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Article

MicroRNA‑577 inhibits the migration and invasion of hepatocellular carcinoma cells by targeting homeobox A1

  • Authors:
    • Shaoshan Han
    • Zhikui Liu
    • Yufeng Wang
    • Liang Wang
    • Bowen Yao
    • Cheng Guo
    • Tao Song
    • Kangsheng Tu
    • Qingguang Liu
  • View Affiliations / Copyright

    Affiliations: Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China
  • Pages: 2987-2995
    |
    Published online on: April 23, 2018
       https://doi.org/10.3892/or.2018.6388
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Abstract

Research has confirmed that abnormally expressed miRNAs are involved in the occurrence and development of hepatocellular carcinoma (HCC). In the present study, we confirmed that miR‑577 expression both in HCC tissues and cell lines was markedly downregulated. Clinically, downregulated expression of miR‑577 is notably related to malignant clinicopathological features, such as venous invasion and advanced TNM stage. Additionally, miR‑577 may act as a valuable tumor marker to predict the prognosis of HCC patients. Through knockdown and overexpression of miR‑577, miR‑577 was identified as an inhibitor of cell metastatic ability and EMT progress in HCC. Furthermore, miR‑577 was able to directly bind to the 3'‑UTR of homeobox A1 (HOXA1) to regulate the expression of HOXA1. In addition, there existed a negative correlation between the expression of miR‑577 and HOXA1 in HCC specimens. Rescue experiments revealed that the influence of miR‑577 on the migration, invasion and EMT of HCC cells was reversed by HOXA1. Taken together, our findings demonstrated that miR‑577 functions as an anti‑oncogene to suppress the migration, invasion and EMT of HCC cells through direct interaction with HOXA1. miR‑577 may act as a valuable target for the molecular‑targeted therapy of HCC.
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Copy and paste a formatted citation
Spandidos Publications style
Han S, Liu Z, Wang Y, Wang L, Yao B, Guo C, Song T, Tu K and Liu Q: MicroRNA‑577 inhibits the migration and invasion of hepatocellular carcinoma cells by targeting homeobox A1. Oncol Rep 39: 2987-2995, 2018.
APA
Han, S., Liu, Z., Wang, Y., Wang, L., Yao, B., Guo, C. ... Liu, Q. (2018). MicroRNA‑577 inhibits the migration and invasion of hepatocellular carcinoma cells by targeting homeobox A1. Oncology Reports, 39, 2987-2995. https://doi.org/10.3892/or.2018.6388
MLA
Han, S., Liu, Z., Wang, Y., Wang, L., Yao, B., Guo, C., Song, T., Tu, K., Liu, Q."MicroRNA‑577 inhibits the migration and invasion of hepatocellular carcinoma cells by targeting homeobox A1". Oncology Reports 39.6 (2018): 2987-2995.
Chicago
Han, S., Liu, Z., Wang, Y., Wang, L., Yao, B., Guo, C., Song, T., Tu, K., Liu, Q."MicroRNA‑577 inhibits the migration and invasion of hepatocellular carcinoma cells by targeting homeobox A1". Oncology Reports 39, no. 6 (2018): 2987-2995. https://doi.org/10.3892/or.2018.6388
Copy and paste a formatted citation
x
Spandidos Publications style
Han S, Liu Z, Wang Y, Wang L, Yao B, Guo C, Song T, Tu K and Liu Q: MicroRNA‑577 inhibits the migration and invasion of hepatocellular carcinoma cells by targeting homeobox A1. Oncol Rep 39: 2987-2995, 2018.
APA
Han, S., Liu, Z., Wang, Y., Wang, L., Yao, B., Guo, C. ... Liu, Q. (2018). MicroRNA‑577 inhibits the migration and invasion of hepatocellular carcinoma cells by targeting homeobox A1. Oncology Reports, 39, 2987-2995. https://doi.org/10.3892/or.2018.6388
MLA
Han, S., Liu, Z., Wang, Y., Wang, L., Yao, B., Guo, C., Song, T., Tu, K., Liu, Q."MicroRNA‑577 inhibits the migration and invasion of hepatocellular carcinoma cells by targeting homeobox A1". Oncology Reports 39.6 (2018): 2987-2995.
Chicago
Han, S., Liu, Z., Wang, Y., Wang, L., Yao, B., Guo, C., Song, T., Tu, K., Liu, Q."MicroRNA‑577 inhibits the migration and invasion of hepatocellular carcinoma cells by targeting homeobox A1". Oncology Reports 39, no. 6 (2018): 2987-2995. https://doi.org/10.3892/or.2018.6388
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