Open Access

Downregulation of NONO induces apoptosis, suppressing growth and invasion in esophageal squamous cell carcinoma

  • Authors:
    • Rui Cheng
    • Shengtao Zhu
    • Shuilong Guo
    • Li Min
    • Jie Xing
    • Qingdong Guo
    • Peng Li
    • Shutian Zhang
  • View Affiliations

  • Published online on: March 27, 2018     https://doi.org/10.3892/or.2018.6334
  • Pages: 2575-2583
  • Copyright: © Cheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Esophageal squamous cell carcinoma (ESCC) is one of the most common malignancies in China, and is associated with high morbidity and mortality. However, the molecular mechanisms that control ESCC tumorigenicity and metastasis remain unclear. Here, we report that the RNA splicing factor, NONO, is an important regulator of ESCC growth, apoptosis and invasion. NONO protein levels were dramatically upregulated in ESCC when compared with that in adjacent benign esophageal squamous epithelium. Particularly, NONO expression was statistically higher in tumors with greater tumor invasion depth. Using multiple ESCC cell models, we further showed that NONO depletion using siRNA significantly inhibited proliferation, invasion, and promoted apoptosis of ESCC cells. In addition we found that knockdown of NONO could reduce protein levels of phosphorylated Akt and Erk1/2. Our findings suggest that NONO plays a potent role in multiple biological aspects of ESCC through activation of the Akt and Erk1/2 signaling pathways. Taken together, our findings suggest that NONO might play an important role in promoting tumorigenesis of ESCC. It may provide a promising approach to prevent the progress of ESCC.
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June-2018
Volume 39 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Cheng R, Zhu S, Guo S, Min L, Xing J, Guo Q, Li P and Zhang S: Downregulation of NONO induces apoptosis, suppressing growth and invasion in esophageal squamous cell carcinoma. Oncol Rep 39: 2575-2583, 2018
APA
Cheng, R., Zhu, S., Guo, S., Min, L., Xing, J., Guo, Q. ... Zhang, S. (2018). Downregulation of NONO induces apoptosis, suppressing growth and invasion in esophageal squamous cell carcinoma. Oncology Reports, 39, 2575-2583. https://doi.org/10.3892/or.2018.6334
MLA
Cheng, R., Zhu, S., Guo, S., Min, L., Xing, J., Guo, Q., Li, P., Zhang, S."Downregulation of NONO induces apoptosis, suppressing growth and invasion in esophageal squamous cell carcinoma". Oncology Reports 39.6 (2018): 2575-2583.
Chicago
Cheng, R., Zhu, S., Guo, S., Min, L., Xing, J., Guo, Q., Li, P., Zhang, S."Downregulation of NONO induces apoptosis, suppressing growth and invasion in esophageal squamous cell carcinoma". Oncology Reports 39, no. 6 (2018): 2575-2583. https://doi.org/10.3892/or.2018.6334