Journal Articles

Open Access

Improving diagnosis, prognosis and prediction by using biomarkers in CRC patients (Review)

Taxiarchis Konstantinos Nikolouzakis, Loukia Vassilopoulou, Persefoni Fragkiadaki, Theodoros Mariolis Sapsakos, Georgios Z. Papadakis, Demetrios A. Spandidos, Aristides M. Tsatsakis, John Tsiaoussis

Pages: 2455-2472 Published online on: 21 March 2018

Autophagy regulation and its dual role in blood cancers: A novel target for therapeutic development (Review)

Shenhe Jin, Juying Wei, Liangshun You, Hui Liu, Wenbin Qian

Pages: 2473-2481 Published online on: 13 April 2018
Open Access

Translational control of the undifferentiated phenotype in ER‑positive breast tumor cells: Cytoplasmic localization of ERα and impact of IRES inhibition

Christos Vaklavas, Kurt R. Zinn, Sharon L. Samuel, Zheng Meng, William E. Grizzle, Hyoungsoo Choi, Scott W. Blume

Pages: 2482-2498 Published online on: 23 March 2018
Open Access

Screening potential biomarkers for colorectal cancer based on circular RNA chips

Shuo Chen, Lin Zhang, Yinan Su, Xipeng Zhang

Pages: 2499-2512 Published online on: 16 April 2018
Open Access

Role of COL6A3 in colorectal cancer

Wei Liu, Li Li, Hua Ye, Huan Tao, Huaqin He

Pages: 2527-2536 Published online on: 23 March 2018
Open Access

Enrichment and mutation detection of circulating tumor cells from blood samples

Ruqin Kou, Jian Zhao, Priya Gogoi, Shannon Carskadon, Will Chow, Clara Hwang, Nallasivam Palanisamy, Conrad Leung, Yixin Wang

Pages: 2537-2544 Published online on: 30 March 2018
Open Access

Corilagin induces the apoptosis of hepatocellular carcinoma cells through the mitochondrial apoptotic and death receptor pathways

Yuan Deng, Xudan Li, Xuan Li, Zhizhong Zheng, Wen Huang, Lianghua Chen, Qingxuan Tong, Yanlin Ming

Pages: 2545-2552 Published online on: 23 April 2018
Open Access

Upregulation of UHRF1 promotes the progression of melanoma by inducing cell proliferation

Chuanyuan Wei, Nanhang Lu, Lu Wang, Yong Zhang, Zihao Feng, Yanwen Yang, Fazhi Qi, Jianying Gu

Pages: 2553-2562 Published online on: 04 April 2018
Open Access

MicroRNA-384 inhibits the progression of breast cancer by targeting ACVR1

Yongxia Wang, Zheying Zhang, Jianqiang Wang

Pages: 2563-2574 Published online on: 20 April 2018
Open Access

Downregulation of NONO induces apoptosis, suppressing growth and invasion in esophageal squamous cell carcinoma

Rui Cheng, Shengtao Zhu, Shuilong Guo, Li Min, Jie Xing, Qingdong Guo, Peng Li, Shutian Zhang

Pages: 2575-2583 Published online on: 27 March 2018
Open Access

Expression and oncogenic properties of membranous Notch1 in oral leukoplakia and oral squamous cell carcinoma

Xu Ding, Yang Zheng, Zhao Wang, Wei Zhang, Yibo Dong, Wantao Chen, Jiang Li, Weiming Chu, Yi Zhong, Li Mao, Xiaomeng Song, Yunong Wu

Pages: 2584-2594 Published online on: 27 March 2018
Open Access

Cucurbitacin D impedes gastric cancer cell survival via activation of the iNOS/NO and inhibition of the Akt signalling pathway

Yan Zhen Zhang, Chun Feng Wang, Lian Feng Zhang

Pages: 2595-2603 Published online on: 10 April 2018
Open Access

Protein arginine N-methyltransferase 2 reverses tamoxifen resistance in breast cancer cells through suppression of ER-α36

Yingying Shen, Jing Zhong, Jianghua Liu, Kehuang Liu, Jun Zhao, Ting Xu, Ting Zeng, Zhimei Li, Yajun Chen, Wenjun Ding, Gebo Wen, Xuyu Zu, Renxian Cao

Pages: 2604-2612 Published online on: 02 April 2018
Open Access

miR‑29a suppresses IL‑13‑induced cell invasion by inhibiting YY1 in the AKT pathway in lung adenocarcinoma A549 cells

