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Article

β‑arrestin2 promotes 5‑FU‑induced apoptosis via the NF‑κB pathway in colorectal cancer

  • Authors:
    • Weixia Ren
    • Tingting Wang
    • Xiangjun He
    • Qi Zhang
    • Jianhua Zhou
    • Fangfang Liu
    • Fangfang Gao
    • Yujun Zhang
    • Yulan Liu
  • View Affiliations / Copyright

    Affiliations: Institute of Clinical Molecular Biology and Central Laboratory, Peking University, People's Hospital, Beijing 100044, P.R. China, Department of Gastroenterology, Peking University, People's Hospital, Beijing 100044, P.R. China, Institute of Clinical Molecular Biology and Central Laboratory, Peking University, People's Hospital, Beijing 100044, P.R. China, Department of Pathology, Peking University, People's Hospital, Beijing 100044, P.R. China
  • Pages: 2711-2720
    |
    Published online on: March 30, 2018
       https://doi.org/10.3892/or.2018.6340
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Abstract

It has been demonstrated that β‑arrestin2 is involved in the initiation and development of many types of cancers. However, its role in colorectal cancer (CRC) remains poorly understood. The present study investigated the role of β‑arrestin2 in CRC using CRC patient tissues as well as the LoVo and HCT116 CRC cell lines. Briefly, significantly higher expression of β‑arrestin2 was observed in CRC tissues compared with normal colon tissues. In addition, the downregulation of β‑arrestin2 reduced 5‑FU‑induced apoptosis in the LoVo cells, while the overexpression of β‑arrestin2 increased the apoptosis of HCT116 cells in vitro. Furthermore, the downregulation of β‑arrestin2 reduced the expression of the pro‑apoptotic proteins cleaved‑caspase‑3 and Bax, and increased the expression of the anti‑apoptotic protein Bcl‑2 after 5‑FU treatment. In addition, the expression of p‑p65 was increased after the β‑arrestin2 downregulation and was decreased after the β‑arrestin2 overexpression. However, β‑arrestin2 downregulation had no effect on the proliferation, migration and invasion capacity of the LoVo cells. In conclusion, these results indicated that β‑arrestin2 promoted 5‑FU‑induced CRC cell apoptosis via the NF‑κB pathway and may be used as a prognosis marker for CRC.
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View References

1 

Siegel RL, Miller KD, Fedewa SA, Ahnen DJ, Meester RGS, Barzi A and Jemal A: Colorectal cancer statistics, 2017. CA Cancer J Clin. 67:177–193. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2017. CA Cancer J Clin. 67:7–30. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ and He J: Cancer statistics in China, 2015. CA Cancer J Clin. 66:115–132. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Douaiher J, Ravipati A, Grams B, Chowdhury S, Alatise O and Are C: Colorectal cancer-global burden, trends, and geographical variations. J Surg Oncol. 115:619–630. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Lefkowitz RJ and Shenoy SK: Transduction of receptor signals by beta-arrestins. Science. 308:512–517. 2005. View Article : Google Scholar : PubMed/NCBI

6 

Luttrell LM and Lefkowitz RJ: The role of beta-arrestins in the termination and transduction of G-protein-coupled receptor signals. J Cell Sci. 115:455–465. 2002.PubMed/NCBI

7 

Lefkowitz RJ, Rajagopal K and Whalen EJ: New roles for beta-arrestins in cell signaling: Not just for seven-transmembrane receptors. Mol Cell. 24:643–652. 2006. View Article : Google Scholar : PubMed/NCBI

