Open Access

Role of COL6A3 in colorectal cancer

  • Authors:
    • Wei Liu
    • Li Li
    • Hua Ye
    • Huan Tao
    • Huaqin He
  • View Affiliations

  • Published online on: March 23, 2018     https://doi.org/10.3892/or.2018.6331
  • Pages: 2527-2536
  • Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Public transcriptome databases provide a valuable resource for genome‑wide co‑expression network analysis and investigation of the molecular mechanisms that underlie pathogenesis. To discover genes that may affect patient survival, a large‑scale analysis of human colorectal cancer (CRC) datasets that were retrieved from the NCBI Gene Expression Omnibus was performed. A gene co‑expression network was constructed using weighted gene co‑expression network analysis (WGCNA). A total of 18 co‑expressed gene modules were identified, of which two genes corresponded to cell migration and the cell cycle, two genes were involved in immune responses, two genes corresponded to mitochondrial function, and one gene corresponded to RNA splicing. A total of eight hub genes in the cell migration/extracellular matrix module were associated with poor prognosis in CRC, and the P‑value for collagen type VI α3 chain (COL6A3) was the lowest. In silico analysis of cell type‑specific gene expression and COL6A3 knockout experiments indicated the clinical relevance of COL6A3 in the development of CRC. In summary, the present analysis provides a basis for understanding the molecular characterization of CRC at the transcription level. COL6A3 may be a promising biomarker or target for the prognosis and treatment of CRC.
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June-2018
Volume 39 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Liu W, Li L, Ye H, Tao H and He H: Role of COL6A3 in colorectal cancer. Oncol Rep 39: 2527-2536, 2018
APA
Liu, W., Li, L., Ye, H., Tao, H., & He, H. (2018). Role of COL6A3 in colorectal cancer. Oncology Reports, 39, 2527-2536. https://doi.org/10.3892/or.2018.6331
MLA
Liu, W., Li, L., Ye, H., Tao, H., He, H."Role of COL6A3 in colorectal cancer". Oncology Reports 39.6 (2018): 2527-2536.
Chicago
Liu, W., Li, L., Ye, H., Tao, H., He, H."Role of COL6A3 in colorectal cancer". Oncology Reports 39, no. 6 (2018): 2527-2536. https://doi.org/10.3892/or.2018.6331