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Article

Norepinephrine enhances cell viability and invasion, and inhibits apoptosis of pancreatic cancer cells in a Notch‑1‑dependent manner

  • Authors:
    • Weikun Qian
    • Shifang Lv
    • Jie Li
    • Ke Chen
    • Zhengdong Jiang
    • Liang Cheng
    • Cancan Zhou
    • Bin Yan
    • Junyu Cao
    • Qingyong Ma
    • Wanxing Duan
  • View Affiliations / Copyright

    Affiliations: Department of Hepatobiliary Surgery, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China, Department of Abdominal Surgery, Tumor Hospital of Linyi City, Linyi, Shandong 276001, P.R. China, Department of Hepatobiliary Surgery, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China
  • Pages: 3015-3023
    |
    Published online on: September 10, 2018
       https://doi.org/10.3892/or.2018.6696
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Abstract

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive types of cancer, which is associated with a poor prognosis due to complexities in prevention, early diagnosis and effective treatment. The lack of understanding regarding its induction and specific pro‑cancer mechanisms may contribute to its poor prognosis. The Notch‑1 pathway is widely considered to be a critical tumor‑promoting factor in PDAC. Previous studies have indicated that chronic psychological stress may promote the development of PDAC partially via the main downstream stress hormone, norepinephrine (NE); however, to the best of our knowledge, the role of the Notch‑1 pathway in this process has not been studied. Therefore, the present study aimed to explore this process. The expression levels of Notch‑1 pathway‑associated molecules were measured in response to NE using reverse transcription‑quantitative polymerase chain reaction and western blotting. Alongside NE treatment, two Notch‑1 pathway blockers, Notch‑1‑specific small interfering (si)RNA and DAPT (an inhibitor of the Notch‑1 pathway), were used to explore the relationship between NE and the Notch‑1 pathway in the development of pancreatic cell malignant biological behaviors, including cell viability, apoptosis and cell invasion. The results demonstrated that treatment with NE enhanced cell viability and invasion, and inhibited apoptosis of PDAC cells; however, these effects were suppressed following treatment with Notch‑1‑specific siRNA and DAPT. In conclusion, NE may enhance the malignant biological behaviors of PDAC via activating the Notch‑1 pathway.
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View References

1 

Siegel RL, Miller KD and Jemal A: Cancer Statistics, 2017. CA Cancer J Clin. 67:7–30. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Kamisawa T, Wood LD, Itoi T and Takaori K: Pancreatic cancer. Lancet. 388:73–85. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Conti CM, Maccauro G and Fulcheri M: Psychological stress and cancer. Int J Immunopathol Pharmacol. 24:1–5. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Clarke DM and Currie KC: Depression, anxiety and their relationship with chronic diseases: A review of the epidemiology, risk and treatment evidence. Med J Aust. 190:S54–S60. 2009.PubMed/NCBI

5 

Lara HE, Dorfman M, Venegas M, Luza SM, Luna SL, Mayerhofer A, Guimaraes MA, Rosa E, Silva AA and Ramírez VD: Changes in sympathetic nerve activity of the mammalian ovary during a normal estrous cycle and in polycystic ovary syndrome: Studies on norepinephrine release. Microsc Res Tech. 59:495–502. 2002. View Article : Google Scholar : PubMed/NCBI

6 

Quốc Lu'o'ng KV and Nguyễn LT: The roles of beta-adrenergic receptors in tumorigenesis and the possible use of beta-adrenergic blockers for cancer treatment: Possible genetic and cell-signaling mechanisms. Cancer Manag Res. 4:431–445. 2012.PubMed/NCBI

7 

Chan C, Lin HJ and Lin J: Stress-associated hormone, norepinephrine, increases proliferation and IL-6 levels of human pancreatic duct epithelial cells and can be inhibited by the dietary agent, sulforaphane. Int J Oncol. 33:415–419. 2008.PubMed/NCBI

8 

Guo K, Ma Q, Li J, Wang Z, Shan T, Li W, Xu Q and Xie K: Interaction of the sympathetic nerve with pancreatic cancer cells promotes perineural invasion through the activation of STAT3 signaling. Mol Cancer Ther. 12:264–273. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Huang XY, Wang HC, Yuan Z, Huang J and Zheng Q: Norepinephrine stimulates pancreatic cancer cell proliferation, migration and invasion via β-adrenergic receptor-dependent activation of P38/MAPK pathway. Hepatogastroenterology. 59:889–893. 2012.PubMed/NCBI

