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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
September-2018 Volume 40 Issue 3

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Article Open Access

DUSP1 induces apatinib resistance by activating the MAPK pathway in gastric cancer

Fei Teng, Zhiyuan Xu, Jiahui Chen, Guowei Zheng, Guodian Zheng, Hang Lv, Yiping Wang, Lijing Wang, Xiangdong Cheng
Pages: 1203-1222
Published online on: 25 June 2018

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Article Open Access

miR‑495 enhances the efficacy of radiotherapy by targeting GRP78 to regulate EMT in nasopharyngeal carcinoma cells

Xueping Feng, Wuwu Lv, Shuanglian Wang, Qian He
Pages: 1223-1232
Published online on: 02 July 2018

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Article Open Access

Inhibition of RAD54B suppresses proliferation and promotes apoptosis in hepatoma cells

Rui Wang, Yawei Li, Yufo Chen, Lei Wang, Qiong Wu, Yuanyuan Guo, Yumei Li, Jing Liu, Liwei Wang
Pages: 1233-1242
Published online on: 25 June 2018

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Article

Upregulation of the Kank1 gene inhibits human lung cancer progression in vitro and in vivo

Yingchun Gu, Min Zhang
Pages: 1243-1250
Published online on: 26 June 2018

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Article Open Access

Downregulation of TRIM58 expression is associated with a poor patient outcome and enhances colorectal cancer cell invasion

Min Liu, Xiaowen Zhang, Jian Cai, Yichen Li, Qianxin Luo, Haiyong Wu, Zihuan Yang, Lei Wang, Daici Chen
Pages: 1251-1260
Published online on: 26 June 2018

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Article Open Access

Overexpression of HES6 has prognostic value and promotes metastasis via the Wnt/β-catenin signaling pathway in colorectal cancer Corrigendum in /10.3892/or.2022.8309

Yuandong Xu, Xuejuan Liu, Huizhong Zhang, Ziyuan Zhu, Xianqiu Wu, Xiaobing Wu, Shuling Li, Libing Song, Xuehu Xu
Pages: 1261-1274
Published online on: 02 July 2018

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Article Open Access

High expression of leucine‑rich repeat‑containing 8A is indicative of a worse outcome of colon cancer patients by enhancing cancer cell growth and metastasis

Haifeng Zhang, Zhiqin Deng, Dongxia Zhang, Huarong Li, Lei Zhang, Jin Niu, Wanhong Zuo, Rao Fu, Lihong Fan, Jiang‑Hong Ye, Junjun She
Pages: 1275-1286
Published online on: 10 July 2018

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Article Open Access

Caveolin‑1 enhances RANKL‑induced gastric cancer cell migration

Yan Wang, Yongxi Song, Xiaofang Che, Lingyun Zhang, Qian Wang, Xiaomeng Zhang, Jinglei Qu, Zhi Li, Ling Xu, Ye Zhang, Yibo Fan, Kezuo Hou, Yunpeng Liu, Xiujuan Qu
Pages: 1287-1296
Published online on: 05 July 2018

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Article Open Access

TMEM165, a Golgi transmembrane protein, is a novel marker for hepatocellular carcinoma and its depletion impairs invasion activity

Jee‑San Lee, Mi‑Yeun Kim, Eun‑Ran Park, Yan Nan Shen, Ju‑Yeon Jeon, Eung‑Ho Cho, Sun‑Hoo Park, Chul Ju Han, Dong Wook Choi, Ja June Jang, Kyung‑Suk Suh, Jungil Hong, Sang Bum Kim, Kee‑Ho Lee
Pages: 1297-1306
Published online on: 12 July 2018

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Article Open Access

TIPE2 inhibits GC via regulation of cell proliferation, apoptosis and inflammation

Zhenhe Lin, Wenming Liu, Chuanxing Xiao, Yanyun Fan, Guohong Zhuang, Zhongquan Qi
Pages: 1307-1316
Published online on: 13 July 2018

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Article Open Access

HOXA5 is a tumor suppressor gene that is decreased in gastric cancer

Xudong Peng, Lang Zha, Anqi Chen, Ziwei Wang
Pages: 1317-1329
Published online on: 02 July 2018

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Article Open Access

Adiponectin inhibits migration and invasion by reversing epithelial‑mesenchymal transition in non‑small cell lung carcinoma

Enhai Cui, Huihui Guo, Mo Shen, Huanming Yu, Donghua Gu, Wei Mao, Xiang Wang
Pages: 1330-1338
Published online on: 25 June 2018

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Article Open Access

Ophiopogonin B suppresses the metastasis and angiogenesis of A549 cells in vitro and in vivo by inhibiting the EphA2/Akt signaling pathway Corrigendum in /10.3892/or.2024.8774

Meijuan Chen, Cheng Hu, Yuanyuan Guo, Rilei Jiang, Huimin Jiang, Yu Zhou, Haian Fu, Mianhua Wu, Xu Zhang
Pages: 1339-1347
Published online on: 27 June 2018

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Article Open Access

Moxidectin inhibits glioma cell viability by inducing G0/G1 cell cycle arrest and apoptosis