8 

Barki-Harrington L and Rockman HA: Beta-arrestins: Multifunctional cellular mediators. Physiology. 23:17–22. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Sobolesky PM and Moussa O: The role of β-arrestins in cancer. Prog Mol Biol Transl Sci. 118:395–411. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Hu S, Wang D, Wu J, Jin J, Wei W and Sun W: Involvement of β-arrestins in cancer progression. Mol Biol Rep. 40:1065–1071. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Fereshteh M, Ito T, Kovacs JJ, Zhao C, Kwon HY, Tornini V, Konuma T, Chen M, Lefkowitz RJ and Reya T: β-Arrestin2 mediates the initiation and progression of myeloid leukemia. Proc Natl Acad Sci USA. 109:12532–12537. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Bonnans C, Flacelière M, Grillet F, Dantec C, Desvignes JP, Pannequin J, Severac D, Dubois E, Bibeau F, Escriou V, et al: Essential requirement for β-arrestin2 in mouse intestinal tumors with elevated Wnt signaling. Proc Natl Acad Sci USA. 109:3047–3052. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Duan X, Kong Z, Liu Y, Zeng Z, Li S, Wu W, Ji W, Yang B, Zhao Z and Zeng G: β-Arrestin2 contributes to cell viability and proliferation via the down-regulation of FOXO1 in castration-resistant prostate cancer. J Cell Physiol. 230:2371–2381. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Raghuwanshi SK, Nasser MW, Chen X, Strieter RM and Richardson RM: Depletion of beta-arrestin-2 promotes tumor growth and angiogenesis in a murine model of lung cancer. J Immunol. 180:5699–5706. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Sun WY, Hu SS, Wu JJ, Huang Q, Ma Y, Wang QT, Chen JY and Wei W: Down-regulation of β-arrestin2 promotes tumour invasion and indicates poor prognosis of hepatocellular carcinoma. Sci Rep. 6:356092016. View Article : Google Scholar : PubMed/NCBI

16 

Goertzen CG, Dragan M, Turley E, Babwah AV and Bhattacharya M: KISS1R signaling promotes invadopodia formation in human breast cancer cell via β-arrestin2/ERK. Cell Signal. 28:165–176. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Liu Z, Tian H, Jiang J, Yang Y, Tan S, Lin X, Liu H and Wu B: β-Arrestin-2 modulates radiation-induced intestinal crypt progenitor/stem cell injury. Cell Death Differ. 23:1529–1541. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Jing X, Zhang H, Hu J, Su P, Zhang W, Jia M, Cheng H, Li W and Zhou G: β-arrestin 2 is associated with multidrug resistance in breast cancer cells through regulating MDR1 gene expression. Int J Clin Exp Pathol. 8:1354–1363. 2015.PubMed/NCBI

19 

DeWire SM, Ahn S, Lefkowitz RJ and Shenoy SK: Beta-arrestins and cell signaling. Annu Rev Physiol. 69:483–510. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Li TT, Alemayehu M, Aziziyeh AI, Pape C, Pampillo M, Postovit LM, Mills GB, Babwah AV and Bhattacharya M: Beta-arrestin/Ral signaling regulates lysophosphatidic acid-mediated migration and invasion of human breast tumor cells. Mol Cancer Res. 7:1064–1077. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Wu Z, Tong W, Tan Z, Wang S and Lin P: The clinical significance of β-arrestin 2 expression in the serum of non-small cell lung cancer patients. Zhongguo Fei Ai Za Zhi. 14:497–501. 2011.(In Chinese). PubMed/NCBI

22 

Alemayehu M, Dragan M, Pape C, Siddiqui I, Sacks DB, Di Guglielmo GM, Babwah AV and Bhattacharya M: β-Arrestin2 regulates lysophosphatidic acid-induced human breast tumor cell migration and invasion via Rap1 and IQGAP1. PLoS One. 8:e561742013. View Article : Google Scholar : PubMed/NCBI

23 

Sharma D and Parameswaran N: Multifaceted role of β-arrestins in inflammation and disease. Genes Immun. 16:499–513. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Revankar CM, Vines CM, Cimino DF and Prossnitz ER: Arrestins block G protein-coupled receptor-mediated apoptosis. J Biol Chem. 279:24578–24584. 2004. View Article : Google Scholar : PubMed/NCBI

