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Article

Gallic acid sensitizes paclitaxel-resistant human ovarian carcinoma cells through an increase in reactive oxygen species and subsequent downregulation of ERK activation

  • Authors:
    • Jessica Nayelli Sánchez-Carranza
    • J. Fernando Díaz
    • Mariano Redondo-Horcajo
    • Isabel Barasoain
    • Laura Alvarez
    • Pedro Lastres
    • Antonio Romero-Estrada
    • Patricio Aller
    • Leticia González-Maya
  • View Affiliations / Copyright

    Affiliations: Faculty of Pharmacy, Autonomous University of Morelos State (UAEM), Cuernavaca, Morelos 62209, México, Biological Research Center (CIB), Spanish National Research Council - CSIC, 28040 Madrid, Spain, The Center of Chemical Research (CIQ)-IICBA, Autonomous University of Morelos State (UAEM), Cuernavaca, Morelos 62209, México
  • Pages: 3007-3014
    |
    Published online on: April 18, 2018
       https://doi.org/10.3892/or.2018.6382
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Abstract

Paclitaxel (PTX) is currently used as a front-line chemotherapeutic agent for several types of cancer, including ovarian carcinoma; however, PTX-resistance frequently arises through multiple mechanisms. The development of new strategies using natural compounds and PTX in combination has been the aim of several prior studies, in order to enhance the efficacy of chemotherapy. In this study, we found the following: (i) gallic acid (GA), a phenolic compound, potentiated the capacity of PTX to decrease proliferation and to cause G2/M cycle arrest in the PTX-resistant A2780AD ovarian cancer cell line; (ii) GA exerted a pro-oxidant action by increasing the production of reactive oxygen species (ROS), and co-treatment with the antioxidant agent N‑acetyl-L‑cysteine (NAC) prevented GA+PTX-induced cell proliferation inhibition and G2/M phase arrest; (iii) PTX stimulated ERK phosphorylation/activation, and co-treatment with the MEK/ERK inhibitor PD98049 potentiated the proliferation inhibition and G2/M phase arrest; (iv) and finally, GA abrogated the PTX-induced stimulation of ERK phosphorylation, a response that was prevented by co-treatment with NAC. Taken together, these results indicate that GA sensitizes PTX-resistant ovarian carcinoma cells via the ROS‑mediated inactivation of ERK, and suggest that GA could represent a useful co-adjuvant to PTX in ovarian carcinoma treatment.
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View References

1 

Parkin DM, Bray F, Ferlay J and Pisani P: Global cancer statistics, 2002. CA Cancer J Clin. 55:74–108. 2005. View Article : Google Scholar : PubMed/NCBI

2 

Fuchs DA and Johnson RK: Cytologic evidence that taxol, an antineoplastic agent from Taxus brevifolia, acts as a mitotic spindle poison. Cancer Treat Rep. 62:1219–1222. 1978.PubMed/NCBI

3 

Jordan MA, Toso RJ, Thrower D and Wilson L: Mechanism of mitotic block and inhibition of cell proliferation by taxol at low concentrations. Proc Natl Acad Sci USA. 90:9552–9556. 1993. View Article : Google Scholar : PubMed/NCBI

4 

Jordan MA and Wilson L: Microtubules as a target for anticancer drugs. Nat Rev Cancer. 4:253–265. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Conte PF, Cianci C and Gadducci A: Up date in the management of advanced ovarian carcinoma. Crit Rev Oncol Hematol. 32:49–58. 1999. View Article : Google Scholar : PubMed/NCBI

6 

Kumar S, Mahdi H, Bryant C, Shah JP, Garg G and Munkarah A: Clinical trials and progress with paclitaxel in ovarian cancer. Int J Womens Health. 2:411–427. 2010. View Article : Google Scholar : PubMed/NCBI

7 

McGrail DJ, Khambhati NN, Qi MX, Patel KS, Ravikumar N, Brandenburg CP and Dawson MR: Alterations in ovarian cancer cell adhesion drive taxol resistance by increasing microtubule dynamics in a FAK-dependent manner. Sci Rep. 5:95292015. View Article : Google Scholar : PubMed/NCBI

