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Article

Prognostic signatures for renal cancer as identified by long non-coding and miRNA competing endogenous network analysis.

  • Authors:
    • Hongwei Gao
    • Xuanrong Chen
    • Zhiqun Shang
    • Yuanjie Niu
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin 300211, P.R. China
  • Pages: 959-967
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    Published online on: June 6, 2018
       https://doi.org/10.3892/or.2018.6476
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Abstract

Long non-coding RNAs (lncRNAs) make up a significant portion of transcripts that are not translated into proteins and lncRNAs were previously thought to be transcriptional noise. Recently, there has been increased interest in lncRNAs due to their diverse functions in human cancers. At present, lncRNAs are considered to be the main component of the competing endogenous RNA (ceRNA) network due to their regulatory role in protein-coding gene expression by acting as microRNA (miRNA) sponges. However, the function of the lncRNA-mediated ceRNA network in renal cell carcinoma remains unknown. To examine the specific mechanism, we compared the expression profiles of mRNAs, lncRNAs, and miRNAs between renal cell carcinoma tissues and non-tumor normal tissues using the Gene Expression Omnibus database. As a result, 5 lncRNAs were identified as aberrantly expressed and significantly correlated with the tumorigenesis and/or progression of renal cell carcinoma with the threshold value of absolute log2 fold change >1 and corrected P<0.05. Among the 5 dysregulated lncRNAs, 2 of them were prognostic biomarkers according to the overall survival analysis for patients with renal cell carcinoma. We successfully constructed a dysregulated lncRNA-associated ceRNA network, which included 4 renal cell carcinoma‑specific lncRNAs, 17 mRNAs and 2 miRNAs. In summary, the present study identified new lncRNA biomarkers and potential targets for renal cell carcinoma therapy. In particular, the novel ceRNA network identified in our study will be vital for understanding the regulatory mechanisms mediated by lncRNAs in the pathogenesis of renal cell carcinoma.
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View References

1 

Jonasch E, Gao J and Rathmell WK: Renal cell carcinoma. BMJ. 349:g47972014. View Article : Google Scholar : PubMed/NCBI

2 

Ljungberg B, Campbell SC, Choi HY, Jacqmin D, Lee JE, Weikert S and Kiemeney LA: The epidemiology of renal cell carcinoma. Eur Urol. 60:615–621. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Gupta S, Kang HC, Ganeshan DM, Bathala TK and Kundra V: Diagnostic approach to hereditary renal cell carcinoma. AJR Am J Roentgenol. 204:1031–1041. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Bex A, Jonasch E, Kirkali Z, Mejean A, Mulders P, Oudard S, Patard JJ, Powles T, van Poppel H and Wood CG: Integrating surgery with targeted therapies for renal cell carcinoma: Current evidence and ongoing trials. Eur Urol. 58:819–828. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Siegel R, Ma J, Zou Z and Jemal A: Cancer statistics, 2014. CA Cancer J Clin. 64:9–29. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Wyczólkowski M, Klima W, Bieda W and Walas K: Spontaneous regression of hepatic metastases after nephrectomy and metastasectomy of renal cell carcinoma. Urol Int. 66:119–120. 2001. View Article : Google Scholar : PubMed/NCBI

7 

International Human Genome Sequencing Consortium: Finishing the euchromatic sequence of the human genome. Nature. 431:931–945. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Bergmann JH and Spector DL: Long non-coding RNAs: Modulators of nuclear structure and function. Curr Opin Cell Biol. 26:10–18. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Guttman M, Garber M, Levin JZ, Donaghey J, Robinson J, Adiconis X, Fan L, Koziol MJ, Gnirke A, Nusbaum C, et al: Ab initio reconstruction of cell type-specific transcriptomes in mouse reveals the conserved multi-exonic structure of lincRNAs. Nat Biotechnol. 28:503–510. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Cabili MN, Trapnell C, Goff L, Koziol M, Tazon-Vega B, Regev A and Rinn JL: Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific subclasses. Genes Dev. 25:1915–1927. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Guttman M, Amit I, Garber M, French C, Lin MF, Feldser D, Huarte M, Zuk O, Carey BW, Cassady JP, et al: Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals. Nature. 458:223–227. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Geisler S and Coller J: RNA in unexpected places: Long non-coding RNA functions in diverse cellular contexts. Nat Rev Mol Cell Biol. 14:699–712. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Tripathi V, Shen Z, Chakraborty A, Giri S, Freier SM, Wu X, Zhang Y, Gorospe M, Prasanth SG, Lal A and Prasanth KV: Long noncoding RNA MALAT1 controls cell cycle progression by regulating the expression of oncogenic transcription factor B-MYB. PLoS Genet. 9:e10033682013. View Article : Google Scholar : PubMed/NCBI

