|
1
|
Helleday T, Eshtad S and Nik-Zainal S:
Mechanisms underlying mutational signatures in human cancers. Nat
Rev Genet. 15:585–598. 2014. View
Article : Google Scholar : PubMed/NCBI
|
|
2
|
Kanungo J: DNA-dependent protein kinase
and DNA repair: Relevance to Alzheimer's disease. Alzheimers Res
Ther. 5:132013. View
Article : Google Scholar : PubMed/NCBI
|
|
3
|
Guerrero EN, Wang H, Mitra J, Hegde PM,
Stowell SE, Liachko NF, Kraemer BC, Garruto RM, Rao KS and Hegde
ML: TDP-43/FUS in motor neuron disease: Complexity and challenges.
Prog Neurobiol. 145–146:78–97. 2016. View Article : Google Scholar
|
|
4
|
Polo SE and Jackson SP: Dynamics of DNA
damage response proteins at DNA breaks: A focus on protein
modifications. Genes Dev. 25:409–433. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Freeman AK and Monteiro AN: Phosphatases
in the cellular response to DNA damage. Cell Commun Signal.
8:272010. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Srivastava M and Raghavan SC: DNA
double-strand break repair inhibitors as cancer therapeutics. Chem
Biol. 22:17–29. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Davies H, Glodzik D, Morganella S, Yates
LR, Staaf J, Zou X, Ramakrishna M, Martin S, Boyault S, Sieuwerts
AM, et al: HRDetect is a predictor of BRCA1 and BRCA2
deficiency based on mutational signatures. Nat Med. 23:517–525.
2017. View
Article : Google Scholar : PubMed/NCBI
|
|
8
|
Delaney G, Jacob S, Featherstone C and
Barton M: The role of radiotherapy in cancer treatment: Estimating
optimal utilization from a review of evidence-based clinical
guidelines. Cancer. 104:1129–1137. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Zhang B, Chen J, Ren Z, Chen Y, Li J, Miao
X, Song Y, Zhao T, Li Y, Shi Y, et al: A specific miRNA signature
promotes radioresistance of human cervical cancer cells. Cancer
Cell Int. 13:1182013. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Begg AC, Stewart FA and Vens C: Strategies
to improve radiotherapy with targeted drugs. Nat Rev Cancer.
11:239–253. 2011. View
Article : Google Scholar : PubMed/NCBI
|
|
11
|
Krause M, Dubrovska A, Linge A and Baumann
M: Cancer stem cells: Radioresistance, prediction of radiotherapy
outcome and specific targets for combined treatments. Adv Drug
Deliv Rev. 109:63–73. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Thoms J and Bristow RG: DNA repair
targeting and radiotherapy: A focus on the therapeutic ratio. Semin
Radiat Oncol. 20:217–222. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Mladenova V, Mladenov E and Iliakis G:
Novel biological approaches for testing the contributions of single
DSBs and DSB clusters to the biological effects of high LET
radiation. Front Oncol. 6:1632016. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Malik A, Sultana M, Qazi A, Qazi MH,
Parveen G, Waquar S, Ashraf AB and Rasool M: Role of natural
radiosensitizers and cancer cell radioresistance: An update. Anal
Cell Pathol. 2016:61465952016. View Article : Google Scholar
|
|
15
|
Hegde ML: Molecular characterization of
neuroprotective activities of plant based products could revive
their utilization and lead discovery of new drug candidates for
brain diseases. J Pharm Bioallied Sci. 6:63–64. 2014.PubMed/NCBI
|
|
16
|
Yamasaki H: Pharmacology of sinomenine, an
anti-rheumatic alkaloid from sinomenium acutum. Acta Med Okayama.
30:1–20. 1976.PubMed/NCBI
|
|
17
|
Kok TW, Yue PY, Mak NK, Fan TP, Liu L and
Wong RN: The anti-angiogenic effect of sinomenine. Angiogenesis.
8:3–12. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Ju XD, Deng M, Ao YF, Yu CL, Wang JQ, Yu
JK, Cui GQ and Hu YL: Protective effect of sinomenine on cartilage
degradation and chondrocytes apoptosis. Yakugaku Zasshi.
