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Moxidectin inhibits glioma cell viability by inducing G0/G1 cell cycle arrest and apoptosis

  • Authors:
    • Dandan Song
    • Hongsheng Liang
    • Bo Qu
    • Yijing Li
    • Jingjing Liu
    • Chen Chen
    • Daming Zhang
    • Xiangtong Zhang
    • Aili Gao
  • View Affiliations / Copyright

    Affiliations: School of Life Science, Northeast Agricultural University, Harbin, Heilongjiang 150030, P.R. China, Key Laboratory of Neurosurgery, College of Heilongjiang Province; The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China, School of Life Science, Northeast Agricultural University, Harbin, Heilongjiang 150030, P.R. China, College of Veterinary Medicine, Northeast Agricultural University, Harbin, Heilongjiang 150030, P.R. China, Key Laboratory of Neurosurgery, College of Heilongjiang Province; The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China
    Copyright: © Song et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1348-1358
    |
    Published online on: July 12, 2018
       https://doi.org/10.3892/or.2018.6561
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Abstract

Moxidectin (MOX), a broad‑spectrum antiparasitic agent, belongs to the milbemycin family and is similar to avermectins in terms of its chemical structure. Previous research has revealed that milbemycins, including MOX, may potentially function as effective multidrug resistance agents. In the present study, the impact of MOX on the viability of glioma cells was examined by MTT and colony formation assay, and the molecular mechanisms underlying MOX‑mediated glioma cell apoptosis were explored by using flow cytometry and apoptosis rates. The results demonstrated that MOX exerts an inhibitory effect on glioma cell viability and colony formations in vitro and xenograft growth in vivo and is not active against normal cells. Additionally, as shown by western blot assay, it was demonstrated that MOX arrests the cell cycle at the G0/G1 phase by downregulating the expression levels of cyclin‑dependent kinase (CDK)2, CDK4, CDK6, cyclin D1 and cyclin E. Furthermore, it was revealed that MOX is able to induce cell apoptosis by increasing the Bcl‑2‑associated X protein/B‑cell lymphoma 2 ratio and activating the caspase‑3/‑9 cascade. In conclusion, these results suggest that MOX may inhibit the viability of glioma cells by inducing cell apoptosis and cell cycle arrest, and may be able to function as a potent and promising agent in the treatment of glioma.
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1 

Gao JH, Wang ZL, Liu HH, Wang LM and Huang GH: Liposome encapsulated of temozolomide for the treatment of glioma tumor: Preparation, characterization and evaluation. Drug Discov Ther. 9:205–212. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Furnari FB, Fenton T, Bachoo RM, Mukasa A, Stommel JM, Stegh A, Hahn WC, Liqon KL, Louis DN, Brennan C, et al: Malignant astrocytic glioma: Genetics, biology, and paths to treatment. Genes Dev. 21:2683–2710. 2007. View Article : Google Scholar : PubMed/NCBI

3 

Gilbert MR, Wang M, Aldape KD, Stupp R, Hegi ME, Jaeckle KA, Armstrong TS, Wefel JS, Won M, Blumenthal DT, et al: Dose-dense temozolomide for newly diagnosed glioblastoma: A randomized phase III clinical trial. J Clin. Oncol. 31:4085–4091. 2013.

4 

Lan YL, Wang X, Xing JS, Lou JC, Ma XC and Zhang B: The potential roles of dopamine in malignant glioma. Acta Neurol Belg. 117:613–621. 2017. View Article : Google Scholar : PubMed/NCBI

5 

McKellar QA and Benchaoui HA: Avermectins and milbemycins. J Vet Pharmacol Ther. 19:331–351. 1996. View Article : Google Scholar : PubMed/NCBI

6 

Cotreau MM, Warren S, Ryan JL, Fleckenstein L, Vanapalli SR, Brown KR, Rock D, Chen CY and Schwertschlag US: The antiparasitic moxidectin: Safety, tolerability, and pharmacokinetics in humans. J Clin Pharmacol. 43:1108–1115. 2003. View Article : Google Scholar : PubMed/NCBI

7 

Prichard R, Ménez C and Lespine A: Moxidectin and the avermectins: Consanguinity but not identity. Int J Parasitol Drugs and Drug Resist. 14:134–153. 2012. View Article : Google Scholar

8 

Perez M, Blazquez AG, Real R, Mendoza G, Prieto JG, Merino G and Alvarez AI: In vitro and in vivo interaction of moxidectin with BCRP/ABCG2. Chem Biol Interact. 180:106–112. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Zulalian J, Stout SJ, Cunha AR, Garces T and Miller P: Absorption, tissue distribution, metabolism, and excretion of moxidectin in cattle. J Agric Food Chem. 42:381–387. 1994. View Article : Google Scholar

