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Article Open Access

miR-142-5p regulates CD4+ T cells in human non-small cell lung cancer through PD-L1 expression via the PTEN pathway

  • Authors:
    • Jun Wan
    • Xiean Ling
    • Bin Peng
    • Guanggui Ding
  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Surgery, The Shenzhen People's Hospital, The Second Clinical Medicine College of Jinan University, Shenzhen, Guangdong 518020, P.R. China
    Copyright: © Wan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 272-282
    |
    Published online on: May 16, 2018
       https://doi.org/10.3892/or.2018.6439
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Abstract

The present study aimed to evaluate the function of microRNA (miR)-142-5p on cancer immunity to induce apoptosis in human non-small cell lung cancer (NSCLC) and its mechanism. miR-142-5p expression was upregulated, and CD4+ T cell levels were reduced in patients with NSCLC. Overexpression of miR-142-5p expression inhibited the cancer effects of CD4+ T cells on NSCLC cell lines, and downregulation of miR-142-5p increased the cancer effects of CD4+ T cells on NSCLC cell lines, compared with the control group. In addition, we found that overexpression of miR-142-5p suppressed PTEN protein expression and induced PI3K, p-Akt and PD-L1 protein expression in an in vitro model of NSCLC. Downregulation of miR-142-5p induced PTEN and PD-L1 protein expression and suppressed PI3K and p-Akt and protein expression in an in vitro model of NSCLC. The suppression of PD-L1 reduced the cancer effects of CD4+ T cells on NSCLC cell lines following miR-142-5p downregulation. The inhibition of PTEN also reduced the cancer effects of CD4+ T cells on NSCLC cell lines following miR-142-5p downregulation. Therefore, our study demonstrated that miR-142-5p regulated CD4+ T cells in human NSCLC through PD-L1 expression via the PTEN pathway.
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Copy and paste a formatted citation
Spandidos Publications style
Wan J, Ling X, Peng B and Ding G: miR-142-5p regulates CD4+ T cells in human non-small cell lung cancer through PD-L1 expression via the PTEN pathway. Oncol Rep 40: 272-282, 2018.
APA
Wan, J., Ling, X., Peng, B., & Ding, G. (2018). miR-142-5p regulates CD4+ T cells in human non-small cell lung cancer through PD-L1 expression via the PTEN pathway. Oncology Reports, 40, 272-282. https://doi.org/10.3892/or.2018.6439
MLA
Wan, J., Ling, X., Peng, B., Ding, G."miR-142-5p regulates CD4+ T cells in human non-small cell lung cancer through PD-L1 expression via the PTEN pathway". Oncology Reports 40.1 (2018): 272-282.
Chicago
Wan, J., Ling, X., Peng, B., Ding, G."miR-142-5p regulates CD4+ T cells in human non-small cell lung cancer through PD-L1 expression via the PTEN pathway". Oncology Reports 40, no. 1 (2018): 272-282. https://doi.org/10.3892/or.2018.6439
Copy and paste a formatted citation
x
Spandidos Publications style
Wan J, Ling X, Peng B and Ding G: miR-142-5p regulates CD4+ T cells in human non-small cell lung cancer through PD-L1 expression via the PTEN pathway. Oncol Rep 40: 272-282, 2018.
APA
Wan, J., Ling, X., Peng, B., & Ding, G. (2018). miR-142-5p regulates CD4+ T cells in human non-small cell lung cancer through PD-L1 expression via the PTEN pathway. Oncology Reports, 40, 272-282. https://doi.org/10.3892/or.2018.6439
MLA
Wan, J., Ling, X., Peng, B., Ding, G."miR-142-5p regulates CD4+ T cells in human non-small cell lung cancer through PD-L1 expression via the PTEN pathway". Oncology Reports 40.1 (2018): 272-282.
Chicago
Wan, J., Ling, X., Peng, B., Ding, G."miR-142-5p regulates CD4+ T cells in human non-small cell lung cancer through PD-L1 expression via the PTEN pathway". Oncology Reports 40, no. 1 (2018): 272-282. https://doi.org/10.3892/or.2018.6439
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