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Article

Taurolidine promotes cell apoptosis by enhancing GRIM‑19 expression in liver cancer

  • Authors:
    • Feifei Li
    • Jianni Qi
    • Chengyong Qin
    • Zhaoqing Fu
    • Wanhua Ren
  • View Affiliations / Copyright

    Affiliations: Department of Infectious Diseases, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China, Shandong Provincial Engineering and Technological Research Center for Liver Diseases Prevention and Control, Jinan, Shandong 250021, P.R. China, Department of Infectious Diseases, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China, Department of Thoracic Surgery, Shandong University of Traditional Chinese Medicine Affiliated Hospital, Jinan, Shandong 250014, P.R. China
  • Pages: 3743-3751
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    Published online on: September 18, 2018
       https://doi.org/10.3892/or.2018.6711
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Abstract

Taurolidine (TRD) is a substance derived from the amino sulfonic acid taurine, which was originally used to treat peritonitis and catheter‑associated bloodstream infections, due to its antimicrobial and anti‑inflammatory properties. A recent study reported the anticancer function of TRD in malignant tumors; however, the effects and mechanisms of TRD in liver cancer remain unclear. The present study aimed to investigate the effects and mechanism of TRD treatment on human liver cancer cells. The viability and apoptosis of liver cancer cells were evaluated using the MTT assay and flow cytometry. Subsequently, small interfering RNA (siRNA) was used to knock down the expression of gene associated with retinoid‑interferon‑induced mortality‑19 (GRIM‑19), after which, reverse transcription‑quantitative polymerase chain reaction was used to detect the mRNA expression levels of GRIM‑19, whereas immunofluorescence was used to analyze the location of GRIM‑19. Furthermore, western blotting was performed to detect the protein expression levels of GRIM‑19, cyclin D1, signal transducer and activator of transcription 3 (STAT3), phosphorylated (p)‑STAT3, B‑cell lymphoma 2 (Bcl‑2) and Bcl‑2‑associated X protein (Bax). The STAT3 pathway was inhibited using niclosamide. The results revealed that TRD reduced the viability of liver cancer cells and induced apoptosis at higher frequencies. In addition, the expression levels of GRIM‑19 were increased in a time‑ and dose‑dependent manner following TRD treatment. Alongside GRIM‑19 upregulation, the expression levels of Bax were increased, whereas those of cyclin D1, Bcl‑2 and p‑STAT3 were decreased. Furthermore, following GRIM‑19 knockdown, the effects of TRD on the viability and apoptosis of HepG2 cells, and the expression of downstream target genes (including cyclin D1, STAT3, p‑STAT3, Bcl‑2 and Bax) were reversed. Conversely, treatment with a p‑STAT3 inhibitor had an inverse effect on the expression of these genes but did not affect GRIM‑19 expression compared with the TRD group. These results indicated that TRD may contribute to cell apoptosis by inducing GRIM‑19 expression and deactivating the STAT3 signaling pathway in liver cancer cells.
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1 

Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ and He J: Cancer statistics in China, 2015. CA Cancer J Clin. 66:115–132. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Mittal S and El-Serag HB: Epidemiology of hepatocellular carcinoma: Consider the population. J Clin Gastroenterol. 47 Suppl:S2–S6. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Pinter M, Trauner M, Peck-Radosavljevic M and Sieghart W: Cancer and liver cirrhosis: Implications on prognosis and management. ESMO Open. 1:e0000422016. View Article : Google Scholar : PubMed/NCBI

4 

Kanda T, Ogasawara S, Chiba T, Haga Y, Omata M and Yokosuka O: Current management of patients with hepatocellular carcinoma. World J Hepatol. 7:1913–1920. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Chromik AM, Daigeler A, Bulut D, Flier A, May C, Harati K, Roschinsky J, Sülberg D, Ritter PR, Mittelkötter U, et al: Comparative analysis of cell death induction by Taurolidine in different malignant human cancer cell lines. J Exp Clin Cancer Res. 29:212010. View Article : Google Scholar : PubMed/NCBI

6 

Stendel R, Stoltenburgdidinger G, Al Keikh CL, Wattrodt M and Brock M: The effect of taurolidine on brain tumor cells. Anticancer Res. 22:809–814. 2002.PubMed/NCBI

