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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
June-2018 Volume 39 Issue 6

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review Open Access

Improving diagnosis, prognosis and prediction by using biomarkers in CRC patients (Review)

Taxiarchis Konstantinos Nikolouzakis, Loukia Vassilopoulou, Persefoni Fragkiadaki, Theodoros Mariolis Sapsakos, Georgios Z. Papadakis, Demetrios A. Spandidos, Aristides M. Tsatsakis, John Tsiaoussis
Pages: 2455-2472
Published online on: 21 March 2018

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Review

Autophagy regulation and its dual role in blood cancers: A novel target for therapeutic development (Review)

Shenhe Jin, Juying Wei, Liangshun You, Hui Liu, Wenbin Qian
Pages: 2473-2481
Published online on: 13 April 2018

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Article Open Access

Translational control of the undifferentiated phenotype in ER‑positive breast tumor cells: Cytoplasmic localization of ERα and impact of IRES inhibition

Christos Vaklavas, Kurt R. Zinn, Sharon L. Samuel, Zheng Meng, William E. Grizzle, Hyoungsoo Choi, Scott W. Blume
Pages: 2482-2498
Published online on: 23 March 2018

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Article Open Access

Screening potential biomarkers for colorectal cancer based on circular RNA chips

Shuo Chen, Lin Zhang, Yinan Su, Xipeng Zhang
Pages: 2499-2512
Published online on: 16 April 2018

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Article Open Access

Salidroside prevents skin carcinogenesis induced by DMBA/TPA in a mouse model through suppression of inflammation and promotion of apoptosis

Ying-Hui Kong, Su-Ping Xu
Pages: 2513-2526
Published online on: 18 April 2018

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Article Open Access

Role of COL6A3 in colorectal cancer

Wei Liu, Li Li, Hua Ye, Huan Tao, Huaqin He
Pages: 2527-2536
Published online on: 23 March 2018

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Article Open Access

Enrichment and mutation detection of circulating tumor cells from blood samples

Ruqin Kou, Jian Zhao, Priya Gogoi, Shannon Carskadon, Will Chow, Clara Hwang, Nallasivam Palanisamy, Conrad Leung, Yixin Wang
Pages: 2537-2544
Published online on: 30 March 2018

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Article Open Access

Corilagin induces the apoptosis of hepatocellular carcinoma cells through the mitochondrial apoptotic and death receptor pathways

Yuan Deng, Xudan Li, Xuan Li, Zhizhong Zheng, Wen Huang, Lianghua Chen, Qingxuan Tong, Yanlin Ming
Pages: 2545-2552
Published online on: 23 April 2018

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Article Open Access

Upregulation of UHRF1 promotes the progression of melanoma by inducing cell proliferation

Chuanyuan Wei, Nanhang Lu, Lu Wang, Yong Zhang, Zihao Feng, Yanwen Yang, Fazhi Qi, Jianying Gu
Pages: 2553-2562
Published online on: 04 April 2018

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Article Open Access

MicroRNA-384 inhibits the progression of breast cancer by targeting ACVR1

Yongxia Wang, Zheying Zhang, Jianqiang Wang
Pages: 2563-2574
Published online on: 20 April 2018

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Article Open Access

Downregulation of NONO induces apoptosis, suppressing growth and invasion in esophageal squamous cell carcinoma

Rui Cheng, Shengtao Zhu, Shuilong Guo, Li Min, Jie Xing, Qingdong Guo, Peng Li, Shutian Zhang
Pages: 2575-2583
Published online on: 27 March 2018

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Article Open Access

Expression and oncogenic properties of membranous Notch1 in oral leukoplakia and oral squamous cell carcinoma

Xu Ding, Yang Zheng, Zhao Wang, Wei Zhang, Yibo Dong, Wantao Chen, Jiang Li, Weiming Chu, Yi Zhong, Li Mao, Xiaomeng Song, Yunong Wu
Pages: 2584-2594
Published online on: 27 March 2018

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Article Open Access

Cucurbitacin D impedes gastric cancer cell survival via activation of the iNOS/NO and inhibition of the Akt signalling pathway

Yan Zhen Zhang, Chun Feng Wang, Lian Feng Zhang
Pages: 2595-2603
Published online on: 10 April 2018

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Article Open Access

Protein arginine N-methyltransferase 2 reverses tamoxifen resistance in breast cancer cells through suppression of ER-α36

