Long non-coding RNA FOXD2-AS1 plays an oncogenic role in hepatocellular carcinoma by targeting miR‑206

Chang,Yuanhong; Zhang,Jie; Zhou,Cancan; Qiu,Guanglin; Wang,Guanghui; Wang,Shufeng; Chang,Xinming; Li,Xuqi; Fan,Lin

doi:10.3892/or.2018.6752

Long non-coding RNA FOXD2-AS1 plays an oncogenic role in hepatocellular carcinoma by targeting miR‑206

Authors:
- Yuanhong Chang
- Jie Zhang
- Cancan Zhou
- Guanglin Qiu
- Guanghui Wang
- Shufeng Wang
- Xinming Chang
- Xuqi Li
- Lin Fan
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Affiliations: Department of Gastroenterology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China, First Department of General Surgery, Shaanxi Provincial Tumor Hospital, Xi'an, Shaanxi 710068, P.R. China, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China, Department of General Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China
Published online on: September 28, 2018 https://doi.org/10.3892/or.2018.6752
Pages: 3625-3634

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Abstract

Recently, long non-coding RNA (lncRNA) FOXD2 adjacent opposite strand RNA 1 (FOXD2-AS1) has been recognized to function as an oncogene in several human tumors, and FOXD2‑AS1 dysregulation has been closely associated with carcinogenesis and tumor progression. Nevertheless, the correlation between the aberrant expression of FOXD2‑AS1 and the prognosis of hepatocellular carcinoma (HCC) has not yet been elucidated. In the present study, FOXD2‑AS1 was found to be overexpressed in HCC tissues, and FOXD2‑AS1 overexpression resulted in significantly shortened patient survival. FOXD2‑AS1 overexpression enhanced the viability and metastasis of HCC cells in vitro and in vivo, as revealed by MTT, wound healing and cell migration assays. In addition, mechanistic studies revealed that FOXD2‑AS1 upregulated the expression of the miR‑206 target gene annexin A2 (ANXA2) by acting as a miR‑206 sponge. In summary, FOXD2‑AS1 was concluded to function as an oncogene in HCC and to upregulate ANXA2 expression in part by ‘sponging’ miR‑206.

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