130:1053–1060. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Wang Q and Li XK: Immunosuppressive and
anti-inflammatory activities of sinomenine. Int Immunopharmacol.
11:373–376. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Teng P, Liu HL, Zhang L, Feng LL, Huai Y,
Deng ZS, Sun Y, Xu Q and Li JX: Synthesis and biological evaluation
of novel sinomenine derivatives as anti-inflammatory agents. Eur J
Med Chem. 50:63–74. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Shu L, Yin W, Zhang J, Tang B, Kang YX,
Ding F and Hua ZC: Sinomenine inhibits primary CD4+
T-cell proliferation via apoptosis. Cell Biol Int. 31:784–789.
2007. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Zhu Q, Sun Y, Zhu J, Fang T, Zhang W and
Li JX: Antinociceptive effects of sinomenine in a rat model of
neuropathic pain. Sci Rep. 4:72702014. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Jiang T, Zhou L, Zhang W, Qu D, Xu X, Yang
Y and Li S: Effects of sinomenine on proliferation and apoptosis in
human lung cancer cell line NCI-H460 in vitro. Mol Med Rep.
3:51–56. 2010.PubMed/NCBI
|
|
24
|
Lv Y, Li C, Li S and Hao Z: Sinomenine
inhibits proliferation of SGC-7901 gastric adenocarcinoma cells via
suppression of cyclooxygenase-2 expression. Oncol Lett. 2:741–745.
2011. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Lu XL, Zeng J, Chen YL, He PM, Wen MX, Ren
MD, Hu YN, Lu GF and He SX: Sinomenine hydrochloride inhibits human
hepatocellular carcinoma cell growth in vitro and in vivo:
Involvement of cell cycle arrest and apoptosis induction. Int J
Oncol. 42:229–238. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Song L, Liu D, Zhao Y, He J, Kang H, Dai
Z, Wang X, Zhang S and Zan Y: Sinomenine inhibits breast cancer
cell invasion and migration by suppressing NF-κB activation
mediated by IL-4/miR-324-5p/CUEDC2 axis. Biochem Biophys Res
Commun. 464:705–710. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Hasselbach L, Haase S, Fischer D, Kolberg
HC and Sturzbecher HW: Characterisation of the promoter region of
the human DNA-repair gene rad51. Eur J Gynaecol Oncol. 26:589–598.
2005.PubMed/NCBI
|
|
28
|
Li X, Wang K, Ren Y, Zhang L, Tang XJ,
Zhang HM, Zhao CQ, Liu PJ, Zhang JM and He JJ: MAPK signaling
mediates sinomenine hydrochloride-induced human breast cancer cell
death via both reactive oxygen species-dependent and -independent
pathways: An in vitro and in vivo study. Cell Death Dis.
5:e13562014. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Rogakou EP, Pilch DR, Orr AH, Ivanova VS
and Bonner WM: DNA double-stranded breaks induce histone H2AX
phosphorylation on serine 139. J Biol Chem. 273:5858–5868. 1998.
View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Wang H, Adhikari S, Butler BE, Pandita TK,
Mitra S and Hegde ML: A perspective on chromosomal double strand
break markers in mammalian cells. Jacobs J Radiat Oncol.
1:0032014.PubMed/NCBI
|
|
31
|
Sancar A, Lindsey-Boltz LA, Unsal-Kacmaz K
and Linn S: Molecular mechanisms of mammalian DNA repair and the
DNA damage checkpoints. Annu Rev Biochem. 73:39–85. 2004.
View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Wang Y, Cheng J, Li D, Duan H, Yang H, Bin
P, Dai Y, Huang C, Liang X, Leng S, et al: Modulation of DNA repair
capacity by ataxia telangiectasia mutated gene polymorphisms among
polycyclic aromatic hydrocarbons-exposed studyers. Toxicol Sci.
124:99–108. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Wilson KA and Stern DF: NFBD1/MDC1, 53BP1
and BRCA1 have both redundant and unique roles in the ATM pathway.
