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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
September-2018 Volume 40 Issue 3

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Article Open Access

DUSP1 induces apatinib resistance by activating the MAPK pathway in gastric cancer

Fei Teng, Zhiyuan Xu, Jiahui Chen, Guowei Zheng, Guodian Zheng, Hang Lv, Yiping Wang, Lijing Wang, Xiangdong Cheng
Pages: 1203-1222
Published online on: 25 June 2018

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Article Open Access

miR‑495 enhances the efficacy of radiotherapy by targeting GRP78 to regulate EMT in nasopharyngeal carcinoma cells

Xueping Feng, Wuwu Lv, Shuanglian Wang, Qian He
Pages: 1223-1232
Published online on: 02 July 2018

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Article Open Access

Inhibition of RAD54B suppresses proliferation and promotes apoptosis in hepatoma cells

Rui Wang, Yawei Li, Yufo Chen, Lei Wang, Qiong Wu, Yuanyuan Guo, Yumei Li, Jing Liu, Liwei Wang
Pages: 1233-1242
Published online on: 25 June 2018

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Article

Upregulation of the Kank1 gene inhibits human lung cancer progression in vitro and in vivo

Yingchun Gu, Min Zhang
Pages: 1243-1250
Published online on: 26 June 2018

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Article Open Access

Downregulation of TRIM58 expression is associated with a poor patient outcome and enhances colorectal cancer cell invasion

Min Liu, Xiaowen Zhang, Jian Cai, Yichen Li, Qianxin Luo, Haiyong Wu, Zihuan Yang, Lei Wang, Daici Chen
Pages: 1251-1260
Published online on: 26 June 2018

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Article Open Access

Overexpression of HES6 has prognostic value and promotes metastasis via the Wnt/β-catenin signaling pathway in colorectal cancer Corrigendum in /10.3892/or.2022.8309

Yuandong Xu, Xuejuan Liu, Huizhong Zhang, Ziyuan Zhu, Xianqiu Wu, Xiaobing Wu, Shuling Li, Libing Song, Xuehu Xu
Pages: 1261-1274
Published online on: 02 July 2018

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Article Open Access

High expression of leucine‑rich repeat‑containing 8A is indicative of a worse outcome of colon cancer patients by enhancing cancer cell growth and metastasis

Haifeng Zhang, Zhiqin Deng, Dongxia Zhang, Huarong Li, Lei Zhang, Jin Niu, Wanhong Zuo, Rao Fu, Lihong Fan, Jiang‑Hong Ye, Junjun She
Pages: 1275-1286
Published online on: 10 July 2018

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Article Open Access

Caveolin‑1 enhances RANKL‑induced gastric cancer cell migration

Yan Wang, Yongxi Song, Xiaofang Che, Lingyun Zhang, Qian Wang, Xiaomeng Zhang, Jinglei Qu, Zhi Li, Ling Xu, Ye Zhang, Yibo Fan, Kezuo Hou, Yunpeng Liu, Xiujuan Qu
Pages: 1287-1296
Published online on: 05 July 2018

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Article Open Access

TMEM165, a Golgi transmembrane protein, is a novel marker for hepatocellular carcinoma and its depletion impairs invasion activity

Jee‑San Lee, Mi‑Yeun Kim, Eun‑Ran Park, Yan Nan Shen, Ju‑Yeon Jeon, Eung‑Ho Cho, Sun‑Hoo Park, Chul Ju Han, Dong Wook Choi, Ja June Jang, Kyung‑Suk Suh, Jungil Hong, Sang Bum Kim, Kee‑Ho Lee
Pages: 1297-1306
Published online on: 12 July 2018

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Article Open Access

TIPE2 inhibits GC via regulation of cell proliferation, apoptosis and inflammation

Zhenhe Lin, Wenming Liu, Chuanxing Xiao, Yanyun Fan, Guohong Zhuang, Zhongquan Qi
Pages: 1307-1316
Published online on: 13 July 2018

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Article Open Access

HOXA5 is a tumor suppressor gene that is decreased in gastric cancer

Xudong Peng, Lang Zha, Anqi Chen, Ziwei Wang
Pages: 1317-1329
Published online on: 02 July 2018

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Article Open Access

Adiponectin inhibits migration and invasion by reversing epithelial‑mesenchymal transition in non‑small cell lung carcinoma

Enhai Cui, Huihui Guo, Mo Shen, Huanming Yu, Donghua Gu, Wei Mao, Xiang Wang
Pages: 1330-1338
Published online on: 25 June 2018

