Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
November-2018 Volume 40 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2018 Volume 40 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

TAB3 promotes human esophageal squamous cell carcinoma proliferation and invasion via the NF‑κB pathway

  • Authors:
    • Jiyi Zhao
    • Ling Gai
    • Yi Gao
    • Wenkai Xia
    • Dong Shen
    • Qingfeng Lin
    • Weidong Mao
    • Fangjun Wang
    • Pengfei Liu
    • Jie Chen
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, The Jiangyin Clinical College of Xuzhou Medical University, Wuxi, Jiangsu 214400, P.R. China, Department of Oncology, The Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China, Department of Gastroenterology, The Jiangyin Clinical College of Xuzhou Medical University, Wuxi, Jiangsu 214400, P.R. China, Department of Nephrology, The Jiangyin Clinical College of Xuzhou Medical University, Wuxi, Jiangsu 214400, P.R. China, Department of Oncology, The Jiangyin Clinical College of Xuzhou Medical University, Wuxi, Jiangsu 214400, P.R. China, Department of Oncology, The Jiangyin Clinical College of Xuzhou Medical University, Wuxi, Jiangsu 214400, P.R. China
  • Pages: 2876-2885
    |
    Published online on: September 6, 2018
       https://doi.org/10.3892/or.2018.6686
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Esophageal squamous cell carcinoma (ESCC) has become one of the most common causes of cancer‑associated mortality worldwide. Transforming growth factor‑activated kinase (TAK1)‑binding protein 3 (TAB3) is essential for activation of the NF (NF)‑κB pathway in response to TAK1 activation. The NF‑κB pathway serves important roles in tumor cell proliferation and migration; however, the clinical relevance of TAB3 and its biological function in ESCC progression remain elusive. The present study investigated the expression and function of TAB3 in ESCC tissues, and its association with the clinical prognosis of patients. The results demonstrated that TAB3 expression was significantly increased in human ESCC cell lines and tissue samples, and the expression of TAB3 was associated with ESCC lymph node metastasis, T stage, pathological grade and Ki‑67 expression in 80 ESCC samples, as determined by immunohistochemistry. Patients with ESCC and high TAB3 expression exhibited worse overall survival. Furthermore, knockdown of TAB3 by small interfering RNA inhibited the proliferation of ESCC cells, and reduced the migration and invasion of ESCC cells. In addition, knockdown of TAB3 decreased the expression of the NF‑κB pathway in TE‑1 cells. Taken together, these results demonstrated that TAB3 may be a promising therapeutic target for the treatment of ESCC.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ and He J: Cancer statistics in China, 2015. CA Cancer J Clin. 66:115–132. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2017. CA Cancer J Clin. 67:7–30. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Yano T, Muto M, Minashi K, Iwasaki J, Kojima T, Fuse N, Doi T, Kaneko K and Ohtsu A: Photodynamic therapy as salvage treatment for local failure after chemoradiotherapy in patients with esophageal squamous cell carcinoma: A phase II study. Int J Cancer. 131:1228–1234. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Zhang L, Wu YD, Li P, Tu J, Niu YL, Xu CM and Zhang ST: Effects of cyclooxygenase-2 on human esophageal squamous cell carcinoma. World J Gastroenterol. 17:4572–4580. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Lagergren J, Smyth E, Cunningham D and Lagergren P: Oesophageal cancer. Lancet. 390:2383–2396. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Rustgi AK and El-Serag HB: Esophageal carcinoma. N Engl J Med. 371:2499–2509. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Enzinger PC and Mayer RJ: Esophageal cancer. N Engl J Med. 349:2241–2252. 2003. View Article : Google Scholar : PubMed/NCBI

8 

Takaesu G, Kishida S, Hiyama A, Yamaguchi K, Shibuya H, Irie K, Ninomiya-Tsuji J and Matsumoto K: TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway. Mol Cell. 5:649–658. 2000. View Article : Google Scholar : PubMed/NCBI