10 

Afzal J, Stout SJ, da Cunha AR and Miller P: Moxidectin: Absorption, tissue distribution, excretion, and biotransformation of 14C-labeled moxidectin in sheep. J Agric Food Chem. 42:1767–1773. 1994. View Article : Google Scholar

11 

Afzal J, Burke AB, Batten PL, DeLay RL and Miller P: Moxidectin: Metabolic fate and blood pharmacokinetics of 14C-labeled moxidectin in horses. J Agric Food Chem. 45:3627–3633. 1997. View Article : Google Scholar

12 

Traversa D, Di Cesare A, Milillo P, Lohr B, Iorio R, Pampurini F, Schaper R, Paoletti B and Heine J: Efficacy and safety of imidacloprid 10%/moxidectin 1% spot-on formulation in the treatment of feline aelurostrongylosis. Parasitol Res. 105 Suppl 1:S55–S62. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Verma M, Pathak M, Shahab M, Singh K, Mitra K and Misra-Bhattacharya S: Moxidectin causes adult worm mortality of human lymphatic filarial parasite Brugia malayi in rodent models. Folia Parasitol. 61:561–570. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Gao A, Wang X, Xiang W, Liang H, Gao J and Yan Y: Reversal of P-glycoprotein-mediated multidrug resistance in vitro by doramectin and nemadectin. J Pharm Pharmacol. 62:393–399. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Korystov YN, Ermakova NV, Sterlina LN, Levitman MK, Shaposhnikova VV, Mosin VA, Drinyaev VA, Kruglyak EB, Novik TS and Sterlina TS: Avermectins inhibit multidrug resistance of tumor cells. Eur J Pharmacol. 493:57–64. 2004. View Article : Google Scholar : PubMed/NCBI

16 

Mani T, Bourguinat C, Keller K, Asraf S, Blagburn B and Prichard RK: Interaction of macrocyclic lactones with a Dirofilaria immitis P-glycoprotein. Int J Parasitol. 46:631–40. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Dou Q, Chen HN, Wang K, Yuan K, Lei Y, Li K, Lan J, Chen Y, Huang Z, Xie N, et al: Ivermectin induces cytostatic autophagy by blocking the PAK1/Akt axis in breast cancer. Cancer Res. 76:4457–4469. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Liu YY, Fang SS, Sun QS and Liu B: Anthelmintic drug ivermectin inhibits angiogenesis, growth and survival of glioblastoma through inducing mitochondrial dysfunction and oxidative stress. Biochem Biophys Res Commun. 480:415–421. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Farkas R, Hell E and Palfi T: The efficacy of four anthelmintics against small strongyles in a stud farm in Hungary. Magyar Allatorvosok Lapja. 128:291–297. 2006.

20 

Lespine A, Martin S, Dupuy J, Roulet A, Pineau T, Orlowski S and Alvinerie M: Interaction of macrocyclic lactones with P-glycoprotein: Structure-affinity relationship. Eur J Pharm Sci. 30:84–94. 2007. View Article : Google Scholar : PubMed/NCBI

21 

Mounsey KE, Bernigaud C, Chosidow O and McCarthy JS: Prospects for moxidectin as a new oral treatment for human scabies. PLos Negl Trop Dis. 10:e00043892016. View Article : Google Scholar : PubMed/NCBI

22 

Fazzio LE, Streitenberger N, Galvan WR, Sánchez RO, Gimeno EJ and Sanabria RE: Efficacy and productive performance of moxidectin in feedlot calves infected with nematodes resistant to ivermectin. Vet Parasitol. 223:26–29. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Lloberas M, Alvarez L, Entrocasso C, Virkel G, Ballent M, Mate L, Lanusse C and Lifschitz A: Comparative tissue pharmacokinetics and efficacy of moxidectin, abamectin and ivermectin in lambs infected with resistant nematodes: Impact of drug treatments on parasite P-glycoprotein expression. Int. J Parasitol Drugs Drug Resist. 3:20–27. 2013. View Article : Google Scholar

