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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Article

A novel biphenyl urea compound, TPD7, stimulates apoptosis through modulating Fas signaling and Bcl-2 family proteins in cervical cancer

  • Authors:
    • Yingzhuan Zhan
    • Han Zhang
    • Bingling Dai
    • Yanmin Zhang
    • Jie Zhang
    • Langchong He
  • View Affiliations / Copyright

    Affiliations: School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China
  • Pages: 1064-1072
    |
    Published online on: June 4, 2018
       https://doi.org/10.3892/or.2018.6472
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Abstract

We recently reported that TPD7 suppressed tumor cell proliferation, and inhibited invasion, through the suppression of C-X-C chemokine receptor type 4 (CXCR4). In the present study, we investigated the anticancer effect of TPD7 on apoptosis and invasion of cervical cancer HeLa cells. Cell cycle analysis revealed that TPD7 decreased cyclin-dependent kinase (CDK)1 and cyclin D1 expression, and increased cyclin A expression, following S phase blockade. TPD7 induced chromatin condensation and significantly elevated the number of apoptotic cells, suggesting that its inhibitory effect on HeLa cells was due to the induction of cell cycle blockade and apoptosis. Mechanistically, TPD7 altered the extrinsic apoptosis pathway by upregulating Fas expression, and the intrinsic pathway by modulating Bcl-2 family proteins, p53, and NF-κB p65, leading to enhanced apoptosis. TPD7 inhibited HeLa cell invasion by downregulating the expression of matrix metalloproteinase (MMP)-9 and CXCR4 proteins. In vivo experiments revealed that TPD7 inhibited tumor growth in HeLa cell xenografted mice. These findings indicated that TPD7 may be a potential chemoprevention agent for the management of cervical carcinoma.
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Copy and paste a formatted citation
Spandidos Publications style
Zhan Y, Zhang H, Dai B, Zhang Y, Zhang J and He L: A novel biphenyl urea compound, TPD7, stimulates apoptosis through modulating Fas signaling and Bcl-2 family proteins in cervical cancer. Oncol Rep 40: 1064-1072, 2018.
APA
Zhan, Y., Zhang, H., Dai, B., Zhang, Y., Zhang, J., & He, L. (2018). A novel biphenyl urea compound, TPD7, stimulates apoptosis through modulating Fas signaling and Bcl-2 family proteins in cervical cancer. Oncology Reports, 40, 1064-1072. https://doi.org/10.3892/or.2018.6472
MLA
Zhan, Y., Zhang, H., Dai, B., Zhang, Y., Zhang, J., He, L."A novel biphenyl urea compound, TPD7, stimulates apoptosis through modulating Fas signaling and Bcl-2 family proteins in cervical cancer". Oncology Reports 40.2 (2018): 1064-1072.
Chicago
Zhan, Y., Zhang, H., Dai, B., Zhang, Y., Zhang, J., He, L."A novel biphenyl urea compound, TPD7, stimulates apoptosis through modulating Fas signaling and Bcl-2 family proteins in cervical cancer". Oncology Reports 40, no. 2 (2018): 1064-1072. https://doi.org/10.3892/or.2018.6472
Copy and paste a formatted citation
x
Spandidos Publications style
Zhan Y, Zhang H, Dai B, Zhang Y, Zhang J and He L: A novel biphenyl urea compound, TPD7, stimulates apoptosis through modulating Fas signaling and Bcl-2 family proteins in cervical cancer. Oncol Rep 40: 1064-1072, 2018.
APA
Zhan, Y., Zhang, H., Dai, B., Zhang, Y., Zhang, J., & He, L. (2018). A novel biphenyl urea compound, TPD7, stimulates apoptosis through modulating Fas signaling and Bcl-2 family proteins in cervical cancer. Oncology Reports, 40, 1064-1072. https://doi.org/10.3892/or.2018.6472
MLA
Zhan, Y., Zhang, H., Dai, B., Zhang, Y., Zhang, J., He, L."A novel biphenyl urea compound, TPD7, stimulates apoptosis through modulating Fas signaling and Bcl-2 family proteins in cervical cancer". Oncology Reports 40.2 (2018): 1064-1072.
Chicago
Zhan, Y., Zhang, H., Dai, B., Zhang, Y., Zhang, J., He, L."A novel biphenyl urea compound, TPD7, stimulates apoptosis through modulating Fas signaling and Bcl-2 family proteins in cervical cancer". Oncology Reports 40, no. 2 (2018): 1064-1072. https://doi.org/10.3892/or.2018.6472
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