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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
November-2018 Volume 40 Issue 5

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review

Epigenetic roles of PIWI‑interacting RNAs (piRNAs) in cancer metastasis (Review)

Jia Liu, Shujun Zhang, Binglin Cheng
Pages: 2423-2434
Published online on: 06 September 2018

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Article Open Access

3‑Bromopyruvate sensitizes human breast cancer cells to TRAIL‑induced apoptosis via the phosphorylated AMPK‑mediated upregulation of DR5 Corrigendum in /10.3892/or.2022.8264

Yuzhong Chen, Li Wei, Xiaojing Zhang, Xianfu Liu, Yansong Chen, Song Zhang, Lanzhu Zhou, Qixiang Li, Qiong Pan, Surong Zhao, Hao Liu
Pages: 2435-2444
Published online on: 14 August 2018

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Article Open Access

CIP2A depletion potentiates the chemosensitivity of cisplatin by inducing increased apoptosis in bladder cancer cells

Fengbin Gao, Xiaojing Wang, Shanwen Chen, Tianyuan Xu, Xianjin Wang, Yifan Shen, Fan Dong, Shan Zhong, Zhoujun Shen
Pages: 2445-2454
Published online on: 10 August 2018

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Article

Generation of PTEN‑knockout (‑/‑) murine prostate cancer cells using the CRISPR/Cas9 system and comprehensive gene expression profiling

Akiko Takao, Kazuhiro Yoshikawa, Sivasundaram Karnan, Akinobu Ota, Hirotsugu Uemura, Marco A. De Velasco, Yurie Kura, Susumu Suzuki, Ryuzo Ueda, Tokiko Nishino, Yoshitaka Hosokawa
Pages: 2455-2466
Published online on: 05 September 2018

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Article Open Access

Risk assessment model constructed by differentially expressed lncRNAs for the prognosis of glioma

Chenggong Hu, Yongfang Zhou, Chang Liu, Yan Kang
Pages: 2467-2476
Published online on: 10 August 2018

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Article Open Access

Knockdown of POLE2 expression suppresses lung adenocarcinoma cell malignant phenotypes in vitro

Jianying Li, Juanhong Wang, Jun Yu, Yuling Zhao, Ya Dong, Yali Fan, Namiao Li, Yingying Zhang, Yili Wang
Pages: 2477-2486
Published online on: 17 August 2018

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Article Open Access

Cytoplasmic expression of SOX9 as a poor prognostic factor for oral squamous cell carcinoma

Yoshimasa Sumita, Manabu Yamazaki, Satoshi Maruyama, Tatsuya Abé, Jun Cheng, Ritsuo Takagi, Jun‑Ichi Tanuma
Pages: 2487-2496
Published online on: 22 August 2018

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Article Open Access

UCA1 overexpression is associated with less aggressive subtypes of bladder cancer

Laetitia Lebrun, Dina Milowich, Marie Le Mercier, Justine Allard, Yves‑Rémi Van Eycke, Thierry Roumeguere, Christine Decaestecker, Isabelle Salmon, Sandrine Rorive
Pages: 2497-2506
Published online on: 10 September 2018

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Article Open Access

lncRNA LINC01296 regulates the proliferation, metastasis and cell cycle of osteosarcoma through cyclin D1

Xin Yu, Lei Pang, Teng Yang, Pengcheng Liu
Pages: 2507-2514
Published online on: 30 August 2018

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Article Open Access

Identification of MMP9 as a novel key gene in mantle cell lymphoma based on bioinformatic analysis and design of cyclic peptides as MMP9 inhibitors based on molecular docking

Wei Yan, Shawn Xiang Li, Minjie Wei, Hua Gao
Pages: 2515-2524
Published online on: 05 September 2018

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Article Open Access

The role of 17β‑estradiol‑induced upregulation of Piwi‑like 4 in modulating gene expression and motility in breast cancer cells

Zealyn Shi Lin Heng, Jing Yi Lee, Charannya Sozheesvari Subhramanyam, Cheng Wang, Lal Zo Thanga, Qidong Hu
Pages: 2525-2535
Published online on: 31 August 2018

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Article Open Access

hsa‑miR‑24 suppresses metastasis in nasopharyngeal carcinoma by regulating the c‑Myc/epithelial‑mesenchymal transition axis

Bojin Su, Tao Xu, Jeff P. Bruce, Kenneth W. Yip, Ning Zhang, Zeli Huang, Guoyi Zhang, Fei‑Fei Liu, Jiyong Liang, Huiling Yang, François X. Claret
Pages: 2536-2546
Published online on: 07 September 2018

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Article Open Access

CRISPR/Cas9‑mediated hypoxia inducible factor‑1α knockout enhances the antitumor effect of transarterial embolization in hepatocellular carcinoma