10 

Gordon WR, Arnett KL and Blacklow SC: The molecular logic of Notch signaling-a structural and biochemical perspective. J Cell Sci. 121:3109–3119. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Gao J, Long B and Wang Z: Role of Notch signaling pathway in pancreatic cancer. Am J Cancer Res. 7:173–186. 2017.PubMed/NCBI

12 

Vinson KE, George DC, Fender AW, Bertrand FE and Sigounas G: The Notch pathway in colorectal cancer. Int J Cancer. 138:1835–1842. 2016. View Article : Google Scholar : PubMed/NCBI

13 

O'Brien R and Marignol L: The Notch-1 receptor in prostate tumorigenesis. Cancer Treat Rev. 56:36–46. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Brzozowa-Zasada M, Piecuch A, Dittfeld A, Mielańczyk Ł, Michalski M, Wyrobiec G, Harabin-Słowińska M, Kurek J and Wojnicz R: Notch signalling pathway as an oncogenic factor involved in cancer development. Contemp Oncol. 20:267–272. 2016.

15 

Liu J, Shen JX, Wen XF, Guo YX and Zhang GJ: Targeting Notch degradation system provides promise for breast cancer therapeutics. Crit Rev Oncol Hematol. 104:21–29. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Jensen J: Gene regulatory factors in pancreatic development. Dev Dyn. 229:176–200. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Siveke JT, Lubeseder-Martellato C, Lee M, Mazur PK, Nakhai H, Radtke F and Schmid RM: Notch signaling is required for exocrine regeneration after acute pancreatitis. Gastroenterology. 134:544–555. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Miyamoto Y, Maitra A, Ghosh B, Zechner U, Argani P, Iacobuzio-Donahue CA, Sriuranpong V, Iso T, Meszoely IM, Wolfe MS, et al: Notch mediates TGF alpha-induced changes in epithelial differentiation during pancreatic tumorigenesis. Cancer Cell. 3:565–576. 2003. View Article : Google Scholar : PubMed/NCBI

19 

De La O JP, Emerson LL, Goodman JL, Froebe SC, Illum BE, Curtis AB and Murtaugh LC: Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia. Proc Natl Acad Sci USA. 105:18907–18912. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Duncan AW, Rattis FM, DiMascio LN, Congdon KL, Pazianos G, Zhao C, Yoon K, Cook JM, Willert K, Gaiano N, et al: Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance. Nat Immunol. 6:314–322. 2005. View Article : Google Scholar : PubMed/NCBI

21 

Spiegel A, Kalinkovich A, Shivtiel S, Kollet O and Lapidot T: Stem cell regulation via dynamic interactions of the nervous and immune systems with the microenvironment. Cell Stem Cell. 3:484–492. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Chen H, Liu D, Yang Z, Sun L, Deng Q, Yang S, Qian L, Guo L, Yu M, Hu M, et al: Adrenergic signaling promotes angiogenesis through endothelial cell-tumor cell crosstalk. Endocr Relat Cancer. 21:783–795. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2−ΔΔCT method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

24 

Duan W, Chen K, Jiang Z, Chen X, Sun L, Li J, Lei J, Xu Q, Ma J, Li X, et al: Desmoplasia suppression by metformin-mediated AMPK activation inhibits pancreatic cancer progression. Cancer Lett. 385:225–233. 2017. View Article : Google Scholar : PubMed/NCBI

25 

Li X, Ma G, Ma Q, Li W, Liu J, Han L, Duan W, Xu Q, Liu H, Wang Z, et al: Neurotransmitter substance P mediates pancreatic cancer perineural invasion via NK-1R in cancer cells. Mol Cancer Res. 11:294–302. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Liu J, Ma J, Wu Z, Li W, Zhang D, Han L, Wang F, Reindl KM, Wu E and Ma Q: Arginine deiminase augments the chemosensitivity of argininosuccinate synthetase-deficient pancreatic cancer cells to gemcitabine via inhibition of NF-κB signaling. BMC Cancer. 14:6862014. View Article : Google Scholar : PubMed/NCBI

27 

Zhang D, Lei J, Ma J, Chen X, Sheng L, Jiang Z, Nan L, Xu Q, Duan W, Wang Z, et al: β2-adrenogenic signaling regulates NNK-induced pancreatic cancer progression via upregulation of HIF-1α. Oncotarget. 7:17760–17772. 2016.PubMed/NCBI

28 

Weddle DL, Tithoff P, Williams M and Schuller HM: Beta-adrenergic growth regulation of human cancer cell lines derived from pancreatic ductal carcinomas. Carcinogenesis. 22:473–479. 2001. View Article : Google Scholar : PubMed/NCBI

