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Article Open Access

FAT1 inhibits cell migration and invasion by affecting cellular mechanical properties in esophageal squamous cell carcinoma

  • Authors:
    • Xiaoling Hu
    • Yuanfang Zhai
    • Ruyi Shi
    • Yu Qian
    • Heyang Cui
    • Jie Yang
    • Yanghui Bi
    • Ting Yan
    • Jian Yang
    • Yanchun Ma
    • Ling Zhang
    • Yiqian Liu
    • Guodong Li
    • Mingsheng Zhang
    • Yongping Cui
    • Pengzhou Kong
    • Xiaolong Cheng
  • View Affiliations / Copyright

    Affiliations: Translational Medicine Research Center, Shanxi Medical University, Taiyuan, Shanxi 030001, P.R. China, Department of Otorhinolaryngology, Shanxi Provincial People's Hospital, Taiyuan, Shanxi 030001, P.R. China, Department of Pharmacology, Shanxi Medical University, Taiyuan, Shanxi 030001, P.R. China
    Copyright: © Hu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2136-2146
    |
    Published online on: March 20, 2018
       https://doi.org/10.3892/or.2018.6328
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Abstract

FAT atypical cadherin 1 (FAT1) belongs to the cadherin superfamily and has been reported to regulate cell‑cell adhesion and other cell behaviors, suggesting its pivotal roles in human cancers. We previously identified FAT1 as one of the significant mutant genes in esophageal squamous cell carcinoma (ESCC). In the present study, the knockdown of FAT1 expression in YSE2 and Colo680N cell lines was carried out by lentivirus, and we found that knockdown of FAT1 led to acceleration of cell migration and invasion. Furthermore, we detected the cell adhesive force and cell elasticity force by atomic force microscopy (AFM) and found that the suppression of endogenous expression of FAT1 led to a decrease in the cell adhesive force and increase in the cell elasticity force compared with the control groups. In conclusion, our study demonstrated that FAT1 altered cellular mechanical properties leading to deregulation of cell migration and invasion of ESCC, which may be a novel target for ESCC therapy.
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1 

Wheeler JB and Reed CE: Epidemiology of esophageal cancer. Surg Clin North Am. 92:1077–1087. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ and He J: Cancer statistics in China, 2015. CA Cancer J Clin. 66:115–132. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D and Bray F: Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 136:E359–E386. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Pennathur A, Gibson MK, Jobe BA and Luketich JD: Oesophageal carcinoma. Lancet. 381:400–412. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Ferlay J, Shin HR, Bray F, Forman D, Mathers C and Parkin DM: Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 127:2893–2917. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Zhang L, Zhou Y, Cheng C, Cui H, Cheng L, Kong P, Wang J, Li Y, Chen W, Song B, et al: Genomic analyses reveal mutational signatures and frequently altered genes in esophageal squamous cell carcinoma. Am J Hum Genet. 96:597–611. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Cheng C, Zhou Y, Li H, Xiong T, Li S, Bi Y, Kong P, Wang F, Cui H, Li Y, et al: Whole-genome sequencing reveals diverse models of structural variations in esophageal squamous cell carcinoma. Am J Hum Genet. 98:256–274. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Hu X, Zhai Y, Kong P, Cui H, Yan T, Yang J, Qian Y, Ma Y, Wang F, Li H, et al: FAT1 prevents epithelial mesenchymal transition (EMT) via MAPK/ERK signaling pathway in esophageal squamous cell cancer. Cancer Lett. 397:83–93. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Sadeqzadeh E, de Bock CE, Zhang XD, Shipman KL, Scott NM, Song C, Yeadon T, Oliveira CS, Jin B, Hersey P, et al: Dual processing of FAT1 cadherin protein by human melanoma cells generates distinct protein products. J Biol Chem. 286:28181–28191. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Kim KT, Kim BS and Kim JH: Association between FAT1 mutation and overall survival in patients with human papillomavirus-negative head and neck squamous cell carcinoma. Head Neck. 38 Suppl 1:E2021–E2029. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Valletta D, Czech B, Spruss T, Ikenberg K, Wild P, Hartmann A, Weiss TS, Oefner PJ, Müller M, Bosserhoff AK and Hellerbrand C: Regulation and function of the atypical cadherin FAT1 in hepatocellular carcinoma. Carcinogenesis. 35:1407–1415. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Morris LG, Kaufman AM, Gong Y, Ramaswami D, Walsh LA, Turcan Ş, Eng S, Kannan K, Zou Y, Peng L, et al: Recurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation. Nat Genet. 45:253–261. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Settakorn J, Kaewpila N, Burns GF and Leong AS: FAT, E-cadherin, beta catenin, HER 2/neu, Ki67 immuno-expression, and histological grade in intrahepatic cholangiocarcinoma. J Clin Pathol. 58:1249–1254. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Shi X, Zhang X, Xia T and Fang X: Living cell study at the single-molecule and single-cell levels by atomic force microscopy. Nanomedicine. 7:1625–1637. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Zhang L, Yang F, Cai JY, Yang PH and Liang ZH: In-situ detection of resveratrol inhibition effect on epidermal growth factor receptor of living MCF-7 cells by atomic force microscopy. Biosens Bioelectron. 56:271–277. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Tang J, Jiang C, Xiao X, Fang Z, Li L, Han L, Mei A, Feng Y, Guo Y, Li H and Jiang W: Changes in red blood cell membrane structure in G6PD deficiency: An atomic force microscopy study. Clin Chim Acta. 444:264–270. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Kaul-Ghanekar R, Singh S, Mamgain H, Jalota-Badhwar A, Paknikar KM and Chattopadhyay S: Tumor suppressor protein SMAR1 modulates the roughness of cell surface: Combined AFM and SEM study. BMC Cancer. 9:3502009. View Article : Google Scholar : PubMed/NCBI

