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Article

Low expression of LINC00982 and PRDM16 is associated with altered gene expression, damaged pathways and poor survival in lung adenocarcinoma

  • Authors:
    • Wenwen Lv
    • Xiao Yu
    • Wenxing Li
    • Nannan Feng
    • Tienan Feng
    • Yu Wang
    • Hongyan Lin
    • Biyun Qian
  • View Affiliations / Copyright

    Affiliations: Hongqiao International Institute of Medicine, Shanghai Tongren Hospital/School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, P.R. China, State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, P.R. China
  • Pages: 2698-2709
    |
    Published online on: August 14, 2018
       https://doi.org/10.3892/or.2018.6645
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Abstract

Recently, long non‑coding RNAs (lncRNAs) have been shown to play critical roles in lung adenocarcinoma (LUAD). The present study aimed to explore the effect of LINC00982 and PRDM16 on clinical features and survival in LUAD. We found that LUAD patients demonstrated lower expression and copy number variation but higher methylation of long intergenic non‑protein coding RNA 982 (LINC00982) and PR domain containing 16 (PRDM16) compared with controls. Thus, we divided the LUAD patients into two groups according to the median expression of LINC00982 and PRDM16. Through differential expression, KEGG pathway enrichment and Ingenuity® Pathway Analysis (IPA), we found that patients with low expression of both LINC00982 and PRDM16 presented with more deregulated genes, as well as more significant pathways, than patients with high expression of these two genes. In addition, Kaplan‑Meier curves and Cox proportional hazards models revealed that patients with low expression of LINC00982, PRDM16 or both, showed poorer survival than the groups with high expression of LINC00982, PRDM16. We further used multivariate survival models to verify these results. Furthermore, we confirmed that the expression of LINC00982 and PRDM16 was significantly decreased in LUAD cell lines compared to normal cell lines in vitro. In conclusion, the present study revealed that LINC00982 and PRDM16 may serve as biomarkers or potential drug targets for the diagnosis and therapy of LUAD.
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1 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Gazdar AF: Should we continue to use the term non-small-cell lung cancer? Ann Oncol. 21 Suppl 7:vii225–vii229. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Zonderman AB, Ejiogu N, Norbeck J and Evans MK: The influence of health disparities on targeting cancer prevention efforts. Am J Prev Med. 46 3 Suppl 1:S87–S97. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Kang YH, Kim D and Jin EJ: Down-regulation of phospholipase D stimulates death of lung cancer cells involving up-regulation of the long ncRNA ANRIL. Anticancer Res. 35:2795–2803. 2015.PubMed/NCBI

5 

Liu X, Xiao ZD, Han L, Zhang J, Lee SW, Wang W, Lee H, Zhuang L, Chen J, Lin HK, et al: LncRNA NBR2 engages a metabolic checkpoint by regulating AMPK under energy stress. Nat Cell Biol. 18:431–442. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Wang Y, Guo Q, Zhao Y, Chen J, Wang S, Hu J and Sun Y: BRAF-activated long non-coding RNA contributes to cell proliferation and activates autophagy in papillary thyroid carcinoma. Oncol Lett. 8:1947–1952. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Zhao Y, Guo Q, Chen J, Hu J, Wang S and Sun Y: Role of long non-coding RNA HULC in cell proliferation, apoptosis and tumor metastasis of gastric cancer: A clinical and in vitro investigation. Oncol Rep. 31:358–364. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Feng N, Ching T, Wang Y, Liu B, Lin H, Shi O, Zhang X, Zheng M, Zheng X, Gao M, et al: Analysis of microarray data on gene expression and methylation to identify long non-coding RNAs in non-small cell lung cancer. Sci Rep. 6:372332016. View Article : Google Scholar : PubMed/NCBI

9 

Schmidt LH, Spieker T, Koschmieder S, Schäffers S, Humberg J, Jungen D, Bulk E, Hascher A, Wittmer D, Marra A, et al: The long noncoding MALAT-1 RNA indicates a poor prognosis in non-small cell lung cancer and induces migration and tumor growth. J Thorac Oncol. 6:1984–1992. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Loewen G, Jayawickramarajah J, Zhuo Y and Shan B: Functions of lncRNA HOTAIR in lung cancer. J Hematol Oncol. 7:902014. View Article : Google Scholar : PubMed/NCBI

11 

Fei ZH, Yu XJ, Zhou M, Su HF, Zheng Z and Xie CY: Upregulated expression of long non-coding RNA LINC00982 regulates cell proliferation and its clinical relevance in patients with gastric cancer. Tumour Biol. 37:1983–1993. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Cao WJ, Wu HL, He BS, Zhang YS and Zhang ZY: Analysis of long non-coding RNA expression profiles in gastric cancer. World J Gastroenterol. 19:3658–3664. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Lei Q, Liu X, Fu H, Sun Y, Wang L, Xu G, Wang W, Yu Z, Liu C, Li P, et al: miR-101 reverses hypomethylation of the PRDM16 promoter to disrupt mitochondrial function in astrocytoma cells. Oncotarget. 7:5007–5022. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Zhu S, Xu Y, Song M, Chen G, Wang H, Zhao Y, Wang Z and Li F: PRDM16 is associated with evasion of apoptosis by prostatic cancer cells according to RNA interference screening. Mol Med Rep. 14:3357–3361. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Burghel GJ, Lin WY, Whitehouse H, Brock I, Hammond D, Bury J, Stephenson Y, George R and Cox A: Identification of candidate driver genes in common focal chromosomal aberrations of microsatellite stable colorectal cancer. PLoS One. 8:e838592013. View Article : Google Scholar : PubMed/NCBI