9 

Besse A, Lamothe B, Campos AD, Webster WK, Maddineni U, Lin SC, Wu H and Darnay BG: TAK1-dependent signaling requires functional interaction with TAB2/TAB3. J Biol Chem. 282:3918–3928. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Hu Y, Liu JP, Zhu Y and Lu NH: The importance of toll-like receptors in NF-κB signaling pathway activation by helicobacter pylori infection and the regulators of this response. Helicobacter. 21:428–440. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Chen J, Gu J, Feng J, Liu Y, Xue Q, Ni T, Wang Z, Jia L, Mao G and Ji L: TAB3 overexpression promotes cell proliferation in non-small cell lung cancer and mediates chemoresistance to CDDP in A549 cells via the NF-κB pathway. Tumour Biol. 37:3851–3861. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Tao T, He Z, Shao Z and Lu H: TAB3 O-GlcNAcylation promotes metastasis of triple negative breast cancer. Oncotarget. 7:22807–22818. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Chen Y, Wang X, Duan C, Chen J, Su M, Jin Y, Deng Y, Wang D, Chen C, Zhou L, et al: Loss of TAB3 expression by shRNA exhibits suppressive bioactivity and increased chemical sensitivity of ovarian cancer cell lines via the NF-κB pathway. Cell Prolif. 49:657–668. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Sobin LH, Gospodarowicz MK and Wittekind C: TNM classification of malignant tumours. John Wiley & Sons; 2011

15 

Roh YS, Song J and Seki E: TAK1 regulates hepatic cell survival and carcinogenesis. J Gastroenterol. 49:185–194. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Luo C, Yuan R, Chen L, Zhou W, Shen W, Qiu Y and Shao J, Yan J and Shao J: TAB3 upregulates Survivin expression to promote colorectal cancer invasion and metastasis by binding to the TAK1-TRAF6 complex. Oncotarget. 8:106565–106576. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Malumbres M and Carnero A: Cell cycle deregulation: A common motif in cancer. Prog Cell Cycle Res. 5:5–18. 2003.PubMed/NCBI

18 

Boonstra J and Moes MJ: Signal transduction and actin in the regulation of G1-phase progression. Crit Rev Eukaryot Gene Expr. 15:255–276. 2005. View Article : Google Scholar : PubMed/NCBI

19 

Hulleman E and Boonstra J: Regulation of G1 phase progression by growth factors and the extracellular matrix. Cell Mol Life Sci. 58:80–93. 2001. View Article : Google Scholar : PubMed/NCBI

20 

Tashima Y, Hamada H, Okamoto M and Hanai T: Prediction of key factor controlling G1/S phase in the mammalian cell cycle using system analysis. J Biosci Bioeng. 106:368–374. 2008. View Article : Google Scholar : PubMed/NCBI

21 

Gan J, Ke X, Jiang J, Dong H, Yao Z, Lin Y, Lin W, Wu X, Yan S, Zhuang Y, et al: Growth hormone-releasing hormone receptor antagonists inhibit human gastric cancer through downregulation of PAK1-STAT3/NF-kappaB signaling. Proc Natl Acad Sci USA. 113:14745–14750. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Jung JU, Ravi S, Lee DW, McFadden K, Kamradt ML, Toussaint LG and Sitcheran R: NIK/MAP3K14 regulates mitochondrial dynamics and trafficking to promote cell invasion. Curr Biol. 26:3288–3302. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Gan X, Chen B, Shen Z, Liu Y, Li H, Xie X, Xu X, Li H, Huang Z and Chen J: High GPX1 expression promotes esophageal squamous cell carcinoma invasion, migration, proliferation and cisplatin-resistance but can be reduced by vitamin D. Int J Clin Exp Med. 7:2530–2540. 2014.PubMed/NCBI

24 

Han Y, Guo XH, Zheng QF, Zhu YL, Fan YY and Zhang XY: Down-regulation of platelet-derived growth factor-D expression blockades NF-κB pathway to inhibit cell proliferation and invasion as well as induce apoptosis in esophageal squamous cell carcinoma. Mol Biol Rep. 40:2473–2483. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Gao S, Sun Y, Zhang X, Hu L, Liu Y, Chua CY, Phillips LM, Ren H, Fleming JB, Wang H, et al: IGFBP2 activates the NF-κB pathway to drive epithelial-mesenchymal transition and invasive character in pancreatic ductal adenocarcinoma. Cancer Res. 76:6543–6554. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Pires BR, Mencalha AL, Ferreira GM, de Souza WF, Morgado-Díaz JA, Maia AM, Corrêa S and Abdelhay ES: NF-kappaB is involved in the regulation of EMT genes in breast cancer cells. PLoS One. 12:e01696222017. View Article : Google Scholar : PubMed/NCBI

