MicroRNA‑874 is downregulated in cervical cancer and inhibits cancer progression by directly targeting ETS1

Retraction in: /10.3892/or.2022.8380

  • Authors:
    • Haihong Liao
    • Yunfei Pan
    • Yuefen Pan
    • Junjun Shen
    • Quan Qi
    • Liping Zhong
    • Wenshu Han
    • Qi Wang
    • Yizhen Jiang
  • View Affiliations

  • Published online on: August 2, 2018     https://doi.org/10.3892/or.2018.6624
  • Pages: 2389-2398
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Abstract

An increasing number of studies have reported that microRNAs (miRNAs) are dysregulated in cervical cancer and serve critical roles in cervical oncogenesis and progression. Therefore, identifying the aberrantly expressed miRNAs implicated in the formation and progression of cervical cancer may provide key clues for the development of effective therapeutic targets in treating patients with this type of malignancy. In the present study, miRNA‑874 (miR‑874) was downregulated in cervical cancer tissues and cell lines, and this downregulation was associated with International Federation of Gynaecology and Obstetrics stage and lymph node metastasis. The restored expression of miR‑874 prohibited the proliferation, migration and invasion, but promoted the apoptosis of cervical cancer cells. In addition, E26 transformation specific‑1 (ETS1) was identified as the direct target of miR‑874 in cervical cancer. Inhibition of ETS1 served tumour‑suppressive roles similar to miR‑874 overexpression in cervical cancer cells. A series of rescue experiments revealed that restoring ETS1 expression abolished the tumour‑suppressing effects of miR‑874 in cervical cancer cells. Taken together, the results of the present study indicated that miR‑874 may serve as a tumour suppressor in cervical cancer by directly targeting ETS1. This function suggested that miR‑874 holds potential therapeutic applications in treating patients with this type of malignancy.
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October-2018
Volume 40 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Liao H, Pan Y, Pan Y, Shen J, Qi Q, Zhong L, Han W, Wang Q and Jiang Y: MicroRNA‑874 is downregulated in cervical cancer and inhibits cancer progression by directly targeting ETS1 Retraction in /10.3892/or.2022.8380. Oncol Rep 40: 2389-2398, 2018
APA
Liao, H., Pan, Y., Pan, Y., Shen, J., Qi, Q., Zhong, L. ... Jiang, Y. (2018). MicroRNA‑874 is downregulated in cervical cancer and inhibits cancer progression by directly targeting ETS1 Retraction in /10.3892/or.2022.8380. Oncology Reports, 40, 2389-2398. https://doi.org/10.3892/or.2018.6624
MLA
Liao, H., Pan, Y., Pan, Y., Shen, J., Qi, Q., Zhong, L., Han, W., Wang, Q., Jiang, Y."MicroRNA‑874 is downregulated in cervical cancer and inhibits cancer progression by directly targeting ETS1 Retraction in /10.3892/or.2022.8380". Oncology Reports 40.4 (2018): 2389-2398.
Chicago
Liao, H., Pan, Y., Pan, Y., Shen, J., Qi, Q., Zhong, L., Han, W., Wang, Q., Jiang, Y."MicroRNA‑874 is downregulated in cervical cancer and inhibits cancer progression by directly targeting ETS1 Retraction in /10.3892/or.2022.8380". Oncology Reports 40, no. 4 (2018): 2389-2398. https://doi.org/10.3892/or.2018.6624