Dandan Song, Hongsheng Liang, Bo Qu, Yijing Li, Jingjing Liu, Chen Chen, Daming Zhang, Xiangtong Zhang, Aili Gao
Pages: 1348-1358
Published online on: 12 July 2018

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Article Open Access

Impact of sex, body mass index and initial pathologic diagnosis age on the incidence and prognosis of different types of cancer

Xuan Huang, Chuanjun Shu, Li Chen, Bing Yao
Pages: 1359-1369
Published online on: 27 June 2018

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Article Open Access

miR‑195‑5p regulates multi‑drug resistance of gastric cancer cells via targeting ZNF139

Hongfeng Nie, Jixing Mu, Jinsheng Wang, Yong Li
Pages: 1370-1378
Published online on: 25 June 2018

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Article Open Access

miR‑448 targets Rab2B and is pivotal in the suppression of pancreatic cancer

Jing Jin, Yingsheng Wu, Dongkai Zhou, Qiang Sun, Weilin Wang
Pages: 1379-1389
Published online on: 12 July 2018

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Article Open Access

Synergistic effects of tetrandrine combined with ionizing radiation on a murine colorectal carcinoma‑bearing mouse model

Wei‑Chan Lin, Wei‑Hsun Wang, Yi‑Hsien Lin, Jyh‑Der Leu, Shan‑Yun Cheng, Yu‑Jen Chen, Jeng‑Jong Hwang
Pages: 1390-1400
Published online on: 12 July 2018

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Article

Casticin suppresses the carcinogenesis of small cell lung cancer H446 cells through activation of AMPK/FoxO3a signaling

Qian Gong, Xiaozheng Cao, Jianguo Cao, Xiaohong Yang, Wenbin Zeng
Pages: 1401-1410
Published online on: 05 July 2018

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Article

MET‑RON dual inhibitor, BMS‑777607, suppresses cholangiocarcinoma cell growth, and MET‑RON upregulation indicates worse prognosis for intra‑hepatic cholangiocarcinoma patients

Chi‑Tung Cheng, Yen‑Yang Chen, Ren‑Chin Wu, Chun‑Yi Tsai, Kun‑Chun Chiang, Ta‑Sen Yeh, Ming‑Huang Chen, Chun‑Nan Yeh
Pages: 1411-1421
Published online on: 04 July 2018

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Article

A novel three‑miRNA signature predicts survival in cholangiocarcinoma based on RNA‑Seq data

Junyu Cao, Liankang Sun, Jie Li, Cancan Zhou, Liang Cheng, Ke Chen, Bin Yan, Weikun Qian, Qingyong Ma, Wanxing Duan
Pages: 1422-1434
Published online on: 27 June 2018

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Article

Aryl hydrocarbon receptor, a tumor grade‑associated marker of oral cancer, is directly downregulated by polydatin: A pilot study

Manuela Martano, Paola Stiuso, Angelo Facchiano, Salvatore De Maria, Daniela Vanacore, Brunella Restucci, Corrado Rubini, Michele Caraglia, Giampietro Ravagnan, Lorenzo Lo Muzio
Pages: 1435-1442
Published online on: 10 July 2018

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Article

Thymoquinone inhibits metastatic phenotype and epithelial‑mesenchymal transition in renal cell carcinoma by regulating the LKB1/AMPK signaling pathway

Bo Kou, Qingshan Kou, Bo Ma, Jing Zhang, Borui Sun, Yang Yang, Jianpeng Li, Jinsong Zhou, Wei Liu
Pages: 1443-1450
Published online on: 25 June 2018

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Article

Analysis of the causes of the misdiagnosis of hereditary spherocytosis

Shiyue Ma, Xuelian Deng, Lin Liao, Zengfu Deng, Yuling Qiu, Hongying Wei, Faquan Lin
Pages: 1451-1458
Published online on: 13 July 2018

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Article

Let‑7i‑5p inhibits the proliferation and metastasis of colon cancer cells by targeting kallikrein‑related peptidase 6

Jingyi Song, Lijing Wang, Qingxia Ma, Yuecheng Yang, Zhengtao Yang, Bin Wang, Ningning He
Pages: 1459-1466
Published online on: 13 July 2018

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Article

Combined assessment of low PGRMC1/positive ATP1A1 levels has enhanced prognostic value for renal cell carcinoma

Yu He, Peng Zhang, Dan Zhang, Zijing Xia, Xixi Wang, Shi Deng, Haocheng Li, Hongxia Zhu, Ningzhi Xu, Shufang Liang
Pages: 1467-1476
Published online on: 02 July 2018

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Article

Altered susceptibility to apoptosis and N‑glycan profiles of hematopoietic KG1a cells following co‑culture with bone marrow‑derived stromal cells under hypoxic conditions

Xingchen Pang, Yi Wang, Sijie Zhang, Zengqi Tan, Jia Guo, Feng Guan, Xiang Li
Pages: 1477-1486
Published online on: 05 July 2018

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Article

Knockdown of NUPR1 inhibits the growth of U266 and RPMI8226 multiple myeloma cell lines via activating PTEN and caspase activation‑dependent apoptosis