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Article Open Access

Ophiopogonin B suppresses the metastasis and angiogenesis of A549 cells in vitro and in vivo by inhibiting the EphA2/Akt signaling pathway Corrigendum in /10.3892/or.2024.8774

Meijuan Chen, Cheng Hu, Yuanyuan Guo, Rilei Jiang, Huimin Jiang, Yu Zhou, Haian Fu, Mianhua Wu, Xu Zhang
Pages: 1339-1347
Published online on: 27 June 2018

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Article Open Access

Moxidectin inhibits glioma cell viability by inducing G0/G1 cell cycle arrest and apoptosis

Dandan Song, Hongsheng Liang, Bo Qu, Yijing Li, Jingjing Liu, Chen Chen, Daming Zhang, Xiangtong Zhang, Aili Gao
Pages: 1348-1358
Published online on: 12 July 2018

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Article Open Access

Impact of sex, body mass index and initial pathologic diagnosis age on the incidence and prognosis of different types of cancer

Xuan Huang, Chuanjun Shu, Li Chen, Bing Yao
Pages: 1359-1369
Published online on: 27 June 2018

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Article Open Access

miR‑195‑5p regulates multi‑drug resistance of gastric cancer cells via targeting ZNF139

Hongfeng Nie, Jixing Mu, Jinsheng Wang, Yong Li
Pages: 1370-1378
Published online on: 25 June 2018

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Article Open Access

miR‑448 targets Rab2B and is pivotal in the suppression of pancreatic cancer

Jing Jin, Yingsheng Wu, Dongkai Zhou, Qiang Sun, Weilin Wang
Pages: 1379-1389
Published online on: 12 July 2018

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Article Open Access

Synergistic effects of tetrandrine combined with ionizing radiation on a murine colorectal carcinoma‑bearing mouse model

Wei‑Chan Lin, Wei‑Hsun Wang, Yi‑Hsien Lin, Jyh‑Der Leu, Shan‑Yun Cheng, Yu‑Jen Chen, Jeng‑Jong Hwang
Pages: 1390-1400
Published online on: 12 July 2018

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Article

Casticin suppresses the carcinogenesis of small cell lung cancer H446 cells through activation of AMPK/FoxO3a signaling

Qian Gong, Xiaozheng Cao, Jianguo Cao, Xiaohong Yang, Wenbin Zeng
Pages: 1401-1410
Published online on: 05 July 2018

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Article

MET‑RON dual inhibitor, BMS‑777607, suppresses cholangiocarcinoma cell growth, and MET‑RON upregulation indicates worse prognosis for intra‑hepatic cholangiocarcinoma patients

Chi‑Tung Cheng, Yen‑Yang Chen, Ren‑Chin Wu, Chun‑Yi Tsai, Kun‑Chun Chiang, Ta‑Sen Yeh, Ming‑Huang Chen, Chun‑Nan Yeh
Pages: 1411-1421
Published online on: 04 July 2018

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Article

A novel three‑miRNA signature predicts survival in cholangiocarcinoma based on RNA‑Seq data

Junyu Cao, Liankang Sun, Jie Li, Cancan Zhou, Liang Cheng, Ke Chen, Bin Yan, Weikun Qian, Qingyong Ma, Wanxing Duan
Pages: 1422-1434
Published online on: 27 June 2018

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Article

Aryl hydrocarbon receptor, a tumor grade‑associated marker of oral cancer, is directly downregulated by polydatin: A pilot study

Manuela Martano, Paola Stiuso, Angelo Facchiano, Salvatore De Maria, Daniela Vanacore, Brunella Restucci, Corrado Rubini, Michele Caraglia, Giampietro Ravagnan, Lorenzo Lo Muzio
Pages: 1435-1442
Published online on: 10 July 2018

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Article

Thymoquinone inhibits metastatic phenotype and epithelial‑mesenchymal transition in renal cell carcinoma by regulating the LKB1/AMPK signaling pathway

Bo Kou, Qingshan Kou, Bo Ma, Jing Zhang, Borui Sun, Yang Yang, Jianpeng Li, Jinsong Zhou, Wei Liu
Pages: 1443-1450
Published online on: 25 June 2018

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Article

Analysis of the causes of the misdiagnosis of hereditary spherocytosis

Shiyue Ma, Xuelian Deng, Lin Liao, Zengfu Deng, Yuling Qiu, Hongying Wei, Faquan Lin
Pages: 1451-1458
Published online on: 13 July 2018