18 

Cross SE, Jin YS, Rao J and Gimzewski JK: Nanomechanical analysis of cells from cancer patients. Nat Nanotechnol. 2:780–783. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Shi R, Cui H, Bi Y, Huang X, Song B, Cheng C, Zhang L, Liu J, He C, Wang F, et al: Artesunate altered cellular mechanical properties leading to deregulation of cell proliferation and migration in esophageal squamous cell carcinoma. Oncol Lett. 9:2249–2255. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Gao YB, Chen ZL, Li JG, Hu XD, Shi XJ, Sun ZM, Zhang F, Zhao ZR, Li ZT, Liu ZY, et al: Genetic landscape of esophageal squamous cell carcinoma. Nat Genet. 46:1097–1102. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Lin DC, Hao JJ, Nagata Y, Xu L, Shang L, Meng X, Sato Y, Okuno Y, Varela AM, Ding LW, et al: Genomic and molecular characterization of esophageal squamous cell carcinoma. Nat Genet. 46:467–473. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Song Y, Li L, Ou Y, Gao Z, Li E, Li X, Zhang W, Wang J, Xu L, Zhou Y, et al: Identification of genomic alterations in oesophageal squamous cell cancer. Nature. 509:91–95. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Gao J, Aksoy BA, Dogrusoz U, Dresdner G, Gross B, Sumer SO, Sun Y, Jacobsen A, Sinha R, Larsson E, et al: Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal. 6:pl12013. View Article : Google Scholar : PubMed/NCBI

24 

Cerami E, Gao J, Dogrusoz U, Gross BE, Sumer SO, Aksoy BA, Jacobsen A, Byrne CJ, Heuer ML, Larsson E, et al: The cBio cancer genomics portal: An open platform for exploring multidimensional cancer genomics data. Cancer Discov. 2:401–404. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Cancer Genome Atlas Research Network: Comprehensive genomic characterization of squamous cell lung cancers. Nature. 489:519–525. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Pickering CR, Zhang J, Yoo SY, Bengtsson L, Moorthy S, Neskey DM, Zhao M, Alves Ortega MV, Chang K, Drummond J, et al: Integrative genomic characterization of oral squamous cell carcinoma identifies frequent somatic drivers. Cancer Discov. 3:770–781. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Katoh M: Function and cancer genomics of FAT family genes (Review). Int J Oncol. 41:1913–1918. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Tanoue T and Takeichi M: New insights into fat cadherins. J Cell Sci. 118:2347–2353. 2005. View Article : Google Scholar : PubMed/NCBI

