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Article

Comprehensive analysis of a novel lncRNA profile reveals potential prognostic biomarkers in clear cell renal cell carcinoma

  • Authors:
    • Tong Liu
    • Jing Sui
    • Yan Zhang
    • Xiao‑Mei Zhang
    • Wen‑Juan Wu
    • Sheng Yang
    • Si‑Yi Xu
    • Wei‑Wei Hong
    • Hui Peng
    • Li‑Hong Yin
    • Yue‑Pu Pu
    • Ge‑Yu Liang
  • View Affiliations / Copyright

    Affiliations: Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, Jiangsu 210009, P.R. China, Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, Jiangsu 210009, P.R. China, Department of Oncology, Jiangsu Cancer Hospital, Nanjing, Jiangsu 210009, P.R. China
  • Pages: 1503-1514
    |
    Published online on: July 2, 2018
       https://doi.org/10.3892/or.2018.6540
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Abstract

Clear cell renal cell carcinoma (ccRCC) is the main subtype of malignant kidney cancer. Long non‑coding RNA (lncRNA) serves a key role in predicting survival in patients with cancer. The present study aimed to develop an lncRNA‑related signature of prognostic values for patients with ccRCC. RNA sequencing data of 454 patients were analyzed from The Cancer Genome Atlas (TCGA). To identify the differentially expressed lncRNAs, the patients from four groups classified by tumor stages were compared. The association between survival outcome and lncRNA expression profile was assessed by the univariate and multivariate Cox proportional hazards model. Survival was analyzed using the log‑rank test, and functions of target lncRNAs were investigated through Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analysis. Finally, 19 lncRNAs were identified as significantly associated with overall survival (OS) time. These lncRNAs were gathered as a signal prognostic signature, which may be a potential biomarker for the prognosis of ccRCC. The risk score was built to evaluate the predictive value of the lncRNA signature. There was a significant positive correlation between ccRCC patients with the low‑risk score and OS time (P<0.001). Reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) was used to verify the result in 17 pairs of ccRCC and adjacent non‑tumor tissues. Functional enrichment analysis revealed that these lncRNAs were associated with several molecular pathways of the tumor. The RT‑qPCR validation was consistent with the TCGA bioinformatics results. In conclusion, a tumor‑specific lncRNA signature of 19 lncRNAs was identified and the joint prognostic power was evaluated in the present study, and this signature was determined to be a potential biomarker for the prognosis of ccRCC.
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1 

Capitanio U and Montorsi F: Renal cancer. Lancet. 387:894–906. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Ferlay J, Shin HR, Bray F, Forman D, Mathers C and Parkin DM: Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 127:2893–2917. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2015. CA Cancer J Clin. 65:5–29. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Baldewijns MM, van Vlodrop IJ, Schouten LJ, Soetekouw PM, de Bruïne AP and van Engeland M: Genetics and epigenetics of renal cell cancer. Biochim Biophys Acta. 1785:133–155. 2008.PubMed/NCBI

5 

Arsanious A, Bjarnason GA and Yousef GM: From bench to bedside: Current and future applications of molecular profiling in renal cell carcinoma. Mol cancer. 8:202009. View Article : Google Scholar : PubMed/NCBI

6 

Cohen HT and McGovern FJ: Renal-cell carcinoma. N Engl J Med. 353:2477–2490. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Lam JS, Shvarts O, Leppert JT, Pantuck AJ, Figlin RA and Belldegrun AS: Postoperative surveillance protocol for patients with localized and locally advanced renal cell carcinoma based on a validated prognostic nomogram and risk group stratification system. J Urol. 174:466–472; quiz 801. 2005. View Article : Google Scholar : PubMed/NCBI

8 

Tsui KH, Shvarts O, Smith RB, Figlin RA, deKernion JB and Belldegrun A: Prognostic indicators for renal cell carcinoma: A multivariate analysis of 643 patients using the revised 1997 TNM staging criteria. J Urol. 163:1090–1095; quiz 1295. 2000. View Article : Google Scholar : PubMed/NCBI