Cell Cycle. 7:3584–3594. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Carlessi L, Buscemi G, Fontanella E and
Delia D: A protein phosphatase feedback mechanism regulates the
basal phosphorylation of Chk2 kinase in the absence of DNA damage.
Biochim Biophys Acta. 1803:1213–1223. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Choi KS, Kim JY, Lim SK, Choi YW, Kim YH,
Kang SY, Park TJ and Lim IK: TIS21/BTG2/PC3 accelerates
the repair of DNA double strand breaks by enhancing Mre11
methylation and blocking damage signal transfer to the
Chk2T68-p53S20 pathway. DNA Repair (Amst).
11:965–975. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Sorensen CS, Syljuasen RG, Falck J,
Schroeder T, Ronnstrand L, Khanna KK, Zhou BB, Bartek J and Lukas
J: Chk1 regulates the S phase checkpoint by coupling the
physiological turnover and ionizing radiation-induced accelerated
proteolysis of Cdc25A. Cancer Cell. 3:247–258. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Gamper AM, Rofougaran R, Watkins SC,
Greenberger JS, Beumer JH and Bakkenist CJ: ATR kinase activation
in G1 phase facilitates the repair of ionizing radiation-induced
DNA damage. Nucleic Acids Res. 41:10334–10344. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Yang H, Li LW, Shi M, Wang JH, Xiao F,
Zhou B, Diao LQ, Long XL, Liu XL and Xu L: In vivo study of breast
carcinoma radiosensitization by targeting eIF4E. Biochem Biophys
Res Commun. 423:878–883. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Kim JS, Amorino GP, Pyo H, Cao Q, Price JO
and Choy H: The novel taxane analogs, BMS-184476 and BMS-188797,
potentiate the effects of radiation therapy in vitro and in vivo
against human lung cancer cells. Int J Radiat Oncol Biol Phys.
51:525–534. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Torre LA, Islami F, Siegel RL, Ward EM and
Jemal A: Global cancer in women: Burden and trends. Cancer
Epidemiol Biomarkers Prev. 26:444–457. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Kitahara O, Katagiri T, Tsunoda T, Harima
Y and Nakamura Y: Classification of sensitivity or resistance of
cervical cancers to ionizing radiation according to expression
profiles of 62 genes selected by cDNA microarray analysis.
Neoplasia. 4:295–303. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Qin C, Chen X, Bai Q, Davis MR and Fang Y:
Factors associated with radiosensitivity of cervical cancer.
Anticancer Res. 34:4649–4656. 2014.PubMed/NCBI
|
|
43
|
Jeon YT, Song YC, Kim SH, Wu HG, Kim IH,
Park IA, Kim JW, Park NH, Kang SB, Lee HP, et al: Influences of
cyclooxygenase-1 and −2 expression on the radiosensitivities of
human cervical cancer cell lines. Cancer Lett. 256:33–38. 2007.
View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Beskow C, Skikuniene J, Holgersson A,
Nilsson B, Lewensohn R, Kanter L and Viktorsson K: Radioresistant
cervical cancer shows upregulation of the NHEJ proteins DNA-PKcs,
Ku70 and Ku86. Br J Cancer. 101:816–821. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Qing Y, Yang XQ, Zhong ZY, Lei X, Xie JY,
Li MX, Xiang DB, Li ZP, Yang ZZ, Wang G, et al: Microarray analysis
of DNA damage repair gene expression profiles in cervical cancer
cells radioresistant to 252Cf neutron and X-rays. BMC
Cancer. 10:712010. View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Kunos CA, Colussi VC, Pink J,
Radivoyevitch T and Oleinick NL: Radiosensitization of human
cervical cancer cells by inhibiting ribonucleotide reductase:
Enhanced radiation response at low-dose rates. Int J Radiat Oncol
Biol Phys. 80:1198–1204. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Wieringa HW, van der Zee AG, de Vries EG
and van Vugt MA: Breaking the DNA damage response to improve
cervical cancer treatment. Cancer Treat Rev. 42:30–40. 2016.
