Open Access

SB225002 inhibits prostate cancer invasion and attenuates the expression of BSP, OPN and MMP‑2

  • Authors:
    • Meng Xu
    • Huamao Jiang
    • Haiguang Wang
    • Jiajie Liu
    • Baohao Liu
    • Zhongqiang Guo
  • View Affiliations

  • Published online on: June 18, 2018     https://doi.org/10.3892/or.2018.6504
  • Pages: 726-736
  • Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The mechanisms of malignant cell metastasis to secondary sites are complex and multifactorial. Studies have demonstrated that small integrin‑binding ligand N‑linked glycoproteins (SIBLINGs), particularly bone sialoprotein (BSP) and osteopontin (OPN), are involved in neoplastic growth and metastasis. SIBLINGs promote malignant cell invasion and metastasis by enhancing matrix metalloproteinase 2 (MMP‑2) and MMP‑9 expression. Moreover, BSP and OPN can combine with integrin, which is located on the tumor cell surface, to further promote the malignant behavior of tumor cells. In the present study, we investigated whether SB225002, a specific CXCR2 receptor antagonist, can inhibit prostate cancer cell expression of BSP and OPN and reduce cancer cell invasion ability. A series of experiments showed that after SB225002 treatment, the proliferation, invasion and migration of two androgen‑independent prostate cancer cell lines were inhibited, but this inhibitory effect was not observed on androgen‑dependent prostate cancer cells. Western blotting showed that the PI3K signaling pathway could regulate the expression of SIBLING and MMP family proteins, and SB22055 could reduce the expression of BSP, OPN and MMP‑2 in prostate cancer cells by inhibiting AKT/mTOR phosphorylation. Finally, in vivo experiments confirmed that SB225002 inhibited the proliferation of prostate cancer cells in vivo, and the expression levels of BSP, OPN and MMP‑2 were also inhibited.
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August-2018
Volume 40 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Xu M, Jiang H, Wang H, Liu J, Liu B and Guo Z: SB225002 inhibits prostate cancer invasion and attenuates the expression of BSP, OPN and MMP‑2. Oncol Rep 40: 726-736, 2018
APA
Xu, M., Jiang, H., Wang, H., Liu, J., Liu, B., & Guo, Z. (2018). SB225002 inhibits prostate cancer invasion and attenuates the expression of BSP, OPN and MMP‑2. Oncology Reports, 40, 726-736. https://doi.org/10.3892/or.2018.6504
MLA
Xu, M., Jiang, H., Wang, H., Liu, J., Liu, B., Guo, Z."SB225002 inhibits prostate cancer invasion and attenuates the expression of BSP, OPN and MMP‑2". Oncology Reports 40.2 (2018): 726-736.
Chicago
Xu, M., Jiang, H., Wang, H., Liu, J., Liu, B., Guo, Z."SB225002 inhibits prostate cancer invasion and attenuates the expression of BSP, OPN and MMP‑2". Oncology Reports 40, no. 2 (2018): 726-736. https://doi.org/10.3892/or.2018.6504