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Article

miR‑197 promotes the invasion and migration of colorectal cancer by targeting insulin‑like growth factor‑binding protein 3

  • Authors:
    • Na Zhou
    • Zhao Sun
    • Ningning Li
    • Yuping Ge
    • Jianfeng Zhou
    • Qin Han
    • Lin Zhao
    • Chunmei Bai
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, P.R. China, Department of Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, P.R. China, Institute of Basic Medical Sciences, Chinese Academy ofMedical Sciences, School of Basic Medicine Peking Union Medical College, Beijing 100005, P.R. China
  • Pages: 2710-2721
    |
    Published online on: August 10, 2018
       https://doi.org/10.3892/or.2018.6640
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Abstract

The incidence and mortality of colorectal cancer (CRC) have been rising rapidly in China. A number of miRNAs have been confirmed to be involved in diverse biological processes of CRC. However, whether miR‑197 plays a role in migration and invasion of CRC has never been explored. In the present study Transwell chambers were used in in vitro migration and invasion assays. Dual-luciferase reporter assay was employed to confirm the target of miR‑197. RT‑PCR and IHC staining were performed to quantify miR‑197 and IGFBP3 expression, respectively. Clinicopathological features were collected for statistical analysis. We observed that the overexpression of miR‑197 significantly promoted migration and invasion in 3 CRC cell lines including HCT8, HCT116 and SW480 (P<0.05), while the inhibition of miR‑197 weakened both biological processes (P<0.05). In bioinformatics and dual-luciferase reporter assay, luciferase activities of IGFBP3‑WT‑transfected cells significantly decreased upon miR‑197 overexpression and this inhibitory effect was abolished when miR‑197 binding region in IGFBP3 3'‑UTR was mutated, which indicated that miR‑197 directly suppressed the expression of IGFBP3 in CRC cells by targeting its 3'UTR. Downregulation of the expression of IGFBP3 by using targeted siRNA led to significant enhancement of cell migration and invasion in two CRC cell lines including HCT8 and HCT116 (P<0.05). Finally, in cancerous tissues of CRC patients, the miR‑197 level was inversely correlated with the expression of IGFBP3 (P=0.026), which indicated that miR‑197 may modulate cell migration and invasion by targeting IGFBP3 in CRC patients. In conclusion, we revealed that miR‑197 modulates IGFBP3 and therefore plays a critical role in regulating CRC migration and invasion.
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1 

Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ and He J: Cancer statistics in China, 2015. CA Cancer J Clin. 66:115–132. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Zhang Y, Shi J, Huang H, Ren J, Li N and Dai M: Burden of colorectal cancer in China. Zhonghua Liu Xing Bing Xue Za Zhi. 36:709–914. 2015.(In Chinese). PubMed/NCBI

3 

Chen X, Guo X, Zhang H, Xiang Y, Chen J, Yin Y, Cai X, Wang K, Wang G, Ba Y, et al: Role of miR-143 targeting KRAS in colorectal tumorigenesis. Oncogene. 28:1385–1392. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Mendell JT and Olson EN: MicroRNAs in stress signaling and human disease. Cell. 148:1172–1187. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Yamakuchi M, Ferlito M and Lowenstein CJ: miR-34a repression of SIRT1 regulates apoptosis. Proc Natl Acad Sci USA. 105:13421–13426. 2008. View Article : Google Scholar : PubMed/NCBI

