|
1
|
Lin YY, Hsu YH, Huang HY, Shann YJ, Huang
CY, Wei SC, Chen CL and Jou TS: Aberrant nuclear localization of
EBP50 promotes colorectal carcinogenesis in xenotransplanted mice
by modulating TCF-1 and β-catenin interactions. J Clin Invest.
122:1881–1894. 2012. View
Article : Google Scholar : PubMed/NCBI
|
|
2
|
Giles RH, van Es JH and Clevers H: Caught
up in a wnt storm: Wnt signaling in cancer. Biochim Biophys Acta.
1653:1–24. 2003.PubMed/NCBI
|
|
3
|
Wangefjord S, Brandstedt J, Lindquist KE,
Nodin B, Jirstrom K and Eberhard J: Associations of beta-catenin
alterations and MSI screening status with expression of key cell
cycle regulating proteins and survival from colorectal cancer.
Diagn Pathol. 8:102013. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Stanczak A, Stec R, Bodnar L, Olszewski W,
Cichowicz M, Kozlowski W, Szczylik C, Pietrucha T, Wieczorek M and
Lamparska-Przybysz M: Prognostic significance of Wnt-1, β-catenin
and E-cadherin expression in advanced colorectal carcinoma. Pathol
Oncol Res. 17:955–963. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Kreimann EL, Morales FC, de Orbeta-Cruz J,
Takahashi Y, Adams H, Liu TJ, McCrea PD and Georgescu MM: Cortical
stabilization of beta-catenin contributes to NHERF1/EBP50 tumor
suppressor function. Oncogene. 26:5290–5299. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Georgescu MM, Gagea M and Cote G:
NHERF1/EBP50 suppresses wnt-β-catenin pathway-driven intestinal
neoplasia. Neoplasia. 18:512–523. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Parsons DW, Wang TL, Samuels Y, Bardelli
A, Cummins JM, DeLong L, Silliman N, Ptak J, Szabo S, Willson JK,
et al: Colorectal cancer: Mutations in a signalling pathway.
Nature. 436:7922005. View
Article : Google Scholar : PubMed/NCBI
|
|
8
|
Azzolin L, Panciera T, Soligo S, Enzo E,
Bicciato S, Dupont S, Bresolin S, Frasson C, Basso G, Guzzardo V,
et al: YAP/TAZ incorporation in the β-catenin destruction complex
orchestrates the Wnt response. Cell. 158:157–170. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Hayashi Y, Molina JR, Hamilton SR and
Georgescu MM: NHERF1/EBP50 is a new marker in colorectal cancer.
Neoplasia. 12:1013–1022. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Barrett T, Wilhite SE, Ledoux P,
Evangelista C, Kim IF, Tomashevsky M, Marshall KA, Phillippy KH,
Sherman PM, Holko M, et al: NCBI GEO: Archive for functional
genomics data sets-update. Nucleic Acids Res. 41:D991–D995. 2013.
View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Cai Y, Tsai HC, Yen RC, Zhang YW, Kong X,
Wang W, Xia L and Baylin SB: Critical threshold levels of DNA
methyltransferase 1 are required to maintain DNA methylation across
the genome in human cancer cells. Genome Res. 27:533–544. 2017.
View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Flesner BK, Kumar SR and Bryan JN:
6-Thioguanine and zebularine down-regulate DNMT1 and globally
demethylate canine malignant lymphoid cells. BMC Vet Res.
10:2902014. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Wheeler DS, Barrick SR, Grubisha MJ,
Brufsky AM, Friedman PA and Romero G: Direct interaction between
NHERF1 and Frizzled regulates β-catenin signaling. Oncogene.
30:32–42. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Molina JR, Agarwal NK, Morales FC, Hayashi
Y, Aldape KD, Cote G and Georgescu MM: PTEN, NHERF1 and PHLPP form
a tumor suppressor network that is disabled in glioblastoma.
Oncogene. 31:1264–1274. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Molina JR, Morales FC, Hayashi Y, Aldape
KD and Georgescu MM: Loss of PTEN binding adapter protein NHERF1
from plasma membrane in glioblastoma contributes to PTEN
inactivation. Cancer Res. 70:6697–6703. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Mahon MJ, Donowitz M, Yun CC and Segre GV:
Na+/H+ exchanger regulatory factor 2 directs
parathyroid hormone 1 receptor signalling. Nature. 417:858–861.
2002. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Morales FC, Takahashi Y, Kreimann EL and
Georgescu MM: Ezrin-radixin-moesin (ERM)-binding phosphoprotein 50
organizes ERM proteins at the apical membrane of polarized
epithelia. Proc Natl Acad Sci USA. 101:17705–17710. 2004.
View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Shenolikar S, Voltz JW, Minkoff CM, Wade
JB and Weinman EJ: Targeted disruption of the mouse NHERF-1 gene
promotes internalization of proximal tubule sodium-phosphate
cotransporter type IIa and renal phosphate wasting. Proc Natl Acad
Sci USA. 99:11470–11475. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Dai JL, Wang L, Sahin AA, Broemeling LD,
Schutte M and Pan Y: NHERF (Na+/H+ exchanger
regulatory factor) gene mutations in human breast cancer. Oncogene.
