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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
October-2018 Volume 40 Issue 4

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review

Long non‑coding RNAs in small cell lung cancer: A potential opening to combat the disease (Review)

Tian‑Tian Li, Rong‑Quan He, Jie Ma, Zu‑Yun Li, Xiao‑Hua Hu, Gang Chen
Pages: 1831-1842
Published online on: 07 August 2018

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Article Open Access

Induction of microRNA‑let‑7a inhibits lung adenocarcinoma cell growth by regulating cyclin D1 Corrigendum in /10.3892/or.2024.8721

Wei Zhao, Jin‑Xia Hu, Rui‑Min Hao, Qian Zhang, Jun‑Qi Guo, You‑Jie Li, Ning Xie, Lu‑Ying Liu, Ping‑Yu Wang, Can Zhang, Shu‑Yang Xie
Pages: 1843-1854
Published online on: 24 July 2018

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Article Open Access

Bioinformatic analysis suggests that UGT2B15 activates the Hippo‑YAP signaling pathway leading to the pathogenesis of gastric cancer

Xuanmin Chen, Defeng Li, Nannan Wang, Meifeng Yang, Aijun Liao, Shuling Wang, Guangsheng Hu, Bing Zeng, Yuhong Yao, Diqun Liu, Han Liu, Weiwei Zhou, Weisheng Xiao, Peiyuan Li, Chen Ming, Song Ping, Pingfang Chen, Li Jing, Yu Bai, Jun Yao
Pages: 1855-1862
Published online on: 26 July 2018

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Article Open Access

SET7/9 promotes hepatocellular carcinoma progression through regulation of E2F1

Ye Gu, Xinling Wang, Hong Liu, Guimei Li, Weiping Yu, Qing Ma
Pages: 1863-1874
Published online on: 02 August 2018

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Article Open Access

Silencing of CDCA5 inhibits cancer progression and serves as a prognostic biomarker for hepatocellular carcinoma

Jianlin Wang, Congcong Xia, Meng Pu, Bin Dai, Xisheng Yang, Runze Shang, Zhen Yang, Ruohan Zhang, Kaishan Tao, Kefeng Dou
Pages: 1875-1884
Published online on: 17 July 2018

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Article Open Access

GPR56 promotes proliferation of colorectal cancer cells and enhances metastasis via epithelial‑mesenchymal transition through PI3K/AKT signaling activation

Bing Ji, Yifei Feng, Ye Sun, Dongjian Ji, Wenwei Qian, Zhiyuan Zhang, Qingyuan Wang, Yue Zhang, Chuan Zhang, Yueming Sun
Pages: 1885-1896
Published online on: 20 July 2018

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Article Open Access

Prognostic values of the inhibitor of DNA‑binding family members in breast cancer

Xiao‑Ling Zhou, De Zeng, Yan‑Hong Ye, Shu‑Ming Sun, Xiao‑Feng Lu, Wei‑Quan Liang, Chun‑Fa Chen, Hao‑Yu Lin
Pages: 1897-1906
Published online on: 23 July 2018

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Article Open Access

Dowregulation of OTX1 attenuates gastric cancer cell proliferation, migration and invasion

Shi‑Chen Qin, Zhong Zhao, Jin‑Xin Sheng, Xiang‑Hui Xu, Jie Yao, Jin‑Jun Lu, Bin Chen, Guo‑Dong Zhao, Xiao‑Yong Wang, Yan‑Dong Yang
Pages: 1907-1916
Published online on: 24 July 2018

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Article Open Access

MicroRNA‑320a suppresses tumour cell proliferation and invasion of renal cancer cells by targeting FoxM1 Retraction in /10.3892/or.2024.8754

Shiyue Zhao, Yangwei Wang, Yan Lou, Yonggang Wang, Jing Sun, Manyu Luo, Wen Li, Lining Miao
Pages: 1917-1926
Published online on: 25 July 2018

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Article Open Access

Beclin1 overexpression suppresses tumor cell proliferation and survival via an autophagy‑dependent pathway in human synovial sarcoma cells

Jialin Zhu, Yongsong Cai, Ke Xu, Xiaoyu Ren, Jian Sun, Shemin Lu, Jinghong Chen, Peng Xu
Pages: 1927-1936
Published online on: 25 July 2018

