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Article Open Access

Norcantharidin reverses cisplatin resistance and inhibits the epithelial mesenchymal transition of human non‑small lung cancer cells by regulating the YAP pathway

Retraction in: /10.3892/or.2020.7830
  • Authors:
    • Dan Jin
    • Yan Wu
    • Cuijie Shao
    • Yong Gao
    • Deqiang Wang
    • Jiwei Guo
  • View Affiliations / Copyright

    Affiliations: Department of Pain Medicine, Binzhou Medical University Hospital, Binzhou, Shandong 256603, P.R. China, Cancer Research Institute, Binzhou Medical University Hospital, Binzhou, Shandong 256603, P.R. China, Department of Pain Medicine, Binzhou Medical University Hospital, Binzhou, Shandong 256603, P.R. China
    Copyright: © Jin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 609-620
    |
    Published online on: June 12, 2018
       https://doi.org/10.3892/or.2018.6486
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Abstract

Non‑small cell lung cancer (NSCLC) accounts for >80% of all lung cancer cases, which are the leading cause of cancer‑related mortality worldwide. The clinical efficacy of available therapies for NSCLC is often limited due to the development of resistance to anticancer drugs, particularly to cisplatin (DDP). Norcantharidin (NCTD) is a traditional Chinese medicine used in the treatment of many types of cancer, to which patients do not develop resistance. The aim of the present study was to examine the potential synergistic effects of NCTD and DPP on the viability of the the DDP‑resistant NSCLC cell line, A549/DDP. We further explored the potential underlying mechanisms by examining the expression of the oncogene, Yes-associated protein 1 (YAP), whose activation was recently found to be associated with drug resistance. We further examined a series of human lung cancer cell lines and tissues from patients with lung cancer, which revealed that YAP activation contributed to lung cancer initiation, progression and metastasis, and was associated with a poor prognosis, and confering resistance against targeted therapies. Moreover, YAP expression was evaluated in the A549/DDP cells treated with NCTD, DDP, or both drugs. The combined treatment significantly sensitized the A549/DDP cells to DDP‑induced growth inhibition by reducing YAP promoter activity (based on transcriptional expression) and the expression of its target genes, connective tissue growth factor (CTGF) and cysteine rich angiogenic inducer 61 (CYR61). Furthermore, compared to the individual treatments, combined treatment increased cell apoptosis and senescence, and decreased epithelial‑to‑mesenchymal transition and the cell migratory and invasive ability. On the whole, our data indicate that the application of NCTD with reverses DDP resistance and thus, this combined treatment may have promising prospects for use in improving the outcome of patients with NSCLC.
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View References

1 

Siegel R, Naishadham D and Jemal A: Cancer statistics, 2013. CA Cancer J Clin. 63:11–30. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Ferlay J, Shin HR, Bray F, Forman D, Mathers C and Parkin DM: Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 127:2893–2917. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Ramalingam SS, Owonikoko TK and Khuri FR: Lung cancer: New biological insights and recent therapeutic advances. CA Cancer J Clin. 61:91–112. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Hurria A and Kris MG: Management of lung cancer in older adults. CA Cancer J Clin. 53:325–341. 2003. View Article : Google Scholar : PubMed/NCBI

5 

Judson I and Kelland LR: New developments and approaches in the platinum arena. Drugs. 59 (Suppl 4):S29–S38. 2000. View Article : Google Scholar

6 

Oliver TG, Mercer KL, Sayles LC, Burke JR, Mendus D, Lovejoy KS, Cheng MH, Subramanian A, Mu D, Powers S, et al: Chronic cisplatin treatment promotes enhanced damage repair and tumor progression in a mouse model of lung cancer. Genes Dev. 24:837–852. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Valle J, Wasan H, Palmer DH, Cunningham D, Anthoney A, Maraveyas A, Madhusudan S, Iveson T, Hughes S, Pereira SP, et al: Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer. New Engl J Med. 362:1273–1281. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Shen DW, Pouliot LM, Hall MD and Gottesman MM: Cisplatin resistance: A cellular self-defense mechanism resulting from multiple epigenetic and genetic changes. Pharmacol Rev. 64:706–721. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Rosell R, Lord RV, Taron M and Reguart N: DNA repair and cisplatin resistance in non-small-cell lung cancer. Lung Cancer. 38:217–227. 2002. View Article : Google Scholar : PubMed/NCBI