Chensi Zeng, Xingxin Li, Anmao Li, Bei Yi, Xi Peng, Xi Huang, Jianbin Chen
Pages: 1487-1494
Published online on: 04 July 2018

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Article

Metformin suppresses the invasive ability of pancreatic cancer cells by blocking autocrine TGF‑β1 signaling

Wanxing Duan, Weikun Qian, Cancan Zhou, Junyu Cao, Tao Qin, Ying Xiao, Liang Cheng, Jie Li, Ke Chen, Xuqi Li, Jiguang Ma, Qingyong Ma
Pages: 1495-1502
Published online on: 22 June 2018

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Article

Comprehensive analysis of a novel lncRNA profile reveals potential prognostic biomarkers in clear cell renal cell carcinoma

Tong Liu, Jing Sui, Yan Zhang, Xiao‑Mei Zhang, Wen‑Juan Wu, Sheng Yang, Si‑Yi Xu, Wei‑Wei Hong, Hui Peng, Li‑Hong Yin, Yue‑Pu Pu, Ge‑Yu Liang
Pages: 1503-1514
Published online on: 02 July 2018

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Article

Combined antitumor effects of 1,25‑dihydroxy vitamin D3 and Notch inhibitor in liver cancer

Lijing Cai, Lifang Luo, Zhimou Tang, Xiaohui Meng
Pages: 1515-1524
Published online on: 05 July 2018

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Article

Berberine, a natural plant alkaloid, synergistically sensitizes human liver cancer cells to sorafenib

Yuezhao Huang, Kunyuan Wang, Chengxin Gu, Ganxiang Yu, Dan Zhao, Weijian Mai, Yun Zhong, Shiming Liu, Yuqiang Nie, Hui Yang
Pages: 1525-1532
Published online on: 10 July 2018

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Article

Pin2/TRF1‑binding protein X1 inhibits colorectal cancer cell migration and invasion in vitro and metastasis in vivo via the nuclear factor‑κB signaling pathway Retraction in /10.3892/or.2023.8477

Tao Jiang, Haiqing Li, Ranran Jiang, Hailong Li, Pingfu Hou, Yansu Chen, Jin Bai, Jun Song
Pages: 1533-1544
Published online on: 13 July 2018

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Article

Daily or weekly dosing with EGFR inhibitors, gefitinib and lapatinib, and AKt inhibitor MK2206 in mammary cancer models Corrigendum in /10.3892/or.2018.6802

Ronald A. Lubet, Vernon E. Steele, M. M. Juliana, Ann Bode, Fariba Moeinpour, Clinton J. Grubbs
Pages: 1545-1553
Published online on: 14 March 2018

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Article

Downregulation of long non‑coding RNA UCA1 enhances the radiosensitivity and inhibits migration via suppression of epithelial‑mesenchymal transition in colorectal cancer cells

Xiaodong Yang, Wei Liu, Xiaohui Xu, Junjia Zhu, Yong Wu, Kui Zhao, Songbin He, Ming Li, Yongyou Wu, Shuyu Zhang, Jianping Cao, Zhenyu Ye, Chungen Xing
Pages: 1554-1564
Published online on: 13 July 2018

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Article

NFIB promotes cell growth, aggressiveness, metastasis and EMT of gastric cancer through the Akt/Stat3 signaling pathway

Chuanqing Wu, Xiaojie Zhu, Weizhen Liu, Tuo Ruan, Wenze Wan, Kaixiong Tao
Pages: 1565-1573
Published online on: 13 July 2018

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Article

S100B promotes chemoresistance in ovarian cancer stem cells by regulating p53

Tao Yang, Jianan Cheng, Junhao You, Bing Yan, Hui Liu, Fang Li
Pages: 1574-1582
Published online on: 27 June 2018

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Article

Tumor‑penetrating peptide fused EGFR single‑domain antibody enhances radiation responses following EGFR inhibition in gastric cancer Corrigendum in /10.3892/or.2020.7834

Fuzhi Ji, Huizi Sha, Fanyan Meng, Anqing Zhu, Naiqing Ding, Hang Zhang, Hui Xu, Hanqing Qian, Lixia Yu, Qizhan Liu, Baorui Liu
Pages: 1583-1591
Published online on: 27 June 2018

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Article

Discovery of rafoxanide as a dual CDK4/6 inhibitor for the treatment of skin cancer

Xinan Shi, Hongjian Li, Anhua Shi, Hong Yao, Kunbin Ke, Chao Dong, Ying Zhu, Yi Qin, Ying Ding, Yan Hong He, Xu Liu, Ling Li, Ling Lei, Qingshan Hai, Wei Chen, Kwong‑Sak Leung, Man‑Hon Wong, Hsiang‑Fu Kung, Marie Chia‑Mi Lin
Pages: 1592-1600
Published online on: 27 June 2018

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Article

Genome‑wide profiling of lncRNA expression patterns in patients with acute promyelocytic leukemia with differentiation therapy

Jian Yu, Xiao‑Ling Guo, Yuan‑Yuan Bai, Jun‑Jun Yang, Xiao‑Qun Zheng, Ji‑Chen Ruan, Zhan‑Guo Chen
Pages: 1601-1613
Published online on: 25 June 2018