7 

Stendel R, Biefer HR, Dékány GM, Kubota H, Münz C, Wang S, Mohler H, Yonekawa Y and Frei K: The antibacterial substance taurolidine exhibits anti-neoplastic action based on a mixed type of programmed cell death. Autophagy. 5:194–210. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Braumann C, Jacobi CA, Rogalla S, Menenakos C, Fuehrer K, Trefzer U and Hofmann M: The tumor suppressive reagent taurolidine inhibits growth of malignant melanoma-a mouse model. J Surg Res. 143:372–378. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Sun BS, Wang JH, Liu LL, Gong SL and Redmond HP: Taurolidine induces apoptosis of murine melanoma cells in vitro and in vivo by modulation of the Bcl-2 family proteins. J Surg Oncol. 96:241–248. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Opitz I, Sigrist B, Hillinger S, Lardinois D, Stahel R, Weder W and Hopkins-Donaldson S: Taurolidine and povidone-iodine induce different types of cell death in malignant pleural mesothelioma. Lung Cancer. 56:327–336. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Aceto N, Bertino P, Barbone D, Tassi G, Manzo L, Porta C, Mutti L and Gaudino G: Taurolidine and oxidative stress: A rationale for local treatment of mesothelioma. Eur Respir J. 34:1399–1407. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Braumann C, Schoenbeck M, Menenakos C, Kilian M and Jacobi CA: Effects of increasing doses of a bolus injection and an intravenous long-term therapy of taurolidine on subcutaneous (metastatic) tumor growth in rats. Clin Exp Metastasis. 22:77–83. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Chromik AM, Daigeler A, Hilgert C, Bulut D, Geisler A, Liu V, Otte JM, Uhl W and Mittelkötter U: Synergistic effects in apoptosis induction by taurolidine and TRAIL in HCT-15 colon carcinoma cells. J Invest Surg. 20:339–348. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Daigeler A, Chromik AM, Geisler A, Bulut D, Hilgert C, Krieg A, Klein-Hitpass L, Lehnhardt M, Uhl W and Mittelkötter U: Synergistic apoptotic effects of taurolidine and TRAIL on squamous carcinoma cells of the esophagus. Int J Oncol. 32:1205–1220. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Walters DK, Muff R, Langsam B, Gruber P, Born W and Fuchs B: Taurolidine: A novel anti-neoplastic agent induces apoptosis of osteosarcoma cell lines. Invest New Drugs. 25:305–312. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Daigeler A, Brenzel C, Bulut D, Geisler A, Hilgert C, Lehnhardt M, Steinau HU, Flier A, Steinstraesser L, Klein-Hitpass L, et al: TRAIL and Taurolidine induce apoptosis and decrease proliferation in human fibrosarcoma. J Exp Clin Cancer Res. 27:822008. View Article : Google Scholar : PubMed/NCBI

17 

Chidambaram NV, Angell JE, Ling W, Hofmann ER and Kalvakolanu DV: Chromosomal localization of human GRIM-19, a novel IFN-beta and retinoic acid-activated regulator of cell death. J Interferon Cytokine Res. 20:661–665. 2000. View Article : Google Scholar : PubMed/NCBI

18 

Chen Y, Lu H, Liu Q, Huang G, Lim CP, Zhang L, Hao A and Cao X: Function of GRIM-19, a mitochondrial respiratory chain complex I protein, in innate immunity. J Biol Chem. 287:27227–27235. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Li F, Ren W, Zhao Y, Fu Z, Ji Y, Zhu Y and Qin C: Downregulation of GRIM-19 is associated with hyperactivation of p-STAT3 in hepatocellular carcinoma. Med Oncol. 29:3046–3054. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Zhao J, Nie W, Li W, Zhou X, Sun H, Zhu J, Chen J and Peng J: Interferon-β combined with all-trans retinoic acid supresses proliferation and promote apoptosis by inhibiting JAK2/STAT3 pathway in HepG2 human hepatocellular carcinoma cells. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 32:901–905. 2016.(In Chinese). PubMed/NCBI

21 

Gong L, Greenberg HE, Perhach JL, Waldman SA and Kraft WK: The pharmacokinetics of taurolidine metabolites in healthy volunteers. J Clin Pharmacol. 47:697–703. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Braumann C, Winkler G, Rogalla P, Menenakos C and Jacobi CA: Prevention of disease progression in a patient with a gastric cancer-re-recurrence. Outcome after intravenous treatment with the novel antineoplastic agent taurolidine. Report of a case. World J Surg Oncol. 4:342006. View Article : Google Scholar : PubMed/NCBI