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Article Open Access

Calpain 2 knockdown promotes cell apoptosis and restores gefitinib sensitivity through epidermal growth factor receptor/protein kinase B/survivin signaling

Ge Zhang, Tao Fang, Meijia Chang, Jing Li, Qunying Hong, Chunxue Bai, Jian Zhou
Pages: 1937-1946
Published online on: 02 August 2018

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Article Open Access

Genome‑scale analysis to identify potential prognostic microRNA biomarkers for predicting overall survival in patients with colon adenocarcinoma

Hao‑Tang Wei, Er‑Na Guo, Xi‑Wen Liao, Li‑Sheng Chen, Jia‑Lei Wang, Min Ni, Chi Liang
Pages: 1947-1958
Published online on: 30 July 2018

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Article Open Access

MicroRNA‑181a promotes cell proliferation and inhibits apoptosis in gastric cancer by targeting RASSF1A

Junhui Yu, Jie Qi, Xuejun Sun, Wei Wang, Guangbing Wei, Yunhua Wu, Qi Gao, Jianbao Zheng
Pages: 1959-1970
Published online on: 07 August 2018

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Article Open Access

Downregulation of GSDMD attenuates tumor proliferation via the intrinsic mitochondrial apoptotic pathway and inhibition of EGFR/Akt signaling and predicts a good prognosis in non‑small cell lung cancer

Jianwei Gao, Xiangyu Qiu, Guangmin Xi, Hongbing Liu, Fang Zhang, Tangfeng Lv, Yong Song
Pages: 1971-1984
Published online on: 07 August 2018

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Article Open Access

Emodin induces apoptosis in human hepatocellular carcinoma HepaRG cells via the mitochondrial caspase‑dependent pathway

Xiaoxv Dong, Boran Ni, Jing Fu, Xingbin Yin, Longtai You, Xin Leng, Xiao Liang, Jian Ni
Pages: 1985-1993
Published online on: 02 August 2018

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Article Open Access

Inhibition of ornithine decarboxylase 1 facilitates pegylated arginase treatment in lung adenocarcinoma xenograft models

Sze‑Kwan Lam, Kin Pong U, Yuan‑Yuan Li, Shi Xu, Paul Ning‑Man Cheng, James Chung‑Man Ho
Pages: 1994-2004
Published online on: 25 July 2018

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Article Open Access

Inhibition of GSK3 and MEK induced cancer stem cell generation via the Wnt and MEK signaling pathways

Shengtao Liao, Li Gan, Wanxiang Qin, Chang Liu, Zhechuan Mei
Pages: 2005-2013
Published online on: 25 July 2018

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Article Open Access

Transcriptome-wide analysis of alternative mRNA splicing signature in the diagnosis and prognosis of stomach adenocarcinoma

Yu Shi, Zuhua Chen, Juanjuan Gao, Si Wu, Haer Gao, Guoshuang Feng
Pages: 2014-2022
Published online on: 02 August 2018

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Article Open Access

CLEC3B is downregulated and inhibits proliferation in clear cell renal cell carcinoma

Jian Liu, Zhe Liu, Qun Liu, Lina Li, Xiaona Fan, Tao Wen, Guangyu An
Pages: 2023-2035
Published online on: 23 July 2018

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Article Open Access

CKAP2 expression is associated with glioma tumor growth and acts as a prognostic factor in high‑grade glioma

Kuanyu Wang, Ruoyu Huang, Guanzhang Li, Fan Zeng, Zheng Zhao, Yanwei Liu, Huimin Hu, Tao Jiang
Pages: 2036-2046
Published online on: 01 August 2018

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Article Open Access

Inhibitor of apoptosis protein‑like protein‑2: A novel growth accelerator for breast cancer cells

Lin Zhu, Weihua Zhou, Xidi Zhu, Siqi Xiang, Siyuan Wang, Yingxia Peng, Bangyun Lu, Peizhi Tang, Qian Chen, Mengjuan Wu, Xia Peng, Ziyu Chen, Ziyi Sun, Kunliang Yang, Mingjun Xiang, Dandan Yu
Pages: 2047-2055
Published online on: 03 August 2018

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Article Open Access

miR‑590‑5p inhibits tumor growth in malignant melanoma by suppressing YAP1 expression