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Article

Apoptotic effect of pyrroloquinoline quinone on chondrosarcoma cells through activation of the mitochondrial caspase‑dependent and caspase‑independent pathways

Ronghuan Wu, Jun Pan, Miaoda Shen, Chunyang Xing
Pages: 1614-1620
Published online on: 12 July 2018

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Article

Overexpression of miR‑221 and miR‑222 in the cancer stroma is associated with malignant potential in colorectal cancer

Michihisa Iida, Shoichi Hazama, Ryouichi Tsunedomi, Hironori Tanaka, Hiroko Takenouchi, Shinsuke Kanekiyo, Yukio Tokumitsu, Shinobu Tomochika, Yoshihiro Tokuhisa, Kazuhiko Sakamoto, Nobuaki Suzuki, Shigeru Takeda, Tomio Ueno, Shigeru Yamamoto, Shigefumi Yoshino, Koji Fujita, Masahiko Kuroda, Hiroaki Nagano
Pages: 1621-1631
Published online on: 13 July 2018

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Article

DMBA promotes ErbB2‑mediated carcinogenesis via ErbB2 and estrogen receptor pathway activation and genomic instability

Zhikun Ma, Young Mi Kim, Erin W. Howard, Xiaoshan Feng, Stanley D. Kosanke, Shihe Yang, Yunbo Jiang, Amanda B. Parris, Xia Cao, Shibo Li, Xiaohe Yang
Pages: 1632-1640
Published online on: 04 July 2018

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Article

E‑cadherin is downregulated by microenvironmental changes in pancreatic cancer and induces EMT

Weibin Wang, Liangbo Dong, Bangbo Zhao, Jun Lu, Yupei Zhao
Pages: 1641-1649
Published online on: 27 June 2018

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Article

Structure activity relationships of chrysoeriol and analogs as dual c‑Met and VEGFR2 tyrosine kinase inhibitors

Shuang Lai, Jun‑Ning Chen, Han‑Wei Huang, Xiang‑Yu Zhang, Hai‑Lun Jiang, Wei Li, Peng‑Liang Wang, Jian Wang, Fu‑Nan Liu
Pages: 1650-1656
Published online on: 02 July 2018

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Article

Homeobox containing 1 inhibits liver cancer progression by promoting autophagy as well as inhibiting stemness and immune escape

Hengli Zhao, Huifeng Jia, Qiuju Han, Jian Zhang
Pages: 1657-1665
Published online on: 10 July 2018

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Article

Suppression of the SDF‑1/CXCR4/β‑catenin axis contributes to bladder cancer cell growth inhibition in vitro and in vivo

Tao Zhang, Fei Yang, Wenbiao Li, Bolong Liu, Wende Li, Zhiyi Chen, Can Wang
Pages: 1666-1674
Published online on: 04 July 2018

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Article

Downregulation of hypoxia‑inducible factor-1α inhibits growth, invasion, and angiogenesis of human salivary adenoid cystic carcinoma cells under hypoxia

Chu Xiao, Yi Pan, Xiaoping Zeng, Lingyun Wang, Ziyang Li, Songxin Yan, Hongmei Wang
Pages: 1675-1683
Published online on: 12 July 2018

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Article

MicroRNA‑449a is a potential predictor of colitis‑associated colorectal cancer progression

Yun Feng, Yu‑Wei Dong, Yun‑Na Song, Jun‑Hua Xiao, Xing‑Ya Guo, Wei‑Liang Jiang, Lun‑Gen Lu
Pages: 1684-1694
Published online on: 12 July 2018

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Article

Developing a radiosensitivity gene signature for Caucasian patients with breast cancer

Ye Ji, Qinghua Jiang, Guohao Jian, Haitong Sun, Yamin Wang, Hualong Qin, Shuyu Zhang, Jianping Cao, Zaixiang Tang
Pages: 1695-1705
Published online on: 12 July 2018

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Article

High expression of microRNA‑31 and its host gene LOC554202 predict favorable outcomes in patients with colorectal cancer treated with oxaliplatin

Yalun Li, Shijie Xin, Huizhe Wu, Chengzhong Xing, Liren Duan, Weifeng Sun, Xiaoyun Hu, Ruoran Lin, Fangxiao Zhang
Pages: 1706-1724
Published online on: 13 July 2018

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Article

LAMA4 expression is activated by zinc finger E‑box‑binding homeobox 1 and independently predicts poor overall survival in gastric cancer

Xiangjun Wang, Qinge Hou, Xinling Zhou
Pages: 1725-1733
Published online on: 12 July 2018

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Article

ESE‑1 suppresses the growth, invasion and migration of human NSCLC cells and tumor formation in vivo

Zhiyuan Lou, Bok‑Soon Lee, Taekyu Ha, Yanrui Xu, Haeng‑Jun Kim, Chul‑Ho Kim, Seong‑Ho Lee
Pages: 1734-1742
Published online on: 12 July 2018

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Article

BMP9 inhibits the growth of breast cancer cells by downregulation of the PI3K/Akt signaling pathway