10 

Wei F, Jiang X, Gao HY and Gao SH: Liquiritin induces apoptosis and autophagy in cisplatin (DDP)-resistant gastric cancer cells in vitro and xenograft nude mice in vivo. Int J Oncol. 51:1383–1394. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Chaib I, Karachaliou N, Pilotto S, Codony Servat J, Cai X, Li X, Drozdowskyj A, Servat CC, Yang J, Hu C, et al: Co-activation of STAT3 and YES-associated protein 1 (YAP1) pathway in EGFR-mutant NSCLC. J Natl Cancer Inst. 109:2017. View Article : Google Scholar : PubMed/NCBI

12 

Zhang W, Gao Y, Li F, Tong X, Ren Y, Han X, Yao S, Long F, Yang Z, Fan H, et al: YAP promotes malignant progression of Lkb1-deficient lung adenocarcinoma through downstream regulation of survivin. Cancer Res. 75:4450–4457. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Karachaliou N, Chaib I, Pilotto S, Codony J, Cai X, Li X, Marin S, Zhou C, Cao P and Rosell R: 76P An innovative co-targeting of signal transducer and activator of transcription 3 (STAT3) and Src-YAP pathways in EGFR mutant non-small cell lung cancer (NSCLC). J Thorac Oncol. 11 (Suppl 4):S87–S88. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Pan D: Hippo signaling in organ size control. Genes Dev. 21:886–897. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Zanconato F, Cordenonsi M and Piccolo S: YAP/TAZ at the roots of cancer. Cancer Cell. 29:783–803. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Guo L and Teng L: YAP/TAZ for cancer therapy: Opportunities and challenges (Review). Int J Oncol. 46:1444–1452. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Morikawa Y, Heallen T, Each JL, Xiao Y and Martin JF: Dystrophin-glycoprotein complex sequesters Yap to inhibit cardiomyocyte proliferation. Nature. 547:227–231. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Britschgi A, Duss S, Kim S, Couto JP, Brinkhaus H, Koren S, De Silva D, Mertz KD, Kaup D, Varga Z, et al: The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERα. Nature. 541:541–545. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Gregorieff A, Liu Y, Inanlou MR, Khomchuk Y and Wrana JL: Yap-dependent reprogramming of Lgr5+ stem cells drives intestinal regeneration and cancer. Nature. 526:715–718. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Park HW, Kim YC, Yu B, Moroishi T, Mo JS, Plouffe SW, Meng ZP, Lin KC, Yu FX, Alexander CM, et al: Alternative Wnt signaling activates YAP/TAZ. Cell. 162:780–794. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Wang GS: Medical uses of mylabris in ancient China and recent studies. J Ethnopharmacol. 26:147–162. 1989. View Article : Google Scholar : PubMed/NCBI

22 

Yu CC, Ko FY, Yu CS, Lin CC, Huang YP, Yang JS, Lin JP and Chung JG: Norcantharidin triggers cell death and DNA damage through S-phase arrest and ROS-modulated apoptotic pathways in TSGH 8301 human urinary bladder carcinoma cells. Int J Oncol. 41:1050–1060. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Zhang JT, Fan YZ, Chen CQ, Zhao ZM and Sun W: Norcantharidin: A potential antiangiogenic agent for gallbladder cancers in vitro and in vivo. Int J Oncol. 40:1501–1514. 2012.PubMed/NCBI

24 

Chen QY, Jiao DM, Wang J, Hu H, Tang X, Chen J, Mou H and Lu W: miR-206 regulates cisplatin resistance and EMT in human lung adenocarcinoma cells partly by targeting MET. Oncotarget. 7:24510–24526. 2016.PubMed/NCBI