Kuanhou Mou, Meiling Ding, Dan Han, Yan Zhou, Xin Mu, Wenli Liu, Lijuan Wang
Pages: 2056-2066
Published online on: 07 August 2018

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Article

Farnesoid X receptor inhibits proliferation of human colorectal cancer cells via the miR‑135A1/CCNG2 signaling pathway Retraction in /10.3892/or.2025.8896

Pengfei Qiao, Shenglong Li, Haogang Zhang, Lei Yao, Fujing Wang
Pages: 2067-2078
Published online on: 07 August 2018

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Article

Transcutaneous carbon dioxide application suppresses bone destruction caused by breast cancer metastasis

Toshiyuki Takemori, Teruya Kawamoto, Takeshi Ueha, Mitsunori Toda, Masayuki Morishita, Etsuko Kamata, Naomasa Fukase, Hitomi Hara, Shuichi Fujiwara, Takahiro Niikura, Ryosuke Kuroda, Toshihiro Akisue
Pages: 2079-2087
Published online on: 30 July 2018

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Article

Screening diagnostic biomarkers of OSCC via an LCM-based proteomic approach

Ruinan Wang, Yao Yuan, Yuqiao Zhou, Dunfang Zhang, Lewei Zhang, Xin Zeng, Ning Ji, Min Zhou, Xinhua Liang, Yu Chen, Ning Geng, Jing Li, Qianming Chen
Pages: 2088-2096
Published online on: 30 July 2018

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Article

Nicotine enhances store‑operated calcium entry by upregulating HIF‑1α and SOCC components in non‑small cell lung cancer cells

Yan Wang, Jianxing He, Hua Jiang, Qi Zhang, Haihong Yang, Xiaoming Xu, Chenting Zhang, Chuyi Xu, Jian Wang, Wenju Lu
Pages: 2097-2104
Published online on: 17 July 2018

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Article

Mesothelial cells facilitate cancer stem‑like properties in spheroids of ovarian cancer cells

Akemi Shishido, Seiji Mori, Yuhki Yokoyama, Yoshinosuke Hamada, Kazumasa Minami, Yamin Qian, Jiaqi Wang, Haruka Hirose, Xin Wu, Naomasa Kawaguchi, Sachiko Nagumo, Nariaki Matsuura, Hirofumi Yamamoto
Pages: 2105-2114
Published online on: 27 July 2018

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Article

Association between Tim‑3 and Gal‑9 expression and gastric cancer prognosis

Yangyang Wang, Enhao Zhao, Zizhen Zhang, Gang Zhao, Hui Cao
Pages: 2115-2126
Published online on: 06 August 2018

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Article

Higenamine enhances the antitumor effects of cucurbitacin B in breast cancer by inhibiting the interaction of AKT and CDK2

Zi-Qi Jin, Jian Hao, Xue Yang, Jing-Hua He, Jing Liang, Jin-Wei Yuan, Yu Mao, Dan Liu, Rui Cao, Xiong-Zhi Wu, Xin Li, Dan Chen
Pages: 2127-2136
Published online on: 06 August 2018

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Article

Protective role of ABCG2 against oxidative stress in colorectal cancer and its potential underlying mechanism

Shuang Nie, Yaqing Huang, Mengyue Shi, Xuetian Qian, Hongzhen Li, Chunyan Peng, Bo Kong, Xiaoping Zou, Shanshan Shen
Pages: 2137-2146
Published online on: 24 July 2018

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Article

Estrogen enhances tumor growth and angiogenesis indirectly via mediation of bone marrow‑derived cells as well as directly through stimulation of tumor and endothelial cells

Yingchen Zhuo, Xueqian Li, Qiaowei Zheng, Xingjun Fan, Wenbing Ma, Jingguo Chen, Xue Zhao, Peipei Zhao, Xuanlin Liu, Fengru Tang, Kai Cheng, Weiyi Feng
Pages: 2147-2156
Published online on: 07 August 2018

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Article

Staurosporine alleviates cisplatin chemoresistance in human cancer cell models by suppressing the induction of SQSTM1/p62

Khaldoon Alsamman, Omar S. El‑Masry
Pages: 2157-2162
Published online on: 01 August 2018