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Article

Let‑7i‑5p inhibits the proliferation and metastasis of colon cancer cells by targeting kallikrein‑related peptidase 6

Jingyi Song, Lijing Wang, Qingxia Ma, Yuecheng Yang, Zhengtao Yang, Bin Wang, Ningning He
Pages: 1459-1466
Published online on: 13 July 2018

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Article

Combined assessment of low PGRMC1/positive ATP1A1 levels has enhanced prognostic value for renal cell carcinoma

Yu He, Peng Zhang, Dan Zhang, Zijing Xia, Xixi Wang, Shi Deng, Haocheng Li, Hongxia Zhu, Ningzhi Xu, Shufang Liang
Pages: 1467-1476
Published online on: 02 July 2018

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Article

Altered susceptibility to apoptosis and N‑glycan profiles of hematopoietic KG1a cells following co‑culture with bone marrow‑derived stromal cells under hypoxic conditions

Xingchen Pang, Yi Wang, Sijie Zhang, Zengqi Tan, Jia Guo, Feng Guan, Xiang Li
Pages: 1477-1486
Published online on: 05 July 2018

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Article

Knockdown of NUPR1 inhibits the growth of U266 and RPMI8226 multiple myeloma cell lines via activating PTEN and caspase activation‑dependent apoptosis

Chensi Zeng, Xingxin Li, Anmao Li, Bei Yi, Xi Peng, Xi Huang, Jianbin Chen
Pages: 1487-1494
Published online on: 04 July 2018

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Article

Metformin suppresses the invasive ability of pancreatic cancer cells by blocking autocrine TGF‑β1 signaling

Wanxing Duan, Weikun Qian, Cancan Zhou, Junyu Cao, Tao Qin, Ying Xiao, Liang Cheng, Jie Li, Ke Chen, Xuqi Li, Jiguang Ma, Qingyong Ma
Pages: 1495-1502
Published online on: 22 June 2018

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Article

Comprehensive analysis of a novel lncRNA profile reveals potential prognostic biomarkers in clear cell renal cell carcinoma

Tong Liu, Jing Sui, Yan Zhang, Xiao‑Mei Zhang, Wen‑Juan Wu, Sheng Yang, Si‑Yi Xu, Wei‑Wei Hong, Hui Peng, Li‑Hong Yin, Yue‑Pu Pu, Ge‑Yu Liang
Pages: 1503-1514
Published online on: 02 July 2018

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Article

Combined antitumor effects of 1,25‑dihydroxy vitamin D3 and Notch inhibitor in liver cancer

Lijing Cai, Lifang Luo, Zhimou Tang, Xiaohui Meng
Pages: 1515-1524
Published online on: 05 July 2018

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Article

Berberine, a natural plant alkaloid, synergistically sensitizes human liver cancer cells to sorafenib

Yuezhao Huang, Kunyuan Wang, Chengxin Gu, Ganxiang Yu, Dan Zhao, Weijian Mai, Yun Zhong, Shiming Liu, Yuqiang Nie, Hui Yang
Pages: 1525-1532
Published online on: 10 July 2018

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Article

Pin2/TRF1‑binding protein X1 inhibits colorectal cancer cell migration and invasion in vitro and metastasis in vivo via the nuclear factor‑κB signaling pathway Retraction in /10.3892/or.2023.8477

Tao Jiang, Haiqing Li, Ranran Jiang, Hailong Li, Pingfu Hou, Yansu Chen, Jin Bai, Jun Song
Pages: 1533-1544
Published online on: 13 July 2018

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Article

Daily or weekly dosing with EGFR inhibitors, gefitinib and lapatinib, and AKt inhibitor MK2206 in mammary cancer models Corrigendum in /10.3892/or.2018.6802

Ronald A. Lubet, Vernon E. Steele, M. M. Juliana, Ann Bode, Fariba Moeinpour, Clinton J. Grubbs
Pages: 1545-1553
Published online on: 14 March 2018

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Article

Downregulation of long non‑coding RNA UCA1 enhances the radiosensitivity and inhibits migration via suppression of epithelial‑mesenchymal transition in colorectal cancer cells

Xiaodong Yang, Wei Liu, Xiaohui Xu, Junjia Zhu, Yong Wu, Kui Zhao, Songbin He, Ming Li, Yongyou Wu, Shuyu Zhang, Jianping Cao, Zhenyu Ye, Chungen Xing
Pages: 1554-1564
Published online on: 13 July 2018