Shu Li, Hongying Dai, Yong He, Shusheng Peng, Tianjin Zhu, Yang Wu, Chenwei Li, Ke Wang
Pages: 1743-1751
Published online on: 13 July 2018

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Article

Ursolic acid elicits intrinsic apoptotic machinery by downregulating the phosphorylation of AKT/BAD signaling in human cisplatin‑resistant oral cancer CAR cells

Chin‑Fu Chen, Jai‑Sing Yang, Wen‑Kang Chen, Chi‑Cheng Lu, Jo‑Hua Chiang, Hong‑Yi Chiu, Shih‑Chang Tsai, Yu‑Ning Juan, Hao‑Jen Huang, Tzong‑Der Way
Pages: 1752-1760
Published online on: 27 June 2018

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Article

Growth inhibition of KRAS‑ and EGFR‑mutant lung adenocarcinoma by cosuppression of STAT3 and the SRC/ARHGAP35 axis

Ken Onodera, Akira Sakurada, Hirotsugu Notsuda, Tatsuaki Watanabe, Yasushi Matsuda, Masafumi Noda, Chiaki Endo, Yoshinori Okada
Pages: 1761-1768
Published online on: 02 July 2018

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Suppression of Elk1 inhibits thyroid cancer progression by mediating PTEN expression

Yakun Kong, Junjie Yin, Yun Fu, Yufeng Chen, Yanhong Zhou, Xiuqin Geng
Pages: 1769-1776
Published online on: 10 July 2018

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MicroRNA‑758 inhibits malignant progression of retinoblastoma by directly targeting PAX6

Jun Li, Xinying You
Pages: 1777-1786
Published online on: 12 July 2018

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Hydrogen peroxide inhibits the growth of lung cancer cells via the induction of cell death and G1‑phase arrest

Woo Hyun Park
Pages: 1787-1794
Published online on: 28 June 2018

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Overexpression of IQGAP1 promotes the angiogenesis of esophageal squamous cell carcinoma through the AKT and ERK‑mediated VEGF‑VEGFR2 signaling pathway

Chao‑Hui Li, Xue‑Jiao Sun, Shi‑Shi Niu, Cheng‑Yuan Yang, Yue‑Peng Hao, Jun‑Ting Kou, Xiao‑Zhong Li, Xiao‑Xia Wang
Pages: 1795-1802
Published online on: 11 July 2018

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A novel regulatory circuit of miR‑152 and DNMT1 in human bladder cancer

Haiqing Zhang, Defeng Qi, Jinhui Li, Tao Peng, Linqing Yang, Jianhui Yuan, Yuying Zhang, Yuan Hu, Jialin Su, Biao Que, Mengxi Li, Guoren Zhou, Yuxin Chen, Wenjuan Zhang, Weidong Ji
Pages: 1803-1812
Published online on: 10 July 2018

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Associations of miR‑146aC>G, miR‑149C>T, miR‑196a2C>T and miR‑499A>G polymorphisms with brain tumors

Jaejoon Lim, Jung Oh Kim, Han Sung Park, In Bo Han, Kyubum Kwack, Nam Keun Kim, Kyunggi Cho
Pages: 1813-1823
Published online on: 11 July 2018

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Journal Cover
April-2026 Volume 55 Issue 4

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Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Article Open Access

KDM5D expression is lost in cisplatin‑resistant neuroblastoma cells

Natalia Podhorska, Jan Hrabeta, Marie Belhajova, Tomas Eckschlager
Article Number: 79
Published online on: 25 February 2026

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Role of iron and TfR1 in the application of high‑dose ascorbate against pancreatic cancer

Alban Piotrowsky, Christian Leischner, Hendrik Schmieder, Katja Detert, Kathrin Schneider, Johanna Schulte, Sabrina Hammerschmidt, Luigi Marongiu, Olga Renner, Markus Burkard, Sascha Venturelli
Article Number: 78
Published online on: 24 February 2026

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Advances in immunotherapy and targeted therapy for nasopharyngeal carcinoma: Current progress and combined approaches (Review)

Zhen Yang, Huajun Liu, Meilin Chen, Liming Zhang, Meiling Gong, Ruilian Yu
Article Number: 77
Published online on: 24 February 2026

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[Retracted] Overexpression of SHP2 tyrosine phosphatase promotes the tumorigenesis of breast carcinoma

Zhongqian Hu, Haoshu Fang, Xinyi Wang, Danlei Chen, Zhuo Chen, Siying Wang
Article Number: 76
Published online on: 24 February 2026

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NR4A1 mediates chemotherapy‑induced senescence via the PI3K/AKT pathway in gastric cancer cells

Tingyu Zhang, Yue Wang, Jiuna Zhang, Xueshuai Ye, Yanfeng Shen, Zhiwei Zhang
Article Number: 75
Published online on: 18 February 2026

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Hypoxia‑induced miR‑135b‑5p promotes neuroendocrine differentiation of prostate cancer cells through HIF1AN‑HIF1α axis

Pampana Sandhya Venkata Lakshmi, Jagrati Parashar, Biswajit Biswas, Ramesh Ummanni
Article Number: 74
Published online on: 16 February 2026

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Retraction Open Access

[Retracted] Knockdown of human antigen R reduces the growth and invasion of breast cancer cells in vitro and affects expression of cyclin D1 and MMP‑9