23 

Stendel R, Picht T, Schilling A, Heidenreich J, Loddenkemper C, Jänisch W and Brock M: Treatment of glioblastoma with intravenous taurolidine. First clinical experience. Anticancer Res. 24:1143–1147. 2004.PubMed/NCBI

24 

Stendel R, Scheurer L, Schlatterer K, Stalder U, Pfirrmann RW, Fiss I, Möhler H and Bigler L: Pharmacokinetics of taurolidine following repeated intravenous infusions measured by HPLC-ESI-MS/MS of the derivatives taurultame and taurinamide in glioblastoma patients. Clin Pharmacokinet. 46:513–524. 2007. View Article : Google Scholar : PubMed/NCBI

25 

Darnowski JW, Goulette FA, Cousens LP, Chatterjee D and Calabresi P: Mechanistic and antineoplastic evaluation of taurolidine in the DU145 model of human prostate cancer. Cancer Chemother Pharmacol. 54:249–258. 2004. View Article : Google Scholar : PubMed/NCBI

26 

Han Z, Ribbizi I, Pantazis P, Wyche J, Darnowski J and Calabresi P: The antibacterial drug taurolidine induces apoptosis by a mitochondrial cytochrome c-dependent mechanism. Anticancer Res. 22:1959–1964. 2002.PubMed/NCBI

27 

Rodak R, Kubota H, Ishihara H, Eugster HP, Könü D, Möhler H, Yonekawa Y and Frei K: Induction of reactive oxygen intermediates-dependent programmed cell death in human malignant ex vivo glioma cells and inhibition of the vascular endothelial growth factor production by taurolidine. J Neurosurg. 102:1055–1068. 2005. View Article : Google Scholar : PubMed/NCBI

28 

Stendel R, Scheurer L, Stoltenburg-Didinger G, Brock M and Möhler H: Enhancement of Fas-ligand-mediated programmed cell death by taurolidine. Anticancer Res. 23:2309–2314. 2003.PubMed/NCBI

29 

Kolligs FT, Nieman MT, Winer I, Hu G, Van Mater D, Feng Y, Smith IM, Wu R, Zhai Y, Cho KR, et al: ITF-2, a downstream target of the Wnt/TCF pathway, is activated in human cancers with beta-catenin defects and promotes neoplastic transformation. Cancer Cell. 1:145–155. 2002. View Article : Google Scholar : PubMed/NCBI

30 

Ottaviano AJ, Sun L, Ananthanarayanan V and Munshi HG: Extracellular matrix-mediated membrane-type 1 matrix metalloproteinase expression in pancreatic ductal cells is regulated by transforming growth factor-beta1. Cancer Res. 66:7032–7040. 2006. View Article : Google Scholar : PubMed/NCBI

31 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2−ΔΔCT method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

32 

Wei D, Le X, Zheng L, Wang L, Frey JA, Gao AC, Peng Z, Huang S, Xiong HQ, Abbruzzese JL and Xie K: Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis. Oncogene. 22:319–329. 2003. View Article : Google Scholar : PubMed/NCBI

33 

Jacobi CA, Menenakos C and Braumann C: Taurolidine-a new drug with anti-tumor and anti-angiogenic effects. Anticancer Drugs. 16:917–921. 2005. View Article : Google Scholar : PubMed/NCBI

34 

Mccourt M, Wang JH, Sookhai S and Redmond HP: Taurolidine inhibits tumor cell growth in vitro and in vivo. Ann Surg Oncol. 7:685–691. 2000. View Article : Google Scholar : PubMed/NCBI

35 

Petrovic L, Schlegel KA, Ries J, Park J, Diebel E, Schultze-Mosgau S and Wiltfang J: In vitro effect of taurolidine on squamous cell carcinoma in the oral cavity. Mund Kiefer Gesichtschir. 7:102–107. 2003.(In German). View Article : Google Scholar : PubMed/NCBI

36 

Gallagher KA, Liu ZJ, Xiao M, Chen H, Goldstein LJ, Buerk DG, Nedeau A, Thom SR and Velazquez OC: Diabetic impairments in NO-mediated endothelial progenitor cell mobilization and homing are reversed by hyperoxia and SDF-1. J Clin Invest. 117:1249–1259. 2007. View Article : Google Scholar : PubMed/NCBI