25 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2−ΔΔCT method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

26 

Guo J, Wu Y, Yang L, Du J, Gong K, Chen W, Dai J, Li X and Xi S: Repression of YAP by NCTD disrupts NSCLC progression. Oncotarget. 8:2307–2319. 2017.PubMed/NCBI

27 

Li K, Guo J, Wu Y, Jin D, Jiang H, Liu C and Qin C: Suppression of YAP by DDP disrupts colon tumor progression. Oncol Rep. 39:2114–2126. 2018.PubMed/NCBI

28 

Lee TF, Tseng YC, Nguyen PA, Li YC, Ho CC and Wu CW: Enhanced YAP expression leads to EGFR TKI resistance in lung adenocarcinomas. Sci Rep. 8:2712017. View Article : Google Scholar

29 

Singh A and Settleman J: EMT, cancer stem cells and drug resistance: An emerging axis of evil in the war on cancer. Oncogene. 29:4741–4751. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Shao DD, Xue W, Krall EB, Bhutkar A, Piccioni F, Wang X, Schinzel AC, Sood S, Rosenbluh J, Kim JW, et al: KRAS and YAP1 converge to regulate EMT and tumor survival. Cell. 158:171–184. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Hsieh CH, Chao KS, Liao HF and Chen YJ: Norcantharidin, derivative of cantharidin, for cancer stem cells. Evid Based Complement Alternat Med. 2013:8386512013. View Article : Google Scholar : PubMed/NCBI

32 

Bae JS, Kim SM and Lee H: The Hippo signaling pathway provides novel anti-cancer drug targets. Oncotarget. 8:16084–16098. 2017. View Article : Google Scholar : PubMed/NCBI

33 

Wang Y, Ding W, Chen C, Niu Z, Pan M and Zhang H: Roles of Hippo signaling in lung cancer. Indian J Cancer. 52 (Suppl 1):e1–e5. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Song S, Honjo S, Jin J, Chang SS, Scott AW, Chen Q, Kalhor N, Correa AM, Hofstetter WL, Albarracin CT, et al: The Hippo coactivator YAP1 mediates EGFR overexpression and confers chemoresistance in esophageal cancer. Clin Cancer Res. 21:2580–2590. 2015. View Article : Google Scholar : PubMed/NCBI

35 

Xiao L, Shi XY, Zhang Y, Zhu Y, Zhu L, Tian W, Zhu BK and Wei ZL: YAP induces cisplatin resistance through activation of autophagy in human ovarian carcinoma cells. Onco Targets Ther. 9:1105–1114. 2016.PubMed/NCBI

36 

Kim MH and Kim J: Role of YAP/TAZ transcriptional regulators in resistance to anti-cancer therapies. Cell Mol Life Sci. 74:1457–1474. 2017. View Article : Google Scholar : PubMed/NCBI

37 

Ye LY, Hu S, Xu HE, Xu RR, Kong H, Zeng XN, Xie WP and Wang H: The effect of tetrandrine combined with cisplatin on proliferation and apoptosis of A549/DDP cells and A549 cells. Cancer Cell Int. 17:402017. View Article : Google Scholar : PubMed/NCBI

38 

Rosenbluh J, Nijhawan D, Cox AG, Li X, Neal JT, Schafer EJ, Zack TI, Wang X, Tsherniak A, Schinzel AC, et al: β-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis. Cell. 151:1457–1473. 2012. View Article : Google Scholar : PubMed/NCBI

39 

Lin L, Sabnis AJ, Chan E, Olivas V, Cade L, Pazarentzos E, Asthana S, Neel D, Yan JJ, Lu X, et al: The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies. Nat Genet. 47:250–256. 2015. View Article : Google Scholar : PubMed/NCBI

40 

Zheng HC: The molecular mechanisms of chemoresistance in cancers. Oncotarget. 8:59950–59964. 2017.PubMed/NCBI