Zhu Yuan, Andrew J. Sanders, Lin Ye, Yu Wang, Wen G. Jiang
Article Number: 73
Published online on: 16 February 2026

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Liquid biopsy in malignant primary bone tumors: Clinical applications of circulating tumor DNA and circulating tumor cells for diagnosis, prognosis and treatment monitoring (Review)

Bin Tian, Xuesong Chen, Jiang Zheng, Xin Kang
Article Number: 72
Published online on: 12 February 2026

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Tumor visualization and evaluation of glioblastoma in mice using small animal 9.4T MRI and PET‑CT with high resolution

Shuangyi Li, Wenjiao Gu, Ying Jiang, Ting Liu, Limei Shuai, Yujie Wei, Youming Shi, Havyarimana Juvenal, Zhimin Wang, Yucai Wei, Bofan Wu, Xiaochun Zhou, Yumin Li, Futian Tang
Article Number: 71
Published online on: 12 February 2026

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Expression of Concern Open Access

[Expression of Concern] Interference of STAT 5b expression enhances the chemo‑sensitivity of gastric cancer cells to gefitinib by promoting mitochondrial pathway‑mediated cell apoptosis

Tao Sun, Yanfei Jia, Dongjie Xiao
Article Number: 70
Published online on: 11 February 2026

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Regorafenib and Nifuroxazide exert enhanced suppression of hepatocellular carcinoma by inhibiting STAT3 and immune remodeling

Kun Li, Jinwei Chen, Zhi Zheng, Yichun Gao, Jiayu Zhang, Wenya Ding, Tongguo Yang, Yuyang Gu, Xuhua Duan, Tiesuo Zhao, Huijie Jia, Pengfei Chen, Jianzhuang Ren
Article Number: 69
Published online on: 11 February 2026

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Suppressive role of SCN4B in the epithelial‑mesenchymal transition of lung adenocarcinoma

Mengnan Guo, He Li, Zhifang Zhao, Yuanyuan Wang, Jiaqi Tang, Binghan Zhong, Yunxia Zhao
Article Number: 68
Published online on: 10 February 2026

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[Retracted] miR‑218 suppresses cardiac myxoma proliferation by targeting myocyte enhancer factor 2D

Quanxing Cao, Pingshuan Dong, Yanyu Wang, Junwei Zhang, Xinge Shi, Yongsheng Wang
Article Number: 67
Published online on: 09 February 2026

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Impact of the intratumoral resident microbiome on the immune microenvironment of malignant tumors (Review)

Han Na Oh, Hoon Hur
Article Number: 66
Published online on: 06 February 2026

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[Corrigendum] Hypoxia and macrophages promote glioblastoma invasion by the CCL4‑CCR5 axis

Ying Wang, Tao Liu, Ning Yang, Shuo Xu, Xingang Li, Donghai Wang
Article Number: 65
Published online on: 04 February 2026

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Origin dictates function: The dual roles of exosomes derived from diverse origins in the onset and progression of colorectal cancer (Review)

Zhao Guo, Haoyan Zhuang, Qingfeng Liu
Article Number: 64
Published online on: 03 February 2026

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Quercetin reduces expression of ATP‑binding cassette transporters by regulating the PTEN/PI3K/AKT signaling pathway in breast cancer cells

Wentao Fu, Leying Lin, Jie Li, Fei Qin, Chuan Chen, Yinglian Cai, Yilun Cai, Yiling Huang, Wang Yang, Shanshan Zhu
Article Number: 63
Published online on: 02 February 2026

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POSTN+ fibroblast‑secreted small extracellular vesicles drive macrophage M2 polarization through BMP4/BMPR2/Smad signaling

Chenyang Zhang, Si Chen, Chenghui Qian, Wanqi Lv, Qian Zhang, Yanjin Wang, Yuqiong Wu, Xue Liu
Article Number: 62
Published online on: 02 February 2026

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Retraction Open Access

[Retracted] EGFR/HER2 inhibitors effectively reduce the malignant potential of MDR breast cancer evoked by P‑gp substrates in vitro and in vivo

Yiting Jin, Wei Zhang, Hongying Wang, Zijing Zhang, Chengyu Chu, Xiuping Liu, Qiang Zou
Article Number: 61
Published online on: 02 February 2026

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Article

Tumor‑associated glucocorticoid inhibition by mifepristone reduces polymorphonuclear myeloid‑derived suppressor cells and promotes antitumor immunity in triple‑negative breast cancer‑bearing mice

Masato Kobayashi, Chisana Konno, Ayato Shimizu, Masanori Kobayashi, Tatsuya Hori
Article Number: 60
Published online on: 30 January 2026

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Mitochondria in T‑cell tumor immunity and tumor therapies targeting mitochondria (Review)

Minjie Zhou, Yijie Xie, Zhipeng Liu, Yi He, Yibing Yin, Keyu Chen, Zhengyu Zhao, Chengshun Zhang, Dingjun Cai
Article Number: 59
Published online on: 29 January 2026

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TRIM46 deficiency‑induced DNA damage enhances the sensitivity of cisplatin in non‑small cell lung cancer by regulating the Akt signaling pathway