37 

Calabresi P, Goulette FA and Darnowski JW: Taurolidine: Cytotoxic and mechanistic evaluation of a novel antineoplastic agent. Cancer Res. 61:6816–6821. 2001.PubMed/NCBI

38 

Braumann C, Henke W, Jacobi CA and Dubiel W: The tumor-suppressive reagent taurolidine is an inhibitor of protein biosynthesis. Int J Cancer. 112:225–230. 2004. View Article : Google Scholar : PubMed/NCBI

39 

Neary PM, Hallihan P, Wang JH, Pfirrmann RW, Bouchier-Hayes DJ and Redmond HP: The evolving role of taurolidine in cancer therapy. Ann Surg Oncol. 17:1135–1143. 2010. View Article : Google Scholar : PubMed/NCBI

40 

Haura EB, Turkson J and Jove R: Mechanisms of disease: Insights into the emerging role of signal transducers and activators of transcription in cancer. Nat Clin Pract Oncol. 2:315–324. 2005. View Article : Google Scholar : PubMed/NCBI

41 

Oltvai ZN, Milliman CL and Korsmeyer SJ: Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death. Cell. 74:609–619. 1993. View Article : Google Scholar : PubMed/NCBI

42 

Korsmeyer SJ, Shutter JR, Veis DJ, Merry DE and Oltvai ZN: Bcl-2/Bax: A rheostat that regulates an anti-oxidant pathway and cell death. Semin Cancer Biol. 4:327–332. 1993.PubMed/NCBI

43 

Tsukahara S, Yamamoto S, Tin-Tin-Win-Shwe, Ahmed S, Kunugita N, Arashidani K and Fujimaki H: Inhalation of low-level formaldehyde increases the Bcl-2/Bax expression ratio in the hippocampus of immunologically sensitized mice. Neuroimmunomodulation. 13:63–68. 2006. View Article : Google Scholar : PubMed/NCBI

44 

Walensky LD: BCL-2 in the crosshairs: Tipping the balance of life and death. Cell Death Differ. 13:1339–1350. 2006. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li F, Qi J, Qin C, Fu Z and Ren W: Taurolidine promotes cell apoptosis by enhancing GRIM‑19 expression in liver cancer. Oncol Rep 40: 3743-3751, 2018.
APA
Li, F., Qi, J., Qin, C., Fu, Z., & Ren, W. (2018). Taurolidine promotes cell apoptosis by enhancing GRIM‑19 expression in liver cancer. Oncology Reports, 40, 3743-3751. https://doi.org/10.3892/or.2018.6711
MLA
Li, F., Qi, J., Qin, C., Fu, Z., Ren, W."Taurolidine promotes cell apoptosis by enhancing GRIM‑19 expression in liver cancer". Oncology Reports 40.6 (2018): 3743-3751.
Chicago
Li, F., Qi, J., Qin, C., Fu, Z., Ren, W."Taurolidine promotes cell apoptosis by enhancing GRIM‑19 expression in liver cancer". Oncology Reports 40, no. 6 (2018): 3743-3751. https://doi.org/10.3892/or.2018.6711
Copy and paste a formatted citation
x
Spandidos Publications style
Li F, Qi J, Qin C, Fu Z and Ren W: Taurolidine promotes cell apoptosis by enhancing GRIM‑19 expression in liver cancer. Oncol Rep 40: 3743-3751, 2018.
APA
Li, F., Qi, J., Qin, C., Fu, Z., & Ren, W. (2018). Taurolidine promotes cell apoptosis by enhancing GRIM‑19 expression in liver cancer. Oncology Reports, 40, 3743-3751. https://doi.org/10.3892/or.2018.6711
MLA
Li, F., Qi, J., Qin, C., Fu, Z., Ren, W."Taurolidine promotes cell apoptosis by enhancing GRIM‑19 expression in liver cancer". Oncology Reports 40.6 (2018): 3743-3751.
Chicago
Li, F., Qi, J., Qin, C., Fu, Z., Ren, W."Taurolidine promotes cell apoptosis by enhancing GRIM‑19 expression in liver cancer". Oncology Reports 40, no. 6 (2018): 3743-3751. https://doi.org/10.3892/or.2018.6711
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