23:8681–8687. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Shibata T, Chuma M, Kokubu A, Sakamoto M
and Hirohashi S: EBP50, a beta-catenin-associating protein,
enhances Wnt signaling and is over-expressed in hepatocellular
carcinoma. Hepatology. 38:178–186. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Mangia A, Saponaro C, Malfettone A,
Bisceglie D, Bellizzi A, Asselti M, Popescu O, Reshkin SJ, Paradiso
A and Simone G: Involvement of nuclear NHERF1 in colorectal cancer
progression. Oncol Rep. 28:889–894. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Malfettone A, Silvestris N, Paradiso A,
Mattioli E, Simone G and Mangia A: Overexpression of nuclear NHERF1
in advanced colorectal cancer: Association with hypoxic
microenvironment and tumor invasive phenotype. Exp Mol Pathol.
92:296–303. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Gu Y, Yu H, Hao C, Martin TA, Hargest R,
He J, Cheng S and Jiang WG: NHERF1 regulates the progression of
colorectal cancer through the interplay with VEGFR2 pathway.
Oncotarget. 8:7753–7765. 2017.PubMed/NCBI
|
|
24
|
Vaquero J, Nguyen Ho-Bouldoires TH,
Claperon A and Fouassier L: Role of the PDZ-scaffold protein
NHERF1/EBP50 in cancer biology: From signaling regulation to
clinical relevance. Oncogene. 36:3067–3079. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Song GJ, Leslie KL, Barrick S, Mamonova T,
Fitzpatrick JM, Drombosky KW, Peyser N, Wang B, Pellegrini M, Bauer
PM, et al: Phosphorylation of ezrin-radixin-moesin-binding
phosphoprotein 50 (EBP50) by Akt promotes stability and mitogenic
function of S-phase kinase-associated protein-2 (Skp2). J Biol
Chem. 290:2879–2887. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
He J, Lau AG, Yaffe MB and Hall RA:
Phosphorylation and cell cycle-dependent regulation of
Na+/H+ exchanger regulatory factor-1 by Cdc2
kinase. J Biol Chem. 276:41559–41565. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Peng Z, Wang Q, Zhang Y, He J and Zheng J:
EBP50 interacts with EGFR and regulates EGFR signaling to affect
the prognosis of cervical cancer patients. Int J Oncol.
49:1737–1745. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Ji MY, Fan DK, Lv XG, Peng XL, Lei XF and
Dong WG: The detection of EBP50 expression using quantum dot
immunohistochemistry in pancreatic cancer tissue and down-regulated
EBP50 effect on PC-2 cells. J Mol Histol. 43:517–526. 2012.
View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Smith PM, Cowan A, Milgram SL and White
BA: Tissue-specific regulation by estrogen of ezrin and
ezrin/radixin/moesin-binding protein 50. Endocrine. 22:119–126.
2003. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Fouassier L, Rosenberg P, Mergey M,
Saubaméa B, Clapéron A, Kinnman N, Chignard N, Jacobsson-Ekman G,
Strandvik B, Rey C, et al: Ezrin-radixin-moesin-binding
phosphoprotein (EBP50), an estrogen-inducible scaffold protein,
contributes to biliary epithelial cell proliferation. Am J Pathol.
174:869–880. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Ediger TR, Kraus WL, Weinman EJ and
Katzenellenbogen BS: Estrogen receptor regulation of the
Na+/H+ exchange regulatory factor.
Endocrinology. 140:2976–2982. 1999. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Harrington WR, Sheng S, Barnett DH, Petz
LN, Katzenellenbogen JA and Katzenellenbogen BS: Activities of
estrogen receptor alpha- and beta-selective ligands at diverse
estrogen responsive gene sites mediating transactivation or
transrepression. Mol Cell Endocrinol. 206:13–22. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Stemmer-Rachamimov AO, Wiederhold T,
Nielsen GP, James M, Pinney-Michalowski D, Roy JE, Cohen WA, Ramesh
V and Louis DN: NHE-RF, a merlin-interacting protein, is primarily
expressed in luminal epithelia, proliferative endometrium, and
estrogen receptor-positive breast carcinomas. Am J Pathol.
158:57–62. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Diala ES and Hoffman RM: Hypomethylation
of HeLa cell DNA and the absence of 5-methylcytosine in SV40 and
adenovirus (type 2) DNA: Analysis by HPLC. Biochem Biophys Res
Commun. 107:19–26. 1982. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Mudbhary R, Hoshida Y, Chernyavskaya Y,
Jacob V, Villanueva A, Fiel MI, Chen X, Kojima K, Thung S, Bronson
RT, et al: UHRF1 overexpression drives DNA hypomethylation and
hepatocellular carcinoma. Cancer Cell. 25:196–209. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Costello JF, Fruhwald MC, Smiraglia DJ,
Rush LJ, Robertson GP, Gao X, Wright FA, Feramisco JD, Peltomäki P,
Lang JC, et al: Aberrant CpG-island methylation has non-random and
tumour-type-specific patterns. Nat Genet. 24:132–138. 2000.
View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Hoffman RM: Altered methionine metabolism,
DNA methylation and oncogene expression in carcinogenesis. A review
and synthesis. Biochim Biophys Acta. 738:49–87. 1984.
|
|
38
|
Lao VV and Grady WM: Epigenetics and
colorectal cancer. Nat Rev Gastroenterol Hepatol. 8:686–700. 2011.
View Article : Google Scholar : PubMed/NCBI
|