Song Jin, Dandan Zhang, Zhicheng Liao, Lingpei Yu, Yuanyuan Wang, Pengcheng Jia, Minmin Pan, Yifan Li, Jizhou Zhang
Article Number: 58
Published online on: 28 January 2026

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Advances in isolation and detection technologies and immunotherapy applications of circulating tumor cells (Review)

Ping Zhou, Qin Ye, Yiyun Huang, Yumei Feng, Li Zhou, Ke Xie
Article Number: 57
Published online on: 28 January 2026

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Correction Open Access

[Corrigendum] 3‑Bromopyruvate sensitizes human breast cancer cells to TRAIL‑induced apoptosis via the phosphorylated AMPK‑mediated upregulation of DR5

Yuzhong Chen, Li Wei, Xiaojing Zhang, Xianfu Liu, Yansong Chen, Song Zhang, Lanzhu Zhou, Qixiang Li, Qiong Pan, Surong Zhao, Hao Liu
Article Number: 56
Published online on: 28 January 2026

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Article Open Access

High RMI1 expression is associated with cancer cell progression and poor prognosis in prostate cancer

Pengliang Shen, Xiaosong Wang, Xiaoting Yan, Hongyang Du, Bo Wu, Xiaoming Cao
Article Number: 55
Published online on: 27 January 2026

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Retraction Open Access

[Retracted] MicroRNA‑615‑5p targets insulin‑like growth factor 2 and exerts tumor‑suppressing functions in human esophageal squamous cell carcinoma

Bingyin Yang, Rui Xie, Shang-Nong Wu, Cheng-Cheng Gao, Xiao-Zhong Yang, Jing-Fang Zhou
Article Number: 54
Published online on: 26 January 2026

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Journal Cover
May-2026 Volume 55 Issue 5

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Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Article Open Access

ZBTB7A promotes malignant phenotypes in ovarian cancer through transcriptional activation of CRLF1

Xiaobai Hao, Yu Chen
Article Number: 102
Published online on: 24 March 2026

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MS4322 is a selective protein arginine methyltransferase 5 degrader with antitumor effects in cervical cancer cells

Rui Luo, Jingping Chen, Zhaojie Chen, Surong Wang, Tianfeng Liu, Yang Xu
Article Number: 101
Published online on: 24 March 2026

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[Retracted] Roles of the SNHG7/microRNA‑9‑5p/DPP4 ceRNA network in the growth and 131I resistance of thyroid carcinoma cells through PI3K/Akt activation

Wanzhi Chen, Jichun Yu, Rong Xie, Tao Zhou, Chengfeng Xiong, Shuyong Zhang, Meijun Zhong
Article Number: 100
Published online on: 23 March 2026

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Andrographis exerts antitumor effects and enhances 5‑FU efficacy via the alteration of ferroptosis‑related genes in esophageal squamous cell carcinoma

Kosuke Yoshimura, Tadanobu Shimura, Ruiya Ma, Yaxuan Huang, Takahito Kitajima, Shinji Yamashita, Yuki Sato, Koki Higashi, Mikio Kawamura, Hiromi Yasuda, Yuhki Koike, Yoshiki Okita, Shigeyuki Yoshiyama, Minako Kobayashi, Masaki Ohi, Hiroki Ohge, Shinya Takahashi, Ajay Goel, Yoshinaga Okugawa, Yuji Toiyama
Article Number: 99
Published online on: 20 March 2026

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Sphingosine‑1‑phosphate receptor 1 enhances olfactory receptor 51E1‑mediated inhibition of proliferation via Src/JNK signaling in prostate cancer cells

Kiheon Kim, Jinwoo Lee, Chulwon Choi, Jungnam Bae, Hee-Jung Choi, Won-Ki Huh
Article Number: 98
Published online on: 19 March 2026

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Mechanistic insights into the roles of astragalosides and Astragalus polysaccharides in gynecological and breast cancers (Review)

Ruixin Liu, Zhanyu Lin, Yuelin Li, Yuetong Ci, Zhengqi Guo, Zhenguo Xu
Article Number: 97
Published online on: 19 March 2026

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[Retracted] Inhibition of tankyrase 1 in human gastric cancer cells enhances telomere shortening by telomerase inhibitors 

Hao Zhang, Meng-Hua Yang, Jing-Jing Zhao, Ling Chen, Song-Tao Yu, Xu-Dong Tang, Dian-Chun Fang, Shi-Ming Yang
Article Number: 96
Published online on: 16 March 2026

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Silencing of SIVA‑1 promotes cisplatin resistance in gastric cancer via the Bcl‑2/BAX‑mediated mitochondria‑dependent apoptosis pathway

Zheng-Yi Shi, Zheng-Rong Ding, Yu-Liang Huang, Yuan-Rui Lei, Hai-Bin Huang, Yan Qing, Miao-Ren Deng, Xu-Man Lu, Xu-Dong Dong, Long-Jie Xia, Sheng Xu, Xiao-Gang Zhong, Lei Li, Fan-Biao Kong, Xiao-Tong Wang
Article Number: 95
Published online on: 13 March 2026