Quan Liu, Dahua Fan, Dickson Adah, Zhengzhi Wu, Renyan Liu, Qiao‑Ting Yan, Yue Zhang, Zhi‑Yong Du, Dou Wang, Yan Li, Shi‑Yun Bao, Li‑Ping Liu
Pages: 2547-2557
Published online on: 23 August 2018

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Article Open Access

Tumor associated macrophages induce epithelial to mesenchymal transition via the EGFR/ERK1/2 pathway in head and neck squamous cell carcinoma

Lu Gao, Wei Zhang, Wen‑Qun Zhong, Zhuo‑Jue Liu, Hui‑Min Li, Zi‑Li Yu, Yi‑Fang Zhao
Pages: 2558-2572
Published online on: 17 August 2018

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Article Open Access

HOXA10‑AS: A novel oncogenic long non‑coding RNA in glioma

Cheng‑Ya Dong, Jiayue Cui, Dian‑He Li, Qi Li, Xin‑Yu Hong
Pages: 2573-2583
Published online on: 21 August 2018

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Article Open Access

Characterization of selective exosomal microRNA expression profile derived from laryngeal squamous cell carcinoma detected by next generation sequencing

Qiang Huang, Jiechao Yang, Juan Zheng, Chiyao Hsueh, Yang Guo, Liang Zhou
Pages: 2584-2594
Published online on: 24 August 2018

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Article Open Access

Interaction of hematopoietic CD34+ CD45+ stem cells and cancer cells stimulated by TGF‑β1 in a model of glioblastoma in vitro

Elena Milkina, Arina Ponomarenko, Maria Korneyko, Irina Lyakhova, Yulia Zayats, Sergey Zaitsev, Polina Mischenko, Marina Eliseikina, Yuri Khotimchenko, Valeryi Shevchenko, Hari Sharma, Igor Bryukhovetskiy
Pages: 2595-2607
Published online on: 24 August 2018

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Article Open Access

KLF5 promotes the tumorigenesis and metastatic potential of thyroid cancer cells through the NF-κB signaling pathway

Yuehua Ma, Qingzhu Wang, Fei Liu, Xiaojun Ma, Lina Wu, Feng Guo, Shuiying Zhao, Fengjuan Huang, Guijun Qin
Pages: 2608-2618
Published online on: 06 September 2018

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Article Open Access

STAT1‑HDAC4 signaling induces epithelial‑mesenchymal transition and sphere formation of cancer cells overexpressing the oncogene, CUG2

Sirichat Kaowinn, Chutima Kaewpiboon, Sang Seok Koh, Oliver H. Krämer, Young‑Hwa Chung
Pages: 2619-2627
Published online on: 12 September 2018

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Article Open Access

Upregulation of macrophage migration inhibitory factor promotes tumor metastasis and correlates with poor prognosis of pancreatic ductal adenocarcinoma

Dong Wang, Ruizhi Wang, Anpei Huang, Zeng Fang, Kebing Wang, Meifang He, Jin‑Tang Xia, Wen Li
Pages: 2628-2636
Published online on: 12 September 2018

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Article Open Access

An integrated methylation and gene expression microarray analysis reveals significant prognostic biomarkers in oral squamous cell carcinoma

Chenguang Zhao, Huiru Zou, Jun Zhang, Jinhui Wang, Hao Liu
Pages: 2637-2647
Published online on: 12 September 2018

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Article Open Access

Biological functions and clinical significance of the newly identified long non‑coding RNA RP1‑85F18.6 in colorectal cancer

Yeshuo Ma, Yifei Chen, Changwei Lin, Gui Hu
Pages: 2648-2658
Published online on: 10 September 2018

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Article Open Access

Prediction of candidate RNA signatures for recurrent ovarian cancer prognosis by the construction of an integrated competing endogenous RNA network

Xin Wang, Lei Han, Ling Zhou, Li Wang, Lan‑Mei Zhang
Pages: 2659-2673
Published online on: 13 September 2018

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Article

Regulatory mechanism of fatty acid‑CoA metabolic enzymes under endoplasmic reticulum stress in lung cancer

Kuan‑Ting Liu, I‑Jeng Yeh, Shih‑Kai Chou, Meng‑Chi Yen, Po‑Lin Kuo
Pages: 2674-2682
Published online on: 21 August 2018

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Article

MALAT1 promotes angiogenesis of breast cancer

Xiao‑Juan Huang, Yu Xia, Gui‑Fang He, Lu‑Lu Zheng, Yong‑Ping Cai, Yu Yin, Qiang Wu
Pages: 2683-2689
Published online on: 13 September 2018

