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Article

PSMB4 overexpression enhances the cell growth and viability of breast cancer cells leading to a poor prognosis

  • Authors:
    • Hua Wang
    • Zhixian He
    • Liuwan Xia
    • Wei Zhang
    • Li Xu
    • Xiaosong Yue
    • Xiaoyan Ru
    • Yanbo Xu
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China, Clinical Medicine, Medical College, Nantong University, Nantong, Jiangsu 226001, P.R. China, Department of Neurosurgery, Suzhou Municipal Hospital, Suzhou, Jiangsu, 215000, P.R. China
  • Pages: 2343-2352
    |
    Published online on: July 20, 2018
       https://doi.org/10.3892/or.2018.6588
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Abstract

PSMB4, proteasome subunit β4, is a member of the ubiquitin-proteasome family, and is elevated in a variety of malignancies. However, the expression level and related mechanism of PSMB4 in breast cancer remains unclear. Therefore, the present study investigated the expression level of PSMB4 in eight pairs of breast cancer and adjacent normal tissues. In addition, the relationship between the expression of PSMB4 and the clinical data of 92 breast cancer patients was discussed. First, it was found that PSMB4 expression was obviously upregulated in breast cancer tumor tissues and cell lines (MDA-MB-231 and MCF-7), and its level was significantly associated with tumor grade (P=0.005), tumor size (P=0.047), Ki-67 expression (P=0.040) and the poor prognosis of breast cancer. The present results demonstrated that PSMB4 could promote the proliferation of breast cancer cells, and was positively correlated with the expression of PCNA using an in vitro starvation-refeeding experiment. In addition, PSMB4‑siRNA transfection assay suggested that PSMB4 knockdown can decrease NF-κB activity and cell viability, and result in cell cycle arrest at the G1/S phase. These findings revealed that PSMB4 might facilitate breast cancer progression by promoting cell proliferation and viability. In summary, PSMB4 may be recognized as an efficacious prognostic marker and potential therapeutic target for breast cancer.
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1 

Parkin DM, Bray F, Ferlay J and Pisani P: Global cancer statistics, 2002. CA Cancer J Clin. 55:74–108. 2005. View Article : Google Scholar : PubMed/NCBI

2 

Secginli S: Mammography self-efficacy scale and breast cancer fear scale: Psychometric testing of the Turkish versions. Cancer Nurs. 35:365–373. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Peters JM, Franke WW and Kleinschmidt JA: Distinct 19 S and 20 S subcomplexes of the 26 S proteasome and their distribution in the nucleus and the cytoplasm. J Biol Chem. 269:7709–7718. 1994.PubMed/NCBI

4 

Tsakiri EN and Trougakos IP: The amazing ubiquitin-proteasome system: Structural components and implication in aging. Int Rev Cell Mol Biol. 314:171–237. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Ling Q and Jarvis P: Functions of plastid protein import and the ubiquitin-proteasome system in plastid development. Biochim Biophys Acta. 1847:939–948. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Csizmar CM, Kim DH and Sachs Z: The role of the proteasome in AML. Blood Cancer J. 6:e5032016. View Article : Google Scholar : PubMed/NCBI

7 

Lee GY, Haverty PM, Li L, Kljavin NM, Bourgon R, Lee J, Stern H, Modrusan Z, Seshagiri S, Zhang Z, et al: Comparative oncogenomics identifies PSMB4 and SHMT2 as potential cancer driver genes. Cancer Res. 74:3114–3126. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Zhong J, Shaik S, Wan L, Tron AE, Wang Z, Sun L, Inuzuka H and Wei W: SCF β-TRCP targets MTSS1 for ubiquitination-mediated destruction to regulate cancer cell proliferation and migration. Oncotarget. 4:2339–2353. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Kim YH, Kim JH, Choi YW, Lim SK, Yim H, Kang SY, Chung YS, Lee GY and Park TJ: Gankyrin is frequently overexpressed in breast cancer and is associated with ErbB2 expression. Exp Mol Pathol. 94:360–365. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Manasanch EE and Orlowski RZ: Proteasome inhibitors in cancer therapy. Nat Rev Clin Oncol. 14:417–433. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Pellom ST Jr and Shanker A: Development of proteasome inhibitors as therapeutic drugs. J Clin Cell Immunol. S5:52012.PubMed/NCBI

12 

Nandi D, Woodward E, Ginsburg DB and Monaco JJ: Intermediates in the formation of mouse 20S proteasomes: Implications for the assembly of precursor beta subunits. EMBO J. 16:5363–5375. 1997. View Article : Google Scholar : PubMed/NCBI