14 

Tay Y, Rinn J and Pandolfi PP: The multilayered complexity of ceRNA crosstalk and competition. Nature. 505:344–352. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Prensner JR and Chinnaiyan AM: The emergence of lncRNAs in cancer biology. Cancer Discov. 1:391–407. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Hammond SM: An overview of microRNAs. Adv Drug Deliv Rev. 87:3–14. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Ye W, Lv Q, Wong CK, Hu S, Fu C, Hua Z, Cai G, Li G, Yang BB and Zhang Y: The effect of central loops in miRNA: MRE duplexes on the efficiency of miRNA-mediated gene regulation. PLoS One. 3:e17192008. View Article : Google Scholar : PubMed/NCBI

18 

Amirkhah R, Schmitz U, Linnebacher M, Wolkenhauer O and Farazmand A: MicroRNA-mRNA interactions in colorectal cancer and their role in tumor progression. Genes Chromosomes Cancer. 54:129–141. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Wang C, Hu DZ and Liu JZ: Identification of critical TF-miRNA-mRNA regulation loops for colorectal cancer metastasis. Genet Mol Res. 14:5485–5495. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Salmena L, Poliseno L, Tay Y, Kats L and Pandolfi PP: A ceRNA hypothesis: The Rosetta Stone of a hidden RNA language? Cell. 146:353–358. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Qi X, Zhang DH, Wu N, Xiao JH, Wang X and Ma W: ceRNA in cancer: Possible functions and clinical implications. J Med Genet. 52:710–718. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Militello G, Weirick T, John D, Döring C, Dimmeler S and Uchida S: Screening and validation of lncRNAs and circRNAs as miRNA sponges. Brief Bioinform. 18:780–788. 2017.PubMed/NCBI

23 

Kallen AN, Zhou XB, Xu J, Qiao C, Ma J, Yan L, Lu L, Liu C, Yi JS, Zhang H, et al: The imprinted H19 lncRNA antagonizes let-7 microRNAs. Mol Cell. 52:101–112. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Imig J, Brunschweiger A, Brümmer A, Guennewig B, Mittal N, Kishore S, Tsikrika P, Gerber AP, Zavolan M and Hall J: miR-CLIP capture of a miRNA targetome uncovers a lincRNA H19-miR-106a interaction. Nat Chem Biol. 11:107–114. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Cesana M, Cacchiarelli D, Legnini I, Santini T, Sthandier O, Chinappi M, Tramontano A and Bozzoni I: A long noncoding RNA controls muscle differentiation by functioning as a competing endogenous RNA. Cell. 147:358–369. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Xia T, Liao Q, Jiang X, Shao Y, Xiao B, Xi Y and Guo J: Long noncoding RNA associated-competing endogenous RNAs in gastric cancer. Sci Rep. 4:60882014. View Article : Google Scholar : PubMed/NCBI

27 

Zhang J, Fan D, Jian Z, Chen GG and Lai PB: Cancer specific long noncoding RNAs show differential expression patterns and competing endogenous RNA potential in hepatocellular carcinoma. PLoS One. 10:e01410422015. View Article : Google Scholar : PubMed/NCBI

28 

Zhou X, Liu J and Wang W: Construction and investigation of breast-cancer-specific ceRNA network based on the mRNA and miRNA expression data. IET Syst Biol. 8:96–103. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Zhou M, Diao Z, Yue X, Chen Y, Zhao H, Cheng L and Sun J: Construction and analysis of dysregulated lncRNA-associated ceRNA network identified novel lncRNA biomarkers for early diagnosis of human pancreatic cancer. Oncotarget. 7:56383–56394. 2016.PubMed/NCBI

30 

Wotschofsky Z, Gummlich L, Liep J, Stephan C, Kilic E, Jung K, Billaud JN and Meyer HA: Integrated microRNA and mRNA signature associated with the transition from the locally confined to the metastasized clear cell renal cell carcinoma exemplified by miR-146-5p. PLoS One. 11:e01487462016. View Article : Google Scholar : PubMed/NCBI

31 

Fachel AA, Tahira AC, Vilella-Arias SA, Maracaja-Coutinho V, Gimba ER, Vignal GM, Campos FS, Reis EM and Verjovski-Almeida S: Expression analysis and in silico characterization of intronic long noncoding RNAs in renal cell carcinoma: Emerging functional associations. Mol Cancer. 12:1402013. View Article : Google Scholar : PubMed/NCBI