25 

Ahn S, Kim J, Hara MR, Ren XR and Lefkowitz RJ: {beta}-Arrestin-2 mediates anti-apoptotic signaling through regulation of BAD phosphorylation. J Biol Chem. 284:8855–8865. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Wang P, Gao H, Ni Y, Wang B, Wu Y, Ji L, Qin L, Ma L and Pei G: Beta-arrestin 2 functions as a G-protein-coupled receptor-activated regulator of oncoprotein Mdm2. J Biol Chem. 278:6363–6370. 2003. View Article : Google Scholar : PubMed/NCBI

27 

Luan B, Zhang Z, Wu Y, Kang J and Pei G: Beta-arrestin2 functions as a phosphorylation-regulated suppressor of UV-induced NF-kappaB activation. EMBO J. 24:4237–4246. 2005. View Article : Google Scholar : PubMed/NCBI

28 

Sun X, Zhang Y, Wang J, Wei L, Li H, Hanley G, Zhao M, Li Y and Yin D: Beta-arrestin 2 modulates resveratrol-induced apoptosis and regulation of Akt/GSK3β pathways. Biochim Biophys Acta. 1800:912–918. 2010. View Article : Google Scholar : PubMed/NCBI

29 

Zeng LX, Tao J, Liu HL, Tan SW, Yang YD, Peng XJ, Liu ZH, Jiang J and Wu B: β-Arrestin2 encourages inflammation-induced epithelial apoptosis through ER stress/PUMA in colitis. Mucosal Immunol. 8:683–695. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Chang F, Liu J, Fu H, Wang J, Li F, Yue H, Li W, Zhao J and Yin D: GSK-3β promotes PA-induced apoptosis through changing β-arrestin 2 nucleus location in H9c2 cardiomyocytes. Apoptosis. 21:1045–1055. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Oya M, Takayanagi A, Horiguchi A, Mizuno R, Ohtsubo M, Marumo K, Shimizu N and Murai M: Increased nuclear factor-kappa B activation is related to the tumor development of renal cell carcinoma. Carcinogenesis. 24:377–384. 2003. View Article : Google Scholar : PubMed/NCBI

32 

Lind DS, Hochwald SN, Malaty J, Rekkas S, Hebig P, Mishra G, Moldawer LL, Copeland EM III and Mackay S: Nuclear factor-kappa B is upregulated in colorectal cancer. Surgery. 130:363–369. 2001. View Article : Google Scholar : PubMed/NCBI

33 

Lessard L, Mes-Masson AM, Lamarre L, Wall L, Lattouf JB and Saad F: NF-kappa B nuclear localization and its prognostic significance in prostate cancer. BJU Int. 91:417–420. 2003. View Article : Google Scholar : PubMed/NCBI

34 

Camp ER, Li J, Minnich DJ, Brank A, Moldawer LL, MacKay SL and Hochwald SN: Inducible nuclear factor-kappaB activation contributes to chemotherapy resistance in gastric cancer. J Am Coll Surg. 199:249–258. 2004. View Article : Google Scholar : PubMed/NCBI

35 

Körber MI, Klingenbrunner S, Bartsch R, Steger GG and Mader RM: NF-κB addiction and resistance to 5-fluorouracil in a multi-stage colon carcinoma model. Int J Clin Pharmacol Ther. 51:35–37. 2013. View Article : Google Scholar : PubMed/NCBI

36 

Endo F, Nishizuka SS, Kume K, Ishida K, Katagiri H, Ishida K, Sato K, Iwaya T, Koeda K and Wakabayashi G: A compensatory role of NF-κB to p53 in response to 5-FU-based chemotherapy for gastric cancer cell lines. PLoS One. 9:e901552014. View Article : Google Scholar : PubMed/NCBI

37 

Kwon OH, Kim JH, Kim SY and Kim YS: TWEAK/Fn14 signaling mediates gastric cancer cell resistance to 5-fluorouracil via NF-κB activation. Int J Oncol. 44:583–590. 2014. View Article : Google Scholar : PubMed/NCBI