24 

Jiang Z, Chai J, Chuang HH, Li S, Wang T, Cheng Y, Chen W and Zhou D: Artesunate induces G0/G1 cell cycle arrest and iron-mediated mitochondrial apoptosis in A431 human epidermoid carcinoma cells. Anticancer Drugs. 23:606–613. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Wu X, Wu MY, Jiang M, Zhi QM, Bian J, Xu MD, Gong FR, Hou J, Tao M, Shou LM, et al: TNF-α sensitizes chemotherapy and radiotherapy against breast cancer cells. Cancer Cell Int. 17:132017. View Article : Google Scholar : PubMed/NCBI

26 

Guichet PO, Guelfi S, Ripoll C, Teigell M, Sabourin JC, Bauchet L, Rigau V, Rothhut B and Hugnot JP: Asymmetric distribution of GFAP in glioma multipotent Cells. PLos One. 11:e01512742016. View Article : Google Scholar : PubMed/NCBI

27 

Zhou XM, Sun R, Luo DH, Sun J, Zhang MY, Wang MH, Yang Y, Wang HY and Mai SJ: Upregulated TRIM29 promotes proliferation and metastasis of nasopharyngeal carcinoma via PTEN/AKT/mTOR signal pathway. Oncotarget. 7:13634–13650. 2016.PubMed/NCBI

28 

Janko C and Geyer J: Moxidectin has a lower neurotoxic potential but comparable brain penetration in P-glycoprotein-deficient CF-1 mice compared to ivermectin. J Vet Pharmacol Ther. 36:275–284. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Xiang WS, Gao AL, Liang HS, Li CY, Gao JG, Wang Q, Shuang B, Zhang J, Yan YJ and Wang XJ: Reversal of P-glycoprotein-mediated multidrug resistance in vitro by milbemycin compounds in adriamycin-resistant human breast carcinoma (MCF-7/adr) cells. Toxicol In Vitro. 24:1474–1481. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Mattern J and Volm M: Imbalance of cell proliferation and apoptosis during progression of lung carcinomas. Anticancer Res. 24:4243–4246. 2004.PubMed/NCBI

31 

Wong RS: Apoptosis in cancer: From pathogenesis to treatment. J Exp Clin Cancer Res. 30:872011. View Article : Google Scholar : PubMed/NCBI

32 

Danial NN: BCL-2 family proteins: Critical checkpoints of apoptotic cell death. Clin Cancer Res. 13:7254–7263. 2007. View Article : Google Scholar : PubMed/NCBI

33 

Xiong S, Mu T, Wang G and Jiang X: Mitochondria-mediated apoptosis in mammals. Protein Cell. 5:737–749. 2014. View Article : Google Scholar : PubMed/NCBI

34 

Ekert PG, Read SH, Silke J, Marsden VS, Kaufmann H, Hawkins H, Hawkins CJ, Gerl R, Kumar S and Vaux DL: Apaf-1 and caspase-9 accelerate apoptosis, but do not determine whether factor-deprived or drug-treated cells die. J Cell Biol. 165:835–842. 2004. View Article : Google Scholar : PubMed/NCBI

35 

Youle RJ and Strasser A: The BCL-2 protein family: Opposing activities that mediate cell death. Nat Rev Mol Cell Biol. 9:47–59. 2008. View Article : Google Scholar : PubMed/NCBI

36 

Kang MH and Reynolds CP: Bcl-2 inhibitors: Targeting mitochondrial apoptotic pathways in cancer therapy. Clin Cancer Res. 15:1126–1132. 2009. View Article : Google Scholar : PubMed/NCBI

37 

Liang BX, Liu ZY, Cao YN, Zhu C, Zuo Y, Huang L, Wen G, Shang N, Chen Y, Yue X, et al: MC37, a new mono-carbonyl curcumin analog, induces G2/M cell cycle arrest and mitochondria-mediated apoptosis in human colorectal cancer cells. Eur J Pharmacol. 796:139–148. 2017. View Article : Google Scholar : PubMed/NCBI

38 

Gogvadze V, Orrenius S and Zhivotovsky B: Multiple pathways of cytochrome c release from mitochondria in apoptosis. Biochim Biophys Acta. 1757:639–647. 2006. View Article : Google Scholar : PubMed/NCBI

39 

Singh PK and Kumar A: Mitochondria mediates caspase-dependent and independent retinal cell death in Staphylococcus aureus endophthalmitis. Cell Death Discov. 2:160342016. View Article : Google Scholar : PubMed/NCBI

40 

Lee JH, Jung JY, Jeong YJ, Park JH, Yang KH, Yang KH, Choi NK, Kim SH and Kim WJ: Involvement of both mitochondrial- and death receptor-dependent apoptotic pathways regulated by Bcl-2 family in sodium fluoride-induced apoptosis of the human gingival fibroblasts. Toxicology. 243:340–347. 2008. View Article : Google Scholar : PubMed/NCBI