Yu Zhang, Shujin He, Renmei Mei, Yurong Kang, Jing Duan, Ran Wei, Chuqi Xiang, Yemeng Wu, Xiangtong Lu, Zhenyu Cai, Lixia Xiong

Pages: 2613-2623 Published online on: 04 April 2018
Open Access

Effects of miR‑138‑5p and miR‑204‑5p on the migration and proliferation of gastric cancer cells by targeting EGFR

Yi Wang, Haiyang Zhang, Shaohua Ge, Qian Fan, Likun Zhou, Hongli Li, Ming Bai, Tao Ning, Rui Liu, Xia Wang, Ting Deng, Le Zhang, Guoguang Ying, Yi Ba

Pages: 2624-2634 Published online on: 23 April 2018
Open Access

miR‑30a inhibits epithelial‑mesenchymal transition and metastasis in triple‑negative breast cancer by targeting ROR1

Xin Wang, Huisi Qiu, Ruiming Tang, Huisheng Song, Huilin Pan, Zhengfu Feng, Longhua Chen

Pages: 2635-2643 Published online on: 18 April 2018
Open Access

MALAT1 affects ovarian cancer cell behavior and patient survival

Qunbo Lin, Wencai Guan, Weimin Ren, Lingyun Zhang, Jinguo Zhang, Guoxiong Xu

Pages: 2644-2652 Published online on: 19 April 2018

Significance of Lysyl oxidase‑like 2 gene expression on the epithelial‑mesenchymal status of hepatocellular carcinoma

Go Ninomiya, Suguru Yamada, Masamichi Hayashi, Shigeomi Takeda, Masaya Suenaga, Hideki Takami, Mitsuro Kanda, Naoki Iwata, Yukiko Niwa, Chie Tanaka, Daisuke Kobayashi, Tsutomu Fujii, Goro Nakayama, Hiroyuki Sugimoto, Masahiko Koike, Michitaka Fujiwara, Yasuhiro Kodera

Pages: 2664-2672 Published online on: 02 April 2018

Critical role for non‑GAP function of Gαs in RGS1‑mediated promotion of melanoma progression through AKT and ERK phosphorylation

Meng‑Yan Sun, Yuchong Wang, Ji Zhu, Chuan Lv, Kai Wu, Xin‑Wei Wang, Chun‑Yu Xue

Pages: 2673-2680 Published online on: 30 March 2018

Laterally spreading features of gastrointestinal stromal tumors: A clinicopathological study

Susumu Matsukuma, Michinori Murayama, Yoshitaka Utsumi, Koji Sumi, Kosuke Miyai, Hiroaki Takeo

Pages: 2681-2687 Published online on: 10 April 2018

TIPE attenuates the apoptotic effect of radiation and cisplatin and promotes tumor growth via JNK and p38 activation in Raw264.7 and EL4 cells

Yao Liu, Xiao Yan Ni, Rui Ling Chen, Juan Li, Feng Guang Gao

Pages: 2688-2694 Published online on: 03 April 2018

miR‑186 functions as a tumor suppressor in osteosarcoma cells by suppressing the malignant phenotype and aerobic glycolysis

Qianren Xiao, Zhihui Wei, Yunyun Li, Xin Zhou, Jiajun Chen, Tengyu Wang, Gaohai Shao, Minghua Zhang, Zhongzu Zhang

Pages: 2703-2710 Published online on: 23 April 2018

β‑arrestin2 promotes 5‑FU‑induced apoptosis via the NF‑κB pathway in colorectal cancer

Weixia Ren, Tingting Wang, Xiangjun He, Qi Zhang, Jianhua Zhou, Fangfang Liu, Fangfang Gao, Yujun Zhang, Yulan Liu

Pages: 2711-2720 Published online on: 30 March 2018

NIK‑ and IKKβ‑binding protein contributes to gastric cancer chemoresistance by promoting epithelial‑mesenchymal transition through the NF‑κB signaling pathway

Zhen‑Hua Fu, Shi‑Quan Liu, Meng‑Bin Qin, Jie‑An Huang, Chun‑Yan Xu, Wen‑Hong Wu, Li‑Ye Zhu, Nan Qin, Ming‑Yu Lai