27 

Shin WS, Hong Y, Lee HW and Lee ST: Catalytically defective receptor protein tyrosine kinase PTK7 enhances invasive phenotype by inducing MMP-9 through activation of AP-1 and NF-κB in esophageal squamous cell carcinoma cells. Oncotarget. 7:73242–73256. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Zhou J, Zheng S, Liu T, Liu Q, Chen Y, Tan D, Ma R and Lu X: MCP2 activates NF-κB signaling pathway promoting the migration and invasion of ESCC cells. Cell Biol Int. 42:365–372. 2018. View Article : Google Scholar : PubMed/NCBI

29 

Jin G, Klika A, Callahan M, Faga B, Danzig J, Jiang Z, Li X, Stark GR, Harrington J and Sherf B: Identification of a human NF-kappaB-activating protein, TAB3. Proc Natl Acad Sci USA. 101:2028–2033. 2004. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhao J, Gai L, Gao Y, Xia W, Shen D, Lin Q, Mao W, Wang F, Liu P, Chen J, Chen J, et al: TAB3 promotes human esophageal squamous cell carcinoma proliferation and invasion via the NF‑κB pathway. Oncol Rep 40: 2876-2885, 2018.
APA
Zhao, J., Gai, L., Gao, Y., Xia, W., Shen, D., Lin, Q. ... Chen, J. (2018). TAB3 promotes human esophageal squamous cell carcinoma proliferation and invasion via the NF‑κB pathway. Oncology Reports, 40, 2876-2885. https://doi.org/10.3892/or.2018.6686
MLA
Zhao, J., Gai, L., Gao, Y., Xia, W., Shen, D., Lin, Q., Mao, W., Wang, F., Liu, P., Chen, J."TAB3 promotes human esophageal squamous cell carcinoma proliferation and invasion via the NF‑κB pathway". Oncology Reports 40.5 (2018): 2876-2885.
Chicago
Zhao, J., Gai, L., Gao, Y., Xia, W., Shen, D., Lin, Q., Mao, W., Wang, F., Liu, P., Chen, J."TAB3 promotes human esophageal squamous cell carcinoma proliferation and invasion via the NF‑κB pathway". Oncology Reports 40, no. 5 (2018): 2876-2885. https://doi.org/10.3892/or.2018.6686
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao J, Gai L, Gao Y, Xia W, Shen D, Lin Q, Mao W, Wang F, Liu P, Chen J, Chen J, et al: TAB3 promotes human esophageal squamous cell carcinoma proliferation and invasion via the NF‑κB pathway. Oncol Rep 40: 2876-2885, 2018.
APA
Zhao, J., Gai, L., Gao, Y., Xia, W., Shen, D., Lin, Q. ... Chen, J. (2018). TAB3 promotes human esophageal squamous cell carcinoma proliferation and invasion via the NF‑κB pathway. Oncology Reports, 40, 2876-2885. https://doi.org/10.3892/or.2018.6686
MLA
Zhao, J., Gai, L., Gao, Y., Xia, W., Shen, D., Lin, Q., Mao, W., Wang, F., Liu, P., Chen, J."TAB3 promotes human esophageal squamous cell carcinoma proliferation and invasion via the NF‑κB pathway". Oncology Reports 40.5 (2018): 2876-2885.
Chicago
Zhao, J., Gai, L., Gao, Y., Xia, W., Shen, D., Lin, Q., Mao, W., Wang, F., Liu, P., Chen, J."TAB3 promotes human esophageal squamous cell carcinoma proliferation and invasion via the NF‑κB pathway". Oncology Reports 40, no. 5 (2018): 2876-2885. https://doi.org/10.3892/or.2018.6686
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team