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Article

Downregulation of long non‑coding RNA UCA1 enhances the radiosensitivity and inhibits migration via suppression of epithelial‑mesenchymal transition in colorectal cancer cells

  • Authors:
    • Xiaodong Yang
    • Wei Liu
    • Xiaohui Xu
    • Junjia Zhu
    • Yong Wu
    • Kui Zhao
    • Songbin He
    • Ming Li
    • Yongyou Wu
    • Shuyu Zhang
    • Jianping Cao
    • Zhenyu Ye
    • Chungen Xing
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, P.R. China, Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, P.R. China, School of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou, Jiangsu 215123, P.R. China
  • Pages: 1554-1564
    |
    Published online on: July 13, 2018
       https://doi.org/10.3892/or.2018.6573
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Abstract

Colorectal cancer (CRC) is the third most commonly diagnosed cancer and common cause of cancer‑related deaths. Radiotherapy has become a routine treatment for CRC. However, radioresistance affects therapeutic efficacy. Long non‑coding RNA urothelial carcinoma associated 1 (UCA1) has been demonstrated to be overexpressed in several tumors and predicts a poor prognosis. In the present study, we revealed that lncRNA‑UCA1 was overexpressed in colorectal cancer tissue and colon cancer cells when compared to normal tissue and cells. Quantitative real‑time PCR revealed that the expression of UCA1 was significantly higher in CRC tissues after chemoradiotherapy. Downregulation of UCA1 enhanced the radiosensitivity of CCL244 cells via inhibition of the colony formation, proliferation and promotion of radiation‑induced apoptosis and G2/M arrest. Moreover, downregulation of UCA1 suppressed the epithelial‑mesenchymal transition (EMT) in CCL244 cells.
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Copy and paste a formatted citation
Spandidos Publications style
Yang X, Liu W, Xu X, Zhu J, Wu Y, Zhao K, He S, Li M, Wu Y, Zhang S, Zhang S, et al: Downregulation of long non‑coding RNA UCA1 enhances the radiosensitivity and inhibits migration via suppression of epithelial‑mesenchymal transition in colorectal cancer cells. Oncol Rep 40: 1554-1564, 2018.
APA
Yang, X., Liu, W., Xu, X., Zhu, J., Wu, Y., Zhao, K. ... Xing, C. (2018). Downregulation of long non‑coding RNA UCA1 enhances the radiosensitivity and inhibits migration via suppression of epithelial‑mesenchymal transition in colorectal cancer cells. Oncology Reports, 40, 1554-1564. https://doi.org/10.3892/or.2018.6573
MLA
Yang, X., Liu, W., Xu, X., Zhu, J., Wu, Y., Zhao, K., He, S., Li, M., Wu, Y., Zhang, S., Cao, J., Ye, Z., Xing, C."Downregulation of long non‑coding RNA UCA1 enhances the radiosensitivity and inhibits migration via suppression of epithelial‑mesenchymal transition in colorectal cancer cells". Oncology Reports 40.3 (2018): 1554-1564.
Chicago
Yang, X., Liu, W., Xu, X., Zhu, J., Wu, Y., Zhao, K., He, S., Li, M., Wu, Y., Zhang, S., Cao, J., Ye, Z., Xing, C."Downregulation of long non‑coding RNA UCA1 enhances the radiosensitivity and inhibits migration via suppression of epithelial‑mesenchymal transition in colorectal cancer cells". Oncology Reports 40, no. 3 (2018): 1554-1564. https://doi.org/10.3892/or.2018.6573
Copy and paste a formatted citation
x
Spandidos Publications style
Yang X, Liu W, Xu X, Zhu J, Wu Y, Zhao K, He S, Li M, Wu Y, Zhang S, Zhang S, et al: Downregulation of long non‑coding RNA UCA1 enhances the radiosensitivity and inhibits migration via suppression of epithelial‑mesenchymal transition in colorectal cancer cells. Oncol Rep 40: 1554-1564, 2018.
APA
Yang, X., Liu, W., Xu, X., Zhu, J., Wu, Y., Zhao, K. ... Xing, C. (2018). Downregulation of long non‑coding RNA UCA1 enhances the radiosensitivity and inhibits migration via suppression of epithelial‑mesenchymal transition in colorectal cancer cells. Oncology Reports, 40, 1554-1564. https://doi.org/10.3892/or.2018.6573
MLA
Yang, X., Liu, W., Xu, X., Zhu, J., Wu, Y., Zhao, K., He, S., Li, M., Wu, Y., Zhang, S., Cao, J., Ye, Z., Xing, C."Downregulation of long non‑coding RNA UCA1 enhances the radiosensitivity and inhibits migration via suppression of epithelial‑mesenchymal transition in colorectal cancer cells". Oncology Reports 40.3 (2018): 1554-1564.
Chicago
Yang, X., Liu, W., Xu, X., Zhu, J., Wu, Y., Zhao, K., He, S., Li, M., Wu, Y., Zhang, S., Cao, J., Ye, Z., Xing, C."Downregulation of long non‑coding RNA UCA1 enhances the radiosensitivity and inhibits migration via suppression of epithelial‑mesenchymal transition in colorectal cancer cells". Oncology Reports 40, no. 3 (2018): 1554-1564. https://doi.org/10.3892/or.2018.6573
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