6 

Bommer GT, Gerin I, Feng Y, Kaczorowski AJ, Kuick R, Love RE, Zhai Y, Giordano TJ, Qin ZS, Moore BB, et al: p53-mediated activation of miRNA34 candidate tumor-suppressor genes. Curr Biol. 17:1298–1307. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Xue G, Yan HL, Zhang Y, Hao LQ, Zhu XT, Mei Q and Sun SH: c-Myc-mediated repression of miR-15-16 in hypoxia is induced by increased HIF-2α and promotes tumor angiogenesis and metastasis by upregulating FGF2. Oncogene. 34:1393–1406. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Bracken CP, Gregory PA, Kolesnikoff N, Bert AG, Wang J, Shannon MF and Goodall GJ: A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition. Cancer Res. 68:7846–7854. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Wang DD, Chen X, Yu DD, Yang SJ, Shen HY, Sha HH, Zhong SL, Zhao JH and Tang JH: miR-197: A novel biomarker for cancers. Gene. 591:313–319. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Hamada S, Satoh K, Miura S, Hirota M, Kanno A, Masamune A, Kikuta K, Kume K, Unno J, Egawa S, et al: MiR-197 induces epithelial-mesenchymal transition in pancreatic cancer cells by targeting p120 catenin. J Cell Physiol. 228:1255–1263. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Xu L, Hou Y, Tu G, Chen Y, Du YE, Zhang H, Wen S, Tang X, Yin J, Lang L, et al: Nuclear Drosha enhances cell invasion via an EGFR-ERK1/2-MMP7 signaling pathway induced by dysregulated miRNA-622/197 and their targets LAMC2 and CD82 in gastric cancer. Cell Death Dis. 8:e26422017. View Article : Google Scholar : PubMed/NCBI

12 

Dai W, Wang C, Wang F, Wang Y, Shen M, Chen K, Cheng P, Zhang Y, Yang J, Zhu R, et al: Anti-miR-197 inhibits migration in HCC cells by targeting KAI 1/CD82. Biochem Biophys Res Commun. 446:541–548. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Sun Z, Zhou N, Han Q, Zhao L, Bai C, Chen Y, Zhou J and Zhao RC: MicroRNA-197 influences 5-fluorouracil resistance via thymidylate synthase in colorectal cancer. Clin Transl Oncol. 17:876–883. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Sun Z, Han Q, Zhou N, Wang S, Lu S, Bai C and Zhao RC: Micro RNA-9 enhances migration and invasion through KLF17 in hepatocellular carcinoma. Mol Oncol. 7:884–894. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2−ΔΔCT method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

16 

Fiori ME, Barbini C, Haas TL, Marroncelli N, Patrizii M, Biffoni M and De Maria R: Antitumor effect of miR-197 targeting in p53 wild-type lung cancer. Cell Death Differ. 21:774–782. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Yang Y, Li F, Saha MN, Abdi J, Qiu L and Chang H: miR-137 and miR-197 induce apoptosis and suppress tumorigenicity by targeting MCL-1 in multiple myeloma. Clin Cancer Res. 21:2399–2411. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Tian LQ, Liu EQ, Zhu XD, Wang XG, Li J and Xu GM: MicroRNA-197 inhibits cell proliferation by targeting GAB2 in glioblastoma. Mol Med Rep. 13:4279–4288. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Mavridis K, Gueugnon F, Petit-Courty A, Courty Y, Barascu A, Guyetant S and Scorilas A: The oncomiR miR-197 is a novel prognostic indicator for non-small cell lung cancer patients. Br J Cancer. 112:1527–1535. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Wang R, Wen H, Xu Y, Chen Q, Luo Y, Lin Y, Luo Y and Xu A: Circulating microRNAs as a novel class of diagnostic biomarkers in gastrointestinal tumors detection: A meta-analysis based on 42 articles. PLoS One. 9:e1134012014. View Article : Google Scholar : PubMed/NCBI

21 

Xu M, Kuang Y, Wang M, Han X and Yang Q: A microRNA expression signature as a predictor of survival for colon adenocarcinoma. Neoplasma. 64:56–64. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Firth SM and Baxter RC: Cellular actions of the insulin-like growth factor binding proteins. Endocr Rev. 23:824–854. 2002. View Article : Google Scholar : PubMed/NCBI