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Article

NFIB promotes cell growth, aggressiveness, metastasis and EMT of gastric cancer through the Akt/Stat3 signaling pathway

Chuanqing Wu, Xiaojie Zhu, Weizhen Liu, Tuo Ruan, Wenze Wan, Kaixiong Tao
Pages: 1565-1573
Published online on: 13 July 2018

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Article

S100B promotes chemoresistance in ovarian cancer stem cells by regulating p53

Tao Yang, Jianan Cheng, Junhao You, Bing Yan, Hui Liu, Fang Li
Pages: 1574-1582
Published online on: 27 June 2018

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Article

Tumor‑penetrating peptide fused EGFR single‑domain antibody enhances radiation responses following EGFR inhibition in gastric cancer Corrigendum in /10.3892/or.2020.7834

Fuzhi Ji, Huizi Sha, Fanyan Meng, Anqing Zhu, Naiqing Ding, Hang Zhang, Hui Xu, Hanqing Qian, Lixia Yu, Qizhan Liu, Baorui Liu
Pages: 1583-1591
Published online on: 27 June 2018

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Article

Discovery of rafoxanide as a dual CDK4/6 inhibitor for the treatment of skin cancer

Xinan Shi, Hongjian Li, Anhua Shi, Hong Yao, Kunbin Ke, Chao Dong, Ying Zhu, Yi Qin, Ying Ding, Yan Hong He, Xu Liu, Ling Li, Ling Lei, Qingshan Hai, Wei Chen, Kwong‑Sak Leung, Man‑Hon Wong, Hsiang‑Fu Kung, Marie Chia‑Mi Lin
Pages: 1592-1600
Published online on: 27 June 2018

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Article

Genome‑wide profiling of lncRNA expression patterns in patients with acute promyelocytic leukemia with differentiation therapy

Jian Yu, Xiao‑Ling Guo, Yuan‑Yuan Bai, Jun‑Jun Yang, Xiao‑Qun Zheng, Ji‑Chen Ruan, Zhan‑Guo Chen
Pages: 1601-1613
Published online on: 25 June 2018

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Article

Apoptotic effect of pyrroloquinoline quinone on chondrosarcoma cells through activation of the mitochondrial caspase‑dependent and caspase‑independent pathways

Ronghuan Wu, Jun Pan, Miaoda Shen, Chunyang Xing
Pages: 1614-1620
Published online on: 12 July 2018

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Article

Overexpression of miR‑221 and miR‑222 in the cancer stroma is associated with malignant potential in colorectal cancer

Michihisa Iida, Shoichi Hazama, Ryouichi Tsunedomi, Hironori Tanaka, Hiroko Takenouchi, Shinsuke Kanekiyo, Yukio Tokumitsu, Shinobu Tomochika, Yoshihiro Tokuhisa, Kazuhiko Sakamoto, Nobuaki Suzuki, Shigeru Takeda, Tomio Ueno, Shigeru Yamamoto, Shigefumi Yoshino, Koji Fujita, Masahiko Kuroda, Hiroaki Nagano
Pages: 1621-1631
Published online on: 13 July 2018

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Article

DMBA promotes ErbB2‑mediated carcinogenesis via ErbB2 and estrogen receptor pathway activation and genomic instability

Zhikun Ma, Young Mi Kim, Erin W. Howard, Xiaoshan Feng, Stanley D. Kosanke, Shihe Yang, Yunbo Jiang, Amanda B. Parris, Xia Cao, Shibo Li, Xiaohe Yang
Pages: 1632-1640
Published online on: 04 July 2018

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Article

E‑cadherin is downregulated by microenvironmental changes in pancreatic cancer and induces EMT

Weibin Wang, Liangbo Dong, Bangbo Zhao, Jun Lu, Yupei Zhao
Pages: 1641-1649
Published online on: 27 June 2018

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Article

Structure activity relationships of chrysoeriol and analogs as dual c‑Met and VEGFR2 tyrosine kinase inhibitors

Shuang Lai, Jun‑Ning Chen, Han‑Wei Huang, Xiang‑Yu Zhang, Hai‑Lun Jiang, Wei Li, Peng‑Liang Wang, Jian Wang, Fu‑Nan Liu
Pages: 1650-1656
Published online on: 02 July 2018

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Article

Homeobox containing 1 inhibits liver cancer progression by promoting autophagy as well as inhibiting stemness and immune escape