41 

Wan D, Jiang C, Hua X, Wang T and Chai M: Cell cycle arrest and apoptosis induced by aspidin PB through the p53/p21 and mitochondria-dependent pathways in human osteosarcoma cells. Anticancer Drugs. 26:931–941. 2015. View Article : Google Scholar : PubMed/NCBI

42 

McGinnis GR and Young ME: Circadian regulation of metabolic homeostasis: Causes and consequences. Nat Sci Sleep. 8:163–180. 2016.PubMed/NCBI

43 

Lin CJ, Chang YA, Lin YL, Liu SH, Chang CK and Chen RM: Preclinical effects of honokiol on treating glioblastoma multiforme via G1 phase arrest and cell apoptosis. Phytomedicine. 23:517–527. 2016. View Article : Google Scholar : PubMed/NCBI

44 

Cocquyt CM, Van Amstel S, Cox S, Rohrbach B and Martín-Jiménez T: Pharmacokinetics of moxidectin in alpacas following administration of an oral or subcutaneous formulation. Res Vet Sci. 105:160–164. 2016. View Article : Google Scholar : PubMed/NCBI

45 

Lespine A, Chanoit G, Bousquet-Melou A, Lallemand E, Bassissi FM, Alvinerie M and Toutain PL: Contribution of lymphatic transport to the systemic exposure of orally administered moxidectin in conscious lymph duct-cannulated dogs. Eur J Pharm Sci. 27:37–43. 2006. View Article : Google Scholar : PubMed/NCBI

46 

Dupuy J, Larrieu G, Sutra JF, Eeckhoutte C and Alvinerie M: Influence of verapamil on the efflux and metabolism of 14C moxidectin in cultured rat hepatocytes. J Vet Pharmacol Ther. 24:171–177. 2001. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Song D, Liang H, Qu B, Li Y, Liu J, Chen C, Zhang D, Zhang X and Gao A: Moxidectin inhibits glioma cell viability by inducing G0/G1 cell cycle arrest and apoptosis. Oncol Rep 40: 1348-1358, 2018.
APA
Song, D., Liang, H., Qu, B., Li, Y., Liu, J., Chen, C. ... Gao, A. (2018). Moxidectin inhibits glioma cell viability by inducing G0/G1 cell cycle arrest and apoptosis. Oncology Reports, 40, 1348-1358. https://doi.org/10.3892/or.2018.6561
MLA
Song, D., Liang, H., Qu, B., Li, Y., Liu, J., Chen, C., Zhang, D., Zhang, X., Gao, A."Moxidectin inhibits glioma cell viability by inducing G0/G1 cell cycle arrest and apoptosis". Oncology Reports 40.3 (2018): 1348-1358.
Chicago
Song, D., Liang, H., Qu, B., Li, Y., Liu, J., Chen, C., Zhang, D., Zhang, X., Gao, A."Moxidectin inhibits glioma cell viability by inducing G0/G1 cell cycle arrest and apoptosis". Oncology Reports 40, no. 3 (2018): 1348-1358. https://doi.org/10.3892/or.2018.6561
Copy and paste a formatted citation
x
Spandidos Publications style
Song D, Liang H, Qu B, Li Y, Liu J, Chen C, Zhang D, Zhang X and Gao A: Moxidectin inhibits glioma cell viability by inducing G0/G1 cell cycle arrest and apoptosis. Oncol Rep 40: 1348-1358, 2018.
APA
Song, D., Liang, H., Qu, B., Li, Y., Liu, J., Chen, C. ... Gao, A. (2018). Moxidectin inhibits glioma cell viability by inducing G0/G1 cell cycle arrest and apoptosis. Oncology Reports, 40, 1348-1358. https://doi.org/10.3892/or.2018.6561
MLA
Song, D., Liang, H., Qu, B., Li, Y., Liu, J., Chen, C., Zhang, D., Zhang, X., Gao, A."Moxidectin inhibits glioma cell viability by inducing G0/G1 cell cycle arrest and apoptosis". Oncology Reports 40.3 (2018): 1348-1358.
Chicago
Song, D., Liang, H., Qu, B., Li, Y., Liu, J., Chen, C., Zhang, D., Zhang, X., Gao, A."Moxidectin inhibits glioma cell viability by inducing G0/G1 cell cycle arrest and apoptosis". Oncology Reports 40, no. 3 (2018): 1348-1358. https://doi.org/10.3892/or.2018.6561
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