9 

Thompson RH, Gillett MD, Cheville JC, Lohse CM, Dong H, Webster WS, Krejci KG, Lobo JR, Sengupta S, Chen L, et al: Costimulatory B7-H1 in renal cell carcinoma patients: Indicator of tumor aggressiveness and potential therapeutic target. Proc Natl Acad Sci USA. 101:17174–17179. 2004. View Article : Google Scholar : PubMed/NCBI

10 

Harshman LC, Choueiri TK, Drake C and Stephen Hodi F Jr: Subverting the B7-H1/PD-1 pathway in advanced melanoma and kidney cancer. Cancer J. 20:272–280. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Thompson RH and Kwon ED: Significance of B7-H1 overexpression in kidney cancer. Clinical Genitourin Cancer. 5:206–211. 2006. View Article : Google Scholar

12 

Chandra Gupta S and Nandan Tripathi Y: Potential of long non-coding RNAs in cancer patients: From biomarkers to therapeutic targets. Int J Cancer. 140:1955–1967. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Wang L, Cai Y, Zhao X, Jia X, Zhang J, Liu J, Zhen H, Wang T, Tang X, Liu Y, et al: Down-regulated long non-coding RNA H19 inhibits carcinogenesis of renal cell carcinoma. Neoplasma. 62:412–418. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Hirata H, Hinoda Y, Shahryari V, Deng G, Nakajima K, Tabatabai ZL, Ishii N and Dahiya R: Long noncoding RNA MALAT1 promotes aggressive renal cell carcinoma through Ezh2 and interacts with miR-205. Cancer Res. 75:1322–1331. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Zhang HM, Yang FQ, Yan Y, Che JP and Zheng JH: High expression of long non-coding RNA SPRY4-IT1 predicts poor prognosis of clear cell renal cell carcinoma. Int J Clin Exp Pathol. 7:5801–5809. 2014.PubMed/NCBI

16 

Song S, Wu Z, Wang C, Liu B, Ye X, Chen J, Yang Q, Ye H, Xu B and Wang L: RCCRT1 is correlated with prognosis and promotes cell migration and invasion in renal cell carcinoma. Urology. 84:730.e1–e7. 2014. View Article : Google Scholar

17 

Li CY, Liang GY, Yao WZ, Sui J, Shen X, Zhang YQ, Peng H, Hong WW, Ye YC, Zhang ZY, et al: Identification and functional characterization of microRNAs reveal a potential role in gastric cancer progression. Clin Transl Oncol. 19:162–172. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Chan AC, Fan ST, Poon RT, Cheung TT, Chok KS, Chan SC and Lo CM: Evaluation of the seventh edition of the American Joint Committee on Cancer tumour-node-metastasis (TNM) staging system for patients undergoing curative resection of hepatocellular carcinoma: Implications for the development of a refined staging system. HPB. 15:439–448. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Sui J, Li YH, Zhang YQ, Li CY, Shen X, Yao WZ, Peng H, Hong WW, Yin LH, Pu YP, et al: Integrated analysis of long non-coding RNAassociated ceRNA network reveals potential lncRNA biomarkers in human lung adenocarcinoma. Int J Oncol. 49:2023–2036. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Miao Y, Sui J, Xu SY, Liang GY, Pu YP and Yin LH: Comprehensive analysis of a novel four-lncRNA signature as a prognostic biomarker for human gastric cancer. Oncotarget. 8:75007–75024. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Zeng JH, Liang L, He RQ, Tang RX, Cai XY, Chen JQ, Luo DZ and Chen G: Comprehensive investigation of a novel differentially expressed lncRNA expression profile signature to assess the survival of patients with colorectal adenocarcinoma. Oncotarget. 8:16811–16828. 2017.PubMed/NCBI