8 

Link A, Balaguer F and Goel A: Cancer chemoprevention by dietary polyphenols: Promising role for epigenetics. Biochem Pharmacol. 80:1771–1792. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Rattanata N, Klaynongsruang S, Daduang S, Tavichakorntrakool R, Limpaiboon T, Lekphrom R, Boonsiri P and Daduang J: Inhibitory effects of gallic acid isolated from Caesalpinia mimosoides Lamk on cholangiocarcinoma cell lines and foodborne pathogenic bacteria. Asian Pac J Cancer Prev. 17:1341–1345. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Inoue M, Suzuki R, Koide T, Sakaguchi N, Ogihara Y and Yabu Y: Antioxidant, gallic acid, induces apoptosis in HL-60RG cells. Biochem Biophys Res Commun. 204:898–904. 1994. View Article : Google Scholar : PubMed/NCBI

11 

Sakagami H and Satoh K: Prooxidant action of two antioxidants: Ascorbic acid and gallic acid. Anticancer Res. 17A:221–224. 1997.

12 

Strlic M, Radovic T, Kolar J and Pihlar B: Anti- and prooxidative properties of gallic acid in fenton-type systems. J Agric Food Chem. 50:6313–6317. 2002. View Article : Google Scholar : PubMed/NCBI

13 

Fleury C, Mignotte B and Vayssière JL: Mitochondrial reactive oxygen species in cell death signaling. Biochimie. 84:131–141. 2002. View Article : Google Scholar : PubMed/NCBI

14 

Wartenberg M, Hoffmann E, Schwindt H, Grünheck F, Petros J, Arnold JR, Hescheler J and Sauer H: Reactive oxygen species-linked regulation of the multidrug resistance transporter P-glycoprotein in Nox-1 overexpressing prostate tumor spheroids. FEBS Lett. 579:4541–4549. 2005. View Article : Google Scholar : PubMed/NCBI

15 

McCubrey JA, Lahair MM and Franklin RA: Reactive oxygen species-induced activation of the MAP kinase signaling pathways. Antioxid Redox Signal. 8:1775–1789. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Xia Z, Dickens M, Raingeaud J, Davis RJ and Greenberg ME: Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science. 270:1326–1331. 1995. View Article : Google Scholar : PubMed/NCBI

17 

MacKeigan JP, Taxman DJ, Hunter D, Earp HS III, Graves LM and Ting JP: Inactivation of the antiapoptotic phosphatidylinositol 3-kinase-Akt pathway by the combined treatment of taxol and mitogen-activated protein kinase kinase inhibition. Clin Cancer Res. 8:2091–2099. 2002.PubMed/NCBI

18 

Kowalski RJ, Giannakakou P, Gunasekera SP, Longley RE, Day BW and Hamel E: The microtubule-stabilizing agent discodermolide competitively inhibits the binding of paclitaxel (Taxol) to tubulin polymers, enhances tubulin nucleation reactions more potently than paclitaxel, and inhibits the growth of paclitaxel-resistant cells. Mol Pharmacol. 52:613–622. 1997. View Article : Google Scholar : PubMed/NCBI

19 

Bakker M, Renes J, Groenhuijzen A, Visser P, Timmer-Bosscha H, Müller M, Groen HJ, Smit EF and de Vries EG: Mechanisms for high methoxymorpholino doxorubicin cytotoxicity in doxorubicin-resistant tumor cell lines. Int J Cancer. 73:362–366. 1997. View Article : Google Scholar : PubMed/NCBI

20 

Buey RM, Barasoain I, Jackson E, Meyer A, Giannakakou P, Paterson I, Mooberry S, Andreu JM and Díaz JF: Microtubule interactions with chemically diverse stabilizing agents: Thermodynamics of binding to the paclitaxel site predicts cytotoxicity. Chem Biol. 12:1269–1279. 2005. View Article : Google Scholar : PubMed/NCBI