Hengli Zhao, Huifeng Jia, Qiuju Han, Jian Zhang
Pages: 1657-1665
Published online on: 10 July 2018

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Article

Suppression of the SDF‑1/CXCR4/β‑catenin axis contributes to bladder cancer cell growth inhibition in vitro and in vivo

Tao Zhang, Fei Yang, Wenbiao Li, Bolong Liu, Wende Li, Zhiyi Chen, Can Wang
Pages: 1666-1674
Published online on: 04 July 2018

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Article

Downregulation of hypoxia‑inducible factor-1α inhibits growth, invasion, and angiogenesis of human salivary adenoid cystic carcinoma cells under hypoxia

Chu Xiao, Yi Pan, Xiaoping Zeng, Lingyun Wang, Ziyang Li, Songxin Yan, Hongmei Wang
Pages: 1675-1683
Published online on: 12 July 2018

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Article

MicroRNA‑449a is a potential predictor of colitis‑associated colorectal cancer progression

Yun Feng, Yu‑Wei Dong, Yun‑Na Song, Jun‑Hua Xiao, Xing‑Ya Guo, Wei‑Liang Jiang, Lun‑Gen Lu
Pages: 1684-1694
Published online on: 12 July 2018

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Article

Developing a radiosensitivity gene signature for Caucasian patients with breast cancer

Ye Ji, Qinghua Jiang, Guohao Jian, Haitong Sun, Yamin Wang, Hualong Qin, Shuyu Zhang, Jianping Cao, Zaixiang Tang
Pages: 1695-1705
Published online on: 12 July 2018

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Article

High expression of microRNA‑31 and its host gene LOC554202 predict favorable outcomes in patients with colorectal cancer treated with oxaliplatin

Yalun Li, Shijie Xin, Huizhe Wu, Chengzhong Xing, Liren Duan, Weifeng Sun, Xiaoyun Hu, Ruoran Lin, Fangxiao Zhang
Pages: 1706-1724
Published online on: 13 July 2018

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Article

LAMA4 expression is activated by zinc finger E‑box‑binding homeobox 1 and independently predicts poor overall survival in gastric cancer

Xiangjun Wang, Qinge Hou, Xinling Zhou
Pages: 1725-1733
Published online on: 12 July 2018

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Article

ESE‑1 suppresses the growth, invasion and migration of human NSCLC cells and tumor formation in vivo

Zhiyuan Lou, Bok‑Soon Lee, Taekyu Ha, Yanrui Xu, Haeng‑Jun Kim, Chul‑Ho Kim, Seong‑Ho Lee
Pages: 1734-1742
Published online on: 12 July 2018

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Article

BMP9 inhibits the growth of breast cancer cells by downregulation of the PI3K/Akt signaling pathway

Shu Li, Hongying Dai, Yong He, Shusheng Peng, Tianjin Zhu, Yang Wu, Chenwei Li, Ke Wang
Pages: 1743-1751
Published online on: 13 July 2018

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Article

Ursolic acid elicits intrinsic apoptotic machinery by downregulating the phosphorylation of AKT/BAD signaling in human cisplatin‑resistant oral cancer CAR cells

Chin‑Fu Chen, Jai‑Sing Yang, Wen‑Kang Chen, Chi‑Cheng Lu, Jo‑Hua Chiang, Hong‑Yi Chiu, Shih‑Chang Tsai, Yu‑Ning Juan, Hao‑Jen Huang, Tzong‑Der Way
Pages: 1752-1760
Published online on: 27 June 2018

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Article

Growth inhibition of KRAS‑ and EGFR‑mutant lung adenocarcinoma by cosuppression of STAT3 and the SRC/ARHGAP35 axis

Ken Onodera, Akira Sakurada, Hirotsugu Notsuda, Tatsuaki Watanabe, Yasushi Matsuda, Masafumi Noda, Chiaki Endo, Yoshinori Okada
Pages: 1761-1768
Published online on: 02 July 2018

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Suppression of Elk1 inhibits thyroid cancer progression by mediating PTEN expression

Yakun Kong, Junjie Yin, Yun Fu, Yufeng Chen, Yanhong Zhou, Xiuqin Geng
Pages: 1769-1776
Published online on: 10 July 2018

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MicroRNA‑758 inhibits malignant progression of retinoblastoma by directly targeting PAX6

Jun Li, Xinying You
Pages: 1777-1786
Published online on: 12 July 2018

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Article

Hydrogen peroxide inhibits the growth of lung cancer cells via the induction of cell death and G1‑phase arrest

