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Potential role of cyclin F mRNA expression in the survival of skin melanoma patients: Comprehensive analysis of the pathways altered due to cyclin F upregulation

  • Authors:
    • Maciej Gagat
    • Adrian Krajewski
    • Dariusz Grzanka
    • Alina Grzanka
  • View Affiliations / Copyright

    Affiliations: Department of Histology and Embryology, Faculty of Medicine, Nicolaus Copernicus University in Toruń, Collegium Medicum in Bydgoszcz, 85-092 Bydgoszcz, Poland, Department of Clinical Pathomorphology, Faculty of Medicine, Nicolaus Copernicus University in Toruń, Collegium Medicum in Bydgoszcz, 85-092 Bydgoszcz, Poland
    Copyright: © Gagat et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 123-144
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    Published online on: May 16, 2018
       https://doi.org/10.3892/or.2018.6435
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Abstract

Cyclin F is a part of the Skp, Cullin, F-box containing ligase complex. The activity of cyclin F includes cell cycle control, centrosome duplication and response to DNA damage. The cyclin F expression pattern is very similar to cyclin A, but cyclin F is an orphan cyclin without its cyclin-dependent kinase partner. There is little evidence concerning the role of cyclin F in cancer. In the present study, for the first time, we present analysis from The Cancer Genome Atlas (TCGA) data in the context of expression of cyclin F mRNA in melanoma patients. Our original in silico analysis, not published elsewhere before, revealed that high expression of cyclin F in melanoma patients is associated with worse overall survival. Cyclin F and ribonucleotide reductase family member 2 (RRM2) compose a functional axis responsible for nucleotide metabolism. Impairment in this pathway may contribute to increased DNA damage repair and drug resistance. Additionally, we analyzed the expression of RRM2 mRNA and discovered that high expression of RRM2 is associated with worse overall survival. To shed more light on cyclin F overexpression in melanoma, we analyzed all protein data available in the TCGA melanoma dataset. It was found that in patients with upregulated cyclin F mRNA, we noted increased activity of pathways related to cell cycle and DNA damage repair. These data will support further in vitro and in vivo studies on the involvement of cyclin F in skin cutaneous melanoma.
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Copy and paste a formatted citation
Spandidos Publications style
Gagat M, Krajewski A, Grzanka D and Grzanka A: Potential role of cyclin F mRNA expression in the survival of skin melanoma patients: Comprehensive analysis of the pathways altered due to cyclin F upregulation. Oncol Rep 40: 123-144, 2018.
APA
Gagat, M., Krajewski, A., Grzanka, D., & Grzanka, A. (2018). Potential role of cyclin F mRNA expression in the survival of skin melanoma patients: Comprehensive analysis of the pathways altered due to cyclin F upregulation. Oncology Reports, 40, 123-144. https://doi.org/10.3892/or.2018.6435
MLA
Gagat, M., Krajewski, A., Grzanka, D., Grzanka, A."Potential role of cyclin F mRNA expression in the survival of skin melanoma patients: Comprehensive analysis of the pathways altered due to cyclin F upregulation". Oncology Reports 40.1 (2018): 123-144.
Chicago
Gagat, M., Krajewski, A., Grzanka, D., Grzanka, A."Potential role of cyclin F mRNA expression in the survival of skin melanoma patients: Comprehensive analysis of the pathways altered due to cyclin F upregulation". Oncology Reports 40, no. 1 (2018): 123-144. https://doi.org/10.3892/or.2018.6435
Copy and paste a formatted citation
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Spandidos Publications style
Gagat M, Krajewski A, Grzanka D and Grzanka A: Potential role of cyclin F mRNA expression in the survival of skin melanoma patients: Comprehensive analysis of the pathways altered due to cyclin F upregulation. Oncol Rep 40: 123-144, 2018.
APA
Gagat, M., Krajewski, A., Grzanka, D., & Grzanka, A. (2018). Potential role of cyclin F mRNA expression in the survival of skin melanoma patients: Comprehensive analysis of the pathways altered due to cyclin F upregulation. Oncology Reports, 40, 123-144. https://doi.org/10.3892/or.2018.6435
MLA
Gagat, M., Krajewski, A., Grzanka, D., Grzanka, A."Potential role of cyclin F mRNA expression in the survival of skin melanoma patients: Comprehensive analysis of the pathways altered due to cyclin F upregulation". Oncology Reports 40.1 (2018): 123-144.
Chicago
Gagat, M., Krajewski, A., Grzanka, D., Grzanka, A."Potential role of cyclin F mRNA expression in the survival of skin melanoma patients: Comprehensive analysis of the pathways altered due to cyclin F upregulation". Oncology Reports 40, no. 1 (2018): 123-144. https://doi.org/10.3892/or.2018.6435
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