|
1
|
Siegel RL, Miller KD and Jemal A: Cancer
Statistics, 2017. CA Cancer J Clin. 67:7–30. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Chen W, Zheng R, Baade PD, Zhang S, Zeng
H, Bray F, Jemal A, Yu XQ and He J: Cancer statistics in China,
2015. CA Cancer J Clin. 66:115–132. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Wolfgang CL, Herman JM, Laheru DA, Klein
AP, Erdek MA, Fishman EK and Hruban RH: Recent progress in
pancreatic cancer. CA Cancer J clin. 63:318–348. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Enomoto A, Murakami H, Asai N, Morone N,
Watanabe T, Kawai K, Murakumo Y, Usukura J, Kaibuchi K and
Takahashi M: Akt/PKB regulates actin organization and cell motility
via Girdin/APE. Dev cell. 9:389–402. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Jiang P, Enomoto A, Jijiwa M, Kato T,
Hasegawa T, Ishida M, Sato T, Asai N, Murakumo Y and Takahashi M:
An actin-binding protein girdin regulates the motility of breast
cancer cells. Cancer Res. 68:1310–1318. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Barbazan J, Dunkel Y, Li H, Nitsche U,
Janssen KP, Messer K and Ghosh P: Prognostic impact of modulators
of G proteins in circulating tumor cells from patients with
metastatic colorectal cancer. Sci Rep. 6:221122016. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Jiang P, Ren YL, Li JL and Luo J: Girdin
expression in cervical carcinoma and its role in the malignant
properties of HeLa cells. Oncol Lett. 11:2440–2444. 2016.
View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Miyake H, Maeda K, Asai N, Shibata R,
Ichimiya H, Isotani-Sakakibara M, Yamamura Y, Kato K, Enomoto A,
Takahashi M and Murohara T: The actin-binding protein Girdin and
its Akt-mediated phosphorylation regulate neointima formation after
vascular injury. Circ Res. 108:1170–1179. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Garcia-Marcos M, Ear J, Farquhar MG and
Ghosh P: A GDI (AGS3) and a GEF (GIV) regulate autophagy by
balancing G protein activity and growth factor signals. Mol Biol
Cell. 22:673–686. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Garcia-Marcos M, Jung BH, Ear J, Cabrera
B, Carethers JM and Ghosh P: Expression of GIV/Girdin, a
metastasis-related protein, predicts patient survival in colon
cancer. FASEB J. 25:590–599. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Anai M, Shojima N, Katagiri H, Ogihara T,
Sakoda H, Onishi Y, Ono H, Fujishiro M, Fukushima Y, Horike N, et
al: A novel protein kinase B (PKB)/AKT-binding protein enhances PKB
kinase activity and regulates DNA synthesis. J Biol Chem.
280:18525–18535. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Fresno Vara JA, Casado E, de Castro J,
Cejas P, Belda-Iniesta C and González-Baron M: PI3K/Akt signalling
pathway and cancer. Cancer Treat Rev. 30:193–204. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Mao Y, Xi L, Li Q, Cai Z, Lai Y, Zhang X
and Yu C: Regulation of cell apoptosis and proliferation in
pancreatic cancer through PI3K/Akt pathway via Polo-like kinase 1.
Oncol Rep. 36:49–56. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Enomoto A, Ping J and Takahashi M: Girdin,
a novel actin-binding protein, and its family of proteins possess
versatile functions in the Akt and Wnt signaling pathways. Ann NY
Acad Sci. 1086:169–184. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Osaki M, Oshimura M and Ito H: PI3K-Akt
pathway: Its functions and alterations in human cancer. Apoptosis.
9:667–676. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Fogel EL, Shahda S, Sandrasegaran K,
DeWitt J, Easler JJ, Agarwal DM, Eagleson M, Zyromski NJ, House MG,
Ellsworth S, et al: A multidisciplinary approach to pancreas cancer
in 2016: A review. Am J Gastroenterol. 112:537–554. 2017.
View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Saif MW: Advanced stage pancreatic cancer:
Novel therapeutic options. Expert Rev Clin Pharmacol. 7:487–498.
2014. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Ghosh P, Garcia-Marcos M, Bornheimer SJ
and Farquhar MG: Activation of Galphai3 triggers cell migration via
regulation of GIV. J Cell Biol. 182:381–393. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Gu F, Wang L, He J, Liu X, Zhang H, Li W,
Fu L and Ma Y: Girdin, an actin-binding protein, is critical for
migration, adhesion, and invasion of human glioblastoma cells. J
Neurochem. 131:457–469. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Cao K, Jiang W, Cao P, Zou Q, Xiao S, Zhou
J and Huang C: Talen-mediated girdin knockout downregulates cell
proliferation, migration and invasion in human esophageal carcinoma
ECA109 cells. Mol Med Rep. 10:848–854. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Ohara K, Enomoto A, Kato T, Hashimoto T,
Isotani-Sakakibara M, Asai N, Ishida-Takagishi M, Weng L, Nakayama
M, Watanabe T, et al: Involvement of girdin in the determination of
cell polarity during cell migration. Plos One. 7:e366812012.
View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Jun BY, Kim SW, Jung CK, Cho YK, Lee IS,
Choi MG, Choi KY and Oh ST: Expression of girdin in human
colorectal cancer and its association with tumor progression. Dis
Colon Rectum. 56:51–57. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Shibata T, Matsuo Y, Shamoto T, Hirokawa
T, Tsuboi K, Takahashi H, Ishiguro H, Kimura M, Takeyama H and
Inagaki H: Girdin, a regulator of cell motility, is a potential
prognostic marker for esophageal squamous cell carcinoma. Oncol
Rep. 29:2127–2132. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Ni W, Fang Y, Tong L, Tong Z1, Yi F, Qiu
J, Wang R and Tong X: Girdin regulates the migration and invasion
of glioma cells via the PI3K-Akt signaling pathway. Mol Medicine
Rep. 12:5086–5092. 2015. View Article : Google Scholar
|
|
25
|
Arlt A, Müerköster SS and Schäfer H:
Targeting apoptosis pathways in pancreatic cancer. Cancer Lett.
332:346–358. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Dan HC, Sun M, Kaneko S, Feldman RI,
Nicosia SV, Wang HG, Tsang BK and Cheng JQ: Akt phosphorylation and
stabilization of X-linked inhibitor of apoptosis protein (XIAP). J
Biol Chem. 291:228462004. View Article : Google Scholar
|
|
27
|
Yamamura Y, Asai N, Enomoto A, Kato T, Mii
S, Kondo Y, Ushida K, Niimi K, Tsunoda N, Nagino M, et al:
Akt-Girdin signaling in cancer-associated fibroblasts contributes
to tumor progression. Cancer Res. 75:813–823. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Lin C, Ear J, Pavlova Y, Mittal Y,
Kufareva I, Ghassemian M, Abagyan R, Garcia-Marcos M and Ghosh P:
Tyrosine phosphorylation of the Gα-interacting protein GIV promotes
activation of phosphoinositide 3-kinase during cell migration. Sci
Signal. 4:ra642011. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Rodon J, Dienstmann R, Serra V and
Tabernero J: Development of PI3K inhibitors: Lessons learned from
early clinical trials. Nat Rev Clin Oncol. 10:143–153. 2013.
View Article : Google Scholar : PubMed/NCBI
|