Yingying Shen, Jing Zhong, Jianghua Liu, Kehuang Liu, Jun Zhao, Ting Xu, Ting Zeng, Zhimei Li, Yajun Chen, Wenjun Ding, Gebo Wen, Xuyu Zu, Renxian Cao
Pages: 2604-2612
Published online on: 02 April 2018

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Article Open Access

miR‑29a suppresses IL‑13‑induced cell invasion by inhibiting YY1 in the AKT pathway in lung adenocarcinoma A549 cells

Yu Zhang, Shujin He, Renmei Mei, Yurong Kang, Jing Duan, Ran Wei, Chuqi Xiang, Yemeng Wu, Xiangtong Lu, Zhenyu Cai, Lixia Xiong
Pages: 2613-2623
Published online on: 04 April 2018

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Article Open Access

Effects of miR‑138‑5p and miR‑204‑5p on the migration and proliferation of gastric cancer cells by targeting EGFR Retraction in /10.3892/or.2023.8677

Yi Wang, Haiyang Zhang, Shaohua Ge, Qian Fan, Likun Zhou, Hongli Li, Ming Bai, Tao Ning, Rui Liu, Xia Wang, Ting Deng, Le Zhang, Guoguang Ying, Yi Ba
Pages: 2624-2634
Published online on: 23 April 2018

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Article Open Access

miR‑30a inhibits epithelial‑mesenchymal transition and metastasis in triple‑negative breast cancer by targeting ROR1

Xin Wang, Huisi Qiu, Ruiming Tang, Huisheng Song, Huilin Pan, Zhengfu Feng, Longhua Chen
Pages: 2635-2643
Published online on: 18 April 2018

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Article Open Access

MALAT1 affects ovarian cancer cell behavior and patient survival

Qunbo Lin, Wencai Guan, Weimin Ren, Lingyun Zhang, Jinguo Zhang, Guoxiong Xu
Pages: 2644-2652
Published online on: 19 April 2018

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Article Open Access

Identifying genes as potential prognostic indicators in patients with serous ovarian cancer resistant to carboplatin using integrated bioinformatics analysis

Shi‑Jie Zhan, Bin Liu, Hua Linghu
Pages: 2653-2663
Published online on: 19 April 2018

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Article

Significance of Lysyl oxidase‑like 2 gene expression on the epithelial‑mesenchymal status of hepatocellular carcinoma

Go Ninomiya, Suguru Yamada, Masamichi Hayashi, Shigeomi Takeda, Masaya Suenaga, Hideki Takami, Mitsuro Kanda, Naoki Iwata, Yukiko Niwa, Chie Tanaka, Daisuke Kobayashi, Tsutomu Fujii, Goro Nakayama, Hiroyuki Sugimoto, Masahiko Koike, Michitaka Fujiwara, Yasuhiro Kodera
Pages: 2664-2672
Published online on: 02 April 2018

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Article

Critical role for non‑GAP function of Gαs in RGS1‑mediated promotion of melanoma progression through AKT and ERK phosphorylation

Meng‑Yan Sun, Yuchong Wang, Ji Zhu, Chuan Lv, Kai Wu, Xin‑Wei Wang, Chun‑Yu Xue
Pages: 2673-2680
Published online on: 30 March 2018

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Article

Laterally spreading features of gastrointestinal stromal tumors: A clinicopathological study

Susumu Matsukuma, Michinori Murayama, Yoshitaka Utsumi, Koji Sumi, Kosuke Miyai, Hiroaki Takeo
Pages: 2681-2687
Published online on: 10 April 2018

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Article

TIPE attenuates the apoptotic effect of radiation and cisplatin and promotes tumor growth via JNK and p38 activation in Raw264.7 and EL4 cells

Yao Liu, Xiao Yan Ni, Rui Ling Chen, Juan Li, Feng Guang Gao
Pages: 2688-2694
Published online on: 03 April 2018

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Article

A functional polymorphism at miR‑491‑5p binding site in the 3'UTR of MMP9 gene confers increased risk for pressure ulcers after hip fracture

Rui Yang, Li Han, Xiantie Zeng
Pages: 2695-2702
Published online on: 28 March 2018

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Article

miR‑186 functions as a tumor suppressor in osteosarcoma cells by suppressing the malignant phenotype and aerobic glycolysis

Qianren Xiao, Zhihui Wei, Yunyun Li, Xin Zhou, Jiajun Chen, Tengyu Wang, Gaohai Shao, Minghua Zhang, Zhongzu Zhang
Pages: 2703-2710
Published online on: 23 April 2018

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Article

β‑arrestin2 promotes 5‑FU‑induced apoptosis via the NF‑κB pathway in colorectal cancer