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Article

Sonodynamic therapy improves anti‑tumor immune effect by increasing the infiltration of CD8+ T cells and altering tumor blood vessels in murine B16F10 melanoma xenograft

Yan Peng, Limin Jia, Shan Wang, Wenwu Cao, Jinhua Zheng
Pages: 2163-2170
Published online on: 01 August 2018

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Article

Inhibition of YAP reverses primary resistance to EGFR inhibitors in colorectal cancer cells

Bi‑Sheng Liu, Hong‑Wei Xia, Sheng Zhou, Qing Liu, Qiu‑Lin Tang, Na‑Xi Bi, Ji‑Tao Zhou, Qi‑Yong Gong, Yong‑Zhan Nie, Feng Bi
Pages: 2171-2182
Published online on: 07 August 2018

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Article

Integrin β4 reduces DNA damage‑induced p53 activation in colorectal cancer

Jinsong Wu, Runyuan Zhao, Jing Lin, Baohua Liu
Pages: 2183-2192
Published online on: 06 August 2018

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Article

Decreasing O-GlcNAcylation affects the malignant transformation of MCF-7 cells via Hsp27 expression and its O-GlcNAc modification

Pukkavadee Netsirisawan, Parunya Chaiyawat, Daranee Chokchaichamnankit, Kriengsak Lirdprapamongkol, Chantragan Srisomsap, Jisnuson Svasti, Voraratt Champattanachai
Pages: 2193-2205
Published online on: 01 August 2018

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Article

Inhibition of cFLIP overcomes acquired resistance to sorafenib via reducing ER stress‑related autophagy in hepatocellular carcinoma

Dong Liu, Yifu Fan, Jun Li, Binbin Cheng, Wanfu Lin, Xiaoyan Li, Juan Du, Changquan Ling
Pages: 2206-2214
Published online on: 27 July 2018

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Article

Knockdown of metadherin inhibits cell proliferation and migration in colorectal cancer

Jian‑Wang Li, Chun‑Zhen Huang, Jian‑Hua Li, Jian‑Hua Yuan, Qiong‑Hui Chen, Wei‑Fang Zhang, Zhen‑Sheng Xu, Ying‑Ping Liu, Yong Li, Mei‑Xiao Zhan, Li‑Gong Lu
Pages: 2215-2223
Published online on: 17 July 2018

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Article

Histone deacetylase 5 promotes the proliferation and invasion of lung cancer cells

Lou Zhong, Siyuan Sun, Sumei Yao, Xiao Han, Mingming Gu, Jiahai Shi
Pages: 2224-2232
Published online on: 24 July 2018

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Article

Enolase-phosphatase 1 as a novel potential malignant glioma indicator promotes cell proliferation and migration

Li Su, Ke Yang, Shun Li, Chen Liu, Jianguo Han, Yuan Zhang, Guozheng Xu
Pages: 2233-2241
Published online on: 24 July 2018

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Article

Efficacy of gefitinib‑celecoxib combination therapy in docetaxel‑resistant prostate cancer

Jian‑Zhong Lin, Irbaz Hameed, Zhen Xu, Yang Yu, Zhi‑Yun Ren, Jia‑Geng Zhu
Pages: 2242-2250
Published online on: 24 July 2018

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Article

MicroRNA‑106a regulates the proliferation and invasion of human osteosarcoma cells by targeting VNN2

Yao Chen, Tao Huang, Xiaofan Yang, Chaowu Liu, Pengcheng Li, Zhihang Wang, Shengpeng Zhi
Pages: 2251-2259
Published online on: 26 July 2018

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Article

Effect and mechanisms of celastrol on the apoptosis of HOS osteosarcoma cells

Yanyang Chen, Yunsheng Ou, Yong Tao, Huzhe Liu, Hang Yin, Shenxi Zhong, Haoyang Yu, Zenghui Zhao, Bin He
Pages: 2260-2268
Published online on: 01 August 2018

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Article

Zinc enhances chemosensitivity to paclitaxel in PC‑3 prostate cancer cells

Ping Zhang, Yang Li, Xinyu Tang, Rui Guo, Jiuling Li, Ying Ying Chen, Hua Guo, Jing Su, Liankun Sun, Yanan Liu
Pages: 2269-2277
Published online on: 02 August 2018

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Article

Caspase-dependent mitochondrial apoptotic pathway is involved in astilbin-mediated cytotoxicity in breast carcinoma cells