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Article

EGF ligand fused to truncated Pseudomonas aeruginosa exotoxin A specifically targets and inhibits EGFR‑positive cancer cells

Saeed M. Hashimi, Brock Grant, Naif Alqurashi, Faisal Alowaidi, Ming Q. Wei
Pages: 2690-2697
Published online on: 06 September 2018

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Article

Low expression of LINC00982 and PRDM16 is associated with altered gene expression, damaged pathways and poor survival in lung adenocarcinoma

Wenwen Lv, Xiao Yu, Wenxing Li, Nannan Feng, Tienan Feng, Yu Wang, Hongyan Lin, Biyun Qian
Pages: 2698-2709
Published online on: 14 August 2018

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Article

miR‑197 promotes the invasion and migration of colorectal cancer by targeting insulin‑like growth factor‑binding protein 3

Na Zhou, Zhao Sun, Ningning Li, Yuping Ge, Jianfeng Zhou, Qin Han, Lin Zhao, Chunmei Bai
Pages: 2710-2721
Published online on: 10 August 2018

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Article

B7‑H3 promotes malignant progression of muscle‑invasive bladder cancer

Zhi‑Li Xu, Yi Zhang, Ling Wang, Feng Li, Hong‑Wei Man, Peng‑Fei Li, Bao‑En Shan
Pages: 2722-2733
Published online on: 17 August 2018

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Article

C‑C chemokine receptor type 2 promotes epithelial‑to‑mesenchymal transition by upregulating matrix metalloproteinase‑2 in human liver cancer

Huijin Li, Hui Li, Xiao‑Peng Li, Haojun Zou, Liting Liu, Wangqiao Liu, Tao Duan
Pages: 2734-2741
Published online on: 17 August 2018

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Article

APOBEC3B is expressed in human glioma, and influences cell proliferation and temozolomide resistance

Christina Schmitt, Ralph Lucius, Michael Synowitz, Janka Held‑Feindt, Kirsten Hattermann
Pages: 2742-2749
Published online on: 10 September 2018

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Article

MicroRNA‑342‑3p suppresses proliferation and invasion of nasopharyngeal carcinoma cells by directly targeting Cdc42

Lu Shi, Ruowen Xiao, Menghe Wang, Meiyin Zhang, Nuoqing Weng, Xinge Zhao, X.f. Steven Zheng, Huiyun Wang, Shijuan Mai
Pages: 2750-2757
Published online on: 10 August 2018

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Article

Resveratrol inhibited the progression of human hepatocellular carcinoma by inducing autophagy via regulating p53 and the phosphoinositide 3‑kinase/protein kinase B pathway

Baichao Zhang, Xiaoning Yin, Shaoguang Sui
Pages: 2758-2765
Published online on: 17 August 2018

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Article

Breast cancer is associated with methylation and expression of the a disintegrin and metalloproteinase domain 33 (ADAM33) gene affected by endocrine‑disrupting chemicals

Pei‑Jing Yang, Ming‑Feng Hou, Eing‑Mei Tsai, Shih‑Shin Liang, Chien‑Chih Chiu, Fu Ou‑Yang, Jung‑Yu Kan, Chiung‑Yu Peng, Tsu‑Nai Wang
Pages: 2766-2777
Published online on: 30 August 2018

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Article

Low expression of BEX1 predicts poor prognosis in patients with esophageal squamous cell cancer

Hai‑Tao Geng, Zhi‑Wen Cheng, Rui‑Juan Cao, Zhen‑Bo Wang, Shao‑Zhi Xing, Chen Guo, Feng Wang, Chang‑Min Liu, Shao‑Shui Chen, Yu‑Feng Cheng
Pages: 2778-2787
Published online on: 17 August 2018

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Article

Lactate dehydrogenase is correlated with clinical stage and grade and is downregulated by si‑SAΤB1 in ovarian cancer

Jiangdong Xiang, Lina Zhou, Yan Zhuang, Jin Zhang, Ya Sun, Shuangdi Li, Zhenbo Zhang, Gao Zhang, Yinyan He
Pages: 2788-2797
Published online on: 17 August 2018

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Article

Inhibition of miR‑21 promotes cell apoptosis in oral squamous cell carcinoma by upregulating PTEN

Yanliang Zheng, Jingfang Xie, Fangfang Jiang, Yunyun Li, Guanlin Chang, Haiqing Ma
Pages: 2798-2805
Published online on: 21 August 2018

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Article

miR‑20b negatively regulates VEGF expression by targeting STAT3 in H22 hepatocellular carcinoma cells

Yulan Luo, Jing He, Xiangnan Tao, Helong Wang, Qiang Fang, Shujun Guo, Chuanwang Song
Pages: 2806-2813
Published online on: 17 August 2018