Weixia Ren, Tingting Wang, Xiangjun He, Qi Zhang, Jianhua Zhou, Fangfang Liu, Fangfang Gao, Yujun Zhang, Yulan Liu
Pages: 2711-2720
Published online on: 30 March 2018

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Article

NIK‑ and IKKβ‑binding protein contributes to gastric cancer chemoresistance by promoting epithelial‑mesenchymal transition through the NF‑κB signaling pathway

Zhen‑Hua Fu, Shi‑Quan Liu, Meng‑Bin Qin, Jie‑An Huang, Chun‑Yan Xu, Wen‑Hong Wu, Li‑Ye Zhu, Nan Qin, Ming‑Yu Lai
Pages: 2721-2730
Published online on: 30 March 2018

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Article

miR‑22‑3p enhances multi‑chemoresistance by targeting NET1 in bladder cancer cells

Jun Xiao, Sanqiang Niu, Jiahong Zhu, Lei Lv, Hui Deng, Daqing Pan, Deyun Shen, Congyun Xu, Zhou Shen, Tao Tao
Pages: 2731-2740
Published online on: 04 April 2018

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Article

Effect of curcumin on the cell surface markers CD44 and CD24 in breast cancer

Gloria M. Calaf, Richard Ponce-Cusi, Jorge Abarca-Quinones
Pages: 2741-2748
Published online on: 20 April 2018

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Article

Impact of RUNX2 gene silencing on the gemcitabine sensitivity of p53‑mutated pancreatic cancer MiaPaCa‑2 spheres

Meijie Sang, Mizuyo Nakamura, Takehiro Ogata, Dan Sun, Osamu Shimozato, Toshio Nikaido, Toshinori Ozaki
Pages: 2749-2758
Published online on: 30 March 2018

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Article

CT‑1042, a novel anticancer agent, exhibits effects by activating p53 and inhibiting survivin

Jun Yang, Linna Li, Chengwang Xu, Dexuan Yang, Shanshan Wang, Shoujun Yuan
Pages: 2759-2768
Published online on: 04 April 2018

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Article

Anthricin‑induced caspase‑dependent apoptosis through IGF1R/PI3K/AKT pathway inhibition in A549 human non‑small lung cancer cells

Bo‑Ram Park, Seul Ah Lee, Sung Min Moon, Chun Sung Kim
Pages: 2769-2776
Published online on: 27 March 2018

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Article

Corosolic acid induces cell cycle arrest and cell apoptosis in human retinoblastoma Y-79 cells via disruption of MELK-FoxM1 signaling

Ke Wang, Xue Zhu, Yong Yao, Min Yang, Fanfan Zhou, Ling Zhu
Pages: 2777-2786
Published online on: 28 March 2018

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Article

Autophagy inhibition potentiates SAHA‑mediated apoptosis in glioblastoma cells by accumulation of damaged mitochondria

Kovooru Lohitesh, Heena Saini, Abhilasha Srivastava, Sudeshna Mukherjee, Aniruddha Roy, Rajdeep Chowdhury
Pages: 2787-2796
Published online on: 16 April 2018

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Article

Diallyl disulfide inhibits TGF‑β1‑induced upregulation of Rac1 and β‑catenin in epithelial‑mesenchymal transition and tumor growth of gastric cancer

Bo Su, Jian Su, Ying Zeng, En Ding, Fang Liu, Tuo Tan, Hong Xia, You‑Hua Wu, Xi Zeng, Hui Ling, Hao Jiang, Xiao‑Hong Ai, Qi Su
Pages: 2797-2806
Published online on: 30 March 2018

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Article

Chloroquine inhibits cell growth in human A549 lung cancer cells by blocking autophagy and inducing mitochondrial‑mediated apoptosis

Likun Liu, Cuicui Han, Haitao Yu, Wenbin Zhu, Hongxia Cui, Lihong Zheng, Chunjing Zhang, Liling Yue
Pages: 2807-2816
Published online on: 12 April 2018

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Article

Detection of survivin expression in bladder cancer and renal cell carcinoma using specific monoclonal antibodies

Dongmei Chen, Jianjun Xu, Qingyun Zhang
Pages: 2817-2828
Published online on: 05 April 2018

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Article

Protein kinase, membrane‑associated tyrosine/threonine 1 is associated with the progression of colorectal cancer