21 

Eruslanov E and Kusmartsev S: Identification of ROS using oxidized DCFDA and flow-cytometry. Methods Mol Biol. 594:57–72. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Andreu JM and Barasoain I: The interaction of Baccatin III with the Taxol binding site of microtubules determined by a homogeneous assay with fluorescent taxoid. Biochemistry. 40:11975–11984. 2001. View Article : Google Scholar : PubMed/NCBI

23 

Ormerod MG, Collins MKL, Rodriguez-Tarduchy G and Robertson D: Apoptosis in interleukin-3-dependent haemopoietic cells. Quantification by two flow cytometric methods. J Immunol Methods. 153:57–65. 1992. View Article : Google Scholar : PubMed/NCBI

24 

Martindale JL and Holbrook NJ: Cellular response to oxidative stress: Signaling for suicide and survival. J Cell Physiol. 192:1–15. 2002. View Article : Google Scholar : PubMed/NCBI

25 

Johnson GL and Lapadat R: Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science. 298:1911–1912. 2002. View Article : Google Scholar : PubMed/NCBI

26 

Platanias LC: Map kinase signaling pathways and hematologic malignancies. Blood. 101:4667–4679. 2003. View Article : Google Scholar : PubMed/NCBI

27 

Chang L and Karin M: Mammalian MAP kinase signalling cascades. Nature. 410:37–40. 2001. View Article : Google Scholar : PubMed/NCBI

28 

Johnson NL, Gardner AM, Diener KM, Lange-Carter CA, Gleavy J, Jarpe MB, Minden A, Karin M, Zon LI and Johnson GL: Signal transduction pathways regulated by mitogen-activated/extracellular response kinase kinase kinase induce cell death. J Biol Chem. 271:3229–3237. 1996. View Article : Google Scholar : PubMed/NCBI

29 

Wada T and Penninger JM: Mitogen-activated protein kinases in apoptosis regulation. Oncogene. 23:2838–2849. 2004. View Article : Google Scholar : PubMed/NCBI

30 

Sarkar D, Su Z-Z, Lebedeva IV, Sauane M, Gopalkrishnan RV, Valerie K, Dent P and Fisher PB: mda-7 (IL-24) Mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the GADD family of genes by means of p38 MAPK. Proc Natl Acad Sci USA. 99:10054–10059. 2002. View Article : Google Scholar : PubMed/NCBI

31 

Sarwar T, Zafaryab M, Husain MA, Ishqi HM, Rehman SU, Rizvi MM and Tabish M: Redox cycling of endogenous copper by ferulic acid leads to cellular DNA breakage and consequent cell death: A putative cancer chemotherapy mechanism. Toxicol Appl Pharmacol. 289:251–261. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Karthikeyan S, Kanimozhi G, Prasad NR and Mahalakshmi R: Radiosensitizing effect of ferulic acid on human cervical carcinoma cells in vitro. Toxicol In Vitro. 25:1366–1375. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Delman DM, Fabian CJ, Kimler BF, Yeh H and Petroff BK: Effects of flaxseed lignan secoisolariciresinol diglucosideon preneoplastic biomarkers of cancer progression in a model of simultaneous breast and ovarian cancer development. Nutr Cancer. 67:857–864. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Kaur M, Velmurugan B, Rajamanickam S, Agarwal R and Agarwal C: Gallic acid, an active constituent of grape seed extract, exhibits anti-proliferative, pro-apoptotic and anti-tumorigenic effects against prostate carcinoma xenograft growth in nude mice. Pharm Res. 26:2133–2140. 2009. View Article : Google Scholar : PubMed/NCBI

35 

Sánchez-Carranza JN, Alvarez L, Marquina-Bahena S, Salas-Vidal E, Cuevas V, Jiménez EW, Veloz G RA, Carraz M and González-Maya L: Phenolic compounds isolated from Caesalpinia coriaria induce S and G2/M phase cell cycle arrest differentially and trigger cell death by interfering with microtubule dynamics in cancer cell lines. Molecules. 22:6662017. View Article : Google Scholar

