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Article Open Access

Downregulation of RNF138 inhibits cellular proliferation, migration, invasion and EMT in glioma cells via suppression of the Erk signaling pathway

Corrigendum in: /10.3892/or.2022.8337
  • Authors:
    • Haibin Wu
    • Xuetao Li
    • Ming Feng
    • Lin Yao
    • Zhitong Deng
    • Guozheng Zao
    • Youxin Zhou
    • Sansong Chen
    • Ziwei Du
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China, Department of Neurosurgery, Yijishan Hospital, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui 241001, P.R. China
    Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3285-3296
    |
    Published online on: September 28, 2018
       https://doi.org/10.3892/or.2018.6744
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Abstract

Glioma is the most common adult malignant primary brain tumor; however, the effect of chemotherapy is often limited by drug‑resistance and poor prognosis is common. Ring finger protein 138 (RNF138) belongs to the E3 ligase family, and has significantly higher expression level in glioma tissue than in noncancerous brain tissues. Epithelial-mesenchymal-transition (EMT) has a critical role in cancer invasion and metastasis, ultimately leading to increased cell motility and resistance to genotoxic agents. Extracellular‑signal regulated kinase (Erk) pathways promote the growth of glioma cells and enhance tumor invasion, with a role in the progression of EMT. However, the association between RNF138 and human glioma progression remains poorly understood. Relatively little is known about the association between RNF138, Erk, and EMT in glioma progression. In the current study, experiments were performed to explore the potential roles and mechanisms of RNF138 in glioblastoma in vitro and in vivo. Glioma cell line proliferation, migration and invasion were inhibited by knockdown of RNF138 in vitro. By lowering the RNF138 expression, cleaved caspase3 and E‑cadherin were upregulated, while phospho‑Erk1/2, vimentin, MMP2, HIF‑1α and VEGF were downregulated in U87 and U251 cells in vitro. In vivo findings revealed that the growth of U87 cell‑transplanted tumors in nude mice was inhibited in tumors with RNF138 knockdown. These findings suggested that downregulation of RNF138 inhibited glioma cell proliferation, migration, and invasion, and reversed EMT, potentially via Erk signaling pathway. Therefore, RNF138 may be a potential therapeutic target against glioma.
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Copy and paste a formatted citation
Spandidos Publications style
Wu H, Li X, Feng M, Yao L, Deng Z, Zao G, Zhou Y, Chen S and Du Z: Downregulation of RNF138 inhibits cellular proliferation, migration, invasion and EMT in glioma cells via suppression of the Erk signaling pathway Corrigendum in /10.3892/or.2022.8337. Oncol Rep 40: 3285-3296, 2018.
APA
Wu, H., Li, X., Feng, M., Yao, L., Deng, Z., Zao, G. ... Du, Z. (2018). Downregulation of RNF138 inhibits cellular proliferation, migration, invasion and EMT in glioma cells via suppression of the Erk signaling pathway Corrigendum in /10.3892/or.2022.8337. Oncology Reports, 40, 3285-3296. https://doi.org/10.3892/or.2018.6744
MLA
Wu, H., Li, X., Feng, M., Yao, L., Deng, Z., Zao, G., Zhou, Y., Chen, S., Du, Z."Downregulation of RNF138 inhibits cellular proliferation, migration, invasion and EMT in glioma cells via suppression of the Erk signaling pathway Corrigendum in /10.3892/or.2022.8337". Oncology Reports 40.6 (2018): 3285-3296.
Chicago
Wu, H., Li, X., Feng, M., Yao, L., Deng, Z., Zao, G., Zhou, Y., Chen, S., Du, Z."Downregulation of RNF138 inhibits cellular proliferation, migration, invasion and EMT in glioma cells via suppression of the Erk signaling pathway Corrigendum in /10.3892/or.2022.8337". Oncology Reports 40, no. 6 (2018): 3285-3296. https://doi.org/10.3892/or.2018.6744
Copy and paste a formatted citation
x
Spandidos Publications style
Wu H, Li X, Feng M, Yao L, Deng Z, Zao G, Zhou Y, Chen S and Du Z: Downregulation of RNF138 inhibits cellular proliferation, migration, invasion and EMT in glioma cells via suppression of the Erk signaling pathway Corrigendum in /10.3892/or.2022.8337. Oncol Rep 40: 3285-3296, 2018.
APA
Wu, H., Li, X., Feng, M., Yao, L., Deng, Z., Zao, G. ... Du, Z. (2018). Downregulation of RNF138 inhibits cellular proliferation, migration, invasion and EMT in glioma cells via suppression of the Erk signaling pathway Corrigendum in /10.3892/or.2022.8337. Oncology Reports, 40, 3285-3296. https://doi.org/10.3892/or.2018.6744
MLA
Wu, H., Li, X., Feng, M., Yao, L., Deng, Z., Zao, G., Zhou, Y., Chen, S., Du, Z."Downregulation of RNF138 inhibits cellular proliferation, migration, invasion and EMT in glioma cells via suppression of the Erk signaling pathway Corrigendum in /10.3892/or.2022.8337". Oncology Reports 40.6 (2018): 3285-3296.
Chicago
Wu, H., Li, X., Feng, M., Yao, L., Deng, Z., Zao, G., Zhou, Y., Chen, S., Du, Z."Downregulation of RNF138 inhibits cellular proliferation, migration, invasion and EMT in glioma cells via suppression of the Erk signaling pathway Corrigendum in /10.3892/or.2022.8337". Oncology Reports 40, no. 6 (2018): 3285-3296. https://doi.org/10.3892/or.2018.6744
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