22 

Zhao Q and Sun J: Cox survival analysis of microarray gene expression data using correlation principal component regression. Stat Appl Genet Mol Biol. 6:Article 16. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Zhou X, Huang Z, Xu L, Zhu M, Zhang L, Zhang H, Wang X, Li H, Zhu W, Shu Y, et al: A panel of 13-miRNA signature as a potential biomarker for predicting survival in pancreatic cancer. Oncotarget. 7:69616–69624. 2016.PubMed/NCBI

24 

Heagerty PJ, Lumley T and Pepe MS: Time-dependent ROC curves for censored survival data and a diagnostic marker. Biometrics. 56:337–344. 2000. View Article : Google Scholar : PubMed/NCBI

25 

Liu Z, Shao W and Shen Y, Ji M, Chen W, Ye Y and Shen Y: Characterization of new microsatellite markers based on the transcriptome sequencing of Clematis finetiana. Hereditas. 155:232018. View Article : Google Scholar : PubMed/NCBI

26 

Sho S, Court CM, Winograd P, Russell MM and Tomlinson JS: A prognostic mutation panel for predicting cancer recurrence in stages II and III colorectal cancer. J Surg Oncol. 116:996–1004. 2017. View Article : Google Scholar : PubMed/NCBI

27 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2−ΔΔCT method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

28 

Krishnan B, Rose TL, Kardos J, Milowsky MI and Kim WY: Intrinsic genomic differences between African American and white patients with clear cell renal cell carcinoma. JAMA Oncol. Mar 24–2016.(Epub ahead of print). doi: 10.1001/jamaoncol.2016.0005. View Article : Google Scholar : PubMed/NCBI

29 

Eichelberg C, Junker K, Ljungberg B and Moch H: Diagnostic and prognostic molecular markers for renal cell carcinoma: A critical appraisal of the current state of research and clinical applicability. Eur Urol. 55:851–863. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Liu Y, Liu H, Liu W, Zhang W, An H and Xu J: β1,6-N-acetylglucosaminyltransferase V predicts recurrence and survival of patients with clear-cell renal cell carcinoma after surgical resection. World J Urol. 33:1791–1799. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Lin YL, Wang YL, Fu XL and Ma JG: Aberrant methylation of PCDH8 is a potential prognostic biomarker for patients with clear cell renal cell carcinoma. Med Sci Monit. 20:2380–2385. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Zhang Y, Wang DL, Yan HY, Liao JY, He JH, Hu KS, Deng WX, Wang YJ, Xing HT, Koeffler HP, et al: Genome-wide study of ER-regulated lncRNAs shows AP000439.3 may function as a key regulator of cell cycle in breast cancer. Oncol Rep. 38:3227–3237. 2017. View Article : Google Scholar : PubMed/NCBI

33 

Li CY, Liang GY, Yao WZ, Sui J, Shen X, Zhang YQ, Peng H, Hong WW, Ye YC, Zhang ZY, et al: Integrated analysis of long non-coding RNA competing interactions reveals the potential role in progression of human gastric cancer. Int J Oncol. 48:1965–1976. 2016. View Article : Google Scholar : PubMed/NCBI

34 

Zheng S, Zheng D, Dong C, Jiang J, Xie J, Sun Y and Chen H: Development of a novel prognostic signature of long non-coding RNAs in lung adenocarcinoma. J Cancer Res Clin Oncol. 143:1649–1657. 2017. View Article : Google Scholar : PubMed/NCBI

35 

Yao J, Chen Y, Wang Y, Liu S, Yuan X, Pan F and Geng P: Decreased expression of a novel lncRNA CADM1-AS1 is associated with poor prognosis in patients with clear cell renal cell carcinomas. Int J Clin Exp Pathol. 7:2758–2767. 2014.PubMed/NCBI

36 

Xue S, Li QW, Che JP, Guo Y, Yang FQ and Zheng JH: Decreased expression of long non-coding RNA NBAT-1 is associated with poor prognosis in patients with clear cell renal cell carcinoma. Int J Clin Exp Pathol. 8:3765–3774. 2015.PubMed/NCBI

