PD-L1 mRNA expression in EGFR-mutant lung adenocarcinoma

  • Authors:
    • Kazutoshi Isobe
    • Atsushi Kakimoto
    • Tetuo Mikami
    • Kyohei Kaburaki
    • Hiroshi Kobayashi
    • Takahiro Yoshizawa
    • Yuta Nakano
    • Takashi Makino
    • Hajime Otsuka
    • Go Sano
    • Keishi Sugino
    • Susumu Sakamoto
    • Yujiro Takai
    • Naobumi Tochigi
    • Akira Iyoda
    • Sakae Homma
  • View Affiliations

  • Published online on: May 16, 2018     https://doi.org/10.3892/or.2018.6442
  • Pages: 331-338
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Abstract

Molecular mechanisms of programmed death-ligand 1 (PD-L1) mRNA expression and roles of apoptosis and biomarkers are poorly understood in epidermal growth factor receptor (EGFR)-mutant lung adenocarcinoma patients. Thirty-three patients with recurrent postoperative EGFR-mutant lung adenocarcinoma (exon 19 deletion in 16, L858R in 15, G719C in 2 patients) treated with gefitinib were studied. PD-L1 mRNA expression of formalin-fixed paraffin-embedded paratumoral and intratumoral tissues was quantified by PCR. Correlations of PD-L1 mRNA expression with BIM, p53 upregulated modular of apoptosis (PUMA), human epidermal growth factor receptor 2 (HER2), mesenchymal-epithelial transition (MET), EGFR, and vascular endothelial growth factor A (VEGFA) were determined. Eleven of the 33 patients (33.3%) and 14/33 patients (42.4%) expressed intratumoral and paratumoral PD-L1 mRNA, respectively. Patients with intratumoral PD-L1 mRNA expression had significantly higher BIM and lower VEGFA expression compared with paratumoral PD-L1 mRNA patients (P=0.049, P=0.009). PD-L1 mRNA expression was not associated with the expression of PUMA, HER2, EGFR and MET but was positively correlated with BIM expression (r=0.41, P=0.017) and inversely correlated with VEGFA expression (r=-0.33, P=0.043). Patients with intratumoral PD-L1 mRNA expression had significantly shorter median progression-free survival (PFS) after gefitinib therapy compared with no PD-L1 expression (255 vs. 732 days, respectively; P=0.032). Thus, PD-L1 mRNA expression in EGFR-mutant lung adenocarcinoma was associated with BIM and VEGFA mRNA expression and with shorter PFS after gefitinib therapy.
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July-2018
Volume 40 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Isobe K, Kakimoto A, Mikami T, Kaburaki K, Kobayashi H, Yoshizawa T, Nakano Y, Makino T, Otsuka H, Sano G, Sano G, et al: PD-L1 mRNA expression in EGFR-mutant lung adenocarcinoma. Oncol Rep 40: 331-338, 2018
APA
Isobe, K., Kakimoto, A., Mikami, T., Kaburaki, K., Kobayashi, H., Yoshizawa, T. ... Homma, S. (2018). PD-L1 mRNA expression in EGFR-mutant lung adenocarcinoma. Oncology Reports, 40, 331-338. https://doi.org/10.3892/or.2018.6442
MLA
Isobe, K., Kakimoto, A., Mikami, T., Kaburaki, K., Kobayashi, H., Yoshizawa, T., Nakano, Y., Makino, T., Otsuka, H., Sano, G., Sugino, K., Sakamoto, S., Takai, Y., Tochigi, N., Iyoda, A., Homma, S."PD-L1 mRNA expression in EGFR-mutant lung adenocarcinoma". Oncology Reports 40.1 (2018): 331-338.
Chicago
Isobe, K., Kakimoto, A., Mikami, T., Kaburaki, K., Kobayashi, H., Yoshizawa, T., Nakano, Y., Makino, T., Otsuka, H., Sano, G., Sugino, K., Sakamoto, S., Takai, Y., Tochigi, N., Iyoda, A., Homma, S."PD-L1 mRNA expression in EGFR-mutant lung adenocarcinoma". Oncology Reports 40, no. 1 (2018): 331-338. https://doi.org/10.3892/or.2018.6442