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Article Open Access

Purple sweet potato anthocyanin exerts antitumor effect in bladder cancer

  • Authors:
    • Wei-Lin Li
    • Hong-Yuan Yu
    • Xian-Jun Zhang
    • Mang Ke
    • Tao Hong
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Taizhou Hospital Affiliated to Wenzhou Medical University, Taizhou, Zhejiang 317000, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 73-82
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    Published online on: May 8, 2018
       https://doi.org/10.3892/or.2018.6421
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Abstract

Bladder cancer (BC) is the most common malignant disease. The developing of economically sustainable and available agents for the treatment of BC is required. Purple sweet potato anthocyanin (PSPA) has been shown to have antitumor abilities. The present study aimed to evaluate the potential role of PSPA in BC treatment. CCK-8 assay was used to assess the viability of BC cells. Flow cytometry assays were performed to evaluate the mitochondrial membrane potential (MMP), cell apoptosis and cell-cycle distribution. Real-time PCR (RT-PCR) and western blot analysis were performed to determine the expression of the target genes. The results of this study revealed that PSPA reduced the viability of BC in a dose-dependent manner. The MMP collapse was aggravated by the PSPA treatment. The apoptosis rate was higher in the PSPA groups than that in the control group. The expression of the pro-apoptosis genes, including cleaved caspase-3, Fas, Fasl, Bcl-2-associated X proteins (Bax) and anti-apoptotic gene (Bcl-2) was induced and decreased by PSPA, respectively. The cell-cycle progression was suppressed by the presence of PSPA. The activation of the phosphatidylinositol-4,5-bisphosphate 3-kinase/Akt (PI3K/Akt) signaling pathway was suppressed by PSPA treatment during BC treatment. The PI3K/Akt signaling was closely related to the antitumor effect of PSPA in BC. The present study provided evidence regarding the treatment of BC and enhanced the understanding of the potential role that PSPA plays in cancer prevention.
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Copy and paste a formatted citation
Spandidos Publications style
Li W, Yu H, Zhang X, Ke M and Hong T: Purple sweet potato anthocyanin exerts antitumor effect in bladder cancer. Oncol Rep 40: 73-82, 2018.
APA
Li, W., Yu, H., Zhang, X., Ke, M., & Hong, T. (2018). Purple sweet potato anthocyanin exerts antitumor effect in bladder cancer. Oncology Reports, 40, 73-82. https://doi.org/10.3892/or.2018.6421
MLA
Li, W., Yu, H., Zhang, X., Ke, M., Hong, T."Purple sweet potato anthocyanin exerts antitumor effect in bladder cancer". Oncology Reports 40.1 (2018): 73-82.
Chicago
Li, W., Yu, H., Zhang, X., Ke, M., Hong, T."Purple sweet potato anthocyanin exerts antitumor effect in bladder cancer". Oncology Reports 40, no. 1 (2018): 73-82. https://doi.org/10.3892/or.2018.6421
Copy and paste a formatted citation
x
Spandidos Publications style
Li W, Yu H, Zhang X, Ke M and Hong T: Purple sweet potato anthocyanin exerts antitumor effect in bladder cancer. Oncol Rep 40: 73-82, 2018.
APA
Li, W., Yu, H., Zhang, X., Ke, M., & Hong, T. (2018). Purple sweet potato anthocyanin exerts antitumor effect in bladder cancer. Oncology Reports, 40, 73-82. https://doi.org/10.3892/or.2018.6421
MLA
Li, W., Yu, H., Zhang, X., Ke, M., Hong, T."Purple sweet potato anthocyanin exerts antitumor effect in bladder cancer". Oncology Reports 40.1 (2018): 73-82.
Chicago
Li, W., Yu, H., Zhang, X., Ke, M., Hong, T."Purple sweet potato anthocyanin exerts antitumor effect in bladder cancer". Oncology Reports 40, no. 1 (2018): 73-82. https://doi.org/10.3892/or.2018.6421
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