Pages: 2721-2730 Published online on: 30 March 2018

miR‑22‑3p enhances multi‑chemoresistance by targeting NET1 in bladder cancer cells

Jun Xiao, Sanqiang Niu, Jiahong Zhu, Lei Lv, Hui Deng, Daqing Pan, Deyun Shen, Congyun Xu, Zhou Shen, Tao Tao

Pages: 2731-2740 Published online on: 04 April 2018

Effect of curcumin on the cell surface markers CD44 and CD24 in breast cancer

Gloria M. Calaf, Richard Ponce-Cusi, Jorge Abarca-Quinones

Pages: 2741-2748 Published online on: 20 April 2018

Impact of RUNX2 gene silencing on the gemcitabine sensitivity of p53‑mutated pancreatic cancer MiaPaCa‑2 spheres

Meijie Sang, Mizuyo Nakamura, Takehiro Ogata, Dan Sun, Osamu Shimozato, Toshio Nikaido, Toshinori Ozaki

Pages: 2749-2758 Published online on: 30 March 2018

CT‑1042, a novel anticancer agent, exhibits effects by activating p53 and inhibiting survivin

Jun Yang, Linna Li, Chengwang Xu, Dexuan Yang, Shanshan Wang, Shoujun Yuan

Pages: 2759-2768 Published online on: 04 April 2018

Anthricin‑induced caspase‑dependent apoptosis through IGF1R/PI3K/AKT pathway inhibition in A549 human non‑small lung cancer cells

Bo‑Ram Park, Seul Ah Lee, Sung Min Moon, Chun Sung Kim

Pages: 2769-2776 Published online on: 27 March 2018

Corosolic acid induces cell cycle arrest and cell apoptosis in human retinoblastoma Y-79 cells via disruption of MELK-FoxM1 signaling

Ke Wang, Xue Zhu, Yong Yao, Min Yang, Fanfan Zhou, Ling Zhu

Pages: 2777-2786 Published online on: 28 March 2018

Autophagy inhibition potentiates SAHA‑mediated apoptosis in glioblastoma cells by accumulation of damaged mitochondria

Kovooru Lohitesh, Heena Saini, Abhilasha Srivastava, Sudeshna Mukherjee, Aniruddha Roy, Rajdeep Chowdhury

Pages: 2787-2796 Published online on: 16 April 2018

Diallyl disulfide inhibits TGF‑β1‑induced upregulation of Rac1 and β‑catenin in epithelial‑mesenchymal transition and tumor growth of gastric cancer

Bo Su, Jian Su, Ying Zeng, En Ding, Fang Liu, Tuo Tan, Hong Xia, You‑Hua Wu, Xi Zeng, Hui Ling, Hao Jiang, Xiao‑Hong Ai, Qi Su

Pages: 2797-2806 Published online on: 30 March 2018

Chloroquine inhibits cell growth in human A549 lung cancer cells by blocking autophagy and inducing mitochondrial‑mediated apoptosis

Likun Liu, Cuicui Han, Haitao Yu, Wenbin Zhu, Hongxia Cui, Lihong Zheng, Chunjing Zhang, Liling Yue

Pages: 2807-2816 Published online on: 12 April 2018

Detection of survivin expression in bladder cancer and renal cell carcinoma using specific monoclonal antibodies

Dongmei Chen, Jianjun Xu, Qingyun Zhang

Pages: 2817-2828 Published online on: 05 April 2018

Protein kinase, membrane‑associated tyrosine/threonine 1 is associated with the progression of colorectal cancer

Dongjun Jeong, Hyeongjoo Kim, Doyeon Kim, Seona Ban, Seunghyun Oh, Sanghee Ji, Donghuyn Kang, Hyunyong Lee, Tae Sung Ahn, Han Jo Kim, Sang Byung Bae, Moon Soo Lee, Chang‑Jin Kim, Hyog Young Kwon, Moo‑Jun Baek

Pages: 2829-2836 Published online on: 13 April 2018

A novel monoclonal antibody targeting a novel epitope of VE‑cadherin inhibits vasculogenic mimicry of lung cancer cells

Jie Ding, Xi Jia, Bin Zuo, Jun He, Jianfeng Yang, Yang He

Pages: 2837-2844 Published online on: 16 April 2018

Spermidine‑induced growth inhibition and apoptosis via autophagic activation in cervical cancer

