|
1
|
Cojoc M, Peitzsch C, Kurth I, Trautmann F,
Kunz-Schughart LA, Telegeev GD, Stakhovsky EA, Walker JR, Simin K,
Lyle S, et al: Aldehyde dehydrogenase is regulated by β-catenin/TCF
and promotes radioresistance in prostate cancer progenitor cells.
Cancer Res. 75:1482–1494. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Rycaj K and Tang DG: Cancer stem cells and
radioresistance. Int J Radiat Biol. 90:615–621. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Shimura T, Noma N, Sano Y, Ochiai Y,
Oikawa T, Fukumoto M and Kunugita N: AKT-mediated enhanced aerobic
glycolysis causes acquired radioresistance by human tumor cells.
Radiother Oncol. 112:302–307. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Chang L, Graham PH, Hao J, Ni J, Bucci J,
Cozzi PJ, Kearsley JH and Li Y: PI3K/Akt/mTOR pathway inhibitors
enhance radiosensitivity in radioresistant prostate cancer cells
through inducing apoptosis, reducing autophagy, suppressing NHEJ
and HR repair pathways. Cell Death Dis. 5:e14372014. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Wang Y, Yuan JL, Zhang YT, Ma JJ, Xu P,
Shi CH, Zhang W, Li YM, Fu Q, Zhu GF, et al: Inhibition of both
EGFR and IGF1R sensitized prostate cancer cells to radiation by
synergistic suppression of DNA homologous recombination repair.
PLoS One. 8:e687842013. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Kang KB, Zhu C, Yong SK, Gao Q and Wong
MC: Enhanced sensitivity of celecoxib in human glioblastoma cells:
Induction of DNA damage leading to p53-dependent G1 cell cycle
arrest and autophagy. Mol Cancer. 8:662009. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Ito H, Daido S, Kanzawa T, Kondo S and
Kondo Y: Radiation-induced autophagy is associated with LC3 and its
inhibition sensitizes malignant glioma cells. Int J Oncol.
26:1401–1410. 2005.PubMed/NCBI
|
|
8
|
Raffoul JJ, Wang Y, Kucuk O, Forman JD,
Sarkar FH and Hillman GG: Genistein inhibits radiation-induced
activation of NF-κB in prostate cancer cells promoting apoptosis
and G2/M cell cycle arrest. BMC Cancer. 6:1072006.
View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Yang J, Wu LJ, Tashino S, Onodera S and
Ikejima T: Protein tyrosine kinase pathway-derived ROS/NO
productions contribute to G2/M cell cycle arrest in
evodiamine-treated human cervix carcinoma HeLa cells. Free Radic
Res. 44:792–802. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Hartwell LH and Kastan MB: Cell cycle
control and cancer. Science. 266:1821–1828. 1994. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Su H, Jin X, Shen L, Fang Y, Fei Z, Zhang
X, Xie C and Chen X: Inhibition of cyclin D1 enhances sensitivity
to radiotherapy and reverses epithelial to mesenchymal transition
for esophageal cancer cells. Tumor Biol. 37:5355–5363. 2016.
View Article : Google Scholar
|
|
12
|
Cui S, Wienhoefer N and Bilitewski U:
Genistein induces morphology change and G2/M cell cycle arrest by
inducing p38 MAPK activation in macrophages. Int Immunopharmacol.
18:142–150. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Chitnis MM, Lodhia KA, Aleksic T, Gao S,
Protheroe AS and Macaulay VM: IGF-1R inhibition enhances
radiosensitivity and delays double-strand break repair by both
non-homologous end-joining and homologous recombination. Oncogene.