Woo Hyun Park
Pages: 1787-1794
Published online on: 28 June 2018

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Article

Overexpression of IQGAP1 promotes the angiogenesis of esophageal squamous cell carcinoma through the AKT and ERK‑mediated VEGF‑VEGFR2 signaling pathway

Chao‑Hui Li, Xue‑Jiao Sun, Shi‑Shi Niu, Cheng‑Yuan Yang, Yue‑Peng Hao, Jun‑Ting Kou, Xiao‑Zhong Li, Xiao‑Xia Wang
Pages: 1795-1802
Published online on: 11 July 2018

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Article

A novel regulatory circuit of miR‑152 and DNMT1 in human bladder cancer

Haiqing Zhang, Defeng Qi, Jinhui Li, Tao Peng, Linqing Yang, Jianhui Yuan, Yuying Zhang, Yuan Hu, Jialin Su, Biao Que, Mengxi Li, Guoren Zhou, Yuxin Chen, Wenjuan Zhang, Weidong Ji
Pages: 1803-1812
Published online on: 10 July 2018

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Article

Associations of miR‑146aC>G, miR‑149C>T, miR‑196a2C>T and miR‑499A>G polymorphisms with brain tumors

Jaejoon Lim, Jung Oh Kim, Han Sung Park, In Bo Han, Kyubum Kwack, Nam Keun Kim, Kyunggi Cho
Pages: 1813-1823
Published online on: 11 July 2018

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Journal Cover
January-2026 Volume 55 Issue 1

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review Open Access

Harnessing ferroptosis for cancer therapy: Mechanisms and therapeutic strategies (Review)

Nabil Mouawad, Nour El Jaafari, Mirvat El Sibai, Ralph J. Abi-Habib
Article Number: 24
Published online on: 24 November 2025

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Expression of Concern Open Access

[Expression of Concern] Promoter methylation of death‑associated protein kinase and its role in irradiation response in cervical cancer

Rebecca Ching-Yu Leung, Stephanie Si Liu, Kelvin Yuen-Kwong Chan, Kar-Fai Tam, Kar-Loen Chan, Ling-Chui Wong, Hextan Yuen-Sheung Ngan
Article Number: 23
Published online on: 24 November 2025

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Article Open Access

Oxaliplatin resistance in pancreatic ductal adenocarcinoma is non‑significantly mediated by diminished drug uptake but is highly linked to a poor apoptotic response to the cytotoxic threat

Hellen Röttgen, Lana Theurer, Teresa Peccerella, Ketaki Sandu, Johanna Weiss, Jürgen Burhenne, John P. Neoptolemos, Beate Köberle, Dirk Theile
Article Number: 22
Published online on: 19 November 2025

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Correction Open Access

[Corrigendum] Src homology phosphotyrosyl phosphatase 2 mediates cisplatin‑related drug resistance by inhibiting apoptosis and activating the Ras/PI3K/Akt1/survivin pathway in lung cancer cells

Chunlan Tang, Hu Luo, Dan Luo, Heping Yang, Xiangdong Zhou
Article Number: 21
Published online on: 19 November 2025

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S100B drives glioblastoma invasion and migration through TGF‑β2‑mediated epithelial‑mesenchymal transition

Xuemei Liao, Yuan Xu, Honghong Zhou, Qin Yi, Shifang Dong, Bin Tan
Article Number: 20
Published online on: 19 November 2025

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Review Open Access

Role of the SOX family in non‑small cell lung cancer: Molecular mechanisms and therapeutic implications (Review)

Kaiwei Wang, Yaoqi Li, Zhening Guo, Lin Song, Xiaoliang Ding, Linsheng Liu, Tao Hu, Yicong Bian, Chenrong Huang, Liyan Miao
Article Number: 19
Published online on: 18 November 2025

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Retraction Open Access

[Retracted] MicroRNA‑18a enhances the radiosensitivity of cervical cancer cells by promoting radiation‑induced apoptosis

Sha Liu, Xiaofen Pan, Qin Yang, Lu Wen, Yao Jiang, Yingchao Zhao, Guiling Li
Article Number: 18
Published online on: 17 November 2025

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Review Open Access

Role of histone deacetylases in blood cancer: Exploring peptide‑based inhibitors as therapeutic strategies for leukemia treatment (Review)

Yaneenart Suwanwong, Phornthip Ploensil
Article Number: 17
Published online on: 14 November 2025