Xiaoqi Sun, Hong Zhang, Yingyu Zhang, Qi Yang, Shujie Zhao
Pages: 2278-2286
Published online on: 26 July 2018

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Article

α7‑nAchR agonist GTS‑21 reduces radiation‑induced lung injury

Zijie Mei, Xiaoli Tian, Jing Chen, Yacheng Wang, Ye Yao, Xin Li, Chunxu Yang, Shimin Zhang, Conghua Xie
Pages: 2287-2297
Published online on: 01 August 2018

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Article

Lycorine inhibits cell proliferation and migration by inhibiting ROCK1/cofilin‑induced actin dynamics in HepG2 hepatoblastoma cells. Corrigendum in /10.3892/or.2019.7362

Wuyi Liu, Qian Zhang, Qin Tang, Changpeng Hu, Jingbin Huang, Yali Liu, Yanyi Lu, Qing Wang, Guobing Li, Rong Zhang
Pages: 2298-2306
Published online on: 30 July 2018

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Article

Impact of RNA‑binding motif 3 expression on the whole transcriptome of prostate cancer cells: An RNA sequencing study

Qingzhuo Dong, Chengcheng Lv, Gejun Zhang, Zi Yu, Chuize Kong, Cheng Fu, Yu Zeng
Pages: 2307-2315
Published online on: 01 August 2018

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Article

Identification of the potential molecular mechanism and driving mutations in the pathogenesis of familial intestinal gastric cancer by whole exome sequencing

Haixiang Chen, Juan Wang, Yi Zhuang, Hao Wu
Pages: 2316-2324
Published online on: 01 August 2018

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Article

Netrin‑1 induces the proliferation of gastric cancer cells via the ERK/MAPK signaling pathway and FAK activation Corrigendum in /10.3892/or.2018.6863

Kai Yin, Mengyuan Shang, Shengchun Dang, Linjun Wang, Yiwen Xia, Lei Cui, Xin Fan, Jianguo Qu, Jixiang Chen, Zekuan Xu
Pages: 2325-2333
Published online on: 01 August 2018

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Article

Conditioned medium mimicking the tumor microenvironment augments chemotherapeutic resistance via ataxia‑telangiectasia mutated and nuclear factor‑κB pathways in gastric cancer cells

Xinguo Zhuang, Xun Li, Jiaqin Zhang, Yi Hu, Bin Hu, Yi Shi, Yao Sun, Guolin Hong
Pages: 2334-2342
Published online on: 07 August 2018

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Article

PSMB4 overexpression enhances the cell growth and viability of breast cancer cells leading to a poor prognosis

Hua Wang, Zhixian He, Liuwan Xia, Wei Zhang, Li Xu, Xiaosong Yue, Xiaoyan Ru, Yanbo Xu
Pages: 2343-2352
Published online on: 20 July 2018

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Article

Co-treatment with BEZ235 enhances chemosensitivity of A549/DDP cells to cisplatin via inhibition of PI3K/Akt/mTOR signaling and downregulation of ERCC1 expression

Anzhou Xia, Huanhuan Li, Ran Li, Linghong Lu, Xiaoli Wu
Pages: 2353-2362
Published online on: 20 July 2018

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Article

Upregulation and activation of p53 by erastin‑induced reactive oxygen species contribute to cytotoxic and cytostatic effects in A549 lung cancer cells

Chaoli Huang, Mengchang Yang, Jia Deng, Peng Li, Wenjie Su, Rong Jiang
Pages: 2363-2370
Published online on: 20 July 2018

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Article

lncRNA GAS5 inhibits colorectal cancer cell proliferation via the miR‑182‑5p/FOXO3a axis

Kangwen Cheng, Zhenguo Zhao, Guihe Wang, Jian Wang, Weiming Zhu
Pages: 2371-2380
Published online on: 20 July 2018

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Article

Curcumin and paclitaxel induce cell death in breast cancer cell lines

Gloria M. Calaf, Richard Ponce-Cusi, Flavio Carrión
Pages: 2381-2388
Published online on: 26 July 2018

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Article

MicroRNA‑874 is downregulated in cervical cancer and inhibits cancer progression by directly targeting ETS1 Retraction in /10.3892/or.2022.8380