13 

Liu R, Lu S, Deng Y, Yang S, He S, Cai J, Qiang F, Chen C, Zhang W, Zhao S, et al: PSMB4 expression associates with epithelial ovarian cancer growth and poor prognosis. Arch Gynecol Obstet. 293:1297–1307. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Zhang Y, Liu H, Cui M, Liu J, Yi R, Niu Y, Chen T and Zhao Y: Effect of the HBV whole-X gene on the expression of hepatocellular carcinoma associated proteins. J Microbiol Immunol Infect. 49:335–343. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Valdagni R, Rancati T, Ghilotti M, Cozzarini C, Vavassori V, Fellin G, Fiorino C, Girelli G, Barra S, Zaffaroni N, et al: To bleed or not to bleed. A prediction based on individual gene profiling combined with dose-volume histogram shapes in prostate cancer patients undergoing three-dimensional conformal radiation therapy. Int J Radiat Oncol Biol Phys. 74:1431–1440. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Zheng-Hao D, Ji-Fang W, De-Sheng X and Jian-Hua Z: Galectin-1 is up-regulated by RASSF1A gene in human gastric carcinoma cell line SGC7901. APMIS. 120:582–590. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Thaker NG, Zhang F, McDonald PR, Shun TY, Lewen MD, Pollack IF and Lazo JS: Identification of survival genes in human glioblastoma cells by small interfering RNA screening. Mol Pharmacol. 76:1246–1255. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Zheng P, Guo H, Li G, Han S, Luo F and Liu Y: PSMB4 promotes multiple myeloma cell growth by activating NF-κB-miR-21 signaling. Biochem Biophys Res Commun. 458:328–333. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Runowicz CD, Leach CR, Henry NL, Henry KS, Mackey HT, Cowens-Alvarado RL, Cannady RS, Pratt-Chapman ML, Edge SB, Jacobs LA, et al: American Cancer Society/American Society of Clinical Oncology Breast Cancer Survivorship Care Guideline. J Clin Oncol. 34:611–635. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Adamczyk A, Niemiec JA, Ambicka A, Mucha-Małecka A, Mituś J and Ryś J: CD44/CD24 as potential prognostic markers in node-positive invasive ductal breast cancer patients treated with adjuvant chemotherapy. J Mol Histol. 45:35–45. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Chen XS, Wu JY, Huang O, Chen CM, Wu J, Lu JS, Shao ZM, Shen ZZ and Shen KW: Molecular subtype can predict the response and outcome of Chinese locally advanced breast cancer patients treated with preoperative therapy. Oncol Rep. 23:1213–1220. 2010.PubMed/NCBI

22 

Yao N, Song Z, Wang X, Yang S and Song H: Prognostic Impact of Progesterone Receptor Status in Chinese Estrogen Receptor Positive Invasive Breast Cancer Patients. J Breast Cancer. 20:160–169. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Hirano Y, Kaneko T, Okamoto K, Bai M, Yashiroda H, Furuyama K, Kato K, Tanaka K and Murata S: Dissecting beta-ring assembly pathway of the mammalian 20S proteasome. EMBO J. 27:2204–2213. 2008. View Article : Google Scholar : PubMed/NCBI

24 

Poulaki V, Mitsiades CS, Kotoula V, Negri J, McMillin D, Miller JW and Mitsiades N: The proteasome inhibitor bortezomib induces apoptosis in human retinoblastoma cell lines in vitro. Invest Ophthalmol Vis Sci. 48:4706–4719. 2007. View Article : Google Scholar : PubMed/NCBI

25 

Yin D, Zhou H, Kumagai T, Liu G, Ong JM, Black KL and Koeffler HP: Proteasome inhibitor PS-341 causes cell growth arrest and apoptosis in human glioblastoma multiforme (GBM). Oncogene. 24:344–354. 2005. View Article : Google Scholar : PubMed/NCBI

26 

Fribley A, Zeng Q and Wang CY: Proteasome inhibitor PS-341 induces apoptosis through induction of endoplasmic reticulum stress-reactive oxygen species in head and neck squamous cell carcinoma cells. Mol Cell Biol. 24:9695–9704. 2004. View Article : Google Scholar : PubMed/NCBI

27 

Zhou B, Damrauer JS, Bailey ST, Hadzic T, Jeong Y, Clark K, Fan C, Murphy L, Lee CY, Troester MA, et al: Erythropoietin promotes breast tumorigenesis through tumor-initiating cell self-renewal. J Clin Invest. 124:553–563. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Templin J, Atanackovic D, Hasche D, Radhakrishnan SV and Luetkens T: Oscillating expression of interleukin-16 in multiple myeloma is associated with proliferation, clonogenic growth, and PI3K/NFKB/MAPK activation. Oncotarget. 8:49253–49263. 2017. View Article : Google Scholar : PubMed/NCBI