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Review Open Access

The multidimensional regulatory network of the PD‑1/PD‑L1 axis in the esophageal squamous cell carcinoma microenvironment: Implications for novel combination therapies and precision immunotherapy (Review)

Haoyue Lai, Lu Qi, Zhixuan Lin, Zhongwen Li
Article Number: 16
Published online on: 13 November 2025

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Review Open Access

From modification to malignancy: Bridging acetylation mechanisms and therapeutic innovations in melanoma (Review)

Jingwen Wu, Xuxia Cai, Zimo Zhu, Xiahong Li, Kaoyuan Zhang, Chenchen Wu, Bo Yu, Cong Huang
Article Number: 15
Published online on: 12 November 2025

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Retraction Open Access

[Retracted] MicroRNA‑92b promotes tumor growth and activation of NF‑κB signaling via regulation of NLK in oral squamous cell carcinoma

Zhiming Liu, Cynthia Diep, Tiantian Mao, Li Huang, Robert Merrill, Zhouwen Zhang, Youjian Peng
Article Number: 14
Published online on: 11 November 2025

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Article Open Access

C‑terminal HSP90 inhibitor NCT‑58 impairs the cancer stem‑like phenotype and enhances chemotherapy efficacy in TNBC

Eunsun Jung, Yoon-Jae Kim, Kyoungmin Lee, Seojin Jang, Soeun Park, Eunhye Oh, Minsu Park, Seongjae Kim, Dongmi Ko, Yong Koo Kang, Kee Dal Nam, Lee Farrand, Cong-Truong Nguyen, Minh Thanh La, Jihyae Ann, Jeewoo Lee, Ji Young Kim, Jae Hong Seo
Article Number: 13
Published online on: 11 November 2025

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Correction Open Access

[Corrigendum] Compound 225# inhibits the proliferation of human colorectal cancer cells by promoting cell cycle arrest and apoptosis induction

Xiaoxue Zhang, Liujun He, Yong Li, Yifei Qiu, Wujing Hu, Wanying Lu, Huihui Du, Donglin Yang
Article Number: 12
Published online on: 06 November 2025

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Review Open Access

Immune system, inflammatory response, and regulated cell death in breast cancer research (Review)

Guangyao Li, Binghui Jin, Jialin Zhou, Shifeng Fang, Zhe Fan
Article Number: 11
Published online on: 05 November 2025

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Retraction Open Access

[Retracted] Uvangoletin induces mitochondria‑mediated apoptosis in HL‑60 cells in vitro and in vivo without adverse reactions of myelosuppression, leucopenia and gastrointestinal tract disturbances

Zhuanzhen Zheng, Zhenhua Qiao, Rong Gong, Yalin Wang, Yiqun Zhang, Yanping Ma, Li Zhang, Yujin Lu, Bo Jiang, Guoxia Li, Chunxia Dong, Wenliang Chen
Article Number: 10
Published online on: 03 November 2025

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Article Open Access

Characterization of the anticancer effect of mebendazole and its interaction with standard cytotoxic drugs in patient tumor cells ex vivo and in an in vivo mouse model

Sharmineh Mansoori, Kristin Blom, Claes Andersson, Mårten Fryknäs, Rolf Larsson, Peter Nygren
Article Number: 9
Published online on: 31 October 2025

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Correction Open Access

[Corrigendum] Gemcitabine combined with an engineered oncolytic vaccinia virus exhibits a synergistic suppressive effect on the tumor growth of pancreatic cancer

Wanyuan Chen, Weimin Fan, Guoqing Ru, Fang Huang, Xiaming Lu, Xin Zhang, Xiaozhou Mou, Shibing Wang
Article Number: 8
Published online on: 30 October 2025

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Article Open Access

CD44 knockdown and TGF‑β inhibition modulate cell proliferation and invasion in claudin‑low breast cancer cells

Ryoichi Matsunuma, Kazuo Kinoshita, Sae Imada, Shoko Sato, Ryosuke Hayami, Michiko Tsuneizumi
Article Number: 7
Published online on: 30 October 2025

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Retraction Open Access

[Retracted] MicroRNA‑302a targets GAB2 to suppress cell proliferation, migration and invasion of glioma

Jiuhong Ma, Jia Yu, Jingmei Liu, Xing Yang, Miao Lou, Jinghui Liu, Fuqiang Feng, Peigang Ji, Liang Wang
Article Number: 6
Published online on: 27 October 2025

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Article Open Access

LRRC59 inhibits perk pathway‑induced apoptosis and promotes cell proliferation, migration and invasion in colorectal cancer cells