33:5262–5273. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Hartwell L: Defects in a cell cycle
checkpoint may be responsible for the genomic instability of cancer
cells. Cell. 71:543–546. 1992. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Stegeman H, Kaanders JH, van der Kogel AJ,
Iida M, Wheeler DL, Span PN and Bussink J: Predictive value of
hypoxia, proliferation and tyrosine kinase receptors for
EGFR-inhibition and radiotherapy sensitivity in head and neck
cancer models. Radiother Oncol. 106:383–389. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Rochester MA, Riedemann J, Hellawell GO,
Brewster SF and Macaulay VM: Silencing of the IGF1R gene
enhances sensitivity to DNA-damaging agents in both PTEN wild-type
and mutant human prostate cancer. Cancer Gene Ther. 12:90–100.
2005. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Wen B, Deutsch E, Marangoni E, Frascona V,
Maggiorella L, Abdulkarim B, Chavaudra N and Bourhis J: Tyrphostin
AG 1024 modulates radiosensitivity in human breast cancer cells. Br
J Cancer. 85:2017–2021. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Kisielewska J, Ligeza J and Klein A: The
effect of tyrosine kinase inhibitors, tyrphostins: AG1024 and
SU1498, on autocrine growth of prostate cancer cells (DU145). Folia
Histochem Cytobiol. 46:185–191. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Shukla V, Chandra V, Sankhwar P, Popli P,
Kaushal JB, Sirohi VK and Dwivedi A: Phytoestrogen genistein
inhibits EGFR/PI3K/NF-κB activation and induces apoptosis in human
endometrial hyperplasial cells. RSC Advances. 5:56075–56085. 2015.
View Article : Google Scholar
|
|
20
|
Hari S, Vasudevan V, Kasibhotla S, Reddy
D, Venkatappa M and Devaiah D: Anti-inflammatory dietary
supplements in the chemoprevention of oral cancer. Cancer Res
Front. 2:380–395. 2016. View Article : Google Scholar
|
|
21
|
Akiyama T, Ishida J, Nakagawa S, Ogawara
H, Watanabe S, Itoh N, Shibuya M and Fukami Y: Genistein, a
specific inhibitor of tyrosine-specific protein kinases. J Biol
Chem. 262:5592–5595. 1987.PubMed/NCBI
|
|
22
|
Akiyama T and Ogawara H: Use and
specificity of genistein as inhibitor of protein-tyrosine kinases.
Methods Enzymol. 201:362–370. 1991. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Markovits J, Linassier C, Fossé P, Couprie
J, Pierre J, Jacquemin-Sablon A, Saucier JM, Le Pecq JB and Larsen
AK: Inhibitory effects of the tyrosine kinase inhibitor genistein
on mammalian DNA topoisomerase II. Cancer Res. 49:5111–5117.
1989.PubMed/NCBI
|
|
24
|
Liu XX, Sun C, Jin XD, Li P, Zheng XG,
Zhao T and Li Q: Genistein sensitizes sarcoma cells in vitro and in
vivo by enhancing apoptosis and by inhibiting DSB repair pathways.
J Radiat Res. 57:227–237. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Marampon F, Gravina G, Ju X, Vetuschi A,
Sferra R, Casimiro M, Pompili S, Festuccia C, Colapietro A, Gaudio
E, et al: Cyclin D1 silencing suppresses tumorigenicity, impairs
DNA double strand break repair and thus radiosensitizes
androgen-independent prostate cancer cells to DNA damage.
Oncotarget. 7:5383–5400. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Liu Y, Majumder S, McCall W, Sartor CI,
Mohler JL, Gregory CW, Earp HS and Whang YE: Inhibition of
HER-2/neu kinase impairs androgen receptor recruitment to the
androgen responsive enhancer. Cancer Res. 65:3404–3409. 2005.
View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Fang Y, Zhang Q, Wang X, Yang X, Wang X,
Huang Z, Jiao Y and Wang J: Quantitative phosphoproteomics reveals
genistein as a modulator of cell cycle and DNA damage response
pathways in triple-negative breast cancer cells. Int J Oncol.
48:1016–1028. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Liu X, Sun C, Jin X, Li P, Ye F, Zhao T,
Gong L and Li Q: Genistein enhances the radiosensitivity of breast
cancer cells via G2/M cell cycle arrest and apoptosis. Molecules.