29 

Eroles P, Bosch A, Pérez-Fidalgo JA and Lluch A: Molecular biology in breast cancer: Intrinsic subtypes and signaling pathways. Cancer Treat Rev. 38:698–707. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Abdel-Mageed AB and Agrawal KC: Activation of nuclear factor kappaB: Potential role in metallothionein-mediated mitogenic response. Cancer Res. 58:2335–2338. 1998.PubMed/NCBI

31 

Biswas DK, Cruz AP, Gansberger E and Pardee AB: Epidermal growth factor-induced nuclear factor kappa B activation: A major pathway of cell-cycle progression in estrogen-receptor negative breast cancer cells. Proc Natl Acad Sci USA. 97:8542–8547. 2000. View Article : Google Scholar : PubMed/NCBI

32 

Grundler K, Rotter R, Tilley S, Pircher J, Czermak T, Yakac M, Gaitzsch E, Massberg S, Krötz F, Sohn HY, et al: The proteasome regulates collagen-induced platelet aggregation via nuclear-factor-kappa-B (NFĸB) activation. Thromb Res. 148:15–22. 2016. View Article : Google Scholar : PubMed/NCBI

33 

Di Filippo C, Petronella P, Freda F, Scorzelli M, Ferretti M, Canonico S, Rossi F and D'Amico M: Involvement of the ubiquitin-proteasome system in the formation of experimental postsurgical peritoneal adhesions. Mediators Inflamm. 2012:1947232012. View Article : Google Scholar : PubMed/NCBI

34 

Pajonk F and McBride WH: The proteasome in cancer biology and treatment. Radiat Res. 156:447–459. 2001. View Article : Google Scholar : PubMed/NCBI

35 

Ehrlich ES, Chmura JC, Smith JC, Kalu NN and Hayward GS: KSHV RTA abolishes NFκB responsive gene expression during lytic reactivation by targeting vFLIP for degradation via the proteasome. PLoS One. 9:e913592014. View Article : Google Scholar : PubMed/NCBI

36 

Kiliccioglu I, Konac E, Varol N, Gurocak S and Bilen Yucel C: Apoptotic effects of proteasome and histone deacetylase inhibitors in prostate cancer cell lines. Genet Mol Res. 13:3721–3731. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang H, He Z, Xia L, Zhang W, Xu L, Yue X, Ru X and Xu Y: PSMB4 overexpression enhances the cell growth and viability of breast cancer cells leading to a poor prognosis. Oncol Rep 40: 2343-2352, 2018.
APA
Wang, H., He, Z., Xia, L., Zhang, W., Xu, L., Yue, X. ... Xu, Y. (2018). PSMB4 overexpression enhances the cell growth and viability of breast cancer cells leading to a poor prognosis. Oncology Reports, 40, 2343-2352. https://doi.org/10.3892/or.2018.6588
MLA
Wang, H., He, Z., Xia, L., Zhang, W., Xu, L., Yue, X., Ru, X., Xu, Y."PSMB4 overexpression enhances the cell growth and viability of breast cancer cells leading to a poor prognosis". Oncology Reports 40.4 (2018): 2343-2352.
Chicago
Wang, H., He, Z., Xia, L., Zhang, W., Xu, L., Yue, X., Ru, X., Xu, Y."PSMB4 overexpression enhances the cell growth and viability of breast cancer cells leading to a poor prognosis". Oncology Reports 40, no. 4 (2018): 2343-2352. https://doi.org/10.3892/or.2018.6588
Copy and paste a formatted citation
x
Spandidos Publications style
Wang H, He Z, Xia L, Zhang W, Xu L, Yue X, Ru X and Xu Y: PSMB4 overexpression enhances the cell growth and viability of breast cancer cells leading to a poor prognosis. Oncol Rep 40: 2343-2352, 2018.
APA
Wang, H., He, Z., Xia, L., Zhang, W., Xu, L., Yue, X. ... Xu, Y. (2018). PSMB4 overexpression enhances the cell growth and viability of breast cancer cells leading to a poor prognosis. Oncology Reports, 40, 2343-2352. https://doi.org/10.3892/or.2018.6588
MLA
Wang, H., He, Z., Xia, L., Zhang, W., Xu, L., Yue, X., Ru, X., Xu, Y."PSMB4 overexpression enhances the cell growth and viability of breast cancer cells leading to a poor prognosis". Oncology Reports 40.4 (2018): 2343-2352.
Chicago
Wang, H., He, Z., Xia, L., Zhang, W., Xu, L., Yue, X., Ru, X., Xu, Y."PSMB4 overexpression enhances the cell growth and viability of breast cancer cells leading to a poor prognosis". Oncology Reports 40, no. 4 (2018): 2343-2352. https://doi.org/10.3892/or.2018.6588
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