice guideline for breast scintigraphy with breast-specific gamma-cameras 1.0. J Nucl Med Technol. 38:219–224. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Brem RF, Schoonjans JM, Kieper DA, Majewski S, Goodman S and Civelek C: High-resolution scintimammography: A pilot study. J Nucl Med. 43:909–915. 2002.PubMed/NCBI

15 

Spanu A, Cottu P, Manca A, Chessa F, Sanna D and Madeddu G: Scintimammography with dedicated breast camera in unifocal and multifocal/multicentric primary breast cancer detection: A comparative study with SPECT. Int J Oncol. 31:369–377. 2007.PubMed/NCBI

16 

Spanu A, Chessa F, Meloni GB, Sanna D, Cottu P, Manca A, Nuvoli S and Madeddu G: The role of planar scintimammography with high-resolution dedicated breast camera in the diagnosis of primary breast cancer. Clin Nucl Med. 33:739–742. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Spanu A, Sanna D, Chessa F, Manca A, Cottu P, Fancellu A, Nuvoli S and Madeddu G: The clinical impact of breast scintigraphy acquired with a breast specific γ-camera (BSGC) in the diagnosis of breast cancer: Incremental value versus mammography. Int J Oncol. 41:483–489. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Sun Y, Wei W, Yang HW and Liu JL: Clinical usefulness of breast-specific gamma imaging as an adjunct modality to mammography for diagnosis of breast cancer: A systemic review and meta-analysis. Eur J Nucl Med Mol Imaging. 40:450–463. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Spanu A, Sanna D, Chessa F, Cottu P, Manca A and Madeddu G: Breast scintigraphy with breast-specific γ-camera in the detection of ductal carcinoma in situ: A correlation with mammography and histologic subtype. J Nucl Med. 53:1528–1533. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Edwards C, Williams S, McSwain AP, Damle S, Rapelyea JA, Downs K, Torrente J, Sambamurty A, Brem RF and Teal CB: Breast-specific gamma imaging influences surgical management in patients with breast cancer. Breast J. 19:512–519. 2013.PubMed/NCBI

21 

Rhodes DJ, Hruska CB, Conners AL, Tortorelli CL, Maxwell RW, Jones KN, Toledano AY and O'Connor MK: Journal club: Molecular breast imaging at reduced radiation dose for supplemental screening in mammographically dense breasts. AJR Am J Roentgenol. 204:241–251. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Hsu DF, Freese DL and Levin CS: Breast-Dedicated Radionuclide Imaging Systems. J Nucl Med. 57 Suppl 1:40S–45S. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Hruska CB, Phillips SW, Whaley DH, Rhodes DJ and O'Connor MK: Molecular breast imaging: Use of a dual-head dedicated gamma camera to detect small breast tumors. AJR Am J Roentgenol. 191:1805–1815. 2008. View Article : Google Scholar : PubMed/NCBI

24 

Hruska CB, Weinmann AL, Skjerseth Tello CM, Wagenaar EM, Conners AL, Tortorelli CL, Maxwell RW, Rhodes DJ and O'Connor MK: Proof of concept for low-dose molecular breast imaging with a dual-head CZT gamma camera. Part II. Evaluation in patients. Med Phys. 39:3476–3483. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Wahner-Roedler DL, Boughey JC, Hruska CB, Chen B, Rhodes DJ, Tortorelli CL, Maxwell RW, Cha SS and O'Connor MK: The use of molecular breast imaging to assess response in women undergoing neoadjuvant therapy for breast cancer: A pilot study. Clin Nucl Med. 37:344–350. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Lee HS, Ko BS, Ahn SH, Son BH, Lee JW, Kim HJ, Yu JH, Kim SB, Jung KH, Ahn JH, et al: Diagnostic performance of breast-specific gamma imaging in the assessment of residual tumor after neoadjuvant chemotherapy in breast cancer patients. Breast Cancer Res Treat. 145:91–100. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Menes TS, Golan O, Vainer G, Lerman H, Schneebaum S, Klausner J and Even-Sapir E: Assessment of residual disease with molecular breast imaging in patients undergoing neoadjuvant therapy: Association with molecular subtypes. Clin Breast Cancer. 16:389–395. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Spanu A, Ginesu F, Pirina P, Solinas ME, Schillaci O, Farris A, Chessa F, Madeddu G, Marongiu P, Falchi A, et al: The usefulness of 99mTc-tetrofosmin SPECT in the detection of intrathoracic malignant lesions. Int J Oncol. 22:639–649. 2003.PubMed/NCBI

29 

Schillaci O, Spanu A and Madeddu G: [99mTc]sestamibi and [99mTc]tetrofosmin in oncology: SPET and fusion imaging in lung cancer, malignant lymphomas and brain tumors. Q J Nucl Med Mol Imaging. 49:133–144. 2005.PubMed/NCBI

30 

Spanu A, Sanna D, Chessa F, Farris A, Nuvoli S and Madeddu G: The usefulness of Tc-99m-tetrofosmin SPECT/CT in the detection of residual tumors and axillary lymph node metastases in breast cancer patients following neoadjuvant therapy. Clin Nucl Med. 36:997–1002. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Spanu A, Farris A, Chessa F, Sanna D, Pittalis M, Manca A and Madeddu G: Planar scintimammography and SPECT in neoadjuvant chemo or hormonotherapy response evaluation in locally advanced primary breast cancer. Int J Oncol. 32:1275–1283. 2008.PubMed/NCBI