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Depleting HIF‑1α attenuates the progression of osteosarcoma, but tumorigenicity is sustained through HIF‑independent pathways

Ayaka Kunishima, Takatsune Shimizu, Tetsuya Takimoto, Atsunobu Sagara, Hiroyuki Nobusue, Hidetoshi Hasuwa, Shinya Hasegawa, Yuka Tamaoki, Hitomi Miyake, Yumi Fukuchi, Hideyuki Saya, Akihiro Muto
Article Number: 94
Published online on: 12 March 2026

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Unveiling the role of ANGPT2 in esophageal cancer: A prognostic factor and potential oncogene

Zhigang Zhai, Zhenyu Xue, Yuan Fang, Yixu Fan, Shijiao Li, Yunpeng Yu, Chuansheng Chen, Kaijun Zhang, Deyu Chen, Xiang Tang, Rui Ling
Article Number: 93
Published online on: 12 March 2026

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POLQ promotes tumor progression and immunosuppression via ATM‑P53 signaling in endometrial cancer

Ningning Zhu, Juanjuan Wang, Xiaoli Zhang, Kai Tang, Lei Gong, Yi Hu
Article Number: 92
Published online on: 11 March 2026

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Correction Open Access

[Corrigendum] 3‑Bromopyruvate and sodium citrate target glycolysis, suppress survivin, and induce mitochondrial‑mediated apoptosis in gastric cancer cells and inhibit gastric orthotopic transplantation tumor growth

Ting-An Wang, Xiao-Dong Zhang, Xing-Yu Guo, Shu-Lin Xian, Yun-Fei Lu
Article Number: 91
Published online on: 11 March 2026

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Review Open Access

Unveiling the molecular landscape: Long non-coding RNAs in neuroblastoma (Review)

Zidong Xia, Huishan Zhai, Lei Zheng, Cheng Wang
Article Number: 90
Published online on: 09 March 2026

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Retraction Open Access

[Retracted] Erastin sensitizes glioblastoma cells to temozolomide by restraining xCT and cystathionine‑γ‑lyase function

Liangyu Chen, Xinxing Li, Libo Liu, Bo Yu, Yixue Xue, Yunhui Liu
Article Number: 89
Published online on: 09 March 2026

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Review Open Access

Advances in the application of frailty scoring in the diagnosis and management of elderly patients with multiple myeloma (Review)

Junlun Liu, Danyu Li, Chao Li, Zhuoren Chen
Article Number: 88
Published online on: 06 March 2026

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Expression of Concern Open Access

[Expression of Concern] c‑Fos/ERK promotes the progression from pancreatic intraepithelial neoplasia to pancreatic ductal adenocarcinoma 

Lei You, Xiaoxia Ren, Yongxing Du, Wenjing Zhao, Ming Cui, Ge Chen, Yupei Zhao
Article Number: 87
Published online on: 05 March 2026

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Review Open Access

CXCL1 in triple‑negative breast cancer: Mechanisms, challenges, and therapeutic opportunities (Review)

Hiba Al Sayegh, Zahraa Assi, Amjad Kanaan, Mirvat El Sibai
Article Number: 86
Published online on: 03 March 2026

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Article Open Access

Cellular and inflammatory characteristics of patient‑derived glioblastoma organoids during in vitro cultivation

Jessica Nojszewski, Nils Oliver Schröder, Jacqueline Clüver, Jonna Holler, Hajrullah Ahmeti, Michael Synowitz, Janka Held-Feindt
Article Number: 85
Published online on: 02 March 2026

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Retraction Open Access

[Retracted] Growth and differentiation factor‑9 promotes adhesive and motile capacity of prostate cancer cells by up‑regulating FAK and Paxillin via Smad dependent pathway 

Sivan M. Bokobza, Lin Ye, Howard G. Kynaston, Wen G. Jiang
Article Number: 84
Published online on: 02 March 2026

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Platycodin D sensitizes head and neck squamous cell carcinoma to cisplatin by inducing autophagy arrest

Minji Bae, Min Kyeong Lee, Mi Gyeong Jeong, Yeonseo Lee, Harim Joo, Young Chan Lee, Jung Woo Lee, Su Il Kim, Seong-Gyu Ko, Young-Gyu Eun
Article Number: 83
Published online on: 27 February 2026

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ACSBG1‑driven lipid reprogramming unveiled: A fatty acid metabolism‑associated prognostic model for lung adenocarcinoma

Panxin Hu, Anan Li
Article Number: 82
Published online on: 27 February 2026

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Article Open Access

Knockdown of CCT2 inhibits the malignant progression of hepatocellular carcinoma cells by impairing STAT3 activation

Chao Li, Lei Yang, Yudong Zhang, Baocheng Zhao, Hao Qu
Article Number: 81
Published online on: 25 February 2026

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Retraction Open Access

[Retracted] Songorine suppresses cell growth and metastasis in epithelial ovarian cancer via the Bcl‑2/Bax and GSK3β/β‑catenin signaling pathways

Hongxia Zhang, Ruifeng Dong, Ping Zhang, Yankui Wang
Article Number: 80
Published online on: 25 February 2026

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