29 

Bennett FC and Harvey KF: Fat cadherin modulates organ size in Drosophila via the Salvador/Warts/Hippo signaling pathway. Curr Biol. 16:2101–2110. 2006. View Article : Google Scholar : PubMed/NCBI

30 

Reddy BV and Irvine KD: The fat and warts signaling pathways: New insights into their regulation, mechanism and conservation. Development. 135:2827–2838. 2008. View Article : Google Scholar : PubMed/NCBI

31 

Lee S, Stewart S, Nagtegaal I, Luo J, Wu Y, Colditz G, Medina D and Allred DC: Differentially expressed genes regulating the progression of ductal carcinoma in situ to invasive breast cancer. Cancer Res. 72:4574–4586. 2012. View Article : Google Scholar : PubMed/NCBI

32 

Lee GY and Lim CT: Biomechanics approaches to studying human diseases. Trends Biotechnol. 25:111–118. 2007. View Article : Google Scholar : PubMed/NCBI

33 

Guck J, Schinkinger S, Lincoln B, Wottawah F, Ebert S, Romeyke M, Lenz D, Erickson HM, Ananthakrishnan R, Mitchell D, et al: Optical deformability as an inherent cell marker for testing malignant transformation and metastatic competence. Biophys J. 88:3689–3698. 2005. View Article : Google Scholar : PubMed/NCBI

34 

Suresh S: Biomechanics and biophysics of cancer cells. Acta Biomater. 3:413–438. 2007. View Article : Google Scholar : PubMed/NCBI

35 

Cai X, Gao S, Cai J, Wu Y and Deng H: Artesunate induced morphological and mechanical changes of Jurkat cell studied by AFM. Scanning. 31:83–89. 2009. View Article : Google Scholar : PubMed/NCBI

36 

Fletcher DA and Mullins RD: Cell mechanics and the cytoskeleton. Nature. 463:485–492. 2010. View Article : Google Scholar : PubMed/NCBI

37 

Kumar S and Weaver VM: Mechanics, malignancy, and metastasis: The force journey of a tumor cell. Cancer Metastasis Rev. 28:113–127. 2009. View Article : Google Scholar : PubMed/NCBI

38 

Zhang F, Wang C, Cui Y, Li S, Yao Y, Ci Y, Wang J, Hou W, Wu A and Li E: Effects of propofol on several membrane characteristics of cervical cancer cell lines. Cell Physiol Biochem. 40:172–182. 2016. View Article : Google Scholar : PubMed/NCBI

39 

Lian S, Shi R, Huang X, Hu X, Song B, Bai Y, Yang B, Dong J, Du Z, Zhang Y, et al: Artesunate attenuates glioma proliferation, migration and invasion by affecting cellular mechanical properties. Oncol Rep. 36:984–990. 2016. View Article : Google Scholar : PubMed/NCBI

40 

Khalili AA and Ahmad MR: A review of cell adhesion studies for biomedical and biological applications. Int J Mol Sci. 16:18149–18184. 2015. View Article : Google Scholar : PubMed/NCBI

41 

Siamantouras E, Hills CE, Squires PE and Liu KK: Quantifying cellular mechanics and adhesion in renal tubular injury using single cell force spectroscopy. Nanomedicine. 12:1013–1021. 2016. View Article : Google Scholar : PubMed/NCBI

42 

Fuchs E and Cleveland DW: A structural scaffolding of intermediate filaments in health and disease. Science. 279:514–519. 1998. View Article : Google Scholar : PubMed/NCBI