View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Mountzios G, Soultati A, Pectasides D,
Dimopoulos MA and Papadimitriou CA: Novel approaches for concurrent
irradiation in locally advanced cervical cancer: Platinum
combinations, non-platinum-containing regimens, and molecular
targeted agents. Obstet Gynecol Int. 2013:5367652013.PubMed/NCBI
|
|
49
|
Candelaria M, Garcia-Arias A, Cetina L and
Duenas-Gonzalez A: Radiosensitizers in cervical cancer. Cisplatin
and beyond. Radiat Oncol. 1:152006. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Fuhrman CB, Kilgore J, LaCoursiere YD, Lee
CM, Milash BA, Soisson AP and Zempolich KA: Radiosensitization of
cervical cancer cells via double-strand DNA break repair
inhibition. Gynecol Oncol. 110:93–98. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
51
|
King HO, Brend T, Payne HL, Wright A, Ward
TA, Patel K, Egnuni T, Stead LF, Patel A, Wurdak H, et al: RAD51 is
a selective DNA repair target to radiosensitize glioma stem cells.
Stem Cell Reports. 8:125–139. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
52
|
Balbous A, Cortes U, Guilloteau K, Rivet
P, Pinel B, Duchesne M, Godet J, Boissonnade O, Wager M, Bensadoun
RJ, et al: A radiosensitizing effect of RAD51 inhibition in
glioblastoma stem-like cells. BMC Cancer. 16:6042016. View Article : Google Scholar : PubMed/NCBI
|
|
53
|
Chen X, Wong P, Radany EH, Stark JM,
Laulier C and Wong JY: Suberoylanilide hydroxamic acid as a
radiosensitizer through modulation of RAD51 protein and inhibition
of homology-directed repair in multiple myeloma. Mol Cancer Res.
10:1052–1064. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
54
|
Kobashigawa S, Morikawa K, Mori H and
Kashino G: Gemcitabine induces radiosensitization through
inhibition of RAD51-dependent repair for DNA double-strand breaks.
Anticancer Res. 35:2731–2737. 2015.PubMed/NCBI
|
|
55
|
Liu Q, Jiang H, Liu Z, Wang Y, Zhao M, Hao
C, Feng S, Guo H, Xu B, Yang Q, et al: Berberine radiosensitizes
human esophageal cancer cells by downregulating homologous
recombination repair protein RAD51. PLoS One. 6:e234272011.
View Article : Google Scholar : PubMed/NCBI
|
|
56
|
Gasparini P, Lovat F, Fassan M, Casadei L,
Cascione L, Jacob NK, Carasi S, Palmieri D, Costinean S, Shapiro
CL, et al: Protective role of miR-155 in breast cancer through
RAD51 targeting impairs homologous recombination after
irradiation. Proc Natl Acad Sci USA. 111:4536–4541. 2014.
View Article : Google Scholar : PubMed/NCBI
|
|
57
|
Raderschall E, Stout K, Freier S, Suckow
V, Schweiger S and Haaf T: Elevated levels of Rad51 recombination
protein in tumor cells. Cancer Res. 62:219–225. 2002.PubMed/NCBI
|
|
58
|
Zhuang L, Liu F, Peng P, Xiong H, Qiu H,
Fu X, Xiao Z and Huang X: Effect of Ku80 on the radiosensitization
of cisplatin in the cervical carcinoma cell line HeLa. Oncol Lett.
15:147–154. 2018.PubMed/NCBI
|
|
59
|
Petera J, Sirak I, Beranek M, Vosmik M,
Drastikova M, Paulikova S and Soumarova R: Molecular predictive
factors of outcome of radiotherapy in cervical cancer. Neoplasma.
58:469–475. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
60
|
Hu L, Wu QQ, Wang WB, Jiang HG, Yang L,
Liu Y, Yu HJ, Xie CH, Zhou YF and Zhou FX: Suppression of Ku80
correlates with radiosensitivity and telomere shortening in the
U2OS telomerase-negative osteosarcoma cell line. Asian Pac J Cancer
Prev. 14:795–799. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
61
|
Zhang Y and Reinberg D: Transcription
regulation by histone methylation: Interplay between different
covalent modifications of the core histone tails. Genes Dev.
15:2343–2360. 2001. View Article : Google Scholar : PubMed/NCBI
|