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Article

Long non-coding RNA MYU promotes prostate cancer proliferation by mediating the miR-184/c-Myc axis

Jinhua Wang, Xiaohui Yang, Rong Li, Liang Wang, Yinmin Gu, Yuhui Zhao, Kuo Hsiang Huang, Tianyou Cheng, Yi Yuan, Shan Gao
Pages: 2814-2825
Published online on: 20 August 2018

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Article

A novel clinical multidimensional transcriptome signature predicts prognosis in bladder cancer

Chun‑Peng Liu, Jian‑Hua Zhang, Shuai‑Chao Zheng, Jing Liu, Jin‑Cheng Guo
Pages: 2826-2835
Published online on: 31 August 2018

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Article

2'‑Hydroxyflavanone inhibits epithelial‑mesenchymal transition, and cell migration and invasion via suppression of the Wnt/β‑catenin signaling pathway in prostate cancer Corrigendum in /10.3892/or.2025.8935

Shiqi Wu, Jun Huang, Ke Hui, Yangyang Yue, Yanan Gu, Zhongyun Ning, Xinyang Wang, Dalin He, Kaijie Wu
Pages: 2836-2843
Published online on: 31 August 2018

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Article

Inhibition of epithelial‑mesenchymal transition in gastric cancer cells by miR‑711‑mediated downregulation of CD44 expression

Wei‑Sheng Xiao, De‑Feng Li, Ya‑Ping Tang, Yan‑Zhu Chen, Wen‑Bing Deng, Juan Chen, Wei‑Wei Zhou, Ai‑Jun Liao
Pages: 2844-2853
Published online on: 04 September 2018

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Article

Dermcidin as a novel binding protein of lncRNA STCAT3 and its effect on prognosis in gastric cancer

Jianfeng Zhang, Weifeng Ding, Xiaoling Kuai, Yimin Ji, Zhenglong Zhu, Zhenbiao Mao, Zhiwei Wang
Pages: 2854-2863
Published online on: 24 August 2018

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Article

Effects of microRNA‑125b on multiple myeloma cell growth in vitro and in vivo

Yanxia Jiang, Jianghua Ding, Jing Li, Guoan Chen
Pages: 2864-2875
Published online on: 23 August 2018

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Article

TAB3 promotes human esophageal squamous cell carcinoma proliferation and invasion via the NF‑κB pathway

Jiyi Zhao, Ling Gai, Yi Gao, Wenkai Xia, Dong Shen, Qingfeng Lin, Weidong Mao, Fangjun Wang, Pengfei Liu, Jie Chen
Pages: 2876-2885
Published online on: 06 September 2018

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Article

Sinomenine hydrochloride sensitizes cervical cancer cells to ionizing radiation by impairing DNA damage response

Dan Zhang, Yiping Dong, Ying Zhao, Congya Zhou, Yuanjie Qian, Muralidhar L. Hegde, Haibo Wang, Suxia Han
Pages: 2886-2895
Published online on: 10 September 2018

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Article

18F‑alfatide positron emission tomography may predict anti‑angiogenic responses

Jie Liu, Dongxu Wang, Xue Meng, Xindong Sun, Shuanghu Yuan, Jinming Yu
Pages: 2896-2905
Published online on: 10 September 2018

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Article

Prognostic value of monocarboxylate transporter 4 in patients with esophageal squamous cell carcinoma

Bo Cheng, Xuan Chen, Yankang Li, Xiaochen Huang, Jinming Yu
Pages: 2906-2915
Published online on: 13 September 2018

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Article

The interaction between miR‑148a and DNMT1 suppresses cell migration and invasion by reactivating tumor suppressor genes in pancreatic cancer

Le Hong, Gen Sun, Long Peng, Yi Tu, Zhen Wan, Haiwei Xiong, Yong Li, Weidong Xiao
Pages: 2916-2925
Published online on: 12 September 2018

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Article

Cryptotanshinone inhibits cellular proliferation of human lung cancer cells through downregulation ofIGF-1R/PI3K/Akt signaling pathway

Jingtao Zhang, Guilan Wen, Longhua Sun, Wenxin Yuan, Ran Wang, Qinghua Zeng, Guangyi Zhang, Bentong Yu
Pages: 2926-2934
Published online on: 10 August 2018

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Article

A novel peptide targets CD105 for tumour imaging in vivo

Xiaolong Li, Xiaofeng Huang, Jing Zhang, Hongxing Huang, Long Zhao, Mei Yu, Yan Zhang, Hua Wang
Pages: 2935-2943
Published online on: 14 August 2018

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Article

MicroRNA‑145 inhibits migration and induces apoptosis in human non‑small cell lung cancer cells through regulation of the EGFR/PI3K/AKT signaling pathway

