Open Access

Long noncoding RNAs show differential expression profiles and display ceRNA potential in cholesteatoma pathogenesis

  • Authors:
    • Juanjuan Gao
    • Qi Tang
    • Xiaohui Zhu
    • Shihua Wang
    • Yongli Zhang
    • Wenbin Liu
    • Zhiqiang Gao
    • Hua Yang
  • View Affiliations

  • Published online on: March 16, 2018     https://doi.org/10.3892/or.2018.6320
  • Pages: 2091-2100
  • Copyright: © Gao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cholesteatoma is a pathologically benign but clinically destructive middle ear disease, which is caused by excessive epidermal migration and uncontrolled hyperproliferation of keratinocytes of squamous epithelium, leading to various clinical manifestations and serious complications, such as hearing loss, dizziness, facial paralysis, meningitis, and hydrocephalus. However, the pathogenesis of cholesteatoma is still not fully understood. Herein, we performed microarray analysis to identify the differentially expressed patterns of lncRNAs in cholesteatoma for the first time. Our data indicated that compared with matched normal skin tissue, lncRNA expression profiles were significantly altered in cholesteatoma. A total of 787 lncRNAs were identified (fold change ≥2.0, P<0.05), consisting of 181 upregulated and 606 downregulated lncRNAs. Furthermore, by constructing an lncRNA/miRNA/mRNA competing endogenous RNA (ceRNA) network, we found that lncRNAs, such as lncRNA‑uc001kfc.1, had ceRNA potential in cholesteatoma formation. In conclusion, lncRNAs were aberrantly expressed in cholesteatoma compared with normal skin tissues and may play important roles in cholesteatoma formation. Our findings shed novel light on the molecular mechanism of cholesteatoma pathogenesis and suggest that lncRNAs may be potential therapeutic targets for cholesteatoma.
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May-2018
Volume 39 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Gao J, Tang Q, Zhu X, Wang S, Zhang Y, Liu W, Gao Z and Yang H: Long noncoding RNAs show differential expression profiles and display ceRNA potential in cholesteatoma pathogenesis. Oncol Rep 39: 2091-2100, 2018
APA
Gao, J., Tang, Q., Zhu, X., Wang, S., Zhang, Y., Liu, W. ... Yang, H. (2018). Long noncoding RNAs show differential expression profiles and display ceRNA potential in cholesteatoma pathogenesis. Oncology Reports, 39, 2091-2100. https://doi.org/10.3892/or.2018.6320
MLA
Gao, J., Tang, Q., Zhu, X., Wang, S., Zhang, Y., Liu, W., Gao, Z., Yang, H."Long noncoding RNAs show differential expression profiles and display ceRNA potential in cholesteatoma pathogenesis". Oncology Reports 39.5 (2018): 2091-2100.
Chicago
Gao, J., Tang, Q., Zhu, X., Wang, S., Zhang, Y., Liu, W., Gao, Z., Yang, H."Long noncoding RNAs show differential expression profiles and display ceRNA potential in cholesteatoma pathogenesis". Oncology Reports 39, no. 5 (2018): 2091-2100. https://doi.org/10.3892/or.2018.6320