43 

Yao Y, Shi M, Liu S and Li Y, Guo K, Ci Y, Liu W and Li Y: MARVELD1 modulates cell surface morphology and suppresses epithelial-mesenchymal transition in non-small cell lung cancer. Mol Carcinog. 55:1714–1727. 2016. View Article : Google Scholar : PubMed/NCBI

44 

Wang D, Huang P, Zhu B, Sun L, Huang Q and Wang J: Induction of estrogen receptor α-36 expression by bone morphogenetic protein 2 in breast cancer cell lines. Mol Med Rep. 6:591–596. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Hu X, Zhai Y, Shi R, Qian Y, Cui H, Yang J, Bi Y, Yan T, Yang J, Ma Y, Ma Y, et al: FAT1 inhibits cell migration and invasion by affecting cellular mechanical properties in esophageal squamous cell carcinoma. Oncol Rep 39: 2136-2146, 2018.
APA
Hu, X., Zhai, Y., Shi, R., Qian, Y., Cui, H., Yang, J. ... Cheng, X. (2018). FAT1 inhibits cell migration and invasion by affecting cellular mechanical properties in esophageal squamous cell carcinoma. Oncology Reports, 39, 2136-2146. https://doi.org/10.3892/or.2018.6328
MLA
Hu, X., Zhai, Y., Shi, R., Qian, Y., Cui, H., Yang, J., Bi, Y., Yan, T., Yang, J., Ma, Y., Zhang, L., Liu, Y., Li, G., Zhang, M., Cui, Y., Kong, P., Cheng, X."FAT1 inhibits cell migration and invasion by affecting cellular mechanical properties in esophageal squamous cell carcinoma". Oncology Reports 39.5 (2018): 2136-2146.
Chicago
Hu, X., Zhai, Y., Shi, R., Qian, Y., Cui, H., Yang, J., Bi, Y., Yan, T., Yang, J., Ma, Y., Zhang, L., Liu, Y., Li, G., Zhang, M., Cui, Y., Kong, P., Cheng, X."FAT1 inhibits cell migration and invasion by affecting cellular mechanical properties in esophageal squamous cell carcinoma". Oncology Reports 39, no. 5 (2018): 2136-2146. https://doi.org/10.3892/or.2018.6328
Copy and paste a formatted citation
x
Spandidos Publications style
Hu X, Zhai Y, Shi R, Qian Y, Cui H, Yang J, Bi Y, Yan T, Yang J, Ma Y, Ma Y, et al: FAT1 inhibits cell migration and invasion by affecting cellular mechanical properties in esophageal squamous cell carcinoma. Oncol Rep 39: 2136-2146, 2018.
APA
Hu, X., Zhai, Y., Shi, R., Qian, Y., Cui, H., Yang, J. ... Cheng, X. (2018). FAT1 inhibits cell migration and invasion by affecting cellular mechanical properties in esophageal squamous cell carcinoma. Oncology Reports, 39, 2136-2146. https://doi.org/10.3892/or.2018.6328
MLA
Hu, X., Zhai, Y., Shi, R., Qian, Y., Cui, H., Yang, J., Bi, Y., Yan, T., Yang, J., Ma, Y., Zhang, L., Liu, Y., Li, G., Zhang, M., Cui, Y., Kong, P., Cheng, X."FAT1 inhibits cell migration and invasion by affecting cellular mechanical properties in esophageal squamous cell carcinoma". Oncology Reports 39.5 (2018): 2136-2146.
Chicago
Hu, X., Zhai, Y., Shi, R., Qian, Y., Cui, H., Yang, J., Bi, Y., Yan, T., Yang, J., Ma, Y., Zhang, L., Liu, Y., Li, G., Zhang, M., Cui, Y., Kong, P., Cheng, X."FAT1 inhibits cell migration and invasion by affecting cellular mechanical properties in esophageal squamous cell carcinoma". Oncology Reports 39, no. 5 (2018): 2136-2146. https://doi.org/10.3892/or.2018.6328
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