Bin Li, Cui‑Min Ding, Yan‑Xiao Li, Jing‑Cui Peng, Nan Geng, Wen‑Wen Qin
Pages: 2944-2954
Published online on: 23 August 2018

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Article

miR‑21‑5p targets PDHA1 to regulate glycolysis and cancer progression in gastric cancer

Zhuo Liu, Miao Yu, Bingyuan Fei, Xuedong Fang, Tonghui Ma, Dongxin Wang
Pages: 2955-2963
Published online on: 10 September 2018

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Article

Profile and validation of dysregulated long non‑coding RNAs and mRNAs in ovarian cancer

Yan‑Ming Lu, Yue Wang, Shi‑Qi Liu, Meng‑Ya Zhou, Ya‑Ru Guo
Pages: 2964-2976
Published online on: 17 August 2018

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Article

C16‑ceramide and sphingosine 1‑phosphate/S1PR2 have opposite effects on cell growth through mTOR signaling pathway regulation

Min Hee Kim, Joo‑Won Park, Eun‑Ji Lee, Shin Kim, Sun‑Hye Shin, Jung‑Hyuck Ahn, Yunjae Jung, Inkeun Park, Woo‑Jae Park
Pages: 2977-2987
Published online on: 07 September 2018

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Article

Downregulation of DLL4 predicts poor survival in non‑small cell lung cancer patients due to promotion of lymph node metastasis

Hongzhou Liu, Jie Peng, Meizhen Zhao, Pei Ma, Jun Zhong, Shuang Li, Zhongxin Lu
Pages: 2988-2996
Published online on: 31 August 2018

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Article

Increasing HER2 α2,6 sialylation facilitates gastric cancer progression and resistance via the Akt and ERK pathways

Naihua Liu, Menglu Zhu, Yingjie Linhai, Yuwei Song, Xiujuan Gui, Guoqiang Tan, Jinyuan Li, Yan Liu, Zhendong Deng, Xiaoting Chen, Jing Wang, Lili Jia, Xiuzhen He, Xiaoyu Wang, Shaoqiang Lin
Pages: 2997-3005
Published online on: 31 August 2018

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Article

Human umbilical vein endothelial cell vaccine suppresses the angiogenesis of esophageal squamous cell carcinoma in a humanized mouse model

Hangfan Liu, Jimin Zhao, Yi Yang, Guoguo Jin, Xiaoyan Zhang, Dongyu Wang, Chao Xie, Kangdong Liu, Xinhuan Chen, Xiang Li, Fang Tian, Ziming Dong, Jing Lu
Pages: 3006-3014
Published online on: 17 August 2018

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Article

Norepinephrine enhances cell viability and invasion, and inhibits apoptosis of pancreatic cancer cells in a Notch‑1‑dependent manner

Weikun Qian, Shifang Lv, Jie Li, Ke Chen, Zhengdong Jiang, Liang Cheng, Cancan Zhou, Bin Yan, Junyu Cao, Qingyong Ma, Wanxing Duan
Pages: 3015-3023
Published online on: 10 September 2018

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Article

Antitumor activity of the plant extract morin in tongue squamous cell carcinoma cells

Yawen Ji, Linglu Jia, Yunpeng Zhang, Yixiao Xing, Xuan Wu, Bin Zhao, Dondjiao Zhang, Xin Xu, Xu Qiao
Pages: 3024-3032
Published online on: 17 August 2018

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Article

Serum‑free‑medium‑type mesenchymal stem cell culture supernatant exerts a protective effect on A549 lung epithelial cells in acute lung injury induced by H2O2 Retraction in /10.3892/or.2019.7087

Jian Wu, An‑Quan Shang, Chu Chen, Wei‑Wei Wang, Cun‑Quan Xiong, Nai‑Zhou Guo
Pages: 3033-3039
Published online on: 17 August 2018

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Article

Circadian clock gene Per2 downregulation in non‑small cell lung cancer is associated with tumour progression and metastasis

Run Xiang, Yue Cui, Yanping Wang, Tianpeng Xie, Xiaojun Yang, Zhu Wang, Juan Li, Qiang Li
Pages: 3040-3048
Published online on: 13 September 2018

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Article

Overexpression of Epsin 3 enhances migration and invasion of glioma cells by inducing epithelial‑mesenchymal transition

Yaru Wang, Wen Song, Pengcheng Kan, Chao Huang, Zhuolin Ma, Qiaoli Wu, Xiuhua Yao, Biao Zhang
Pages: 3049-3059
Published online on: 10 September 2018

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Article

Allergen‑removed Rhus verniciflua Stokes suppresses invasion and migration of pancreatic cancer cells through downregulation of the JAK/STAT and Src/FAK signaling pathways