32 

Mitchell D, Hruska CB, Boughey JC, Wahner-Roedler DL, Jones KN, Tortorelli C, Conners AL and O'Connor MK: 99mTc-sestamibi using a direct conversion molecular breast imaging system to assess tumor response to neoadjuvant chemotherapy in women with locally advanced breast cancer. Clin Nucl Med. 38:949–956. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Schillaci O, Scopinaro F, Spanu A, Donnetti M, Danieli R, Di Luzio E, Madeddu G and David V: Detection of axillary lymph node metastases in breast cancer with Tc-99m tetrofosmin scintigraphy. Int J Oncol. 20:483–487. 2002.PubMed/NCBI

34 

Spanu A, Tanda F, Dettori G, Manca A, Chessa F, Porcu A, Falchi A, Nuvoli S and Madeddu G: The role of (99m)Tc-tetrofosmin pinhole-SPECT in breast cancer non palpable axillary lymph node metastases detection. Q J Nucl Med. 47:116–128. 2003.PubMed/NCBI

35 

Madeddu G and Spanu A: Use of tomographic nuclear medicine procedures, SPECT and pinhole SPECT, with cationic lipophilic radiotracers for the evaluation of axillary lymph node status in breast cancer patients. Eur J Nucl Med Mol Imaging. 31 Suppl 1:S23–S34. 2004. View Article : Google Scholar : PubMed/NCBI

36 

Spanu A, Chessa F, Sanna D, Cottu P, Manca A, Nuvoli S and Madeddu G: Breast cancer axillary lymph node metastasis detection by a high-resolution dedicated breast camera: A comparative study with SPECT and pinhole SPECT. Cancer Biother Radiopharm. 22:799–811. 2007. View Article : Google Scholar : PubMed/NCBI

37 

Spanu A, Chessa F, Sanna D, Cottu P, Manca A, Nuvoli S and Madeddu G: Scintimammography with a high resolution dedicated breast camera in comparison with SPECT/CT in primary breast cancer detection. Q J Nucl Med Mol Imaging. 53:271–280. 2009.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Nuvoli S, Galassi S, Gelo I, Rocchitta G, Fancellu A, Serra PA, Madeddu G and Spanu A: The role of molecular breast imaging in predicting complete tumor response to treatment and residual tumor extent following neoadjuvant therapy. Oncol Rep 39: 2055-2062, 2018.
APA
Nuvoli, S., Galassi, S., Gelo, I., Rocchitta, G., Fancellu, A., Serra, P.A. ... Spanu, A. (2018). The role of molecular breast imaging in predicting complete tumor response to treatment and residual tumor extent following neoadjuvant therapy. Oncology Reports, 39, 2055-2062. https://doi.org/10.3892/or.2018.6299
MLA
Nuvoli, S., Galassi, S., Gelo, I., Rocchitta, G., Fancellu, A., Serra, P. A., Madeddu, G., Spanu, A."The role of molecular breast imaging in predicting complete tumor response to treatment and residual tumor extent following neoadjuvant therapy". Oncology Reports 39.5 (2018): 2055-2062.
Chicago
Nuvoli, S., Galassi, S., Gelo, I., Rocchitta, G., Fancellu, A., Serra, P. A., Madeddu, G., Spanu, A."The role of molecular breast imaging in predicting complete tumor response to treatment and residual tumor extent following neoadjuvant therapy". Oncology Reports 39, no. 5 (2018): 2055-2062. https://doi.org/10.3892/or.2018.6299
Copy and paste a formatted citation
x
Spandidos Publications style
Nuvoli S, Galassi S, Gelo I, Rocchitta G, Fancellu A, Serra PA, Madeddu G and Spanu A: The role of molecular breast imaging in predicting complete tumor response to treatment and residual tumor extent following neoadjuvant therapy. Oncol Rep 39: 2055-2062, 2018.
APA
Nuvoli, S., Galassi, S., Gelo, I., Rocchitta, G., Fancellu, A., Serra, P.A. ... Spanu, A. (2018). The role of molecular breast imaging in predicting complete tumor response to treatment and residual tumor extent following neoadjuvant therapy. Oncology Reports, 39, 2055-2062. https://doi.org/10.3892/or.2018.6299
MLA
Nuvoli, S., Galassi, S., Gelo, I., Rocchitta, G., Fancellu, A., Serra, P. A., Madeddu, G., Spanu, A."The role of molecular breast imaging in predicting complete tumor response to treatment and residual tumor extent following neoadjuvant therapy". Oncology Reports 39.5 (2018): 2055-2062.
Chicago
Nuvoli, S., Galassi, S., Gelo, I., Rocchitta, G., Fancellu, A., Serra, P. A., Madeddu, G., Spanu, A."The role of molecular breast imaging in predicting complete tumor response to treatment and residual tumor extent following neoadjuvant therapy". Oncology Reports 39, no. 5 (2018): 2055-2062. https://doi.org/10.3892/or.2018.6299
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