16 

Momi N, Wali RK, Chhaparia A, Calderwood AH, Tiwari AK, Ledbetter SE, DeLaCruz M and Roy HK: Su2000 PRDM16 is a novel proto-oncogene in colorectal cancer (CRC): Modulation of the early warburg effect in field carcinogenesis. Gastroenterology. 150:S6062016. View Article : Google Scholar

17 

Matsuo H, Goyama S, Kamikubo Y and Adachi S: The subtype-specific features of EVI1 and PRDM16 in acute myeloid leukemia. Haematologica. 100:e116–e117. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Li L, Zhao CT, Cui BL, Wu SL, Liu XD, Su Z, Yang J, Wang W, Cui ZG and Zhao HG: Expression of HOXB4, PRDM16 and HOXA9 in patients with acute myeloid leukemia and its clinical significance. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 24:326–331. 2016.(In Chinese). PubMed/NCBI

19 

Tan SX, Hu RC, Liu JJ, Tan YL and Liu WE: Methylation of PRDM2, PRDM5 and PRDM16 genes in lung cancer cells. Int J Clin Exp Pathol. 7:2305–2311. 2014.PubMed/NCBI

20 

Cerami E, Gao J, Dogrusoz U, Gross BE, Sumer SO, Aksoy BA, Jacobsen A, Byrne CJ, Heuer ML, Larsson E, et al: The cBio cancer genomics portal: An open platform for exploring multidimensional cancer genomics data. Cancer Discov. 2:401–404. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Gao J, Aksoy BA, Dogrusoz U, Dresdner G, Gross B, Sumer SO, Sun Y, Jacobsen A, Sinha R, Larsson E, et al: Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal. 6:pl12013. View Article : Google Scholar : PubMed/NCBI

22 

Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W and Smyth GK: limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 43:e472015. View Article : Google Scholar : PubMed/NCBI

23 

Hirsch FR, Varella-Garcia M, Bunn PA Jr, Di Maria MV, Veve R, Bremmes RM, Barón AE, Zeng C and Franklin WA: Epidermal growth factor receptor in non-small-cell lung carcinomas: Correlation between gene copy number and protein expression and impact on prognosis. J Clin Oncol. 21:3798–3807. 2003. View Article : Google Scholar : PubMed/NCBI

24 

Cancer Genome Atlas Research Network: Comprehensive molecular profiling of lung adenocarcinoma. Nature. 511:543–550. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Castillo J, Stueve TR and Marconett CN: Intersecting transcriptomic profiling technologies and long non-coding RNA function in lung adenocarcinoma: Discovery, mechanisms, and therapeutic applications. Oncotarget. 8:81538–81557. 2017. View Article : Google Scholar : PubMed/NCBI

26 

Qiu M, Xu Y, Yang X, Wang J, Hu J, Xu L and Yin R: CCAT2 is a lung adenocarcinoma-specific long non-coding RNA and promotes invasion of non-small cell lung cancer. Tumour Biol. 35:5375–5380. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Lavallée VP, Lemieux S, Boucher G, Gendron P, Boivin I, Girard S, Hébert J and Sauvageau G: Identification of MYC mutations in acute myeloid leukemias with NUP98-NSD1 translocations. Leukemia. 30:1621–1624. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Duhoux FP, Ameye G, Montano-Almendras CP, Bahloula K, Mozziconacci MJ, Laibe S, Wlodarska I, Michaux L, Talmant P, Richebourg S, et al: PRDM16 (1p36) translocations define a distinct entity of myeloid malignancies with poor prognosis but may also occur in lymphoid malignancies. Br J Haematol. 156:76–88. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Vermeulen K, Van Bockstaele DR and Berneman ZN: The cell cycle: A review of regulation, deregulation and therapeutic targets in cancer. Cell Prolif. 36:131–149. 2003. View Article : Google Scholar : PubMed/NCBI

30 

Pagano M and Draetta G: Cyclin A, cell cycle control and oncogenesis. Prog Growth Factor Res. 3:267–277. 1991. View Article : Google Scholar : PubMed/NCBI

31 

Yue W, Zhao X, Zhang L, Xu S, Liu Z, Ma L, Jia W, Qian Z, Zhang C, Wang Y and Yang X: Cell cycle protein cyclin Y is associated with human non-small-cell lung cancer proliferation and tumorigenesis. Clin Lung Cancer. 12:43–50. 2011. View Article : Google Scholar : PubMed/NCBI