Youra Kang, Seong Woo Yoon, Byoungduck Park
Pages: 3060-3068
Published online on: 12 September 2018

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Article

Lysines 207 and 325 methylation of WDR5 catalyzed by SETD6 promotes breast cancer cell proliferation and migration

Ruosi Yao, Yingli Wang, Danyang Han, Yuhui Ma, Musong Ma, Yaping Zhao, Jiang Tan, Jun Lu, Guiying Xu, Xiaoxue Li
Pages: 3069-3077
Published online on: 23 August 2018

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Article

Clinical relevance of the multidrug resistance‑associated protein 1 gene in non‑small cell lung cancer: A systematic review and meta‑analysis

Penghui Hu, Patrick Ting‑Yat Wong, Qinghua Zhou, Lianghe Sheng, Wenbo Niu, Size Chen, Meng Xu, Yiguang Lin
Pages: 3078-3091
Published online on: 17 August 2018

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Article

microRNA‑572 functions as an oncogene and a potential biomarker for renal cell carcinoma prognosis

Xiang Pan, Zuwei Li, Liwen Zhao, Jing Quan, Liang Zhou, Jinling Xu, Weiji Xu, Xin Guan, Hang Li, Shangqi Yang, Yaoting Gui, Yongqing Lai
Pages: 3092-3101
Published online on: 17 August 2018

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Article

Tanshinone IIA can inhibit MiaPaCa‑2 human pancreatic cancer cells by dual blockade of the Ras/Raf/MEK/ERK and PI3K/AKT/mTOR pathways

Chin‑Cheng Su
Pages: 3102-3111
Published online on: 23 August 2018

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Retraction Open Access

[Retracted] Long non‑coding RNA MALAT1 interacts with miR‑124 and modulates tongue cancer growth by targeting JAG1

Tong‑Han Zhang, Li‑Zhong Liang, Xiao‑Ling Liu, Ji‑Nan Wu, Kui Su, Jue‑Yao Chen, Qiao‑Yi Zheng, Hong‑Zhang Huang, Gui‑Qing Liao
Pages: 3112-3112
Published online on: 06 September 2018

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Correction Open Access

[Corrigendum] Intratumoral injection of PKR shRNA expressing plasmid inhibits B16-F10 melanoma growth

Nayara Delgado André, Viviane Aline Oliveira Silva, Maria Angelica Ehara Watanabe, Fernando Luiz De Lucca
Pages: 3113-3113
Published online on: 14 August 2018

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Journal Cover
January-2026 Volume 55 Issue 1

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review Open Access

Harnessing ferroptosis for cancer therapy: Mechanisms and therapeutic strategies (Review)

Nabil Mouawad, Nour El Jaafari, Mirvat El Sibai, Ralph J. Abi-Habib
Article Number: 24
Published online on: 24 November 2025

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Expression of Concern Open Access

[Expression of Concern] Promoter methylation of death‑associated protein kinase and its role in irradiation response in cervical cancer

Rebecca Ching-Yu Leung, Stephanie Si Liu, Kelvin Yuen-Kwong Chan, Kar-Fai Tam, Kar-Loen Chan, Ling-Chui Wong, Hextan Yuen-Sheung Ngan
Article Number: 23
Published online on: 24 November 2025

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Article Open Access

Oxaliplatin resistance in pancreatic ductal adenocarcinoma is non‑significantly mediated by diminished drug uptake but is highly linked to a poor apoptotic response to the cytotoxic threat

Hellen Röttgen, Lana Theurer, Teresa Peccerella, Ketaki Sandu, Johanna Weiss, Jürgen Burhenne, John P. Neoptolemos, Beate Köberle, Dirk Theile
Article Number: 22
Published online on: 19 November 2025

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Correction Open Access

[Corrigendum] Src homology phosphotyrosyl phosphatase 2 mediates cisplatin‑related drug resistance by inhibiting apoptosis and activating the Ras/PI3K/Akt1/survivin pathway in lung cancer cells

Chunlan Tang, Hu Luo, Dan Luo, Heping Yang, Xiangdong Zhou
Article Number: 21
Published online on: 19 November 2025

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Article Open Access

S100B drives glioblastoma invasion and migration through TGF‑β2‑mediated epithelial‑mesenchymal transition

Xuemei Liao, Yuan Xu, Honghong Zhou, Qin Yi, Shifang Dong, Bin Tan
Article Number: 20
Published online on: 19 November 2025

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Review Open Access

Role of the SOX family in non‑small cell lung cancer: Molecular mechanisms and therapeutic implications (Review)