38 

Shakibaei M, Mobasheri A, Lueders C, Busch F, Shayan P and Goel A: Curcumin enhances the effect of chemotherapy against colorectal cancer cells by inhibition of NF-κB and Src protein kinase signaling pathways. PLoS One. 8:e572182013. View Article : Google Scholar : PubMed/NCBI

39 

Xu B, Guo X, Mathew S, Armesilla AL, Cassidy J, Darling JL and Wang W: Triptolide simultaneously induces reactive oxygen species, inhibits NF-kappaB activity and sensitizes 5-fluorouracil in colorectal cancer cell lines. Cancer Lett. 291:200–208. 2010. View Article : Google Scholar : PubMed/NCBI

40 

Gao H, Sun Y, Wu Y, Luan B, Wang Y, Qu B and Pei G: Identification of beta-arrestin2 as a G protein-coupled receptor-stimulated regulator of NF-kappaB pathways. Mol Cell. 14:303–317. 2004. View Article : Google Scholar : PubMed/NCBI

41 

Wang Y, Tang Y, Teng L, Wu Y, Zhao X and Pei G: Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling. Nat Immunol. 7:139–147. 2006. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ren W, Wang T, He X, Zhang Q, Zhou J, Liu F, Gao F, Zhang Y and Liu Y: β‑arrestin2 promotes 5‑FU‑induced apoptosis via the NF‑κB pathway in colorectal cancer. Oncol Rep 39: 2711-2720, 2018.
APA
Ren, W., Wang, T., He, X., Zhang, Q., Zhou, J., Liu, F. ... Liu, Y. (2018). β‑arrestin2 promotes 5‑FU‑induced apoptosis via the NF‑κB pathway in colorectal cancer. Oncology Reports, 39, 2711-2720. https://doi.org/10.3892/or.2018.6340
MLA
Ren, W., Wang, T., He, X., Zhang, Q., Zhou, J., Liu, F., Gao, F., Zhang, Y., Liu, Y."β‑arrestin2 promotes 5‑FU‑induced apoptosis via the NF‑κB pathway in colorectal cancer". Oncology Reports 39.6 (2018): 2711-2720.
Chicago
Ren, W., Wang, T., He, X., Zhang, Q., Zhou, J., Liu, F., Gao, F., Zhang, Y., Liu, Y."β‑arrestin2 promotes 5‑FU‑induced apoptosis via the NF‑κB pathway in colorectal cancer". Oncology Reports 39, no. 6 (2018): 2711-2720. https://doi.org/10.3892/or.2018.6340
Copy and paste a formatted citation
x
Spandidos Publications style
Ren W, Wang T, He X, Zhang Q, Zhou J, Liu F, Gao F, Zhang Y and Liu Y: β‑arrestin2 promotes 5‑FU‑induced apoptosis via the NF‑κB pathway in colorectal cancer. Oncol Rep 39: 2711-2720, 2018.
APA
Ren, W., Wang, T., He, X., Zhang, Q., Zhou, J., Liu, F. ... Liu, Y. (2018). β‑arrestin2 promotes 5‑FU‑induced apoptosis via the NF‑κB pathway in colorectal cancer. Oncology Reports, 39, 2711-2720. https://doi.org/10.3892/or.2018.6340
MLA
Ren, W., Wang, T., He, X., Zhang, Q., Zhou, J., Liu, F., Gao, F., Zhang, Y., Liu, Y."β‑arrestin2 promotes 5‑FU‑induced apoptosis via the NF‑κB pathway in colorectal cancer". Oncology Reports 39.6 (2018): 2711-2720.
Chicago
Ren, W., Wang, T., He, X., Zhang, Q., Zhou, J., Liu, F., Gao, F., Zhang, Y., Liu, Y."β‑arrestin2 promotes 5‑FU‑induced apoptosis via the NF‑κB pathway in colorectal cancer". Oncology Reports 39, no. 6 (2018): 2711-2720. https://doi.org/10.3892/or.2018.6340
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