29 

Vere CC, Streba CT, Streba LM, Ionescu AG and Sima F: Psychosocial stress and liver disease status. World J Gastroenterol. 15:2980–2986. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Schuller HM, Al-Wadei HA, Ullah MF and Plummer HK III: Regulation of pancreatic cancer by neuropsychological stress responses: A novel target for intervention. Carcinogenesis. 33:191–196. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Herman JP, Figueiredo H, Mueller NK, Ulrich-Lai Y, Ostrander MM, Choi DC and Cullinan WE: Central mechanisms of stress integration: Hierarchical circuitry controlling hypothalamo-pituitary-adrenocortical responsiveness. Front Neuroendocrinol. 24:151–180. 2003. View Article : Google Scholar : PubMed/NCBI

32 

Schmidt C and Kraft K: Beta-endorphin and catecholamine concentrations during chronic and acute stress in intensive care patients. Eur J Med Res. 1:528–532. 1996.PubMed/NCBI

33 

Zabora J, BrintzenhofeSzoc K, Curbow B, Hooker C and Piantadosi S: The prevalence of psychological distress by cancer site. Psychooncology. 10:19–28. 2001. View Article : Google Scholar : PubMed/NCBI

34 

Schuller HM, Al-Wadei HA and Majidi M: GABA B receptor is a novel drug target for pancreatic cancer. Cancer. 112:767–778. 2008. View Article : Google Scholar : PubMed/NCBI

35 

Friedman GD, Udaltsova N and Habel LA: Norepinephrine antagonists and cancer risk. Int J Cancer. 128:737–738. 2011. View Article : Google Scholar : PubMed/NCBI

36 

Dotto GP: Notch tumor suppressor function. Oncogene. 27:5115–5123. 2008. View Article : Google Scholar : PubMed/NCBI

37 

Nakhai H, Siveke JT, Klein B, Mendoza-Torres L, Mazur PK, Algül H, Radtke F, Strobl L, Zimber-Strobl U and Schmid RM: Conditional ablation of Notch signaling in pancreatic development. Development. 135:2757–2765. 2008. View Article : Google Scholar : PubMed/NCBI

38 

Mazur PK, Einwächter H, Lee M, Sipos B, Nakhai H, Rad R, Zimber-Strobl U, Strobl LJ, Radtke F, Klöppel G, et al: Notch2 is required for progression of pancreatic intraepithelial neoplasia and development of pancreatic ductal adenocarcinoma. Proc Natl Acad Sci USA. 107:13438–13443. 2010. View Article : Google Scholar : PubMed/NCBI

39 

Hanlon L, Avila JL, Demarest RM, Troutman S, Allen M, Ratti F, Rustgi AK, Stanger BZ, Radtke F, Adsay V, et al: Notch1 functions as a tumor suppressor in a model of K-ras-induced pancreatic ductal adenocarcinoma. Cancer Res. 70:4280–4286. 2010. View Article : Google Scholar : PubMed/NCBI

40 

Feldmann G, Mishra A, Bisht S, Karikari C, Garrido-Laguna I, Rasheed Z, Ottenhof NA, Dadon T, Alvarez H, Fendrich V, et al: Cyclin-dependent kinase inhibitor Dinaciclib (SCH727965) inhibits pancreatic cancer growth and progression in murine xenograft models. Cancer Biol Ther. 12:598–609. 2011. View Article : Google Scholar : PubMed/NCBI

41 

Wang Z, Zhang Y, Banerjee S, Li Y and Sarkar FH: Notch-1 down-regulation by curcumin is associated with the inhibition of cell growth and the induction of apoptosis in pancreatic cancer cells. Cancer. 106:2503–2513. 2006. View Article : Google Scholar : PubMed/NCBI

42 

Gaspar NJ, Li L, Kapoun AM, Medicherla S, Reddy M, Li G, O'Young G, Quon D, Henson M, Damm DL, et al: Inhibition of transforming growth factor beta signaling reduces pancreatic adenocarcinoma growth and invasiveness. Mol Pharmacol. 72:152–161. 2016. View Article : Google Scholar

43 

Bao B, Wang Z, Ali S, Kong D, Li Y, Ahmad A, Banerjee S, Azmi AS, Miele L and Sarkar FH: Notch-1 induces epithelial-mesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells. Cancer Lett. 307:26–36. 2011. View Article : Google Scholar : PubMed/NCBI

44 

Wang Z, Banerjee S, Li Y, Rahman KM, Zhang Y and Sarkar FH: Down-regulation of notch-1 inhibits invasion by inactivation of nuclear factor-kappaB, vascular endothelial growth factor, and matrix metalloproteinase-9 in pancreatic cancer cells. Cancer Res. 66:2778–2784. 2006. View Article : Google Scholar : PubMed/NCBI