Dongjun Jeong, Hyeongjoo Kim, Doyeon Kim, Seona Ban, Seunghyun Oh, Sanghee Ji, Donghuyn Kang, Hyunyong Lee, Tae Sung Ahn, Han Jo Kim, Sang Byung Bae, Moon Soo Lee, Chang‑Jin Kim, Hyog Young Kwon, Moo‑Jun Baek
Pages: 2829-2836
Published online on: 13 April 2018

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Article

A novel monoclonal antibody targeting a novel epitope of VE‑cadherin inhibits vasculogenic mimicry of lung cancer cells

Jie Ding, Xi Jia, Bin Zuo, Jun He, Jianfeng Yang, Yang He
Pages: 2837-2844
Published online on: 16 April 2018

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Article

Spermidine‑induced growth inhibition and apoptosis via autophagic activation in cervical cancer

Yu Chen, Haifeng Zhuang, Xuerui Chen, Zheqi Shi, Xu Wang
Pages: 2845-2854
Published online on: 18 April 2018

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Article

Nodal induced by hypoxia exposure contributes to dacarbazine resistance and the maintenance of stemness in melanoma cancer stem‑like cells

Hong Li, Junjie Chen, Xiao Wang, Mei He, Zhenyu Zhang, Ying Cen
Pages: 2855-2864
Published online on: 23 April 2018

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Article

Bioinformatics analysis of differentially expressed miRNA-related mRNAs and their prognostic value in breast carcinoma Corrigendum in /10.3892/or.2018.6505

Guo-Ming Zhang, Hemant Goyal, Lei-Lei Song
Pages: 2865-2872
Published online on: 23 April 2018

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Article

Microvesicles shed from bortezomib-treated or lenalidomide-treated human myeloma cells inhibit angiogenesis in vitro

Hui-Mei Guo, Li Sun, Lin Yang, Xiao-Jun Liu, Zi-Yuan Nie, Jian-Min Luo
Pages: 2873-2880
Published online on: 23 April 2018

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Article

Assessing stemness and proliferation properties of the newly established colon cancer ‘stem’ cell line, CSC480 and novel approaches to identify dormant cancer cells

Faisal Alowaidi, Saeed Mujahid Hashimi, Naif Alqurashi, Reem Alhulais, Saso Ivanovski, Bernadette Bellette, Adrian Meedenyia, Alfred Lam, Stephen Wood
Pages: 2881-2891
Published online on: 23 April 2018

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Article

ERBB4 promotes the proliferation of gastric cancer cells via the PI3K/Akt signaling pathway

Ji Xu, Lijie Gong, Zhenyuan Qian, Guangyuan Song, Jinming Liu
Pages: 2892-2898
Published online on: 30 March 2018

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Article

Cytochalasin H isolated from mangrove‑derived endophytic fungus induces apoptosis and inhibits migration in lung cancer cells

Yuefan Ma, Xin Wu, Zihan Xiu, Xin Liu, Bingyu Huang, Liang Hu, Jiao Liu, Zhiyuan Zhou, Xudong Tang
Pages: 2899-2905
Published online on: 30 March 2018

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Article

miR-328-5p inhibits MDA-MB-231 breast cancer cell proliferation by targeting RAGE

Tingting Luo, Yueqiong Yan, Qiuxia He, Xiaoqian Ma, Wei Wang
Pages: 2906-2914
Published online on: 04 April 2018

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Article

RIP2 promotes glioma cell growth by regulating TRAF3 and activating the NF‑κB and p38 signaling pathways

Xin Cai, Yongchang Yang, Wengrong Xia, Haibo Kong, Min Wang, Wenliang Fu, Minhui Long, Yuhua Hu, Donggang Xu
Pages: 2915-2923
Published online on: 23 April 2018

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Article

Exogenous regucalcin suppresses the growth of human liver cancer HepG2 cells in vitro

Masayoshi Yamaguchi, Tomiyasu Murata
Pages: 2924-2930
Published online on: 05 April 2018

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Article

The biological role of autophagy in regulating and controlling the proliferation of liver cancer cells induced by bufalin

Xia Sheng, Pengfei Zhu, Jianmin Qin, Qi Li
Pages: 2931-2941
Published online on: 12 April 2018

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Article

Eupatilin inhibits the proliferation of human esophageal cancer TE1 cells by targeting the Akt‑GSK3β and MAPK/ERK signaling cascades

Xiaona Wang, Yanyan Zhu, Lili Zhu, Xinhuan Chen, Yanyan Xu, Yafei Zhao, Yingzhe Shao, Feng Li, Yanan Jiang, Jing Lu, Youtian Huang, Xiaobin Chang, Juan Zhang, Xiang Li, Kangdong Liu, Mingyao Zhao, Ziming Dong, Jimin Zhao
Pages: 2942-2950
Published online on: 23 April 2018