18:13200–13217. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Zhang Z, Wang CZ, Du GJ, Qi LW, Calway T,
He TC, Du W and Yuan CS: Genistein induces G2/M cell cycle arrest
and apoptosis via ATM/p53-dependent pathway in human colon cancer
cells. Int J Oncol. 43:289–296. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Lee J, Ju J, Park S, Hong SJ and Yoon S:
Inhibition of IGF-1 signaling by genistein: Modulation of
E-cadherin expression and downregulation of β-catenin signaling in
hormone refractory PC-3 prostate cancer cells. Nutr Cancer.
64:153–162. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Tsuboy MS, Marcarini JC, de Souza AO, de
Paula NA, Dorta DJ, Mantovani MS and Ribeiro LR: Genistein at
maximal physiologic serum levels induces G0/G1 arrest in MCF-7 and
HB4a cells, but not apoptosis. J Med Food. 17:218–225. 2014.
View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Hwang KA, Kang NH, Yi BR, Lee HR, Park MA
and Choi KC: Genistein, a soy phytoestrogen, prevents the growth of
BG-1 ovarian cancer cells induced by 17β-estradiol or bisphenol A
via the inhibition of cell cycle progression. Int J Oncol.
42:733–740. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Kuerbitz SJ, Plunkett BS, Walsh WV and
Kastan MB: Wild-type p53 is a cell cycle checkpoint determinant
following irradiation. Proc Natl Acad Sci USA. 89:7491–7495. 1992.
View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Maréchal A and Zou L: DNA damage sensing
by the ATM and ATR kinases. Cold Spring Harb Perspect Biol.
5:a0127162013. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Rao F, Cha J, Xu J, Xu R, Vandiver MS,
Tyagi R, Tokhunts R, Koldobskiy MA, Fu C, Barrow R, et al: Inositol
pyrophosphates mediate the DNA-PK/ATM-p53 cell death pathway by
regulating CK2 phosphorylation of Tti1/Tel2. Mol Cell. 54:119–132.
2014. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Elledge SJ: Cell cycle checkpoints:
Preventing an identity crisis. Science. 274:1664–1672. 1996.
View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Du WW, Yang W, Liu E, Yang Z, Dhaliwal P
and Yang BB: Foxo3 circular RNA retards cell cycle progression via
forming ternary complexes with p21 and CDK2. Nucleic Acids Res.
44:2846–2858. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Lee JJ, Lee JH, Gu MJ, Han JH, Cho WK and
Ma JY: Agastache rugosa Kuntze extract, containing the active
component rosmarinic acid, prevents atherosclerosis through
up-regulation of the cyclin-dependent kinase inhibitors p21
WAF1/CIP1 and p27 KIP1. J Functional Food. 30:30–38. 2017.
View Article : Google Scholar
|
|
39
|
Oki T, Sowa Y, Hirose T, Takagaki N,
Horinaka M, Nakanishi R, Yasuda C, Yoshida T, Kanazawa M, Satomi Y,
et al: Genistein induces Gadd45 gene and G2/M cell cycle
arrest in the DU145 human prostate cancer cell line. FEBS Lett.
577:55–59. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Li P, Veldwijk MR, Zhang Q, Li ZB, Xu WC
and Fu S: Co-inhibition of epidermal growth factor receptor and
insulin-like growth factor receptor 1 enhances radiosensitivity in
human breast cancer cells. BMC Cancer. 13:2972013. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Kasten U, Plottner N, Johansen J,
Overgaard J and Dikomey E: Ku70/80 gene expression and
DNA-dependent protein kinase (DNA-PK) activity do not correlate
with double-strand break (dsb) repair capacity and cellular
radiosensitivity in normal human fibroblasts. Br J Cancer.
79:1037–1041. 1999. View Article : Google Scholar : PubMed/NCBI
|