45 

Wang Z, Zhang Y, Li Y, Banerjee S, Liao J and Sarkar FH: Down-regulation of Notch-1 contributes to cell growth inhibition and apoptosis in pancreatic cancer cells. Mol Cancer Ther. 5:483–493. 2006. View Article : Google Scholar : PubMed/NCBI

46 

Yabuuchi S, Pai SG, Campbell NR, de Wilde RF, De Oliveira E, Korangath P, Streppel MM, Rasheed ZA, Hidalgo M, Maitra A, et al: Notch signaling pathway targeted therapy suppresses tumor progression and metastatic spread in pancreatic cancer. Cancer Lett. 335:41–51. 2013. View Article : Google Scholar : PubMed/NCBI

47 

Wang Z, Sengupta R, Banerjee S, Li Y, Zhang Y, Rahman KM, Aboukameel A, Mohammad R, Majumdar AP, Abbruzzese JL, et al: Epidermal growth factor receptor-related protein inhibits cell growth and invasion in pancreatic cancer. Cancer Res. 66:7653–7660. 2006. View Article : Google Scholar : PubMed/NCBI

48 

Koch U and Radtke F: Notch and cancer: A double-edged sword. Cell Mol Life Sci. 64:2746–2762. 2007. View Article : Google Scholar : PubMed/NCBI

49 

South AP, Cho RJ and Aster JC: The double-edged sword of Notch signaling in cancer. Semin Cell Dev Biol. 23:458–464. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Qian W, Lv S, Li J, Chen K, Jiang Z, Cheng L, Zhou C, Yan B, Cao J, Ma Q, Ma Q, et al: Norepinephrine enhances cell viability and invasion, and inhibits apoptosis of pancreatic cancer cells in a Notch‑1‑dependent manner. Oncol Rep 40: 3015-3023, 2018.
APA
Qian, W., Lv, S., Li, J., Chen, K., Jiang, Z., Cheng, L. ... Duan, W. (2018). Norepinephrine enhances cell viability and invasion, and inhibits apoptosis of pancreatic cancer cells in a Notch‑1‑dependent manner. Oncology Reports, 40, 3015-3023. https://doi.org/10.3892/or.2018.6696
MLA
Qian, W., Lv, S., Li, J., Chen, K., Jiang, Z., Cheng, L., Zhou, C., Yan, B., Cao, J., Ma, Q., Duan, W."Norepinephrine enhances cell viability and invasion, and inhibits apoptosis of pancreatic cancer cells in a Notch‑1‑dependent manner". Oncology Reports 40.5 (2018): 3015-3023.
Chicago
Qian, W., Lv, S., Li, J., Chen, K., Jiang, Z., Cheng, L., Zhou, C., Yan, B., Cao, J., Ma, Q., Duan, W."Norepinephrine enhances cell viability and invasion, and inhibits apoptosis of pancreatic cancer cells in a Notch‑1‑dependent manner". Oncology Reports 40, no. 5 (2018): 3015-3023. https://doi.org/10.3892/or.2018.6696
Copy and paste a formatted citation
x
Spandidos Publications style
Qian W, Lv S, Li J, Chen K, Jiang Z, Cheng L, Zhou C, Yan B, Cao J, Ma Q, Ma Q, et al: Norepinephrine enhances cell viability and invasion, and inhibits apoptosis of pancreatic cancer cells in a Notch‑1‑dependent manner. Oncol Rep 40: 3015-3023, 2018.
APA
Qian, W., Lv, S., Li, J., Chen, K., Jiang, Z., Cheng, L. ... Duan, W. (2018). Norepinephrine enhances cell viability and invasion, and inhibits apoptosis of pancreatic cancer cells in a Notch‑1‑dependent manner. Oncology Reports, 40, 3015-3023. https://doi.org/10.3892/or.2018.6696
MLA
Qian, W., Lv, S., Li, J., Chen, K., Jiang, Z., Cheng, L., Zhou, C., Yan, B., Cao, J., Ma, Q., Duan, W."Norepinephrine enhances cell viability and invasion, and inhibits apoptosis of pancreatic cancer cells in a Notch‑1‑dependent manner". Oncology Reports 40.5 (2018): 3015-3023.
Chicago
Qian, W., Lv, S., Li, J., Chen, K., Jiang, Z., Cheng, L., Zhou, C., Yan, B., Cao, J., Ma, Q., Duan, W."Norepinephrine enhances cell viability and invasion, and inhibits apoptosis of pancreatic cancer cells in a Notch‑1‑dependent manner". Oncology Reports 40, no. 5 (2018): 3015-3023. https://doi.org/10.3892/or.2018.6696
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