37 

Flippot R, Mouawad R, Spano JP, Rouprêt M, Compérat E, Bitker MO, Parra J, Vaessen C, Allanic F, Manach Q, et al: : Expression of long non-coding RNA MFI2-AS1 is a strong predictor of recurrence in sporadic localized clear-cell renal cell carcinoma. Sci Rep. 7:85402017. View Article : Google Scholar : PubMed/NCBI

38 

Jin P, Wang J and Liu Y: Downregulation of a novel long non-coding RNA, LOC389332, is associated with poor prognosis and tumor progression in clear cell renal cell carcinoma. Exp Ther Med. 13:1137–1142. 2017. View Article : Google Scholar : PubMed/NCBI

39 

Shi D, Qu Q, Chang Q, Wang Y, Gui Y and Dong D: A five-long non-coding RNA signature to improve prognosis prediction of clear cell renal cell carcinoma. Oncotarget. 8:58699–58708. 2017.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Liu T, Sui J, Zhang Y, Zhang XM, Wu WJ, Yang S, Xu SY, Hong WW, Peng H, Yin LH, Yin LH, et al: Comprehensive analysis of a novel lncRNA profile reveals potential prognostic biomarkers in clear cell renal cell carcinoma. Oncol Rep 40: 1503-1514, 2018.
APA
Liu, T., Sui, J., Zhang, Y., Zhang, X., Wu, W., Yang, S. ... Liang, G. (2018). Comprehensive analysis of a novel lncRNA profile reveals potential prognostic biomarkers in clear cell renal cell carcinoma. Oncology Reports, 40, 1503-1514. https://doi.org/10.3892/or.2018.6540
MLA
Liu, T., Sui, J., Zhang, Y., Zhang, X., Wu, W., Yang, S., Xu, S., Hong, W., Peng, H., Yin, L., Pu, Y., Liang, G."Comprehensive analysis of a novel lncRNA profile reveals potential prognostic biomarkers in clear cell renal cell carcinoma". Oncology Reports 40.3 (2018): 1503-1514.
Chicago
Liu, T., Sui, J., Zhang, Y., Zhang, X., Wu, W., Yang, S., Xu, S., Hong, W., Peng, H., Yin, L., Pu, Y., Liang, G."Comprehensive analysis of a novel lncRNA profile reveals potential prognostic biomarkers in clear cell renal cell carcinoma". Oncology Reports 40, no. 3 (2018): 1503-1514. https://doi.org/10.3892/or.2018.6540
Copy and paste a formatted citation
x
Spandidos Publications style
Liu T, Sui J, Zhang Y, Zhang XM, Wu WJ, Yang S, Xu SY, Hong WW, Peng H, Yin LH, Yin LH, et al: Comprehensive analysis of a novel lncRNA profile reveals potential prognostic biomarkers in clear cell renal cell carcinoma. Oncol Rep 40: 1503-1514, 2018.
APA
Liu, T., Sui, J., Zhang, Y., Zhang, X., Wu, W., Yang, S. ... Liang, G. (2018). Comprehensive analysis of a novel lncRNA profile reveals potential prognostic biomarkers in clear cell renal cell carcinoma. Oncology Reports, 40, 1503-1514. https://doi.org/10.3892/or.2018.6540
MLA
Liu, T., Sui, J., Zhang, Y., Zhang, X., Wu, W., Yang, S., Xu, S., Hong, W., Peng, H., Yin, L., Pu, Y., Liang, G."Comprehensive analysis of a novel lncRNA profile reveals potential prognostic biomarkers in clear cell renal cell carcinoma". Oncology Reports 40.3 (2018): 1503-1514.
Chicago
Liu, T., Sui, J., Zhang, Y., Zhang, X., Wu, W., Yang, S., Xu, S., Hong, W., Peng, H., Yin, L., Pu, Y., Liang, G."Comprehensive analysis of a novel lncRNA profile reveals potential prognostic biomarkers in clear cell renal cell carcinoma". Oncology Reports 40, no. 3 (2018): 1503-1514. https://doi.org/10.3892/or.2018.6540
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