36 

Baran CP, Zeigler MM, Tridandapani S and Marsh CB: The role of ROS and RNS in regulating life and death of blood monocytes. Curr Pharm Des. 10:855–866. 2004. View Article : Google Scholar : PubMed/NCBI

37 

Wallach-Dayan SB, Izbicki G, Cohen PY, Gerstl-Golan R, Fine A and Breuer R: Bleomycin initiates apoptosis of lung epithelial cells by ROS but not by Fas/FasL pathway. Am J Physiol Lung Cell Mol Physiol. 290:L790–L796. 2006. View Article : Google Scholar : PubMed/NCBI

38 

Ji BC, Hsu WH, Yang JS, Hsia TC, Lu CC, Chiang JH, Yang JL, Lin CH, Lin JJ, Suen LJ, et al: Gallic acid induces apoptosis via caspase-3 and mitochondrion-dependent pathways in vitro and suppresses lung xenograft tumor growth in vivo. J Agric Food Chem. 57:7596–7604. 2009. View Article : Google Scholar : PubMed/NCBI

39 

Park WH and Kim SH: MAPK inhibitors augment gallic acid-induced A549 lung cancer cell death through the enhancement of glutathione depletion. Oncol Rep. 30:513–519. 2013. View Article : Google Scholar : PubMed/NCBI

40 

Park WH: The effect of MAPK inhibitors and ROS modulators on cell growth and death of H2O2-treated HeLa cells. Mol Med Rep. 8:557–564. 2013. View Article : Google Scholar : PubMed/NCBI

41 

You BR and Park WH: The enhancement of propyl gallate-induced HeLa cell death by MAPK inhibitors is accompanied by increasing ROS levels. Mol Biol Rep. 38:2349–2358. 2011. View Article : Google Scholar : PubMed/NCBI

42 

Liang CZ, Zhang X, Li H, Tao YQ, Tao LJ, Yang ZR, Zhou XP, Shi ZL and Tao HM: Gallic acid induces the apoptosis of human osteosarcoma cells in vitro and in vivo via the regulation of mitogen-activated protein kinase pathways. Cancer Biother Radiopharm. 27:701–710. 2012. View Article : Google Scholar : PubMed/NCBI

43 

Greenberg VL and Zimmer SG: Paclitaxel induces the phosphorylation of the eukaryotic translation initiation factor 4E-binding protein 1 through a Cdk1-dependent mechanism. Oncogene. 24:4851–4860. 2005. View Article : Google Scholar : PubMed/NCBI

44 

MacKeigan JP, Collins TS and Ting JP-Y: MEK inhibition enhances paclitaxel-induced tumor apoptosis. J Biol Chem. 275:38953–38956. 2000. View Article : Google Scholar : PubMed/NCBI

45 

Henson ES and Gibson SB: Surviving cell death through epidermal growth factor (EGF) signal transduction pathways: Implications for cancer therapy. Cell Signal. 18:2089–2097. 2006. View Article : Google Scholar : PubMed/NCBI

46 

Lee YJ, Kang IJ, Bünger R and Kang YH: Enhanced survival effect of pyruvate correlates MAPK and NF-kappaB activation in hydrogen peroxide-treated human endothelial cells. J Appl Physiol 1985. 96:793–801; discussion 792. 2004. View Article : Google Scholar : PubMed/NCBI

47 

McDaid HM and Horwitz SB: Selective potentiation of paclitaxel (taxol)-induced cell death by mitogen-activated protein kinase kinase inhibition in human cancer cell lines. Mol Pharmacol. 60:290–301. 2001. View Article : Google Scholar : PubMed/NCBI

48 

Zelivianski S, Spellman M, Kellerman M, Kakitelashvilli V, Zhou X-W, Lugo E, Lee M-S, Taylor R, Davis TL, Hauke R, et al: ERK inhibitor PD98059 enhances docetaxel-induced apoptosis of androgen-independent human prostate cancer cells. Int J Cancer. 107:478–485. 2003. View Article : Google Scholar : PubMed/NCBI