Haihong Liao, Yunfei Pan, Yuefen Pan, Junjun Shen, Quan Qi, Liping Zhong, Wenshu Han, Qi Wang, Yizhen Jiang
Pages: 2389-2398
Published online on: 02 August 2018

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Article

Inhibition of eIF4F complex loading inhibits the survival of malignant glioma

Qiu‑Feng Dong, Zhi‑Feng Yan, Peng‑Qi Li, Xin Yang, Jun‑Li Huo, Hai‑Ning Zhen
Pages: 2399-2407
Published online on: 20 July 2018

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Article

EphA3 contributes to tumor growth and angiogenesis in human gastric cancer cells

Xiao‑Ye Lv, Jian Wang, Fang Huang, Peng Wang, Jian‑Guang Zhou, Bo Wei, Shan‑Hu Li
Pages: 2408-2416
Published online on: 20 July 2018

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Journal Cover
January-2026 Volume 55 Issue 1

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Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review Open Access

Harnessing ferroptosis for cancer therapy: Mechanisms and therapeutic strategies (Review)

Nabil Mouawad, Nour El Jaafari, Mirvat El Sibai, Ralph J. Abi-Habib
Article Number: 24
Published online on: 24 November 2025

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Expression of Concern Open Access

[Expression of Concern] Promoter methylation of death‑associated protein kinase and its role in irradiation response in cervical cancer

Rebecca Ching-Yu Leung, Stephanie Si Liu, Kelvin Yuen-Kwong Chan, Kar-Fai Tam, Kar-Loen Chan, Ling-Chui Wong, Hextan Yuen-Sheung Ngan
Article Number: 23
Published online on: 24 November 2025

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Oxaliplatin resistance in pancreatic ductal adenocarcinoma is non‑significantly mediated by diminished drug uptake but is highly linked to a poor apoptotic response to the cytotoxic threat

Hellen Röttgen, Lana Theurer, Teresa Peccerella, Ketaki Sandu, Johanna Weiss, Jürgen Burhenne, John P. Neoptolemos, Beate Köberle, Dirk Theile
Article Number: 22
Published online on: 19 November 2025

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Correction Open Access

[Corrigendum] Src homology phosphotyrosyl phosphatase 2 mediates cisplatin‑related drug resistance by inhibiting apoptosis and activating the Ras/PI3K/Akt1/survivin pathway in lung cancer cells

Chunlan Tang, Hu Luo, Dan Luo, Heping Yang, Xiangdong Zhou
Article Number: 21
Published online on: 19 November 2025

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S100B drives glioblastoma invasion and migration through TGF‑β2‑mediated epithelial‑mesenchymal transition

Xuemei Liao, Yuan Xu, Honghong Zhou, Qin Yi, Shifang Dong, Bin Tan
Article Number: 20
Published online on: 19 November 2025

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Review Open Access

Role of the SOX family in non‑small cell lung cancer: Molecular mechanisms and therapeutic implications (Review)

Kaiwei Wang, Yaoqi Li, Zhening Guo, Lin Song, Xiaoliang Ding, Linsheng Liu, Tao Hu, Yicong Bian, Chenrong Huang, Liyan Miao
Article Number: 19
Published online on: 18 November 2025

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Retraction Open Access

[Retracted] MicroRNA‑18a enhances the radiosensitivity of cervical cancer cells by promoting radiation‑induced apoptosis

Sha Liu, Xiaofen Pan, Qin Yang, Lu Wen, Yao Jiang, Yingchao Zhao, Guiling Li
Article Number: 18
Published online on: 17 November 2025

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Review Open Access

Role of histone deacetylases in blood cancer: Exploring peptide‑based inhibitors as therapeutic strategies for leukemia treatment (Review)

Yaneenart Suwanwong, Phornthip Ploensil
Article Number: 17
Published online on: 14 November 2025

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The multidimensional regulatory network of the PD‑1/PD‑L1 axis in the esophageal squamous cell carcinoma microenvironment: Implications for novel combination therapies and precision immunotherapy (Review)

Haoyue Lai, Lu Qi, Zhixuan Lin, Zhongwen Li
Article Number: 16
Published online on: 13 November 2025

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From modification to malignancy: Bridging acetylation mechanisms and therapeutic innovations in melanoma (Review)