23 

Li H, Batth IS, Qu X, Xu L, Song N, Wang R and Liu Y: IGF-IR signaling in epithelial to mesenchymal transition and targeting IGF-IR therapy: Overview and new insights. Mol Cancer. 16:62017. View Article : Google Scholar : PubMed/NCBI

24 

Yao C, Su L, Shan J, Zhu C, Liu L, Liu C, Xu Y, Yang Z, Bian X, Shao J, et al: IGF/STAT3/NANOG/Slug signaling axis simultaneously controls epithelial-mesenchymal transition and stemness maintenance in colorectal cancer. Stem Cells. 34:820–831. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Lee HJ, Lee JS, Hwang SJ and Lee HY: Insulin-like growth factor binding protein-3 inhibits cell adhesion via suppression of integrin β4 expression. Oncotarget. 6:15150–15163. 2015.PubMed/NCBI

26 

Han J, Jogie-Brahim S, Harada A and Oh Y: Insulin-like growth factor-binding protein-3 suppresses tumor growth via activation of caspase-dependent apoptosis and cross-talk with NF-κB signaling. Cancer Lett. 307:200–210. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Buckbinder L, Talbott R, Velasco-Miguel S, Takenaka I, Faha B, Seizinger BR and Kley N: Induction of the growth inhibitor IGF-binding protein 3 by p53. Nature. 377:646–649. 1995. View Article : Google Scholar : PubMed/NCBI

28 

Zielinska HA, Bahl A, Holly JM and Perks CM: Epithelial-to-mesenchymal transition in breast cancer: A role for insulin-like growth factor I and insulin-like growth factor-binding protein 3? Breast Cancer. 7:9–19. 2015.PubMed/NCBI

29 

Yang CH, Yue J, Pfeffer SR, Fan M, Paulus E, Hosni-Ahmed A, Sims M, Qayyum S, Davidoff AM, Handorf CR and Pfeffer LM: MicroRNA-21 promotes glioblastoma tumorigenesis by down-regulating insulin-like growth factor-binding protein-3 (IGFBP3). J Biol Chem. 289:25079–25087. 2014. View Article : Google Scholar : PubMed/NCBI

30 

El Tayebi HM, Waly AA, Assal RA, Hosny KA, Esmat G and Abdelaziz AI: Transcriptional activation of the IGF-II/IGF-1R axis and inhibition of IGFBP-3 by miR-155 in hepatocellular carcinoma. Oncol Lett. 10:3206–3212. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Wang HH, Wang YC, Wu DW, Hung CS, Chen CY and Lee H: Targeting insulin-like growth factor-binding protein-3 by microRNA-125b promotes tumor invasion and poor outcomes in non-small-cell lung cancer. Tumour Biol. 39:10104283176943162017.PubMed/NCBI

32 

Xiong B, Cheng Y, Ma L and Zhang C: MiR-21 regulates biological behavior thourgh the PTEN/PI-3K/Akt signalling pathway in human colorectal cancer cells. Int J Oncol. 42:219–228. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Iwakawa HO and Tomari Y: The functions of microRNAs: mRNA decay and translational respression. Trends Cell Biol. 25:651–665. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Kundu P, Fabian M, Sonenberg N, Bhattacharyya SN and Filipowicz W: HuR protein attenuates miRNA-mediated repression by promoting miRISC dissociation from the target RNA. Nucleic Acids Res. 40:5088–5100. 2012. View Article : Google Scholar : PubMed/NCBI

35 

Haydon AM, Macinnis RJ, English DR, Morris H and Giles GG: Physical activity, insulin-like growth factor 1, insulin-like growth factor binding protein 3, and survival from colorectal cancer. Gut. 55:689–694. 2006. View Article : Google Scholar : PubMed/NCBI

36 

Fu T, Pappou EP, Guzzetta AA, Mde Calmon F, Sun L, Herrera A, Li F, Wolfgang CL, Baylin SB, Iacobuzio-Donahue CA, et al: IGFBP-3 gene methylation in primary tumor predicts recurrence of stage II colorectal cancers. Ann Surg. 263:337–344. 2016. View Article : Google Scholar : PubMed/NCBI