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Article

PDK1 inhibitor GSK2334470 synergizes with proteasome inhibitor MG‑132 in multiple myeloma cells by inhibiting full AKT activity and increasing nuclear accumulation of the PTEN protein

Jin Zhang, Chunmei Yang, Fengping Zhou, Xiaohui Chen
Pages: 2951-2959
Published online on: 12 April 2018

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Article

MicroRNA-616 promotes the progression of ovarian cancer by targeting TIMP2

Zhongbo Chen, Jianqing Zhu, Yiming Zhu, Junjian Wang
Pages: 2960-2968
Published online on: 12 April 2018

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Article

Anticancer effect of exogenous hydrogen sulfide in cisplatin‑resistant A549/DDP cells

Ying Ma, Zhonghai Yan, Xiaomei Deng, Junqi Guo, Jinxia Hu, Yuan Yu, Fei Jiao
Pages: 2969-2977
Published online on: 12 April 2018

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Article

HSPB8 promotes cancer cell growth by activating the ERK‑CREB pathway and is indicative of a poor prognosis in gastric cancer patients

Jian Shen, Minzhe Li, Li Min
Pages: 2978-2986
Published online on: 18 April 2018

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Article

MicroRNA‑577 inhibits the migration and invasion of hepatocellular carcinoma cells by targeting homeobox A1

Shaoshan Han, Zhikui Liu, Yufeng Wang, Liang Wang, Bowen Yao, Cheng Guo, Tao Song, Kangsheng Tu, Qingguang Liu
Pages: 2987-2995
Published online on: 23 April 2018

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Article

High expression of fructose-bisphosphate aldolase A induces progression of renal cell carcinoma

Zhengkai Huang, Yibo Hua, Ye Tian, Chao Qin, Jian Qian, Meiling Bao, Yiyang Liu, Shangqian Wang, Qiang Cao, Xiaobing Ju, Zengjun Wang, Min Gu
Pages: 2996-3006
Published online on: 18 April 2018

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Article

Gallic acid sensitizes paclitaxel-resistant human ovarian carcinoma cells through an increase in reactive oxygen species and subsequent downregulation of ERK activation

Jessica Nayelli Sánchez-Carranza, J. Fernando Díaz, Mariano Redondo-Horcajo, Isabel Barasoain, Laura Alvarez, Pedro Lastres, Antonio Romero-Estrada, Patricio Aller, Leticia González-Maya
Pages: 3007-3014
Published online on: 18 April 2018

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Article

miR-146a promotes cervical cancer cell viability via targeting IRAK1 and TRAF6

Qiming Hu, Jiacheng Song, Bo Ding, Yugui Cui, Jiale Liang, Suping Han
Pages: 3015-3024
Published online on: 23 April 2018

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Article

Resveratrol decreases Rad51 expression and sensitizes cisplatin‑resistant MCF‑7 breast cancer cells

I. Leon‑Galicia, J. Diaz‑Chavez, M. E. Albino‑Sanchez, E. Garcia‑Villa, R. Bermudez‑Cruz, J. Garcia‑Mena, L. A. Herrera, A. García‑Carrancá, P. Gariglio
Pages: 3025-3033
Published online on: 27 March 2018

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Article

GPNMB silencing suppresses the proliferation and metastasis of osteosarcoma cells by blocking the PI3K/Akt/mTOR signaling pathway

Rui Jin, Ying‑Ying Jin, Yi‑Lun Tang, Hua‑Juan Yang, Xiao‑Qian Zhou, Zhe Lei
Pages: 3034-3040
Published online on: 30 March 2018

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Article

Doxycycline targets aldehyde dehydrogenase‑positive breast cancer stem cells

Chang‑Ching Lin, Miao‑Chia Lo, Rebecca R. Moody, Nicholas O. Stevers, Samantha L. Tinsley, Duxin Sun
Pages: 3041-3047
Published online on: 27 March 2018

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Article

Lower endogenous p53 levels and degradation of AKT protein contribute to potent suppression of the new antibiotic Xiakemycin A on tumor cells

Chuan Chen, Zhongke Jiang, Xiuyuan Ou, Huixian Zhang, Chenghang Sun, Qiyang He
Pages: 3048-3054
Published online on: 18 April 2018

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Article

Huaier suppresses proliferative and metastatic potential of prostate cancer PC3 cells via downregulation of Lamin B1 and induction of autophagy