Jingwen Wu, Xuxia Cai, Zimo Zhu, Xiahong Li, Kaoyuan Zhang, Chenchen Wu, Bo Yu, Cong Huang
Article Number: 15
Published online on: 12 November 2025

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Retraction Open Access

[Retracted] MicroRNA‑92b promotes tumor growth and activation of NF‑κB signaling via regulation of NLK in oral squamous cell carcinoma

Zhiming Liu, Cynthia Diep, Tiantian Mao, Li Huang, Robert Merrill, Zhouwen Zhang, Youjian Peng
Article Number: 14
Published online on: 11 November 2025

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Article Open Access

C‑terminal HSP90 inhibitor NCT‑58 impairs the cancer stem‑like phenotype and enhances chemotherapy efficacy in TNBC

Eunsun Jung, Yoon-Jae Kim, Kyoungmin Lee, Seojin Jang, Soeun Park, Eunhye Oh, Minsu Park, Seongjae Kim, Dongmi Ko, Yong Koo Kang, Kee Dal Nam, Lee Farrand, Cong-Truong Nguyen, Minh Thanh La, Jihyae Ann, Jeewoo Lee, Ji Young Kim, Jae Hong Seo
Article Number: 13
Published online on: 11 November 2025

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Correction Open Access

[Corrigendum] Compound 225# inhibits the proliferation of human colorectal cancer cells by promoting cell cycle arrest and apoptosis induction

Xiaoxue Zhang, Liujun He, Yong Li, Yifei Qiu, Wujing Hu, Wanying Lu, Huihui Du, Donglin Yang
Article Number: 12
Published online on: 06 November 2025

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Immune system, inflammatory response, and regulated cell death in breast cancer research (Review)

Guangyao Li, Binghui Jin, Jialin Zhou, Shifeng Fang, Zhe Fan
Article Number: 11
Published online on: 05 November 2025

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Retraction Open Access

[Retracted] Uvangoletin induces mitochondria‑mediated apoptosis in HL‑60 cells in vitro and in vivo without adverse reactions of myelosuppression, leucopenia and gastrointestinal tract disturbances

Zhuanzhen Zheng, Zhenhua Qiao, Rong Gong, Yalin Wang, Yiqun Zhang, Yanping Ma, Li Zhang, Yujin Lu, Bo Jiang, Guoxia Li, Chunxia Dong, Wenliang Chen
Article Number: 10
Published online on: 03 November 2025

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Article Open Access

Characterization of the anticancer effect of mebendazole and its interaction with standard cytotoxic drugs in patient tumor cells ex vivo and in an in vivo mouse model

Sharmineh Mansoori, Kristin Blom, Claes Andersson, Mårten Fryknäs, Rolf Larsson, Peter Nygren
Article Number: 9
Published online on: 31 October 2025

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Correction Open Access

[Corrigendum] Gemcitabine combined with an engineered oncolytic vaccinia virus exhibits a synergistic suppressive effect on the tumor growth of pancreatic cancer

Wanyuan Chen, Weimin Fan, Guoqing Ru, Fang Huang, Xiaming Lu, Xin Zhang, Xiaozhou Mou, Shibing Wang
Article Number: 8
Published online on: 30 October 2025

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Article Open Access

CD44 knockdown and TGF‑β inhibition modulate cell proliferation and invasion in claudin‑low breast cancer cells

Ryoichi Matsunuma, Kazuo Kinoshita, Sae Imada, Shoko Sato, Ryosuke Hayami, Michiko Tsuneizumi
Article Number: 7
Published online on: 30 October 2025

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Retraction Open Access

[Retracted] MicroRNA‑302a targets GAB2 to suppress cell proliferation, migration and invasion of glioma

Jiuhong Ma, Jia Yu, Jingmei Liu, Xing Yang, Miao Lou, Jinghui Liu, Fuqiang Feng, Peigang Ji, Liang Wang
Article Number: 6
Published online on: 27 October 2025

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Article Open Access

LRRC59 inhibits perk pathway‑induced apoptosis and promotes cell proliferation, migration and invasion in colorectal cancer cells

Xingdong Hou, Yuting Wang, Yuzhuo Chen, Peiyan Zhong, Guangzhi Wang, Baicheng Li, Bowei Lu, Hanyu Jiang, Shili Ning
Article Number: 5
Published online on: 23 October 2025