41 

Wang T, Wei J, Qian X, Ding Y, Yu L and Liu B: Gambogic acid, a potent inhibitor of survivin, reverses docetaxel resistance in gastric cancer cells. Cancer Lett. 262:214–222. 2008. View Article : Google Scholar : PubMed/NCBI

42 

Tian A, Wilson GS, Lie S, Wu G, Hu Z, Hebbard L, Duan W, George J and Qiao L: Synergistic effects of IAP inhibitor LCL161 and paclitaxel on hepatocellular carcinoma cells. Cancer Lett. 351:232–241. 2014. View Article : Google Scholar : PubMed/NCBI

43 

Witta SE, Gemmill RM, Hirsch FR, Coldren CD, Hedman K, Ravdel L, Helfrich B, Dziadziuszko R, Chan DC, Sugita M, et al: Restoring E-cadherin expression increases sensitivity to epidermal growth factor receptor inhibitors in lung cancer cell lines. Cancer Res. 66:944–950. 2006. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Jin D, Wu Y, Shao C, Gao Y, Wang D and Guo J: Norcantharidin reverses cisplatin resistance and inhibits the epithelial mesenchymal transition of human non‑small lung cancer cells by regulating the YAP pathway Retraction in /10.3892/or.2020.7830. Oncol Rep 40: 609-620, 2018.
APA
Jin, D., Wu, Y., Shao, C., Gao, Y., Wang, D., & Guo, J. (2018). Norcantharidin reverses cisplatin resistance and inhibits the epithelial mesenchymal transition of human non‑small lung cancer cells by regulating the YAP pathway Retraction in /10.3892/or.2020.7830. Oncology Reports, 40, 609-620. https://doi.org/10.3892/or.2018.6486
MLA
Jin, D., Wu, Y., Shao, C., Gao, Y., Wang, D., Guo, J."Norcantharidin reverses cisplatin resistance and inhibits the epithelial mesenchymal transition of human non‑small lung cancer cells by regulating the YAP pathway Retraction in /10.3892/or.2020.7830". Oncology Reports 40.2 (2018): 609-620.
Chicago
Jin, D., Wu, Y., Shao, C., Gao, Y., Wang, D., Guo, J."Norcantharidin reverses cisplatin resistance and inhibits the epithelial mesenchymal transition of human non‑small lung cancer cells by regulating the YAP pathway Retraction in /10.3892/or.2020.7830". Oncology Reports 40, no. 2 (2018): 609-620. https://doi.org/10.3892/or.2018.6486
Copy and paste a formatted citation
x
Spandidos Publications style
Jin D, Wu Y, Shao C, Gao Y, Wang D and Guo J: Norcantharidin reverses cisplatin resistance and inhibits the epithelial mesenchymal transition of human non‑small lung cancer cells by regulating the YAP pathway Retraction in /10.3892/or.2020.7830. Oncol Rep 40: 609-620, 2018.
APA
Jin, D., Wu, Y., Shao, C., Gao, Y., Wang, D., & Guo, J. (2018). Norcantharidin reverses cisplatin resistance and inhibits the epithelial mesenchymal transition of human non‑small lung cancer cells by regulating the YAP pathway Retraction in /10.3892/or.2020.7830. Oncology Reports, 40, 609-620. https://doi.org/10.3892/or.2018.6486
MLA
Jin, D., Wu, Y., Shao, C., Gao, Y., Wang, D., Guo, J."Norcantharidin reverses cisplatin resistance and inhibits the epithelial mesenchymal transition of human non‑small lung cancer cells by regulating the YAP pathway Retraction in /10.3892/or.2020.7830". Oncology Reports 40.2 (2018): 609-620.
Chicago
Jin, D., Wu, Y., Shao, C., Gao, Y., Wang, D., Guo, J."Norcantharidin reverses cisplatin resistance and inhibits the epithelial mesenchymal transition of human non‑small lung cancer cells by regulating the YAP pathway Retraction in /10.3892/or.2020.7830". Oncology Reports 40, no. 2 (2018): 609-620. https://doi.org/10.3892/or.2018.6486
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