Kaiwei Wang, Yaoqi Li, Zhening Guo, Lin Song, Xiaoliang Ding, Linsheng Liu, Tao Hu, Yicong Bian, Chenrong Huang, Liyan Miao
Article Number: 19
Published online on: 18 November 2025

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Retraction Open Access

[Retracted] MicroRNA‑18a enhances the radiosensitivity of cervical cancer cells by promoting radiation‑induced apoptosis

Sha Liu, Xiaofen Pan, Qin Yang, Lu Wen, Yao Jiang, Yingchao Zhao, Guiling Li
Article Number: 18
Published online on: 17 November 2025

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Review Open Access

Role of histone deacetylases in blood cancer: Exploring peptide‑based inhibitors as therapeutic strategies for leukemia treatment (Review)

Yaneenart Suwanwong, Phornthip Ploensil
Article Number: 17
Published online on: 14 November 2025

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Review Open Access

The multidimensional regulatory network of the PD‑1/PD‑L1 axis in the esophageal squamous cell carcinoma microenvironment: Implications for novel combination therapies and precision immunotherapy (Review)

Haoyue Lai, Lu Qi, Zhixuan Lin, Zhongwen Li
Article Number: 16
Published online on: 13 November 2025

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Review Open Access

From modification to malignancy: Bridging acetylation mechanisms and therapeutic innovations in melanoma (Review)

Jingwen Wu, Xuxia Cai, Zimo Zhu, Xiahong Li, Kaoyuan Zhang, Chenchen Wu, Bo Yu, Cong Huang
Article Number: 15
Published online on: 12 November 2025

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Retraction Open Access

[Retracted] MicroRNA‑92b promotes tumor growth and activation of NF‑κB signaling via regulation of NLK in oral squamous cell carcinoma

Zhiming Liu, Cynthia Diep, Tiantian Mao, Li Huang, Robert Merrill, Zhouwen Zhang, Youjian Peng
Article Number: 14
Published online on: 11 November 2025

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Article Open Access

C‑terminal HSP90 inhibitor NCT‑58 impairs the cancer stem‑like phenotype and enhances chemotherapy efficacy in TNBC

Eunsun Jung, Yoon-Jae Kim, Kyoungmin Lee, Seojin Jang, Soeun Park, Eunhye Oh, Minsu Park, Seongjae Kim, Dongmi Ko, Yong Koo Kang, Kee Dal Nam, Lee Farrand, Cong-Truong Nguyen, Minh Thanh La, Jihyae Ann, Jeewoo Lee, Ji Young Kim, Jae Hong Seo
Article Number: 13
Published online on: 11 November 2025

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Correction Open Access

[Corrigendum] Compound 225# inhibits the proliferation of human colorectal cancer cells by promoting cell cycle arrest and apoptosis induction

Xiaoxue Zhang, Liujun He, Yong Li, Yifei Qiu, Wujing Hu, Wanying Lu, Huihui Du, Donglin Yang
Article Number: 12
Published online on: 06 November 2025

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Review Open Access

Immune system, inflammatory response, and regulated cell death in breast cancer research (Review)

Guangyao Li, Binghui Jin, Jialin Zhou, Shifeng Fang, Zhe Fan
Article Number: 11
Published online on: 05 November 2025

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Retraction Open Access

[Retracted] Uvangoletin induces mitochondria‑mediated apoptosis in HL‑60 cells in vitro and in vivo without adverse reactions of myelosuppression, leucopenia and gastrointestinal tract disturbances

Zhuanzhen Zheng, Zhenhua Qiao, Rong Gong, Yalin Wang, Yiqun Zhang, Yanping Ma, Li Zhang, Yujin Lu, Bo Jiang, Guoxia Li, Chunxia Dong, Wenliang Chen
Article Number: 10
Published online on: 03 November 2025

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Article Open Access

Characterization of the anticancer effect of mebendazole and its interaction with standard cytotoxic drugs in patient tumor cells ex vivo and in an in vivo mouse model

Sharmineh Mansoori, Kristin Blom, Claes Andersson, Mårten Fryknäs, Rolf Larsson, Peter Nygren
Article Number: 9
Published online on: 31 October 2025

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Correction Open Access

[Corrigendum] Gemcitabine combined with an engineered oncolytic vaccinia virus exhibits a synergistic suppressive effect on the tumor growth of pancreatic cancer

Wanyuan Chen, Weimin Fan, Guoqing Ru, Fang Huang, Xiaming Lu, Xin Zhang, Xiaozhou Mou, Shibing Wang
Article Number: 8
Published online on: 30 October 2025

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Article Open Access

CD44 knockdown and TGF‑β inhibition modulate cell proliferation and invasion in claudin‑low breast cancer cells

Ryoichi Matsunuma, Kazuo Kinoshita, Sae Imada, Shoko Sato, Ryosuke Hayami, Michiko Tsuneizumi
Article Number: 7
Published online on: 30 October 2025