Xingdong Hou, Yuting Wang, Yuzhuo Chen, Peiyan Zhong, Guangzhi Wang, Baicheng Li, Bowei Lu, Hanyu Jiang, Shili Ning
Article Number: 5
Published online on: 23 October 2025

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Article Open Access

Comparative analysis of the efficacy and safety of antibody‑drug conjugates, radionuclide‑drug conjugates and their combination targeting claudin 18.2 in gastric cancer treatment

Huan Du, Xiao-Fei Hao, Bin-Wei Lin, Yu Zhang, Luo Rui, Jing Wang, Ming-Ming Tang, De-Cai Wang, Yi-Han Zhu, Jie Li, Tang-Zhi Dai, Yuchuan Yang, Xia Yang, Xiaobo Du
Article Number: 4
Published online on: 22 October 2025

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Expression of Concern Open Access

[Expression of Concern] CDKN3 is an independent prognostic factor and promotes ovarian carcinoma cell proliferation in ovarian cancer

Tianren Li, Hui Xue, Yi Guo, Kejun Guo
Article Number: 3
Published online on: 16 October 2025

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Review Open Access

Platelet‑circulating tumor cell crosstalk: A pivotal target in cancer diagnosis and therapy (Review)

Lifang Zhang, Ye Yuan, Yan Deng, Lin Wang, Fenghua Chen
Article Number: 2
Published online on: 15 October 2025

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Expression of Concern Open Access

[Expression of Concern] Knockdown of Bmi1 inhibits the stemness properties and tumorigenicity of human bladder cancer stem cell‑like side population cells

Dingjun Zhu, Xuesi Wan, Hai Huang, Xu Chen, Wu Liang, Fengjin Zhao, Tianxin Lin, Jinli Han, Wenlian Xie
Article Number: 1
Published online on: 14 October 2025

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Journal Cover
February-2026 Volume 55 Issue 2

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review Open Access

Alternative splicing in cancer drug resistance: Mechanisms and therapeutic prospects (Review)

Wenpu Zhu, Zikun Wu, Chai Luv, Banghe Bao, Weijie Zhao, Guanglong Chen, Hang Yang, Huihan Ai, Faqiang Liu, Zhi Li
Article Number: 31
Published online on: 05 December 2025

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Inhibition of primary ciliogenesis enhances efficacy of EGFR‑TKIs against non‑small cell lung cancer cells

Liangliang Jin, Li Wei, Junrui Hua, Rong Zhang, Jiaxin Chen, Jinpeng He, Yanli Yang
Article Number: 30
Published online on: 04 December 2025

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Review

Beyond eradication: Therapeutic reprogramming strategies for cancer normalization (Review)

Aliasgar Shahiwala
Article Number: 29
Published online on: 04 December 2025

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Article Open Access

Saikosaponin D overcomes gemcitabine resistance in pancreatic cancer via AKT/mTOR pathway inhibition and synergistic induction of apoptosis and autophagy

Rui Zheng, Yusi Liu, Sen Zhou, Guimei Liu, Xiaobin Liu, Yiyuan Yang, Yufu Zhang
Article Number: 28
Published online on: 04 December 2025

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Retraction Open Access

[Retracted] Downregulation of Bmi‑1 is associated with suppressed tumorigenesis and induced apoptosis in CD44+ nasopharyngeal carcinoma cancer stem‑like cells

Xinhua Xu, Yang Liu, Jin Su, Daojun Li, Juan Hu, Qiao Huang, Mingqian Lu, Xiaoyan Liu, Jinghua Ren, Weihong Chen, Lidan Sun
Article Number: 27
Published online on: 04 December 2025

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Prognostic significance of fibroblast senescence and senescence-associated secretory phenotype factor expression in the tumor microenvironment of pancreatic ductal adenocarcinoma

Yuto Kitano, Tomoharu Miyashita, Takeo Shimasaki, Isamu Makino, Yoshio Endo, Yasuhiko Yamamoto, Noriyuki Inaki, Shintaro Yagi
Article Number: 26
Published online on: 03 December 2025

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Retraction Open Access

[Retracted] Sp1‑CD147 positive feedback loop promotes the invasion ability of ovarian cancer

Jing Zhao, Wei Ye, Juan Wu, Lijuan Liu, Lina Yang, Lu Gao, Biliang Chen, Fanglin Zhang, Hong Yang, Yu Li
Article Number: 25
Published online on: 25 November 2025

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