32 

Wang X, Chen X, Han W, Ruan A, Chen L, Wang R, Xu Z, Xiao P, Lu X, Zhao Y, et al: miR-200c targets CDK2 and suppresses tumorigenesis in renal cell carcinoma. Mol Cancer Res. 13:1567–1577. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Jeggari A, Marks DS and Larsson E: miRcode: A map of putative microRNA target sites in the long non-coding transcriptome. Bioinformatics. 28:2062–2063. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Hsu SD, Tseng YT, Shrestha S, Lin YL, Khaleel A, Chou CH, Chu CF, Huang HY, Lin CM, Ho SY, et al: miRTarBase update 2014: An information resource for experimentally validated miRNA-target interactions. Nucleic Acids Res. 42:D78–D85. 2014. View Article : Google Scholar : PubMed/NCBI

35 

Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B and Ideker T: Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome Res. 13:2498–2504. 2003. View Article : Google Scholar : PubMed/NCBI

36 

Walsh AL, Tuzova AV, Bolton EM, Lynch TH and Perry AS: Long noncoding RNAs and prostate carcinogenesis: The missing ‘linc’? Trends Mol Med. 20:428–436. 2014. View Article : Google Scholar : PubMed/NCBI

37 

Zhang F, Zhang L and Zhang C: Long noncoding RNAs and tumorigenesis: Genetic associations, molecular mechanisms, and therapeutic strategies. Tumour Biol. 37:163–175. 2016. View Article : Google Scholar : PubMed/NCBI

38 

Wang H, Niu L, Jiang S, Zhai J, Wang P, Kong F and Jin X: Comprehensive analysis of aberrantly expressed profiles of lncRNAs and miRNAs with associated ceRNA network in muscle-invasive bladder cancer. Oncotarget. 7:86174–86185. 2016. View Article : Google Scholar : PubMed/NCBI

39 

Hauptman N and Glavač D: Long non-coding RNA in cancer. Int J Mol Sci. 14:4655–4669. 2013. View Article : Google Scholar : PubMed/NCBI

40 

Han D, Gao X, Wang M, Qiao Y, Xu Y, Yang J, Dong N, He J, Sun Q, Lv G, et al: Long noncoding RNA H19 indicates a poor prognosis of colorectal cancer and promotes tumor growth by recruiting and binding to eIF4A3. Oncotarget. 7:22159–22173. 2016.PubMed/NCBI

41 

Honda K: The biological role of actinin-4 (ACTN4) in malignant phenotypes of cancer. Cell Biosci. 5:412015. View Article : Google Scholar : PubMed/NCBI

42 

Honda K, Yamada T, Endo R, Ino Y, Gotoh M, Tsuda H, Yamada Y, Chiba H and Hirohashi S: Actinin-4, a novel actin-bundling protein associated with cell motility and cancer invasion. J Cell Biol. 140:1383–1393. 1998. View Article : Google Scholar : PubMed/NCBI

43 

Yamamoto S, Tsuda H, Honda K, Onozato K, Takano M, Tamai S, Imoto I, Inazawa J, Yamada T and Matsubara O: Actinin-4 gene amplification in ovarian cancer: A candidate oncogene associated with poor patient prognosis and tumor chemoresistance. Mod Pathol. 22:499–507. 2009. View Article : Google Scholar : PubMed/NCBI

44 

Kikuchi S, Honda K, Tsuda H, Hiraoka N, Imoto I, Kosuge T, Umaki T, Onozato K, Shitashige M, Yamaguchi U, et al: Expression and gene amplification of actinin-4 in invasive ductal carcinoma of the pancreas. Clin Cancer Res. 14:5348–5356. 2008. View Article : Google Scholar : PubMed/NCBI

45 

Rojas AM, Fuentes G, Rausell A and Valencia A: The Ras protein superfamily: Evolutionary tree and role of conserved amino acids. J Cell Biol. 196:189–201. 2012. View Article : Google Scholar : PubMed/NCBI

46 

Chen D, Guo J, Miki T, Tachibana M and Gahl WA: Molecular cloning of two novel rab genes from human melanocytes. Gene. 174:129–134. 1996. View Article : Google Scholar : PubMed/NCBI

47 

Abba MC, Hu Y, Sun H, Drake JA, Gaddis S, Baggerly K, Sahin A and Aldaz CM: Gene expression signature of estrogen receptor alpha status in breast cancer. BMC Genomics. 6:372005. View Article : Google Scholar : PubMed/NCBI