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Retraction Open Access

[Retracted] MicroRNA‑302a targets GAB2 to suppress cell proliferation, migration and invasion of glioma

Jiuhong Ma, Jia Yu, Jingmei Liu, Xing Yang, Miao Lou, Jinghui Liu, Fuqiang Feng, Peigang Ji, Liang Wang
Article Number: 6
Published online on: 27 October 2025

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Article Open Access

LRRC59 inhibits perk pathway‑induced apoptosis and promotes cell proliferation, migration and invasion in colorectal cancer cells

Xingdong Hou, Yuting Wang, Yuzhuo Chen, Peiyan Zhong, Guangzhi Wang, Baicheng Li, Bowei Lu, Hanyu Jiang, Shili Ning
Article Number: 5
Published online on: 23 October 2025

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Article Open Access

Comparative analysis of the efficacy and safety of antibody‑drug conjugates, radionuclide‑drug conjugates and their combination targeting claudin 18.2 in gastric cancer treatment

Huan Du, Xiao-Fei Hao, Bin-Wei Lin, Yu Zhang, Luo Rui, Jing Wang, Ming-Ming Tang, De-Cai Wang, Yi-Han Zhu, Jie Li, Tang-Zhi Dai, Yuchuan Yang, Xia Yang, Xiaobo Du
Article Number: 4
Published online on: 22 October 2025

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Expression of Concern Open Access

[Expression of Concern] CDKN3 is an independent prognostic factor and promotes ovarian carcinoma cell proliferation in ovarian cancer

Tianren Li, Hui Xue, Yi Guo, Kejun Guo
Article Number: 3
Published online on: 16 October 2025

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Review Open Access

Platelet‑circulating tumor cell crosstalk: A pivotal target in cancer diagnosis and therapy (Review)

Lifang Zhang, Ye Yuan, Yan Deng, Lin Wang, Fenghua Chen
Article Number: 2
Published online on: 15 October 2025

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Expression of Concern Open Access

[Expression of Concern] Knockdown of Bmi1 inhibits the stemness properties and tumorigenicity of human bladder cancer stem cell‑like side population cells

Dingjun Zhu, Xuesi Wan, Hai Huang, Xu Chen, Wu Liang, Fengjin Zhao, Tianxin Lin, Jinli Han, Wenlian Xie
Article Number: 1
Published online on: 14 October 2025

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Journal Cover
February-2026 Volume 55 Issue 2

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Article Open Access

Inhibition of primary ciliogenesis enhances efficacy of EGFR‑TKIs against non‑small cell lung cancer cells

Liangliang Jin, Li Wei, Junrui Hua, Rong Zhang, Jiaxin Chen, Jinpeng He, Yanli Yang
Article Number: 30
Published online on: 04 December 2025

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Review

Beyond eradication: Therapeutic reprogramming strategies for cancer normalization (Review)

Aliasgar Shahiwala
Article Number: 29
Published online on: 04 December 2025

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Article Open Access

Saikosaponin D overcomes gemcitabine resistance in pancreatic cancer via AKT/mTOR pathway inhibition and synergistic induction of apoptosis and autophagy

Rui Zheng, Yusi Liu, Sen Zhou, Guimei Liu, Xiaobin Liu, Yiyuan Yang, Yufu Zhang
Article Number: 28
Published online on: 04 December 2025

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Retraction Open Access

[Retracted] Downregulation of Bmi‑1 is associated with suppressed tumorigenesis and induced apoptosis in CD44+ nasopharyngeal carcinoma cancer stem‑like cells

Xinhua Xu, Yang Liu, Jin Su, Daojun Li, Juan Hu, Qiao Huang, Mingqian Lu, Xiaoyan Liu, Jinghua Ren, Weihong Chen, Lidan Sun
Article Number: 27
Published online on: 04 December 2025

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Article Open Access

Prognostic significance of fibroblast senescence and senescence-associated secretory phenotype factor expression in the tumor microenvironment of pancreatic ductal adenocarcinoma

Yuto Kitano, Tomoharu Miyashita, Takeo Shimasaki, Isamu Makino, Yoshio Endo, Yasuhiko Yamamoto, Noriyuki Inaki, Shintaro Yagi
Article Number: 26
Published online on: 03 December 2025

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Retraction Open Access

[Retracted] Sp1‑CD147 positive feedback loop promotes the invasion ability of ovarian cancer

Jing Zhao, Wei Ye, Juan Wu, Lijuan Liu, Lina Yang, Lu Gao, Biliang Chen, Fanglin Zhang, Hong Yang, Yu Li
Article Number: 25
Published online on: 25 November 2025

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