Yu Chen, Haifeng Zhuang, Xuerui Chen, Zheqi Shi, Xu Wang

Pages: 2845-2854 Published online on: 18 April 2018

Nodal induced by hypoxia exposure contributes to dacarbazine resistance and the maintenance of stemness in melanoma cancer stem‑like cells

Hong Li, Junjie Chen, Xiao Wang, Mei He, Zhenyu Zhang, Ying Cen

Pages: 2855-2864 Published online on: 23 April 2018

Microvesicles shed from bortezomib-treated or lenalidomide-treated human myeloma cells inhibit angiogenesis in vitro

Hui-Mei Guo, Li Sun, Lin Yang, Xiao-Jun Liu, Zi-Yuan Nie, Jian-Min Luo

Pages: 2873-2880 Published online on: 23 April 2018

Assessing stemness and proliferation properties of the newly established colon cancer ‘stem’ cell line, CSC480 and novel approaches to identify dormant cancer cells

Faisal Alowaidi, Saeed Mujahid Hashimi, Naif Alqurashi, Reem Alhulais, Saso Ivanovski, Bernadette Bellette, Adrian Meedenyia, Alfred Lam, Stephen Wood

Pages: 2881-2891 Published online on: 23 April 2018

ERBB4 promotes the proliferation of gastric cancer cells via the PI3K/Akt signaling pathway

Ji Xu, Lijie Gong, Zhenyuan Qian, Guangyuan Song, Jinming Liu

Pages: 2892-2898 Published online on: 30 March 2018

Cytochalasin H isolated from mangrove‑derived endophytic fungus induces apoptosis and inhibits migration in lung cancer cells

Yuefan Ma, Xin Wu, Zihan Xiu, Xin Liu, Bingyu Huang, Liang Hu, Jiao Liu, Zhiyuan Zhou, Xudong Tang

Pages: 2899-2905 Published online on: 30 March 2018

miR-328-5p inhibits MDA-MB-231 breast cancer cell proliferation by targeting RAGE

Tingting Luo, Yueqiong Yan, Qiuxia He, Xiaoqian Ma, Wei Wang

Pages: 2906-2914 Published online on: 04 April 2018

RIP2 promotes glioma cell growth by regulating TRAF3 and activating the NF‑κB and p38 signaling pathways

Xin Cai, Yongchang Yang, Wengrong Xia, Haibo Kong, Min Wang, Wenliang Fu, Minhui Long, Yuhua Hu, Donggang Xu

Pages: 2915-2923 Published online on: 23 April 2018

Exogenous regucalcin suppresses the growth of human liver cancer HepG2 cells in vitro

Masayoshi Yamaguchi, Tomiyasu Murata

Pages: 2924-2930 Published online on: 05 April 2018

The biological role of autophagy in regulating and controlling the proliferation of liver cancer cells induced by bufalin

Xia Sheng, Pengfei Zhu, Jianmin Qin, Qi Li

Pages: 2931-2941 Published online on: 12 April 2018

Eupatilin inhibits the proliferation of human esophageal cancer TE1 cells by targeting the Akt‑GSK3β and MAPK/ERK signaling cascades

Xiaona Wang, Yanyan Zhu, Lili Zhu, Xinhuan Chen, Yanyan Xu, Yafei Zhao, Yingzhe Shao, Feng Li, Yanan Jiang, Jing Lu, Youtian Huang, Xiaobin Chang, Juan Zhang, Xiang Li, Kangdong Liu, Mingyao Zhao, Ziming Dong, Jimin Zhao

Pages: 2942-2950 Published online on: 23 April 2018

MicroRNA-616 promotes the progression of ovarian cancer by targeting TIMP2

Zhongbo Chen, Jianqing Zhu, Yiming Zhu, Junjian Wang

Pages: 2960-2968 Published online on: 12 April 2018

Anticancer effect of exogenous hydrogen sulfide in cisplatin‑resistant A549/DDP cells

Ying Ma, Zhonghai Yan, Xiaomei Deng, Junqi Guo, Jinxia Hu, Yuan Yu, Fei Jiao

Pages: 2969-2977 Published online on: 12 April 2018

MicroRNA‑577 inhibits the migration and invasion of hepatocellular carcinoma cells by targeting homeobox A1

Shaoshan Han, Zhikui Liu, Yufeng Wang, Liang Wang, Bowen Yao, Cheng Guo, Tao Song, Kangsheng Tu, Qingguang Liu