48 

Luther T, Kotzsch M, Meye A, Langerholc T, Füssel S, Olbricht N, Albrecht S, Ockert D, Muehlenweg B, Friedrich K, et al: Identification of a novel urokinase receptor splice variant and its prognostic relevance in breast cancer. Thromb Haemost. 89:705–717. 2003. View Article : Google Scholar : PubMed/NCBI

49 

Kotzsch M, Farthmann J, Meye A, Fuessel S, Baretton G, Tjan-Heijnen VC, Schmitt M, Luther T, Sweep FC, Magdolen V and Span PN: Prognostic relevance of uPAR-del4/5 and TIMP-3 mRNA expression levels in breast cancer. Eur J Cancer. 41:2760–2768. 2005. View Article : Google Scholar : PubMed/NCBI

50 

Sato S, Kopitz C, Grismayer B, Beaufort N, Reuning U, Schmitt M, Luther T, Kotzsch M, Krüger A and Magdolen V: Overexpression of the urokinase receptor mRNA splice variant uPAR-del4/5 affects tumor-associated processes of breast cancer cells in vitro and in vivo. Breast Cancer Res Treat. 127:649–657. 2011. View Article : Google Scholar : PubMed/NCBI

51 

Kunkle BW, Yoo C and Roy D: Reverse engineering of modified genes by Bayesian network analysis defines molecular determinants critical to the development of glioblastoma. PLoS One. 8:e641402013. View Article : Google Scholar : PubMed/NCBI

52 

Usó M, Jantus-Lewintre E, Sirera R, Bremnes RM and Camps C: miRNA detection methods and clinical implications in lung cancer. Future Oncol. 10:2279–2292. 2014. View Article : Google Scholar : PubMed/NCBI

53 

Yoshino H, Seki N, Itesako T, Chiyomaru T, Nakagawa M and Enokida H: Aberrant expression of microRNAs in bladder cancer. Nat Rev Urol. 10:396–404. 2013. View Article : Google Scholar : PubMed/NCBI

54 

Kumra H and Reinhardt DP: Fibronectin-targeted drug delivery in cancer. Adv Drug Deliv Rev. 97:101–110. 2016. View Article : Google Scholar : PubMed/NCBI

55 

Muller PA and Vousden KH: Mutant p53 in cancer: New functions and therapeutic opportunities. Cancer Cell. 25:304–317. 2014. View Article : Google Scholar : PubMed/NCBI

56 

Huang H, Weng H, Zhou H and Qu L: Attacking c-Myc: Targeted and combined therapies for cancer. Curr Pharm Des. 20:6543–6554. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Gao H, Chen X, Shang Z and Niu Y: Prognostic signatures for renal cancer as identified by long non-coding and miRNA competing endogenous network analysis.. Oncol Rep 40: 959-967, 2018.
APA
Gao, H., Chen, X., Shang, Z., & Niu, Y. (2018). Prognostic signatures for renal cancer as identified by long non-coding and miRNA competing endogenous network analysis.. Oncology Reports, 40, 959-967. https://doi.org/10.3892/or.2018.6476
MLA
Gao, H., Chen, X., Shang, Z., Niu, Y."Prognostic signatures for renal cancer as identified by long non-coding and miRNA competing endogenous network analysis.". Oncology Reports 40.2 (2018): 959-967.
Chicago
Gao, H., Chen, X., Shang, Z., Niu, Y."Prognostic signatures for renal cancer as identified by long non-coding and miRNA competing endogenous network analysis.". Oncology Reports 40, no. 2 (2018): 959-967. https://doi.org/10.3892/or.2018.6476
Copy and paste a formatted citation
x
Spandidos Publications style
Gao H, Chen X, Shang Z and Niu Y: Prognostic signatures for renal cancer as identified by long non-coding and miRNA competing endogenous network analysis.. Oncol Rep 40: 959-967, 2018.
APA
Gao, H., Chen, X., Shang, Z., & Niu, Y. (2018). Prognostic signatures for renal cancer as identified by long non-coding and miRNA competing endogenous network analysis.. Oncology Reports, 40, 959-967. https://doi.org/10.3892/or.2018.6476
MLA
Gao, H., Chen, X., Shang, Z., Niu, Y."Prognostic signatures for renal cancer as identified by long non-coding and miRNA competing endogenous network analysis.". Oncology Reports 40.2 (2018): 959-967.
Chicago
Gao, H., Chen, X., Shang, Z., Niu, Y."Prognostic signatures for renal cancer as identified by long non-coding and miRNA competing endogenous network analysis.". Oncology Reports 40, no. 2 (2018): 959-967. https://doi.org/10.3892/or.2018.6476
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