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Pectolinarigenin inhibits non‑small cell lung cancer progression by regulating the PTEN/PI3K/AKT signaling pathway

  • Authors:
    • Fei Xu
    • Xuan Gao
    • Huiyun Pan
  • View Affiliations / Copyright

    Affiliations: Department of Internal Medicine Ward, The First Affiliated Hospital of the College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China, Department of Respiratory Diseases, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang 310012, P.R. China
    Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3458-3468
    |
    Published online on: October 2, 2018
       https://doi.org/10.3892/or.2018.6759
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Abstract

Lung cancer is the principal cause of cancer‑­associated mortality. Pectolinarigenin (Pec) reportedly has effective antitumor activity against certain cancer types. Phosphatase and tensin homolog (PTEN) is a well‑known tumor suppressor and serves a vital role in cancer progression. However, the effect of Pec on non‑small cell lung cancer (NSCLC) cell proliferation and metastasis, and the underlying mechanism, has not yet been elucidated. In the present study, it was demonstrated that Pec inhibited the proliferation of A549 and Calu‑3 cells in dose‑ and time‑dependent manners. The apoptosis rate significantly increased with increasing doses of Pec. Apoptosis‑associated protein expression was additionally altered by Pec exposure. Pec was able to suppress the metastasis of NSCLC cells; it upregulated the mRNA and protein expression levels of E‑cadherin, and downregulated the mRNA and protein expression levels of vimentin. Additionally, Pec was able to activate PTEN and subsequently downregulate the PI3K/protein kinase B (AKT) signaling pathway. In summary, Pec was able to inhibit cell proliferation, promote apoptosis and suppress metastasis in NSCLC cells through the PTEN/PI3K/AKT signaling pathway, indicating that Pec is a potential agent for NSCLC therapy.
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Copy and paste a formatted citation
Spandidos Publications style
Xu F, Gao X and Pan H: Pectolinarigenin inhibits non‑small cell lung cancer progression by regulating the PTEN/PI3K/AKT signaling pathway. Oncol Rep 40: 3458-3468, 2018.
APA
Xu, F., Gao, X., & Pan, H. (2018). Pectolinarigenin inhibits non‑small cell lung cancer progression by regulating the PTEN/PI3K/AKT signaling pathway. Oncology Reports, 40, 3458-3468. https://doi.org/10.3892/or.2018.6759
MLA
Xu, F., Gao, X., Pan, H."Pectolinarigenin inhibits non‑small cell lung cancer progression by regulating the PTEN/PI3K/AKT signaling pathway". Oncology Reports 40.6 (2018): 3458-3468.
Chicago
Xu, F., Gao, X., Pan, H."Pectolinarigenin inhibits non‑small cell lung cancer progression by regulating the PTEN/PI3K/AKT signaling pathway". Oncology Reports 40, no. 6 (2018): 3458-3468. https://doi.org/10.3892/or.2018.6759
Copy and paste a formatted citation
x
Spandidos Publications style
Xu F, Gao X and Pan H: Pectolinarigenin inhibits non‑small cell lung cancer progression by regulating the PTEN/PI3K/AKT signaling pathway. Oncol Rep 40: 3458-3468, 2018.
APA
Xu, F., Gao, X., & Pan, H. (2018). Pectolinarigenin inhibits non‑small cell lung cancer progression by regulating the PTEN/PI3K/AKT signaling pathway. Oncology Reports, 40, 3458-3468. https://doi.org/10.3892/or.2018.6759
MLA
Xu, F., Gao, X., Pan, H."Pectolinarigenin inhibits non‑small cell lung cancer progression by regulating the PTEN/PI3K/AKT signaling pathway". Oncology Reports 40.6 (2018): 3458-3468.
Chicago
Xu, F., Gao, X., Pan, H."Pectolinarigenin inhibits non‑small cell lung cancer progression by regulating the PTEN/PI3K/AKT signaling pathway". Oncology Reports 40, no. 6 (2018): 3458-3468. https://doi.org/10.3892/or.2018.6759
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