Lycorine inhibits cell proliferation and migration by inhibiting ROCK1/cofilin‑induced actin dynamics in HepG2 hepatoblastoma cells.

Corrigendum in: /10.3892/or.2019.7362

  • Authors:
    • Wuyi Liu
    • Qian Zhang
    • Qin Tang
    • Changpeng Hu
    • Jingbin Huang
    • Yali Liu
    • Yanyi Lu
    • Qing Wang
    • Guobing Li
    • Rong Zhang
  • View Affiliations

  • Published online on: July 30, 2018     https://doi.org/10.3892/or.2018.6609
  • Pages: 2298-2306
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Abstract

Lycorine, a natural alkaloid extracted from the Amaryllidaceae plant family, has been reported to exhibit anti‑cancer effects in various types of cancer cells. However, the molecular mechanisms through which lycorine exhibits anti‑hepatoblastoma activity are unclear. In the present study, the inhibitory effects of lycorine on the proliferation and migration of HepG2 hepatoblastoma cells were investigated. Lycorine inhibited the proliferation of HepG2 cells in a dose‑dependent manner by inducing cell cycle arrest at the G2/M phase, via downregulation of cyclin A, cyclin B1 and cyclin dependent kinase 1. Additionally, wound healing and Transwell assays revealed that treatment with lycorine resulted in a decrease in the migratory ability of HepG2 cells. Also, treatment with lycorine decreased the expression levels of matrix metalloproteinase (MMP)‑9 and MMP‑2. Furthermore, lycorine induced the cleavage/activation of Rho associated coiled‑coil containing protein kinase 1 (ROCK1) and the downregulation of cofilin, accompanied by an increase in polymerized filamentous actin and a loss of depolymerized globular actin. Furthermore, pre‑incubation of cells with Y‑27632, a specific ROCK1 inhibitor, markedly attenuated lycorine‑induced anti‑proliferative and anti‑migration effects. Taken together, the results demonstrated that lycorine inhibited the proliferation and migration of HepG2 cells by suppressing ROCK1/cofilin‑induced actin dynamics, which suggests that lycorine has the potential to be developed into a novel drug for hepatoblastoma treatment.
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October-2018
Volume 40 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Liu W, Zhang Q, Tang Q, Hu C, Huang J, Liu Y, Lu Y, Wang Q, Li G, Zhang R, Zhang R, et al: Lycorine inhibits cell proliferation and migration by inhibiting ROCK1/cofilin‑induced actin dynamics in HepG2 hepatoblastoma cells. Corrigendum in /10.3892/or.2019.7362. Oncol Rep 40: 2298-2306, 2018
APA
Liu, W., Zhang, Q., Tang, Q., Hu, C., Huang, J., Liu, Y. ... Zhang, R. (2018). Lycorine inhibits cell proliferation and migration by inhibiting ROCK1/cofilin‑induced actin dynamics in HepG2 hepatoblastoma cells. Corrigendum in /10.3892/or.2019.7362. Oncology Reports, 40, 2298-2306. https://doi.org/10.3892/or.2018.6609
MLA
Liu, W., Zhang, Q., Tang, Q., Hu, C., Huang, J., Liu, Y., Lu, Y., Wang, Q., Li, G., Zhang, R."Lycorine inhibits cell proliferation and migration by inhibiting ROCK1/cofilin‑induced actin dynamics in HepG2 hepatoblastoma cells. Corrigendum in /10.3892/or.2019.7362". Oncology Reports 40.4 (2018): 2298-2306.
Chicago
Liu, W., Zhang, Q., Tang, Q., Hu, C., Huang, J., Liu, Y., Lu, Y., Wang, Q., Li, G., Zhang, R."Lycorine inhibits cell proliferation and migration by inhibiting ROCK1/cofilin‑induced actin dynamics in HepG2 hepatoblastoma cells. Corrigendum in /10.3892/or.2019.7362". Oncology Reports 40, no. 4 (2018): 2298-2306. https://doi.org/10.3892/or.2018.6609