Ailin Yang, Yanan Zhao, Ying Wang, Xiaojun Zha, Yunfang Zhao, Pengfei Tu, Zhongdong Hu
Pages: 3055-3063
Published online on: 05 April 2018

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Article

Overexpression of IL-9 induced by STAT3 phosphorylation is mediated by miR-155 and miR-21 in chronic lymphocytic leukemia Corrigendum in /10.3892/or.2025.8940

Na Chen, Lili Feng, Huiting Qu, Kang Lu, Peipei Li, Xiao Lv, Xin Wang
Pages: 3064-3072
Published online on: 12 April 2018

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Article

MicroRNA-33b-5p is overexpressed and inhibits GLUT4 by targeting HMGA2 in polycystic ovarian syndrome: An in vivo and in vitro study

Ying Yang, Hua Jiang, Ling Xiao, Xuezhou Yang
Pages: 3073-3085
Published online on: 18 April 2018

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Article

let-7d-3p is associated with apoptosis and response to neoadjuvant chemotherapy in ovarian cancer

Raúl García-Vázquez, Dolores Gallardo Rincón, Erika Ruiz-García, Abelardo Meneses García, Olga N. Hernández De La Cruz, Horacio Astudillo-De La Vega, David Isla-Ortiz, Laurence A. Marchat, Yarely M. Salinas-Vera, Ángeles Carlos-Reyes, Sullivan López-González, Rosalio Ramos-Payan, César López-Camarillo
Pages: 3086-3094
Published online on: 12 April 2018

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Journal Cover
January-2026 Volume 55 Issue 1

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review Open Access

Harnessing ferroptosis for cancer therapy: Mechanisms and therapeutic strategies (Review)

Nabil Mouawad, Nour El Jaafari, Mirvat El Sibai, Ralph J. Abi-Habib
Article Number: 24
Published online on: 24 November 2025

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Expression of Concern Open Access

[Expression of Concern] Promoter methylation of death‑associated protein kinase and its role in irradiation response in cervical cancer

Rebecca Ching-Yu Leung, Stephanie Si Liu, Kelvin Yuen-Kwong Chan, Kar-Fai Tam, Kar-Loen Chan, Ling-Chui Wong, Hextan Yuen-Sheung Ngan
Article Number: 23
Published online on: 24 November 2025

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Article Open Access

Oxaliplatin resistance in pancreatic ductal adenocarcinoma is non‑significantly mediated by diminished drug uptake but is highly linked to a poor apoptotic response to the cytotoxic threat

Hellen Röttgen, Lana Theurer, Teresa Peccerella, Ketaki Sandu, Johanna Weiss, Jürgen Burhenne, John P. Neoptolemos, Beate Köberle, Dirk Theile
Article Number: 22
Published online on: 19 November 2025

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Correction Open Access

[Corrigendum] Src homology phosphotyrosyl phosphatase 2 mediates cisplatin‑related drug resistance by inhibiting apoptosis and activating the Ras/PI3K/Akt1/survivin pathway in lung cancer cells

Chunlan Tang, Hu Luo, Dan Luo, Heping Yang, Xiangdong Zhou
Article Number: 21
Published online on: 19 November 2025

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Article Open Access

S100B drives glioblastoma invasion and migration through TGF‑β2‑mediated epithelial‑mesenchymal transition

Xuemei Liao, Yuan Xu, Honghong Zhou, Qin Yi, Shifang Dong, Bin Tan
Article Number: 20
Published online on: 19 November 2025

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Review Open Access

Role of the SOX family in non‑small cell lung cancer: Molecular mechanisms and therapeutic implications (Review)

Kaiwei Wang, Yaoqi Li, Zhening Guo, Lin Song, Xiaoliang Ding, Linsheng Liu, Tao Hu, Yicong Bian, Chenrong Huang, Liyan Miao
Article Number: 19
Published online on: 18 November 2025

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Retraction Open Access

[Retracted] MicroRNA‑18a enhances the radiosensitivity of cervical cancer cells by promoting radiation‑induced apoptosis

Sha Liu, Xiaofen Pan, Qin Yang, Lu Wen, Yao Jiang, Yingchao Zhao, Guiling Li
Article Number: 18
Published online on: 17 November 2025

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Review Open Access

Role of histone deacetylases in blood cancer: Exploring peptide‑based inhibitors as therapeutic strategies for leukemia treatment (Review)

Yaneenart Suwanwong, Phornthip Ploensil
Article Number: 17
Published online on: 14 November 2025