Pages: 2987-2995 Published online on: 23 April 2018

High expression of fructose-bisphosphate aldolase A induces progression of renal cell carcinoma

Zhengkai Huang, Yibo Hua, Ye Tian, Chao Qin, Jian Qian, Meiling Bao, Yiyang Liu, Shangqian Wang, Qiang Cao, Xiaobing Ju, Zengjun Wang, Min Gu

Pages: 2996-3006 Published online on: 18 April 2018

Gallic acid sensitizes paclitaxel-resistant human ovarian carcinoma cells through an increase in reactive oxygen species and subsequent downregulation of ERK activation

Jessica Nayelli Sánchez-Carranza, J. Fernando Díaz, Mariano Redondo-Horcajo, Isabel Barasoain, Laura Alvarez, Pedro Lastres, Antonio Romero-Estrada, Patricio Aller, Leticia González-Maya

Pages: 3007-3014 Published online on: 18 April 2018

miR-146a promotes cervical cancer cell viability via targeting IRAK1 and TRAF6

Qiming Hu, Jiacheng Song, Bo Ding, Yugui Cui, Jiale Liang, Suping Han

Pages: 3015-3024 Published online on: 23 April 2018

Resveratrol decreases Rad51 expression and sensitizes cisplatin‑resistant MCF‑7 breast cancer cells

I. Leon‑Galicia, J. Diaz‑Chavez, M. E. Albino‑Sanchez, E. Garcia‑Villa, R. Bermudez‑Cruz, J. Garcia‑Mena, L. A. Herrera, A. García‑Carrancá, P. Gariglio

Pages: 3025-3033 Published online on: 27 March 2018

GPNMB silencing suppresses the proliferation and metastasis of osteosarcoma cells by blocking the PI3K/Akt/mTOR signaling pathway

Rui Jin, Ying‑Ying Jin, Yi‑Lun Tang, Hua‑Juan Yang, Xiao‑Qian Zhou, Zhe Lei

Pages: 3034-3040 Published online on: 30 March 2018

Doxycycline targets aldehyde dehydrogenase‑positive breast cancer stem cells

Chang‑Ching Lin, Miao‑Chia Lo, Rebecca R. Moody, Nicholas O. Stevers, Samantha L. Tinsley, Duxin Sun

Pages: 3041-3047 Published online on: 27 March 2018

Lower endogenous p53 levels and degradation of AKT protein contribute to potent suppression of the new antibiotic Xiakemycin A on tumor cells

Chuan Chen, Zhongke Jiang, Xiuyuan Ou, Huixian Zhang, Chenghang Sun, Qiyang He

Pages: 3048-3054 Published online on: 18 April 2018

Huaier suppresses proliferative and metastatic potential of prostate cancer PC3 cells via downregulation of Lamin B1 and induction of autophagy

Ailin Yang, Yanan Zhao, Ying Wang, Xiaojun Zha, Yunfang Zhao, Pengfei Tu, Zhongdong Hu

Pages: 3055-3063 Published online on: 05 April 2018

Overexpression of IL-9 induced by STAT3 phosphorylation is mediated by miR-155 and miR-21 in chronic lymphocytic leukemia

Na Chen, Lili Feng, Huiting Qu, Kang Lu, Peipei Li, Xiao Lv, Xin Wang

Pages: 3064-3072 Published online on: 12 April 2018

MicroRNA-33b-5p is overexpressed and inhibits GLUT4 by targeting HMGA2 in polycystic ovarian syndrome: An in vivo and in vitro study

Ying Yang, Hua Jiang, Ling Xiao, Xuezhou Yang

Pages: 3073-3085 Published online on: 18 April 2018

let-7d-3p is associated with apoptosis and response to neoadjuvant chemotherapy in ovarian cancer

Raúl García-Vázquez, Dolores Gallardo Rincón, Erika Ruiz-García, Abelardo Meneses García, Olga N. Hernández De La Cruz, Horacio Astudillo-De La Vega, David Isla-Ortiz, Laurence A. Marchat, Yarely M. Salinas-Vera, Ángeles Carlos-Reyes, Sullivan López-González, Rosalio Ramos-Payan, César López-Camarillo

Pages: 3086-3094 Published online on: 12 April 2018
Journal Cover

June-2018
Volume 39 Issue 6

Print ISSN: 1021-335X
Online ISSN: 1791-2431

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