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Article Open Access

Comparative analysis of the efficacy and safety of antibody‑drug conjugates, radionuclide‑drug conjugates and their combination targeting claudin 18.2 in gastric cancer treatment

Huan Du, Xiao-Fei Hao, Bin-Wei Lin, Yu Zhang, Luo Rui, Jing Wang, Ming-Ming Tang, De-Cai Wang, Yi-Han Zhu, Jie Li, Tang-Zhi Dai, Yuchuan Yang, Xia Yang, Xiaobo Du
Article Number: 4
Published online on: 22 October 2025

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Expression of Concern Open Access

[Expression of Concern] CDKN3 is an independent prognostic factor and promotes ovarian carcinoma cell proliferation in ovarian cancer

Tianren Li, Hui Xue, Yi Guo, Kejun Guo
Article Number: 3
Published online on: 16 October 2025

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Review Open Access

Platelet‑circulating tumor cell crosstalk: A pivotal target in cancer diagnosis and therapy (Review)

Lifang Zhang, Ye Yuan, Yan Deng, Lin Wang, Fenghua Chen
Article Number: 2
Published online on: 15 October 2025

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Expression of Concern Open Access

[Expression of Concern] Knockdown of Bmi1 inhibits the stemness properties and tumorigenicity of human bladder cancer stem cell‑like side population cells

Dingjun Zhu, Xuesi Wan, Hai Huang, Xu Chen, Wu Liang, Fengjin Zhao, Tianxin Lin, Jinli Han, Wenlian Xie
Article Number: 1
Published online on: 14 October 2025

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Journal Cover
February-2026 Volume 55 Issue 2

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review Open Access

Alternative splicing in cancer drug resistance: Mechanisms and therapeutic prospects (Review)

Wenpu Zhu, Zikun Wu, Chai Luv, Banghe Bao, Weijie Zhao, Guanglong Chen, Hang Yang, Huihan Ai, Faqiang Liu, Zhi Li
Article Number: 31
Published online on: 05 December 2025

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Inhibition of primary ciliogenesis enhances efficacy of EGFR‑TKIs against non‑small cell lung cancer cells

Liangliang Jin, Li Wei, Junrui Hua, Rong Zhang, Jiaxin Chen, Jinpeng He, Yanli Yang
Article Number: 30
Published online on: 04 December 2025

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Review

Beyond eradication: Therapeutic reprogramming strategies for cancer normalization (Review)

Aliasgar Shahiwala
Article Number: 29
Published online on: 04 December 2025

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Article Open Access

Saikosaponin D overcomes gemcitabine resistance in pancreatic cancer via AKT/mTOR pathway inhibition and synergistic induction of apoptosis and autophagy

Rui Zheng, Yusi Liu, Sen Zhou, Guimei Liu, Xiaobin Liu, Yiyuan Yang, Yufu Zhang
Article Number: 28
Published online on: 04 December 2025

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Retraction Open Access

[Retracted] Downregulation of Bmi‑1 is associated with suppressed tumorigenesis and induced apoptosis in CD44+ nasopharyngeal carcinoma cancer stem‑like cells

Xinhua Xu, Yang Liu, Jin Su, Daojun Li, Juan Hu, Qiao Huang, Mingqian Lu, Xiaoyan Liu, Jinghua Ren, Weihong Chen, Lidan Sun
Article Number: 27
Published online on: 04 December 2025

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Prognostic significance of fibroblast senescence and senescence-associated secretory phenotype factor expression in the tumor microenvironment of pancreatic ductal adenocarcinoma

Yuto Kitano, Tomoharu Miyashita, Takeo Shimasaki, Isamu Makino, Yoshio Endo, Yasuhiko Yamamoto, Noriyuki Inaki, Shintaro Yagi
Article Number: 26
Published online on: 03 December 2025

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Retraction Open Access

[Retracted] Sp1‑CD147 positive feedback loop promotes the invasion ability of ovarian cancer

Jing Zhao, Wei Ye, Juan Wu, Lijuan Liu, Lina Yang, Lu Gao, Biliang Chen, Fanglin Zhang, Hong Yang, Yu Li
Article Number: 25
Published online on: 25 November 2025

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