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Article

XBP1 promotes tumor invasion and is associated with poor prognosis in oral squamous cell carcinoma

  • Authors:
    • Yanan Sun
    • Fangyan Jiang
    • Yuemei Pan
    • Xinming Chen
    • Jirong Chen
    • Yu Wang
    • Xueqing Zheng
    • Jiali Zhang
  • View Affiliations / Copyright

    Affiliations: Key Lab for Oral Biomedical Engineering of Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, Hubei 430079, P.R. China, Department of Oral Histopathology, School and Hospital of Stomatology, Wuhan University, Wuhan, Hubei 430079, P.R. China
  • Pages: 988-998
    |
    Published online on: June 18, 2018
       https://doi.org/10.3892/or.2018.6498
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Abstract

X‑box‑binding protein 1 (XBP1) contributes to various types of cancer including breast, bladder cancer and esophageal squamous cell carcinoma. The aim of the study was to examine the metastatic role of XBP1 in oral squamous cell carcinoma (OSCC), and identify possible downstream molecules. Immunohistochemical staining was conducted on tissue microarrays comprising 96 OSCC cases to determine the expression level of XBP1 and analyze its association with metastasis, clinicopathological characteristics and survival prognosis. Compared with the adjacent normal tissues of OSCC, the expression of XBP1 was significantly increased in the tumor center and front area, and lymph nodes metastases (P<0.05). A relatively high XBP1 expression was associated with histological grades (P<0.05), advanced clinical stages (P<0.05), unfavorable 5‑year survival (P=0.027). Suppressed XBP1 expression caused a significant reduction of cell invasion capability (P<0.05). AXL and the downstream molecules, such as PI3K, MMP1, MMP3, and uPA were significantly suppressed when XBP1 expression was inhibited in OSCC cells. Once XBP1 was activated by Thapsigargin, AXL expression was restored. Moreover, aberrant AXL expression was associated with XBP1 overexpression in OSCC tissues (P<0.05). In conclusion, XBP1 is a potential target that is relevant to suppressing cell invasion and is associated with patient prognosis in OSCC.
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Copy and paste a formatted citation
Spandidos Publications style
Sun Y, Jiang F, Pan Y, Chen X, Chen J, Wang Y, Zheng X and Zhang J: XBP1 promotes tumor invasion and is associated with poor prognosis in oral squamous cell carcinoma. Oncol Rep 40: 988-998, 2018.
APA
Sun, Y., Jiang, F., Pan, Y., Chen, X., Chen, J., Wang, Y. ... Zhang, J. (2018). XBP1 promotes tumor invasion and is associated with poor prognosis in oral squamous cell carcinoma. Oncology Reports, 40, 988-998. https://doi.org/10.3892/or.2018.6498
MLA
Sun, Y., Jiang, F., Pan, Y., Chen, X., Chen, J., Wang, Y., Zheng, X., Zhang, J."XBP1 promotes tumor invasion and is associated with poor prognosis in oral squamous cell carcinoma". Oncology Reports 40.2 (2018): 988-998.
Chicago
Sun, Y., Jiang, F., Pan, Y., Chen, X., Chen, J., Wang, Y., Zheng, X., Zhang, J."XBP1 promotes tumor invasion and is associated with poor prognosis in oral squamous cell carcinoma". Oncology Reports 40, no. 2 (2018): 988-998. https://doi.org/10.3892/or.2018.6498
Copy and paste a formatted citation
x
Spandidos Publications style
Sun Y, Jiang F, Pan Y, Chen X, Chen J, Wang Y, Zheng X and Zhang J: XBP1 promotes tumor invasion and is associated with poor prognosis in oral squamous cell carcinoma. Oncol Rep 40: 988-998, 2018.
APA
Sun, Y., Jiang, F., Pan, Y., Chen, X., Chen, J., Wang, Y. ... Zhang, J. (2018). XBP1 promotes tumor invasion and is associated with poor prognosis in oral squamous cell carcinoma. Oncology Reports, 40, 988-998. https://doi.org/10.3892/or.2018.6498
MLA
Sun, Y., Jiang, F., Pan, Y., Chen, X., Chen, J., Wang, Y., Zheng, X., Zhang, J."XBP1 promotes tumor invasion and is associated with poor prognosis in oral squamous cell carcinoma". Oncology Reports 40.2 (2018): 988-998.
Chicago
Sun, Y., Jiang, F., Pan, Y., Chen, X., Chen, J., Wang, Y., Zheng, X., Zhang, J."XBP1 promotes tumor invasion and is associated with poor prognosis in oral squamous cell carcinoma". Oncology Reports 40, no. 2 (2018): 988-998. https://doi.org/10.3892/or.2018.6498
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