49 

Yu C, Wang S, Dent P and Grant S: Sequence-dependent potentiation of paclitaxel-mediated apoptosis in human leukemia cells by inhibitors of the mitogen-activated protein kinase kinase/mitogen-activated protein kinase pathway. Mol Pharmacol. 60:143–154. 2001. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Sánchez-Carranza JN, Díaz JF, Redondo-Horcajo M, Barasoain I, Alvarez L, Lastres P, Romero-Estrada A, Aller P and González-Maya L: Gallic acid sensitizes paclitaxel-resistant human ovarian carcinoma cells through an increase in reactive oxygen species and subsequent downregulation of ERK activation. Oncol Rep 39: 3007-3014, 2018.
APA
Sánchez-Carranza, J.N., Díaz, J.F., Redondo-Horcajo, M., Barasoain, I., Alvarez, L., Lastres, P. ... González-Maya, L. (2018). Gallic acid sensitizes paclitaxel-resistant human ovarian carcinoma cells through an increase in reactive oxygen species and subsequent downregulation of ERK activation. Oncology Reports, 39, 3007-3014. https://doi.org/10.3892/or.2018.6382
MLA
Sánchez-Carranza, J. N., Díaz, J. F., Redondo-Horcajo, M., Barasoain, I., Alvarez, L., Lastres, P., Romero-Estrada, A., Aller, P., González-Maya, L."Gallic acid sensitizes paclitaxel-resistant human ovarian carcinoma cells through an increase in reactive oxygen species and subsequent downregulation of ERK activation". Oncology Reports 39.6 (2018): 3007-3014.
Chicago
Sánchez-Carranza, J. N., Díaz, J. F., Redondo-Horcajo, M., Barasoain, I., Alvarez, L., Lastres, P., Romero-Estrada, A., Aller, P., González-Maya, L."Gallic acid sensitizes paclitaxel-resistant human ovarian carcinoma cells through an increase in reactive oxygen species and subsequent downregulation of ERK activation". Oncology Reports 39, no. 6 (2018): 3007-3014. https://doi.org/10.3892/or.2018.6382
Copy and paste a formatted citation
x
Spandidos Publications style
Sánchez-Carranza JN, Díaz JF, Redondo-Horcajo M, Barasoain I, Alvarez L, Lastres P, Romero-Estrada A, Aller P and González-Maya L: Gallic acid sensitizes paclitaxel-resistant human ovarian carcinoma cells through an increase in reactive oxygen species and subsequent downregulation of ERK activation. Oncol Rep 39: 3007-3014, 2018.
APA
Sánchez-Carranza, J.N., Díaz, J.F., Redondo-Horcajo, M., Barasoain, I., Alvarez, L., Lastres, P. ... González-Maya, L. (2018). Gallic acid sensitizes paclitaxel-resistant human ovarian carcinoma cells through an increase in reactive oxygen species and subsequent downregulation of ERK activation. Oncology Reports, 39, 3007-3014. https://doi.org/10.3892/or.2018.6382
MLA
Sánchez-Carranza, J. N., Díaz, J. F., Redondo-Horcajo, M., Barasoain, I., Alvarez, L., Lastres, P., Romero-Estrada, A., Aller, P., González-Maya, L."Gallic acid sensitizes paclitaxel-resistant human ovarian carcinoma cells through an increase in reactive oxygen species and subsequent downregulation of ERK activation". Oncology Reports 39.6 (2018): 3007-3014.
Chicago
Sánchez-Carranza, J. N., Díaz, J. F., Redondo-Horcajo, M., Barasoain, I., Alvarez, L., Lastres, P., Romero-Estrada, A., Aller, P., González-Maya, L."Gallic acid sensitizes paclitaxel-resistant human ovarian carcinoma cells through an increase in reactive oxygen species and subsequent downregulation of ERK activation". Oncology Reports 39, no. 6 (2018): 3007-3014. https://doi.org/10.3892/or.2018.6382
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