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Article Open Access

Increased resistin suggests poor prognosis and promotes development of lung adenocarcinoma

Retraction in: /10.3892/or.2023.8595
  • Authors:
    • Cui‑Cui Zhao
    • Jing Chen
    • Rui‑Fang Niu
    • Yan Liu
    • Chuan‑Gui Zhang
  • View Affiliations / Copyright

    Affiliations: Department of VIP Ward, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, P.R. China, Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, P.R. China, Department of Public Laboratory, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, P.R. China, Department of VIP Ward, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, P.R. China
    Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3392-3404
    |
    Published online on: September 26, 2018
       https://doi.org/10.3892/or.2018.6736
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Abstract

Resistin is considered to be a risk factor for several types of cancer, but its functions are controversial and not well studied in lung cancer. The present study is aimed to investigate the expression of resistin in lung adenocarcinoma tissues, in order to evaluate its association with the clinicopathological characteristics of cancer patients and to investigate the effects of resistin in lung adenocarcinoma cells. A total of 70 pairs of lung adenocarcinoma tissues and normal tissues were collected and immunohistochemistry was performed to examine resistin expression. Resistin overexpressed cells were established by plasmid transfection in A549 or H1975 cells. Alterations in cell proliferation, apoptosis, migration and invasion were analyzed in vitro. A nude mouse tumorigenicity assay was used to test the effect of resistin in vivo. High expression of resistin was predominantly observed in lung adenocarcinoma tissues but not in adjacent normal lung tissues. Resistin expression was significantly associated with increased tumor size, clinical stage as well as lymph node metastasis while negatively associated with progression-free survival (PFS) and overall survival (OS). Expression of resistin was an independent risk factor for PFS and OS. Overexpression of resistin promoted significant proliferation, migration and invasion, while also inhibited apoptosis in vitro. Resistin also promoted tumor formation in nude mice. The potential molecular mechanism was also investigated by in vitro experiments. In conclusion, the present study revealed that a high level of resistin expression in lung adenocarcinoma tissues is associated with poor clinicopathological status and survival. Resistin, which promotes the development of lung adenocarcinoma in vitro and in vivo may be a novel target for lung adenocarcinoma.
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Copy and paste a formatted citation
Spandidos Publications style
Zhao CC, Chen J, Niu RF, Liu Y and Zhang CG: Increased resistin suggests poor prognosis and promotes development of lung adenocarcinoma Retraction in /10.3892/or.2023.8595. Oncol Rep 40: 3392-3404, 2018.
APA
Zhao, C., Chen, J., Niu, R., Liu, Y., & Zhang, C. (2018). Increased resistin suggests poor prognosis and promotes development of lung adenocarcinoma Retraction in /10.3892/or.2023.8595. Oncology Reports, 40, 3392-3404. https://doi.org/10.3892/or.2018.6736
MLA
Zhao, C., Chen, J., Niu, R., Liu, Y., Zhang, C."Increased resistin suggests poor prognosis and promotes development of lung adenocarcinoma Retraction in /10.3892/or.2023.8595". Oncology Reports 40.6 (2018): 3392-3404.
Chicago
Zhao, C., Chen, J., Niu, R., Liu, Y., Zhang, C."Increased resistin suggests poor prognosis and promotes development of lung adenocarcinoma Retraction in /10.3892/or.2023.8595". Oncology Reports 40, no. 6 (2018): 3392-3404. https://doi.org/10.3892/or.2018.6736
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao CC, Chen J, Niu RF, Liu Y and Zhang CG: Increased resistin suggests poor prognosis and promotes development of lung adenocarcinoma Retraction in /10.3892/or.2023.8595. Oncol Rep 40: 3392-3404, 2018.
APA
Zhao, C., Chen, J., Niu, R., Liu, Y., & Zhang, C. (2018). Increased resistin suggests poor prognosis and promotes development of lung adenocarcinoma Retraction in /10.3892/or.2023.8595. Oncology Reports, 40, 3392-3404. https://doi.org/10.3892/or.2018.6736
MLA
Zhao, C., Chen, J., Niu, R., Liu, Y., Zhang, C."Increased resistin suggests poor prognosis and promotes development of lung adenocarcinoma Retraction in /10.3892/or.2023.8595". Oncology Reports 40.6 (2018): 3392-3404.
Chicago
Zhao, C., Chen, J., Niu, R., Liu, Y., Zhang, C."Increased resistin suggests poor prognosis and promotes development of lung adenocarcinoma Retraction in /10.3892/or.2023.8595". Oncology Reports 40, no. 6 (2018): 3392-3404. https://doi.org/10.3892/or.2018.6736
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