37 

Perez-Carbonell L, Balaguer F, Toiyama Y, Egoavil C, Rojas E, Guarinos C, Andreu M, Llor X, Castells A, Jover R, et al: IGFBP3 methylation is a novel diagnostic and predictive biomarker in colorectal cancer. PLoS One. 9:e1042852014. View Article : Google Scholar : PubMed/NCBI

38 

Wolpin BM, Meyerhardt JA, Chan AT, Ng K, Chan JA, Wu K, Pollak MN, Giovannucci EL and Fuchs CS: Insulin, the insulin-like growth factor axis, and mortality in patients with nonmetastatic colorectal cancer. J Clin Oncol. 27:176–185. 2009. View Article : Google Scholar : PubMed/NCBI

39 

Xue M, Fang Y, Sun G, Zhuo W, Zhong J, Qian C, Wang L, Wang L, Si J and Chen S: IGFBP3, a transcriptional target of homeobox D10, is correlated with the prognosis of gastric cancer. PLoS One. 8:e814232013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhou N, Sun Z, Li N, Ge Y, Zhou J, Han Q, Zhao L and Bai C: miR‑197 promotes the invasion and migration of colorectal cancer by targeting insulin‑like growth factor‑binding protein 3. Oncol Rep 40: 2710-2721, 2018.
APA
Zhou, N., Sun, Z., Li, N., Ge, Y., Zhou, J., Han, Q. ... Bai, C. (2018). miR‑197 promotes the invasion and migration of colorectal cancer by targeting insulin‑like growth factor‑binding protein 3. Oncology Reports, 40, 2710-2721. https://doi.org/10.3892/or.2018.6640
MLA
Zhou, N., Sun, Z., Li, N., Ge, Y., Zhou, J., Han, Q., Zhao, L., Bai, C."miR‑197 promotes the invasion and migration of colorectal cancer by targeting insulin‑like growth factor‑binding protein 3". Oncology Reports 40.5 (2018): 2710-2721.
Chicago
Zhou, N., Sun, Z., Li, N., Ge, Y., Zhou, J., Han, Q., Zhao, L., Bai, C."miR‑197 promotes the invasion and migration of colorectal cancer by targeting insulin‑like growth factor‑binding protein 3". Oncology Reports 40, no. 5 (2018): 2710-2721. https://doi.org/10.3892/or.2018.6640
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou N, Sun Z, Li N, Ge Y, Zhou J, Han Q, Zhao L and Bai C: miR‑197 promotes the invasion and migration of colorectal cancer by targeting insulin‑like growth factor‑binding protein 3. Oncol Rep 40: 2710-2721, 2018.
APA
Zhou, N., Sun, Z., Li, N., Ge, Y., Zhou, J., Han, Q. ... Bai, C. (2018). miR‑197 promotes the invasion and migration of colorectal cancer by targeting insulin‑like growth factor‑binding protein 3. Oncology Reports, 40, 2710-2721. https://doi.org/10.3892/or.2018.6640
MLA
Zhou, N., Sun, Z., Li, N., Ge, Y., Zhou, J., Han, Q., Zhao, L., Bai, C."miR‑197 promotes the invasion and migration of colorectal cancer by targeting insulin‑like growth factor‑binding protein 3". Oncology Reports 40.5 (2018): 2710-2721.
Chicago
Zhou, N., Sun, Z., Li, N., Ge, Y., Zhou, J., Han, Q., Zhao, L., Bai, C."miR‑197 promotes the invasion and migration of colorectal cancer by targeting insulin‑like growth factor‑binding protein 3". Oncology Reports 40, no. 5 (2018): 2710-2721. https://doi.org/10.3892/or.2018.6640
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