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Review Open Access

The multidimensional regulatory network of the PD‑1/PD‑L1 axis in the esophageal squamous cell carcinoma microenvironment: Implications for novel combination therapies and precision immunotherapy (Review)

Haoyue Lai, Lu Qi, Zhixuan Lin, Zhongwen Li
Article Number: 16
Published online on: 13 November 2025

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Review Open Access

From modification to malignancy: Bridging acetylation mechanisms and therapeutic innovations in melanoma (Review)

Jingwen Wu, Xuxia Cai, Zimo Zhu, Xiahong Li, Kaoyuan Zhang, Chenchen Wu, Bo Yu, Cong Huang
Article Number: 15
Published online on: 12 November 2025

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Retraction Open Access

[Retracted] MicroRNA‑92b promotes tumor growth and activation of NF‑κB signaling via regulation of NLK in oral squamous cell carcinoma

Zhiming Liu, Cynthia Diep, Tiantian Mao, Li Huang, Robert Merrill, Zhouwen Zhang, Youjian Peng
Article Number: 14
Published online on: 11 November 2025

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Article Open Access

C‑terminal HSP90 inhibitor NCT‑58 impairs the cancer stem‑like phenotype and enhances chemotherapy efficacy in TNBC

Eunsun Jung, Yoon-Jae Kim, Kyoungmin Lee, Seojin Jang, Soeun Park, Eunhye Oh, Minsu Park, Seongjae Kim, Dongmi Ko, Yong Koo Kang, Kee Dal Nam, Lee Farrand, Cong-Truong Nguyen, Minh Thanh La, Jihyae Ann, Jeewoo Lee, Ji Young Kim, Jae Hong Seo
Article Number: 13
Published online on: 11 November 2025

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Correction Open Access

[Corrigendum] Compound 225# inhibits the proliferation of human colorectal cancer cells by promoting cell cycle arrest and apoptosis induction

Xiaoxue Zhang, Liujun He, Yong Li, Yifei Qiu, Wujing Hu, Wanying Lu, Huihui Du, Donglin Yang
Article Number: 12
Published online on: 06 November 2025

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Review Open Access

Immune system, inflammatory response, and regulated cell death in breast cancer research (Review)

Guangyao Li, Binghui Jin, Jialin Zhou, Shifeng Fang, Zhe Fan
Article Number: 11
Published online on: 05 November 2025

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Retraction Open Access

[Retracted] Uvangoletin induces mitochondria‑mediated apoptosis in HL‑60 cells in vitro and in vivo without adverse reactions of myelosuppression, leucopenia and gastrointestinal tract disturbances

Zhuanzhen Zheng, Zhenhua Qiao, Rong Gong, Yalin Wang, Yiqun Zhang, Yanping Ma, Li Zhang, Yujin Lu, Bo Jiang, Guoxia Li, Chunxia Dong, Wenliang Chen
Article Number: 10
Published online on: 03 November 2025

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Article Open Access

Characterization of the anticancer effect of mebendazole and its interaction with standard cytotoxic drugs in patient tumor cells ex vivo and in an in vivo mouse model

Sharmineh Mansoori, Kristin Blom, Claes Andersson, Mårten Fryknäs, Rolf Larsson, Peter Nygren
Article Number: 9
Published online on: 31 October 2025

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Correction Open Access

[Corrigendum] Gemcitabine combined with an engineered oncolytic vaccinia virus exhibits a synergistic suppressive effect on the tumor growth of pancreatic cancer

Wanyuan Chen, Weimin Fan, Guoqing Ru, Fang Huang, Xiaming Lu, Xin Zhang, Xiaozhou Mou, Shibing Wang
Article Number: 8
Published online on: 30 October 2025

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Article Open Access

CD44 knockdown and TGF‑β inhibition modulate cell proliferation and invasion in claudin‑low breast cancer cells

Ryoichi Matsunuma, Kazuo Kinoshita, Sae Imada, Shoko Sato, Ryosuke Hayami, Michiko Tsuneizumi
Article Number: 7
Published online on: 30 October 2025

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Retraction Open Access

[Retracted] MicroRNA‑302a targets GAB2 to suppress cell proliferation, migration and invasion of glioma

Jiuhong Ma, Jia Yu, Jingmei Liu, Xing Yang, Miao Lou, Jinghui Liu, Fuqiang Feng, Peigang Ji, Liang Wang
Article Number: 6
Published online on: 27 October 2025

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Article Open Access

LRRC59 inhibits perk pathway‑induced apoptosis and promotes cell proliferation, migration and invasion in colorectal cancer cells

