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Article

MET‑RON dual inhibitor, BMS‑777607, suppresses cholangiocarcinoma cell growth, and MET‑RON upregulation indicates worse prognosis for intra‑hepatic cholangiocarcinoma patients

  • Authors:
    • Chi‑Tung Cheng
    • Yen‑Yang Chen
    • Ren‑Chin Wu
    • Chun‑Yi Tsai
    • Kun‑Chun Chiang
    • Ta‑Sen Yeh
    • Ming‑Huang Chen
    • Chun‑Nan Yeh
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Liver Research Center, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan 333, Taiwan, R.O.C., Division of Hematology and Oncology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Chang Gung University, Taoyuan 833, Taiwan, R.O.C., Department of Pathology, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan 333, Taiwan, R.O.C., Department of Surgery, Chang Gung Memorial Hospital, Keelung, Chang Gung University, Taoyuan 204, Taiwan, R.O.C., Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei 112, Taiwan, R.O.C.
  • Pages: 1411-1421
    |
    Published online on: July 4, 2018
       https://doi.org/10.3892/or.2018.6543
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Abstract

Intra‑hepatic cholangiocarcinoma (CCA) is an aggressive cancer with few effective therapeutic options. MET and RON have been found to be increased in a variety of tumors and to be associated with tumor progression and acquired resistance to therapy. The present study evaluated the efficacy of a MET‑RON dual inhibitor (BMS‑777607) for treating CCA and analyzed the prognostic significance of MET‑RON upregulation. We treated CCA cell lines and rats with CCA with BMS‑777607 to determine its effects on tumor growth and measured the MET‑RON protein expression in samples obtained from 96 patients with CCA who previously underwent hepatectomies. A clonogenic assay revealed that BMS‑777607 inhibited the growth of HuCCT1 and KKU‑100 human CCA cells. It also decreased tumor growth in CCA rats. MET‑RON upregulation independently predicted poor survival for CCA patients who previously underwent hepatectomies. In conclusion, MET‑RON upregulation is a poor prognostic factor in CCA patients receiving hepatectomies and may be targeted using BMS‑77760.
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Copy and paste a formatted citation
Spandidos Publications style
Cheng CT, Chen YY, Wu RC, Tsai CY, Chiang KC, Yeh TS, Chen MH and Yeh CN: MET‑RON dual inhibitor, BMS‑777607, suppresses cholangiocarcinoma cell growth, and MET‑RON upregulation indicates worse prognosis for intra‑hepatic cholangiocarcinoma patients. Oncol Rep 40: 1411-1421, 2018.
APA
Cheng, C., Chen, Y., Wu, R., Tsai, C., Chiang, K., Yeh, T. ... Yeh, C. (2018). MET‑RON dual inhibitor, BMS‑777607, suppresses cholangiocarcinoma cell growth, and MET‑RON upregulation indicates worse prognosis for intra‑hepatic cholangiocarcinoma patients. Oncology Reports, 40, 1411-1421. https://doi.org/10.3892/or.2018.6543
MLA
Cheng, C., Chen, Y., Wu, R., Tsai, C., Chiang, K., Yeh, T., Chen, M., Yeh, C."MET‑RON dual inhibitor, BMS‑777607, suppresses cholangiocarcinoma cell growth, and MET‑RON upregulation indicates worse prognosis for intra‑hepatic cholangiocarcinoma patients". Oncology Reports 40.3 (2018): 1411-1421.
Chicago
Cheng, C., Chen, Y., Wu, R., Tsai, C., Chiang, K., Yeh, T., Chen, M., Yeh, C."MET‑RON dual inhibitor, BMS‑777607, suppresses cholangiocarcinoma cell growth, and MET‑RON upregulation indicates worse prognosis for intra‑hepatic cholangiocarcinoma patients". Oncology Reports 40, no. 3 (2018): 1411-1421. https://doi.org/10.3892/or.2018.6543
Copy and paste a formatted citation
x
Spandidos Publications style
Cheng CT, Chen YY, Wu RC, Tsai CY, Chiang KC, Yeh TS, Chen MH and Yeh CN: MET‑RON dual inhibitor, BMS‑777607, suppresses cholangiocarcinoma cell growth, and MET‑RON upregulation indicates worse prognosis for intra‑hepatic cholangiocarcinoma patients. Oncol Rep 40: 1411-1421, 2018.
APA
Cheng, C., Chen, Y., Wu, R., Tsai, C., Chiang, K., Yeh, T. ... Yeh, C. (2018). MET‑RON dual inhibitor, BMS‑777607, suppresses cholangiocarcinoma cell growth, and MET‑RON upregulation indicates worse prognosis for intra‑hepatic cholangiocarcinoma patients. Oncology Reports, 40, 1411-1421. https://doi.org/10.3892/or.2018.6543
MLA
Cheng, C., Chen, Y., Wu, R., Tsai, C., Chiang, K., Yeh, T., Chen, M., Yeh, C."MET‑RON dual inhibitor, BMS‑777607, suppresses cholangiocarcinoma cell growth, and MET‑RON upregulation indicates worse prognosis for intra‑hepatic cholangiocarcinoma patients". Oncology Reports 40.3 (2018): 1411-1421.
Chicago
Cheng, C., Chen, Y., Wu, R., Tsai, C., Chiang, K., Yeh, T., Chen, M., Yeh, C."MET‑RON dual inhibitor, BMS‑777607, suppresses cholangiocarcinoma cell growth, and MET‑RON upregulation indicates worse prognosis for intra‑hepatic cholangiocarcinoma patients". Oncology Reports 40, no. 3 (2018): 1411-1421. https://doi.org/10.3892/or.2018.6543
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