32 

Lamb R, Lehn S, Rogerson L, Clarke RB and Landberg G: Cell cycle regulators cyclin D1 and CDK4/6 have estrogen receptor-dependent divergent functions in breast cancer migration and stem cell-like activity. Cell Cycle. 12:2384–2394. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Jhanwar-Uniyal M: BRCA1 in cancer, cell cycle and genomic stability. Front Biosci. 8:s1107–s1117. 2003. View Article : Google Scholar : PubMed/NCBI

34 

Paternot S, Bockstaele L, Bisteau X, Kooken H, Coulonval K and Roger PP: Rb inactivation in cell cycle and cancer: The puzzle of highly regulated activating phosphorylation of CDK4 versus constitutively active CDK-activating kinase. Cell Cycle. 9:689–699. 2010. View Article : Google Scholar : PubMed/NCBI

35 

Chuikov S, Levi BP, Smith ML and Morrison SJ: Prdm16 promotes stem cell maintenance in multiple tissues, partly by regulating oxidative stress. Nat Cell Biol. 12:999–1006. 2010. View Article : Google Scholar : PubMed/NCBI

36 

Wishart DS: Emerging applications of metabolomics in drug discovery and precision medicine. Nat Rev Drug Discov. 15:473–484. 2016. View Article : Google Scholar : PubMed/NCBI

37 

Zhang EB, Yin DD, Sun M, Kong R, Liu XH, You LH, Han L, Xia R, Wang KM, Yang JS, et al: P53-regulated long non-coding RNA TUG1 affects cell proliferation in human non-small cell lung cancer, partly through epigenetically regulating HOXB7 expression. Cell Death Dis. 5:e12432014. View Article : Google Scholar : PubMed/NCBI

38 

Yang X, Song JH, Cheng Y, Wu W, Bhagat T, Yu Y, Abraham JM, Ibrahim S, Ravich W, Roland BC, et al: Long non-coding RNA HNF1A-AS1 regulates proliferation and migration in oesophageal adenocarcinoma cells. Gut. 63:881–890. 2014. View Article : Google Scholar : PubMed/NCBI

39 

Jamal-Hanjani M, Wilson GA, McGranahan N, Birkbak NJ, Watkins TB, Veeriah S, Shafi S, Johnson DH, Mitter R, Rosenthal R, et al: Tracking the evolution of non-small-cell lung cancer. N Engl J Med. 376:2109–2121. 2017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Lv W, Yu X, Li W, Feng N, Feng T, Wang Y, Lin H and Qian B: Low expression of LINC00982 and PRDM16 is associated with altered gene expression, damaged pathways and poor survival in lung adenocarcinoma. Oncol Rep 40: 2698-2709, 2018.
APA
Lv, W., Yu, X., Li, W., Feng, N., Feng, T., Wang, Y. ... Qian, B. (2018). Low expression of LINC00982 and PRDM16 is associated with altered gene expression, damaged pathways and poor survival in lung adenocarcinoma. Oncology Reports, 40, 2698-2709. https://doi.org/10.3892/or.2018.6645
MLA
Lv, W., Yu, X., Li, W., Feng, N., Feng, T., Wang, Y., Lin, H., Qian, B."Low expression of LINC00982 and PRDM16 is associated with altered gene expression, damaged pathways and poor survival in lung adenocarcinoma". Oncology Reports 40.5 (2018): 2698-2709.
Chicago
Lv, W., Yu, X., Li, W., Feng, N., Feng, T., Wang, Y., Lin, H., Qian, B."Low expression of LINC00982 and PRDM16 is associated with altered gene expression, damaged pathways and poor survival in lung adenocarcinoma". Oncology Reports 40, no. 5 (2018): 2698-2709. https://doi.org/10.3892/or.2018.6645
Copy and paste a formatted citation
x
Spandidos Publications style
Lv W, Yu X, Li W, Feng N, Feng T, Wang Y, Lin H and Qian B: Low expression of LINC00982 and PRDM16 is associated with altered gene expression, damaged pathways and poor survival in lung adenocarcinoma. Oncol Rep 40: 2698-2709, 2018.
APA
Lv, W., Yu, X., Li, W., Feng, N., Feng, T., Wang, Y. ... Qian, B. (2018). Low expression of LINC00982 and PRDM16 is associated with altered gene expression, damaged pathways and poor survival in lung adenocarcinoma. Oncology Reports, 40, 2698-2709. https://doi.org/10.3892/or.2018.6645
MLA
Lv, W., Yu, X., Li, W., Feng, N., Feng, T., Wang, Y., Lin, H., Qian, B."Low expression of LINC00982 and PRDM16 is associated with altered gene expression, damaged pathways and poor survival in lung adenocarcinoma". Oncology Reports 40.5 (2018): 2698-2709.
Chicago
Lv, W., Yu, X., Li, W., Feng, N., Feng, T., Wang, Y., Lin, H., Qian, B."Low expression of LINC00982 and PRDM16 is associated with altered gene expression, damaged pathways and poor survival in lung adenocarcinoma". Oncology Reports 40, no. 5 (2018): 2698-2709. https://doi.org/10.3892/or.2018.6645
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