Xingdong Hou, Yuting Wang, Yuzhuo Chen, Peiyan Zhong, Guangzhi Wang, Baicheng Li, Bowei Lu, Hanyu Jiang, Shili Ning
Article Number: 5
Published online on: 23 October 2025

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Article Open Access

Comparative analysis of the efficacy and safety of antibody‑drug conjugates, radionuclide‑drug conjugates and their combination targeting claudin 18.2 in gastric cancer treatment

Huan Du, Xiao-Fei Hao, Bin-Wei Lin, Yu Zhang, Luo Rui, Jing Wang, Ming-Ming Tang, De-Cai Wang, Yi-Han Zhu, Jie Li, Tang-Zhi Dai, Yuchuan Yang, Xia Yang, Xiaobo Du
Article Number: 4
Published online on: 22 October 2025

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Expression of Concern Open Access

[Expression of Concern] CDKN3 is an independent prognostic factor and promotes ovarian carcinoma cell proliferation in ovarian cancer

Tianren Li, Hui Xue, Yi Guo, Kejun Guo
Article Number: 3
Published online on: 16 October 2025

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Review Open Access

Platelet‑circulating tumor cell crosstalk: A pivotal target in cancer diagnosis and therapy (Review)

Lifang Zhang, Ye Yuan, Yan Deng, Lin Wang, Fenghua Chen
Article Number: 2
Published online on: 15 October 2025

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Expression of Concern Open Access

[Expression of Concern] Knockdown of Bmi1 inhibits the stemness properties and tumorigenicity of human bladder cancer stem cell‑like side population cells

Dingjun Zhu, Xuesi Wan, Hai Huang, Xu Chen, Wu Liang, Fengjin Zhao, Tianxin Lin, Jinli Han, Wenlian Xie
Article Number: 1
Published online on: 14 October 2025

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Journal Cover
February-2026 Volume 55 Issue 2

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review Open Access

Alternative splicing in cancer drug resistance: Mechanisms and therapeutic prospects (Review)

Wenpu Zhu, Zikun Wu, Chai Luv, Banghe Bao, Weijie Zhao, Guanglong Chen, Hang Yang, Huihan Ai, Faqiang Liu, Zhi Li
Article Number: 31
Published online on: 05 December 2025

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Article Open Access

Inhibition of primary ciliogenesis enhances efficacy of EGFR‑TKIs against non‑small cell lung cancer cells

Liangliang Jin, Li Wei, Junrui Hua, Rong Zhang, Jiaxin Chen, Jinpeng He, Yanli Yang
Article Number: 30
Published online on: 04 December 2025

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Review

Beyond eradication: Therapeutic reprogramming strategies for cancer normalization (Review)

Aliasgar Shahiwala
Article Number: 29
Published online on: 04 December 2025

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Article Open Access

Saikosaponin D overcomes gemcitabine resistance in pancreatic cancer via AKT/mTOR pathway inhibition and synergistic induction of apoptosis and autophagy

Rui Zheng, Yusi Liu, Sen Zhou, Guimei Liu, Xiaobin Liu, Yiyuan Yang, Yufu Zhang
Article Number: 28
Published online on: 04 December 2025

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Retraction Open Access

[Retracted] Downregulation of Bmi‑1 is associated with suppressed tumorigenesis and induced apoptosis in CD44+ nasopharyngeal carcinoma cancer stem‑like cells

Xinhua Xu, Yang Liu, Jin Su, Daojun Li, Juan Hu, Qiao Huang, Mingqian Lu, Xiaoyan Liu, Jinghua Ren, Weihong Chen, Lidan Sun
Article Number: 27
Published online on: 04 December 2025

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Article Open Access

Prognostic significance of fibroblast senescence and senescence-associated secretory phenotype factor expression in the tumor microenvironment of pancreatic ductal adenocarcinoma

Yuto Kitano, Tomoharu Miyashita, Takeo Shimasaki, Isamu Makino, Yoshio Endo, Yasuhiko Yamamoto, Noriyuki Inaki, Shintaro Yagi
Article Number: 26
Published online on: 03 December 2025

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Retraction Open Access

[Retracted] Sp1‑CD147 positive feedback loop promotes the invasion ability of ovarian cancer

Jing Zhao, Wei Ye, Juan Wu, Lijuan Liu, Lina Yang, Lu Gao, Biliang Chen, Fanglin Zhang, Hong Yang, Yu Li
Article Number: 25
Published online on: 25 November 2025

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